BG64582B1 - Фармацевтичен състав за комбинирана терапия на остеопороза и използване - Google Patents
Фармацевтичен състав за комбинирана терапия на остеопороза и използване Download PDFInfo
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- BG64582B1 BG64582B1 BG102726A BG10272698A BG64582B1 BG 64582 B1 BG64582 B1 BG 64582B1 BG 102726 A BG102726 A BG 102726A BG 10272698 A BG10272698 A BG 10272698A BG 64582 B1 BG64582 B1 BG 64582B1
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- Prior art keywords
- compound
- phenyl
- pharmaceutical composition
- cis
- hydroxy
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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| US1241296P | 1996-02-28 | 1996-02-28 | |
| PCT/IB1996/001462 WO1997031640A1 (en) | 1996-02-28 | 1996-12-23 | Combination therapy for osteoporosis |
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| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| HN1996000101A (es) | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
| AR008155A1 (es) * | 1996-09-06 | 1999-12-09 | Smithkline Beecham Corp | Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres. |
| GB2324726A (en) * | 1997-05-01 | 1998-11-04 | Merck & Co Inc | Combination Therapy for the Treatment of Osteoporosis |
| SE9702401D0 (sv) * | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| WO1998058911A2 (en) * | 1997-06-23 | 1998-12-30 | Pfizer Inc. | Prostaglandin agonists |
| AU9130298A (en) * | 1997-09-09 | 1999-03-29 | Procter & Gamble Company, The | Method of increasing bone volume |
| UA67754C2 (uk) | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
| EP0950417A3 (de) * | 1998-02-23 | 2000-02-23 | Pfizer Products Inc. | Behandlung von Skeletterkrankungen |
| ATE287876T1 (de) * | 1998-06-03 | 2005-02-15 | Pfizer Prod Inc | 2-aminopyridine mit kondensierten ringsubstituenten als stickstoff-oxid-synthase inhibitoren |
| CN1305378A (zh) * | 1998-06-16 | 2001-07-25 | 辉瑞产品公司 | 治疗肌与骨骼的脆性的(选择性)雌激素受体调节剂(serm)和生长激素促分泌素(ghs)的药物组合物 |
| ES2220005T3 (es) * | 1998-06-16 | 2004-12-01 | Pfizer Products Inc. | Combinaciones terapeuticas que comprenden un modulador selectivo del receptor de estrogeno y prostaglandina e2. |
| PA8475901A1 (es) * | 1998-06-16 | 2000-05-24 | Pfizer Prod Inc | Terapia de combinacion para la fragilidad musculoesqueletica |
| PA8471201A1 (es) * | 1998-06-16 | 2000-09-29 | Pfizer Prod Inc | Combinaciones terapeuticas que comprenden un modulador del receptor de estrogenos selectivo y hormona paratiroidea |
| EP1004306A3 (de) * | 1998-08-06 | 2000-06-07 | Pfizer Products Inc. | Estrogen Agonisten/Antagonisten |
| US6414006B1 (en) | 1998-10-15 | 2002-07-02 | Merck Frosst Canada & Co. | Methods for inhibiting bone resorption |
| OA11670A (en) | 1998-11-03 | 2005-01-12 | Pfizer Prod Inc | Novel macrolide antibiotics. |
| EP1158987A1 (de) * | 1999-03-05 | 2001-12-05 | The Procter & Gamble Company | Verfahren zur erhohung des knochenvolumens mittels nicht natürlich vorkommenden fp agonisten und antiresorptiva |
| GB9913649D0 (en) * | 1999-06-11 | 1999-08-11 | Karobio Ab | Estrogen receptor |
| EP1113007A1 (de) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten |
| CO5251465A1 (es) | 2000-01-26 | 2003-02-28 | Pfizer Prod Inc | Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol |
| PT1229909E (pt) * | 2000-06-01 | 2004-04-30 | Watson Pharmaceiticals Inc | Entrega transdermica de lasofoxifeno |
| EP1192945A3 (de) * | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Verwendung von einem Östrogen Agonist/Antagonist zur Behandlung von Osteoarthritis |
| TWI303990B (en) * | 2000-10-17 | 2008-12-11 | Pfizer Prod Inc | New use of estrogen agonists/antagonists for improving vascular health |
| EP1210951B1 (de) * | 2000-11-30 | 2005-02-02 | Pfizer Products Inc. | Östrogen Agonist-Antagonist und Testosteron enthaltende Zusammensetzung zur Behandlung abnehmender Testosteronspiegel |
| CA2448235A1 (en) * | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| UY28089A1 (es) | 2002-11-26 | 2004-06-30 | Smithkline Beecham Corp | Compuestos calciliticos |
| WO2011159769A2 (en) | 2010-06-17 | 2011-12-22 | Aragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| CA2849910A1 (en) | 2011-09-30 | 2013-04-04 | Perio Sciences, Llc | Antioxidant compositions for treatment of inflammation or oxidative damage |
| CN103142644B (zh) * | 2013-03-21 | 2014-07-23 | 青岛正大海尔制药有限公司 | 骨化三醇和氟化钠的混悬颗粒及其制备方法 |
| KR102623130B1 (ko) | 2016-10-11 | 2024-01-10 | 듀크 유니버시티 | Er+ 유방암의 라소폭시펜 치료 |
| WO2019199891A1 (en) | 2018-04-10 | 2019-10-17 | Duke University | Lasofoxifene treatment of breast cancer |
| CN112384634B (zh) * | 2018-04-24 | 2024-04-16 | 深圳华大生命科学研究院 | 骨质疏松生物标志物及其用途 |
| CN110412289B (zh) * | 2019-07-25 | 2022-08-02 | 北京美迪阿姆科技发展有限公司 | 抑制性t细胞及筛选方法和抑制自身免疫反应中的应用 |
| GB202116903D0 (en) | 2021-11-18 | 2022-01-05 | Sermonix Pharmaceuticals Inc | Lasofoxifene treatment of aromatase-resistant er+ cancer |
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| BR9803596A (pt) | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivados do resorcinol. |
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- 1996-12-23 PL PL35998796A patent/PL187962B1/pl not_active IP Right Cessation
- 1996-12-23 UA UA98073901A patent/UA69372C2/uk unknown
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1997
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1999
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2000
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254594A (en) * | 1991-04-09 | 1993-10-19 | Klinge Pharma Gmbh | Remedies for bone diseases |
| WO1994006750A1 (en) * | 1992-09-11 | 1994-03-31 | Merck & Co., Inc. | Prostaglandin analog for treating osteoporosis |
| EP0605193A1 (de) * | 1992-12-22 | 1994-07-06 | Eli Lilly And Company | Verwendung von Benzothiophene zur Behandlung von Hypercholesterolämie |
| EP0635270A1 (de) * | 1993-07-22 | 1995-01-25 | Eli Lilly And Company | Parathyroid-Hormon und Raloxifen zum Vermehren von Knochenmasse |
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