DE69637651D1 - Kombinationstherapie für osteoporose - Google Patents

Kombinationstherapie für osteoporose

Info

Publication number
DE69637651D1
DE69637651D1 DE69637651T DE69637651T DE69637651D1 DE 69637651 D1 DE69637651 D1 DE 69637651D1 DE 69637651 T DE69637651 T DE 69637651T DE 69637651 T DE69637651 T DE 69637651T DE 69637651 D1 DE69637651 D1 DE 69637651D1
Authority
DE
Germany
Prior art keywords
kombinationstherapie
osteoporose
für
kombinationstherapie für
für osteoporose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637651T
Other languages
English (en)
Inventor
Hua Zhu Ke
David D Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69637651D1 publication Critical patent/DE69637651D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
DE69637651T 1996-02-28 1996-12-23 Kombinationstherapie für osteoporose Expired - Lifetime DE69637651D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1241296P 1996-02-28 1996-02-28
PCT/IB1996/001462 WO1997031640A1 (en) 1996-02-28 1996-12-23 Combination therapy for osteoporosis

Publications (1)

Publication Number Publication Date
DE69637651D1 true DE69637651D1 (en) 2008-10-02

Family

ID=21754846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637651T Expired - Lifetime DE69637651D1 (en) 1996-02-28 1996-12-23 Kombinationstherapie für osteoporose

Country Status (45)

Country Link
US (2) US6323232B1 (de)
EP (3) EP1932543A3 (de)
JP (2) JPH11504352A (de)
KR (1) KR19990087337A (de)
CN (5) CN1515317A (de)
AP (3) AP974A (de)
AR (2) AR005987A1 (de)
AT (1) ATE405273T1 (de)
AU (1) AU703285B2 (de)
BG (1) BG64582B1 (de)
BR (1) BR9612533A (de)
CA (1) CA2247420C (de)
CL (1) CL2004000119A1 (de)
CO (1) CO4761063A1 (de)
CZ (1) CZ297452B6 (de)
DE (1) DE69637651D1 (de)
DK (1) DK0883404T3 (de)
DZ (1) DZ2186A1 (de)
ES (1) ES2312169T3 (de)
GT (2) GT199700009A (de)
HK (1) HK1018210A1 (de)
HN (1) HN1996000101A (de)
HR (1) HRP970118A2 (de)
HU (1) HUP9904123A3 (de)
ID (1) ID19886A (de)
IL (3) IL125493A0 (de)
IS (1) IS4812A (de)
MA (1) MA26420A1 (de)
NO (2) NO323648B1 (de)
NZ (1) NZ323456A (de)
OA (1) OA10837A (de)
PE (2) PE58998A1 (de)
PL (2) PL187219B1 (de)
PT (1) PT883404E (de)
RU (1) RU2190395C2 (de)
SI (1) SI0883404T1 (de)
SK (1) SK118398A3 (de)
TN (1) TNSN97040A1 (de)
TR (1) TR199801679T2 (de)
TW (1) TW464496B (de)
UA (1) UA69372C2 (de)
UY (1) UY24472A1 (de)
WO (1) WO1997031640A1 (de)
YU (1) YU7797A (de)
ZA (1) ZA971719B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
AR008155A1 (es) * 1996-09-06 1999-12-09 Smithkline Beecham Corp Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres.
GB2324726A (en) * 1997-05-01 1998-11-04 Merck & Co Inc Combination Therapy for the Treatment of Osteoporosis
SE9702401D0 (sv) * 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
AU7349298A (en) * 1997-06-23 1999-01-04 Pfizer Inc. Prostaglandin agonists
CN1269720A (zh) * 1997-09-09 2000-10-11 普罗克特和甘保尔公司 增加骨容量的方法
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
EP0950417A3 (de) * 1998-02-23 2000-02-23 Pfizer Products Inc. Behandlung von Skeletterkrankungen
CN1303379A (zh) * 1998-06-03 2001-07-11 辉瑞产品公司 作为氧化氮合酶抑制剂的含稠环取代基的2-氨基吡啶
PA8471201A1 (es) * 1998-06-16 2000-09-29 Pfizer Prod Inc Combinaciones terapeuticas que comprenden un modulador del receptor de estrogenos selectivo y hormona paratiroidea
AU3342099A (en) * 1998-06-16 2000-01-05 Pfizer Products Inc. Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty
DK0966968T3 (da) 1998-06-16 2004-08-30 Pfizer Prod Inc Terapeutiske kombinationer, der omfatter en selektiv östrogenreceptormodulator og prostaglandin E2
PA8475901A1 (es) * 1998-06-16 2000-05-24 Pfizer Prod Inc Terapia de combinacion para la fragilidad musculoesqueletica
EP1004306A3 (de) * 1998-08-06 2000-06-07 Pfizer Products Inc. Estrogen Agonisten/Antagonisten
US6414006B1 (en) 1998-10-15 2002-07-02 Merck Frosst Canada & Co. Methods for inhibiting bone resorption
HUP0104192A3 (en) 1998-11-03 2003-12-29 Pfizer Prod Inc Novel macrolide antibiotics
NZ513827A (en) * 1999-03-05 2001-09-28 Procter & Gamble Methods of increasing bone volume using non-naturally-occurring FP selective agonists and antiresorptive compounds
GB9913649D0 (en) * 1999-06-11 1999-08-11 Karobio Ab Estrogen receptor
EP1113007A1 (de) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
CO5251465A1 (es) 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
KR100795870B1 (ko) * 2000-06-01 2008-01-21 왓슨 파머수티컬즈, 인코포레이티드 라소폭시펜의 경피적 송달
EP1192945A3 (de) * 2000-09-21 2004-03-03 Pfizer Products Inc. Verwendung von einem Östrogen Agonist/Antagonist zur Behandlung von Osteoarthritis
IL145876A0 (en) * 2000-10-17 2002-07-25 Pfizer Prod Inc Methods and kits for improving vascular health
EP1210951B1 (de) * 2000-11-30 2005-02-02 Pfizer Products Inc. Östrogen Agonist-Antagonist und Testosteron enthaltende Zusammensetzung zur Behandlung abnehmender Testosteronspiegel
PL367094A1 (en) * 2001-07-31 2005-02-21 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
MY143244A (en) 2002-11-26 2011-04-15 Smithkline Beecham Corp Calcilytic compounds
US8853423B2 (en) 2010-06-17 2014-10-07 Seragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
WO2013049507A1 (en) 2011-09-30 2013-04-04 Perio Sciences, Llc Antioxidant compositions for treatment of inflammation or oxidative damage
CN103142644B (zh) * 2013-03-21 2014-07-23 青岛正大海尔制药有限公司 骨化三醇和氟化钠的混悬颗粒及其制备方法
KR102623130B1 (ko) 2016-10-11 2024-01-10 듀크 유니버시티 Er+ 유방암의 라소폭시펜 치료
CN117771239A (zh) 2018-04-10 2024-03-29 杜克大学 乳腺癌的拉索昔芬治疗
CN112384634B (zh) * 2018-04-24 2024-04-16 深圳华大生命科学研究院 骨质疏松生物标志物及其用途
CN110412289B (zh) * 2019-07-25 2022-08-02 北京美迪阿姆科技发展有限公司 抑制性t细胞及筛选方法和抑制自身免疫反应中的应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274213A (en) 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3234090A (en) 1962-09-10 1966-02-08 Ciba Geigy Corp Pharmaceutical compositions comprising saturated basic ethers
BE637389A (de) 1962-09-13
US3522319A (en) 1964-01-23 1970-07-28 Ciba Geigy Corp Phenol substituted tetrahydronaphthalenes useful as estrogenics
US3822287A (en) 1969-04-17 1974-07-02 Rexall Drug Chemical Process for preparation of substituted 3,4-(diphenyl)chromans
US3927197A (en) 1974-04-19 1975-12-16 Pfizer Tertiary alcohol stabilized E-series prostaglandins
US3932389A (en) 1974-12-11 1976-01-13 Pfizer Inc. 2-Descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-.omega.-pentanorprostaglandins
US3982016A (en) 1975-08-06 1976-09-21 Pfizer Inc. Bone deposition by 16-aryl-13,14-dihydro-PGE2 p-biphenyl esters
US4000309A (en) 1975-08-06 1976-12-28 Pfizer Inc. Bone deposition by 16-aryl-13,14-dihydro-PGE2 p-biphenyl esters
US4018892A (en) 1975-08-06 1977-04-19 Pfizer Inc. Bone deposition by 16-aryl-13,14-dihydro-PGE2 p-biphenyl esters
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4132847A (en) 1977-07-22 1979-01-02 Pfizer Inc. 4-Pyrone prostaglandin antagonists
DE2860900D1 (en) 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4097601A (en) 1977-08-26 1978-06-27 Pfizer Inc. Bone deposition by 2-descarboxy-2-(tetrazol-5-yl)-11-dexosy-16-aryl prostaglandins
US4171331A (en) 1978-06-05 1979-10-16 Miles Laboratories, Inc. 1 And 2-substituted analogues of certain prostaglandins
US4219483A (en) 1978-09-11 1980-08-26 Pfizer Inc. 4-Pyrone prostaglandin antagonists
DE3046719C2 (de) 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4621100A (en) 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
US4904478A (en) 1983-08-11 1990-02-27 Mission Pharmacal Company Slow-release sodium fluoride tablet and method for treatment of osteoporosis
DE3587956T2 (de) 1984-04-30 1995-05-24 Procter & Gamble Ausrüstung für die Verwendung bei der Behandlung von Osteoporose.
US4729999A (en) 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
GB2196003A (en) 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
US5216183A (en) 1988-04-19 1993-06-01 Teijin Limited Cyclopentanone/cyclopentenone derivative
JP2557779B2 (ja) 1990-11-26 1996-11-27 アール. レッカー,ロバート 2成分型骨粗鬆症用薬剤
JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5180720A (en) 1991-05-03 1993-01-19 G. D. Searle & Co. 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
US5409911A (en) 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
RU2168512C2 (ru) 1992-12-11 2001-06-10 Мерк Энд Ко., Инк. Спиропиперидины, способы их получения (варианты)
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
TW383306B (en) 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
TW303299B (de) 1993-07-22 1997-04-21 Lilly Co Eli
EP0813414A4 (de) * 1993-10-19 1999-07-21 Merck & Co Inc Kombination von bisphosphonaten und die wachstumshormonsekretion fördernden stoffen
SK56296A3 (en) 1993-11-09 1997-02-05 Merck & Co Inc Piperidinal, pyrrolidinal and hexahydro-1h-azepinal derivatives, manufacturing process thereof and pharmaceutical compositions containing them
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
EP0730578A4 (de) 1993-11-24 1997-10-08 Merck & Co Inc Indolyl-gruppen enthaltende verbindungen und deren verwendung zur förderung der freisetzung von wachstumshormonen
US5441966A (en) 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting Turner's syndrome
WO1995034311A1 (en) 1994-06-13 1995-12-21 Merck & Co., Inc. Piperazine compounds promote release of growth hormone
CA2199251A1 (en) * 1994-09-09 1996-03-14 Ann Dunbar Geddes Phosphonates and parathyroid hormone for osteoporosis
US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5767124A (en) 1995-10-27 1998-06-16 Merck & Co., Inc. Polymorphic forms of a growth hormone secretagogue
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
HN1996000101A (es) 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
IL120270A0 (en) 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US6100301A (en) 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
TW491847B (en) 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
AU730856C (en) 1996-05-07 2001-11-15 Pfizer Inc. Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)- indol-2-one(=ziprasidone),it's preparation and it's use as dopamine D2 antagonist
PL330239A1 (en) 1996-05-31 1999-05-10 Novo Nordisk As Growt hormone constituent and bone reserption preventing factor in cyclic (coherent) treatment
GB2324726A (en) 1997-05-01 1998-11-04 Merck & Co Inc Combination Therapy for the Treatment of Osteoporosis
UA53716C2 (uk) * 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
BR9803596A (pt) 1997-09-23 2000-04-25 Pfizer Prod Inc Derivados do resorcinol.
PA8471201A1 (es) * 1998-06-16 2000-09-29 Pfizer Prod Inc Combinaciones terapeuticas que comprenden un modulador del receptor de estrogenos selectivo y hormona paratiroidea

Also Published As

Publication number Publication date
HK1018210A1 (en) 1999-12-17
NO20063853L (no) 1998-08-27
CZ297452B6 (cs) 2006-12-13
ATE405273T1 (de) 2008-09-15
PT883404E (pt) 2008-11-14
PL187219B1 (pl) 2004-06-30
SI0883404T1 (sl) 2008-10-31
HRP970118A2 (en) 1998-04-30
IL154379A0 (en) 2003-09-17
CN1515317A (zh) 2004-07-28
BG102726A (en) 1999-04-30
EP1236475A2 (de) 2002-09-04
EP1932543A3 (de) 2012-01-04
CL2004000119A1 (es) 2005-02-11
PE20011302A1 (es) 2001-12-25
EP0883404A1 (de) 1998-12-16
AR005987A1 (es) 1999-07-21
CO4761063A1 (es) 1999-04-27
AP9700934A0 (en) 1997-04-30
US20010009920A1 (en) 2001-07-26
KR19990087337A (ko) 1999-12-27
RU2190395C2 (ru) 2002-10-10
CN1515258A (zh) 2004-07-28
AP2000001962A0 (en) 2000-12-31
BG64582B1 (bg) 2005-08-31
GT199700009A (es) 1998-07-10
CN1209064A (zh) 1999-02-24
EP0883404B1 (de) 2008-08-20
MA26420A1 (fr) 2004-12-20
ID19886A (id) 1998-08-13
AU1039897A (en) 1997-09-16
CZ271898A3 (cs) 1999-06-16
IL154380A0 (en) 2003-09-17
ZA971719B (en) 1998-08-27
CN1515316A (zh) 2004-07-28
EP1932543A2 (de) 2008-06-18
UA69372C2 (en) 2004-09-15
AR060853A2 (es) 2008-07-16
CA2247420A1 (en) 1997-09-04
US7255984B2 (en) 2007-08-14
NZ323456A (en) 2001-03-30
CN1242813C (zh) 2006-02-22
WO1997031640A1 (en) 1997-09-04
SK118398A3 (en) 2000-07-11
IL125493A0 (en) 1999-03-12
TW464496B (en) 2001-11-21
ES2312169T3 (es) 2009-02-16
JP2002308771A (ja) 2002-10-23
AU703285B2 (en) 1999-03-25
GT199700009AA (es) 1999-01-23
AP1179A (en) 2003-06-30
DK0883404T3 (da) 2008-10-20
PL328831A1 (en) 1999-02-15
PE58998A1 (es) 1998-10-16
YU7797A (sh) 2000-10-30
OA10837A (en) 2001-08-13
IS4812A (is) 1998-07-28
BR9612533A (pt) 1999-07-20
AP975A (en) 2001-06-12
CA2247420C (en) 2011-02-15
NO323648B1 (no) 2007-06-18
HUP9904123A3 (en) 2001-01-29
NO983936D0 (no) 1998-08-27
US6323232B1 (en) 2001-11-27
HN1996000101A (es) 1997-06-26
CN1515254A (zh) 2004-07-28
AP974A (en) 2001-06-12
AP2002002661A0 (en) 2002-12-31
HUP9904123A2 (hu) 2000-05-28
DZ2186A1 (fr) 2002-12-02
NO983936L (no) 1998-08-27
TR199801679T2 (xx) 2001-06-21
PL187962B1 (pl) 2004-11-30
TNSN97040A1 (fr) 2005-03-15
UY24472A1 (es) 2000-09-29
JPH11504352A (ja) 1999-04-20
EP1236475A3 (de) 2003-11-05

Similar Documents

Publication Publication Date Title
DE69637651D1 (en) Kombinationstherapie für osteoporose
DE69818001D1 (en) Osteosynthesesystem für wirbelarthrodese
DE69811237D1 (en) Extrusionsmechanismus für aerosole
DE69526362D1 (en) Mehrfach-pulsstimulation für cochleare-implantate
DE69630235D1 (en) Prothese für anuloplastie
DE69730840D1 (en) Shunt für intravasale bifurkationsprothese
DE69634986D1 (en) Modulares wandlersystem
DE59704951D1 (en) Plättchenförmiges titandioxidpigment
DE69608577D1 (en) Thermostabiler schalldämmstoff
DE69702926D1 (en) Polyurethanhartschäume
DE69705420D1 (en) Polyurethanhartschäume
DE69708059D1 (en) Thiophenopyrimidine
DE59705192D1 (en) Lcp-blends
DE59711450D1 (en) Arylalkanoylpyridazine
DE59700372D1 (en) Blockcopolymere
DE69703480D1 (en) Anionische photokatalysator
DE69621466D1 (en) Thermoplastische hydroxy-phenoxyetherpolymerverbundwerkstoffe
DE69534598D1 (en) Immunotest für mycophenolsäure
DE59707730D1 (en) Peripheralpumpe
DE69716959D1 (en) Robustes navigationssystem für golfplätze
DE59704086D1 (en) Twin-dualmode-filter
DE59703905D1 (en) Linearmotorgetriebene transportanlage
DE59810852D1 (en) Röntgendiagnostikgerät für tomosynthese
HRP970556B1 (en) Candy-toy
DE69725010D1 (en) Halter für computertastatur

Legal Events

Date Code Title Description
8364 No opposition during term of opposition