BG64532B1 - Метод за получаване на 8-алкокси- и 8-бензокси-хинолонкарбоксилни киселини - Google Patents

Метод за получаване на 8-алкокси- и 8-бензокси-хинолонкарбоксилни киселини Download PDF

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Publication number
BG64532B1
BG64532B1 BG104467A BG10446700A BG64532B1 BG 64532 B1 BG64532 B1 BG 64532B1 BG 104467 A BG104467 A BG 104467A BG 10446700 A BG10446700 A BG 10446700A BG 64532 B1 BG64532 B1 BG 64532B1
Authority
BG
Bulgaria
Prior art keywords
formula
solvent
compound
process according
methanol
Prior art date
Application number
BG104467A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104467A (en
Inventor
Reinhold Gehring
Klaus Mohrs
Werner Heilmann
Herbert Diehl
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG104467A publication Critical patent/BG104467A/xx
Publication of BG64532B1 publication Critical patent/BG64532B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG104467A 1997-11-24 2000-05-22 Метод за получаване на 8-алкокси- и 8-бензокси-хинолонкарбоксилни киселини BG64532B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19751948A DE19751948A1 (de) 1997-11-24 1997-11-24 Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren

Publications (2)

Publication Number Publication Date
BG104467A BG104467A (en) 2001-08-31
BG64532B1 true BG64532B1 (bg) 2005-06-30

Family

ID=7849617

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104467A BG64532B1 (bg) 1997-11-24 2000-05-22 Метод за получаване на 8-алкокси- и 8-бензокси-хинолонкарбоксилни киселини

Country Status (41)

Country Link
US (2) US6897315B2 (es)
EP (1) EP1034173B1 (es)
JP (1) JP4445667B2 (es)
KR (1) KR100589549B1 (es)
CN (2) CN1151151C (es)
AR (1) AR016694A1 (es)
AT (1) ATE294169T1 (es)
AU (1) AU732977B2 (es)
BG (1) BG64532B1 (es)
BR (1) BRPI9814894B8 (es)
CA (2) CA2311540C (es)
CO (1) CO5011069A1 (es)
CU (1) CU22953A3 (es)
CZ (1) CZ297212B6 (es)
DE (2) DE19751948A1 (es)
DK (1) DK1034173T3 (es)
EE (1) EE04281B1 (es)
ES (1) ES2241185T3 (es)
HK (2) HK1034080A1 (es)
HN (1) HN1998000179A (es)
HR (1) HRP20000332B1 (es)
HU (1) HU228337B1 (es)
ID (1) ID26840A (es)
IL (1) IL135866A0 (es)
IN (1) IN189753B (es)
MY (1) MY129324A (es)
NO (1) NO315748B1 (es)
NZ (1) NZ504657A (es)
PE (1) PE20000007A1 (es)
PL (1) PL192461B1 (es)
PT (1) PT1034173E (es)
RU (1) RU2219175C2 (es)
SI (1) SI1034173T1 (es)
SK (1) SK285492B6 (es)
SV (1) SV1998000139A (es)
TR (1) TR200001472T2 (es)
TW (1) TW513427B (es)
UA (1) UA56286C2 (es)
UY (1) UY25265A1 (es)
WO (1) WO1999026940A2 (es)
ZA (1) ZA9810669B (es)

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US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
ES2332367T5 (es) * 2003-04-09 2013-12-17 Dr. Reddy's Laboratories Ltd. Forma cristalina III de clorhidrato de moxifloxacina anhidro y su procedimiento de preparación
EP1651630A1 (en) * 2003-08-05 2006-05-03 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride
US7164023B2 (en) 2003-09-04 2007-01-16 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
ITMI20032259A1 (it) * 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
WO2006134491A2 (en) * 2005-06-14 2006-12-21 Aurobindo Pharma Limited New crystalline form of moxifloxacin hydrochloride and process for its preparation
ES2311391B1 (es) * 2007-02-07 2009-12-22 Quimica Sintetica, S.A. Forma cristalina de moxifloxacino base.
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
IT1398952B1 (it) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN102030751B (zh) * 2010-12-01 2012-11-21 上虞京新药业有限公司 一种盐酸莫西沙星的结晶工艺
CN104447742A (zh) * 2014-11-17 2015-03-25 安徽美诺华药物化学有限公司 一种喹诺酮衍生物的制备方法
CN104370906A (zh) * 2014-11-17 2015-02-25 安徽美诺华药物化学有限公司 氟喹诺酮衍生物的制备方法
CN104370907A (zh) * 2014-11-17 2015-02-25 安徽美诺华药物化学有限公司 喹诺酮衍生物的制备方法
CN104447741A (zh) * 2014-11-17 2015-03-25 安徽美诺华药物化学有限公司 一种氟喹诺酮衍生物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106489A2 (en) * 1982-09-09 1984-04-25 Warner-Lambert Company Antibacterial agents
EP0230295A2 (en) * 1986-01-21 1987-07-29 Kyorin Pharmaceutical Co., Ltd. 8-alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same
EP0241206A2 (en) * 1986-03-31 1987-10-14 Sankyo Company Limited Quinoline-3-carboxylic acid derivatives, their preparation and use
EP0350733A2 (de) * 1988-07-15 1990-01-17 Bayer Ag 7-(1-Pyrrolidinyl)-3-chinolon- und -naphthyridoncarbon-säure-Derivate, Verfahren zu ihrer Herstellung sowie substituierte mono-und bicyclische Pyrrolidinderivate als Zwischenprodukte zu ihrer Herstellung, und sie enthaltende antibakterielle Mittel und Futterzusatzstoffe
EP0550903A1 (de) * 1992-01-10 1993-07-14 Bayer Ag Chinolon- und Naphthyridon-Carbonsäurederivate als antibakterielles Mittel

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
PT77267B (en) * 1982-09-07 1986-03-21 Lilly Co Eli Improved process for preparing novel octahydrobenz <f> isoquinolines or compounds relating thereto
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
EP0342675B1 (en) * 1988-05-19 1995-01-25 Chugai Seiyaku Kabushiki Kaisha Novel quinolonecarboxylic acid derivatives
CA1336090C (en) 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
WO1990006305A1 (en) 1988-12-09 1990-06-14 Dainippon Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivatives, process for their preparation and medicinal composition containing same
JP2761566B2 (ja) 1989-03-10 1998-06-04 吉富製薬株式会社 ピリドンカルボン酸化合物
WO1992009579A1 (en) 1990-11-30 1992-06-11 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compound and its use
JPH05117238A (ja) 1991-10-23 1993-05-14 Chugai Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法及びその合成中間体
WO1993022308A1 (en) 1992-04-28 1993-11-11 Chugai Seiyaku Kabushiki Kaisha Process for producing quinolonecarboxylic acid derivative
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4232172A1 (de) 1992-09-25 1994-03-31 Bayer Ag 7-(Aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)chinolon- und Naphthyridoncarbonsäure-Derivate
DE4234078A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
DE4234330A1 (de) 1992-10-12 1994-04-14 Bayer Ag Chinoloncarbonsäuren
WO1994014794A1 (en) * 1992-12-28 1994-07-07 Yoshitomi Pharmaceutical Industries, Ltd. 8-methoxyquinolonecarboxylic acid derivative
CA2114981A1 (en) * 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
US5631266A (en) * 1993-04-26 1997-05-20 Korea Research Institute Of Chemical Technology Quinolone carboxylic acid derivatives and process for preparing the same
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
GB2289674A (en) 1994-05-23 1995-11-29 Pfizer Antibacterial naphthyridine
DE4435479A1 (de) 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
AU713704B2 (en) * 1996-01-31 1999-12-09 Sankyo Company Limited Agents for the treatment and prevention of aids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106489A2 (en) * 1982-09-09 1984-04-25 Warner-Lambert Company Antibacterial agents
EP0230295A2 (en) * 1986-01-21 1987-07-29 Kyorin Pharmaceutical Co., Ltd. 8-alkoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process of preparing the same
EP0241206A2 (en) * 1986-03-31 1987-10-14 Sankyo Company Limited Quinoline-3-carboxylic acid derivatives, their preparation and use
EP0350733A2 (de) * 1988-07-15 1990-01-17 Bayer Ag 7-(1-Pyrrolidinyl)-3-chinolon- und -naphthyridoncarbon-säure-Derivate, Verfahren zu ihrer Herstellung sowie substituierte mono-und bicyclische Pyrrolidinderivate als Zwischenprodukte zu ihrer Herstellung, und sie enthaltende antibakterielle Mittel und Futterzusatzstoffe
EP0550903A1 (de) * 1992-01-10 1993-07-14 Bayer Ag Chinolon- und Naphthyridon-Carbonsäurederivate als antibakterielles Mittel

Also Published As

Publication number Publication date
US20050209276A1 (en) 2005-09-22
HK1034080A1 (en) 2001-10-12
KR100589549B1 (ko) 2006-06-14
US6897315B2 (en) 2005-05-24
HU228337B1 (en) 2013-03-28
HUP0004337A3 (en) 2004-07-28
CA2711645C (en) 2016-04-26
JP2001524477A (ja) 2001-12-04
WO1999026940A2 (de) 1999-06-03
US7115744B2 (en) 2006-10-03
CU22953A3 (es) 2004-06-21
HRP20000332B1 (en) 2009-01-31
EE04281B1 (et) 2004-04-15
CN1151151C (zh) 2004-05-26
BRPI9814894B1 (pt) 2011-10-18
IL135866A0 (en) 2001-05-20
EP1034173B1 (de) 2005-04-27
SI1034173T1 (en) 2005-10-31
CO5011069A1 (es) 2001-02-28
PL341088A1 (en) 2001-03-26
PT1034173E (pt) 2005-08-31
AR016694A1 (es) 2001-07-25
US20030208069A1 (en) 2003-11-06
MY129324A (en) 2007-03-30
IN189753B (es) 2003-04-19
HRP20000332A2 (en) 2001-04-30
CA2711645A1 (en) 1999-06-03
CN1279683A (zh) 2001-01-10
CA2311540C (en) 2011-06-14
SK285492B6 (sk) 2007-02-01
NO20002637L (no) 2000-05-23
AU732977B2 (en) 2001-05-03
BRPI9814894A (pt) 2000-10-03
DK1034173T3 (da) 2005-07-25
CZ297212B6 (cs) 2006-10-11
DE19751948A1 (de) 1999-05-27
NO315748B1 (no) 2003-10-20
ATE294169T1 (de) 2005-05-15
ES2241185T3 (es) 2005-10-16
BRPI9814894B8 (pt) 2021-07-06
CZ20001926A3 (cs) 2000-11-15
CN1200938C (zh) 2005-05-11
NZ504657A (en) 2001-04-27
HUP0004337A2 (hu) 2001-10-28
WO1999026940A3 (de) 1999-08-12
SV1998000139A (es) 1999-04-13
ZA9810669B (en) 1999-05-26
TW513427B (en) 2002-12-11
KR20010032361A (ko) 2001-04-16
HN1998000179A (es) 1999-02-09
HK1056169A1 (en) 2004-02-06
EE200000241A (et) 2001-06-15
CA2311540A1 (en) 1999-06-03
EP1034173A2 (de) 2000-09-13
CN1418879A (zh) 2003-05-21
UY25265A1 (es) 1999-07-19
PE20000007A1 (es) 2000-03-05
RU2219175C2 (ru) 2003-12-20
SK7482000A3 (en) 2000-10-09
UA56286C2 (uk) 2003-05-15
DE59812758D1 (de) 2005-06-02
ID26840A (id) 2001-02-15
TR200001472T2 (tr) 2002-06-21
BG104467A (en) 2001-08-31
NO20002637D0 (no) 2000-05-23
JP4445667B2 (ja) 2010-04-07
AU1561999A (en) 1999-06-15
PL192461B1 (pl) 2006-10-31

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