UY25265A1 - Procedimiento para la preparacion de acidos 8-alcoxi-quinoloncarboxilicos. - Google Patents
Procedimiento para la preparacion de acidos 8-alcoxi-quinoloncarboxilicos.Info
- Publication number
- UY25265A1 UY25265A1 UY25265A UY25265A UY25265A1 UY 25265 A1 UY25265 A1 UY 25265A1 UY 25265 A UY25265 A UY 25265A UY 25265 A UY25265 A UY 25265A UY 25265 A1 UY25265 A1 UY 25265A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- cyclopropyl
- acids
- moc
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
La presente invención se refiere a un procedimiento para la preparación de ácidos 8-metoxi-3-quinoloncarboxílicos, los cuales representan antibióticos con elevada actividad antibacteriana frente a bacterias gram-negativas y gram-positivas. Por consiguiente el objetivo de dicha invención es un procedimiento para la preparación de compuestos de fórmula (I), en la que: R1 representa alquilo, FCH2-CH2, ciclopropil, fenilo o ciclopropilo, dado el caso mono a trisustituido con halógeno; R2 representa alquilo; R3 representa H, halógeno, NH2 o CH3; y el anillo que forman R'-R"-N se selecciona de las estructuras de la figura 2; caracterizado porque se hacen reaccionar derivados de ácidos 8-halógeno-3-quinoloncarboxílicos de fórmula (II), en la que Hal representa flúor o cloro; y R1, R3 y el anillo formado por R'-R"-N tiene el significado anteriormente indicado, en un éter alifático o cicloalifático de 4 a 6 átomos de carbono como disolvente en presencia de alcanoles con M-O-C-(CH3)3 ó M-O-C-(CH3)2-C2H5 en las que M representa sodio o potasio. El disolvente se selecciona del grupo constituido por dimetoxietano, dioxano y tetrahidrofurano. Por ejemplo: ácido 1-ciclopropil-7-((S,S)-2,8-diazabiciclo(4.3.0)-non-8-il)-6-fluoro-1,4-dihidro-8-metoxi-4-oxo-3-qionoloncarboxílico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19751948A DE19751948A1 (de) | 1997-11-24 | 1997-11-24 | Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25265A1 true UY25265A1 (es) | 1999-07-19 |
Family
ID=7849617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25265A UY25265A1 (es) | 1997-11-24 | 1998-11-24 | Procedimiento para la preparacion de acidos 8-alcoxi-quinoloncarboxilicos. |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6897315B2 (es) |
| EP (1) | EP1034173B1 (es) |
| JP (1) | JP4445667B2 (es) |
| KR (1) | KR100589549B1 (es) |
| CN (2) | CN1151151C (es) |
| AR (1) | AR016694A1 (es) |
| AT (1) | ATE294169T1 (es) |
| AU (1) | AU732977B2 (es) |
| BG (1) | BG64532B1 (es) |
| BR (1) | BRPI9814894B8 (es) |
| CA (2) | CA2711645C (es) |
| CO (1) | CO5011069A1 (es) |
| CU (1) | CU22953A3 (es) |
| CZ (1) | CZ297212B6 (es) |
| DE (2) | DE19751948A1 (es) |
| DK (1) | DK1034173T3 (es) |
| EE (1) | EE04281B1 (es) |
| ES (1) | ES2241185T3 (es) |
| HK (2) | HK1034080A1 (es) |
| HN (1) | HN1998000179A (es) |
| HR (1) | HRP20000332B1 (es) |
| HU (1) | HU228337B1 (es) |
| ID (1) | ID26840A (es) |
| IL (1) | IL135866A0 (es) |
| IN (1) | IN189753B (es) |
| MY (1) | MY129324A (es) |
| NO (1) | NO315748B1 (es) |
| NZ (1) | NZ504657A (es) |
| PE (1) | PE20000007A1 (es) |
| PL (1) | PL192461B1 (es) |
| PT (1) | PT1034173E (es) |
| RU (1) | RU2219175C2 (es) |
| SI (1) | SI1034173T1 (es) |
| SK (1) | SK285492B6 (es) |
| SV (1) | SV1998000139A (es) |
| TR (1) | TR200001472T2 (es) |
| TW (1) | TW513427B (es) |
| UA (1) | UA56286C2 (es) |
| UY (1) | UY25265A1 (es) |
| WO (1) | WO1999026940A2 (es) |
| ZA (1) | ZA9810669B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
| US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
| US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
| ES2332367T5 (es) * | 2003-04-09 | 2013-12-17 | Dr. Reddy's Laboratories Ltd. | Forma cristalina III de clorhidrato de moxifloxacina anhidro y su procedimiento de preparación |
| US20060264635A1 (en) * | 2003-08-05 | 2006-11-23 | Chava Satyanarayana | Process for the preparation of moxifloxacin hydrochloride |
| JP5255183B2 (ja) | 2003-09-04 | 2013-08-07 | ウォックハート リミテッド | ベンゾキノリジン−２−カルボン酸アルギニン塩四水和物 |
| ITMI20032259A1 (it) * | 2003-11-20 | 2005-05-21 | Chemi Spa | Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione |
| US7759362B2 (en) * | 2004-04-21 | 2010-07-20 | Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences | Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof |
| WO2006134491A2 (en) * | 2005-06-14 | 2006-12-21 | Aurobindo Pharma Limited | New crystalline form of moxifloxacin hydrochloride and process for its preparation |
| ES2311391B1 (es) * | 2007-02-07 | 2009-12-22 | Quimica Sintetica, S.A. | Forma cristalina de moxifloxacino base. |
| EP2154137A1 (en) | 2008-08-04 | 2010-02-17 | Chemo Ibérica, S.A. | Crystalline form of moxifloxacin base |
| IT1393337B1 (it) | 2009-03-06 | 2012-04-20 | Italiana Sint Spa | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
| IT1398952B1 (it) | 2010-03-19 | 2013-03-28 | F S I Fabbrica Italiana Sint | Processo di preparazione della moxifloxacina e suoi sali |
| CN102030751B (zh) * | 2010-12-01 | 2012-11-21 | 上虞京新药业有限公司 | 一种盐酸莫西沙星的结晶工艺 |
| CN104370907A (zh) * | 2014-11-17 | 2015-02-25 | 安徽美诺华药物化学有限公司 | 喹诺酮衍生物的制备方法 |
| CN104447741A (zh) * | 2014-11-17 | 2015-03-25 | 安徽美诺华药物化学有限公司 | 一种氟喹诺酮衍生物的制备方法 |
| CN104447742A (zh) * | 2014-11-17 | 2015-03-25 | 安徽美诺华药物化学有限公司 | 一种喹诺酮衍生物的制备方法 |
| CN104370906A (zh) * | 2014-11-17 | 2015-02-25 | 安徽美诺华药物化学有限公司 | 氟喹诺酮衍生物的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT77267B (en) * | 1982-09-07 | 1986-03-21 | Lilly Co Eli | Improved process for preparing novel octahydrobenz <f> isoquinolines or compounds relating thereto |
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| JPS62205060A (ja) * | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | ８位置換キノロンカルボン酸誘導体 |
| CN1019114B (zh) * | 1986-03-31 | 1992-11-18 | 三共株式会社 | 喹啉-3-羟酸衍生物的制备方法 |
| ATE117685T1 (de) * | 1988-05-19 | 1995-02-15 | Chugai Pharmaceutical Co Ltd | Chinoloncarbonsäure-derivate. |
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| CA1336090C (en) | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
| AU4638889A (en) | 1988-12-09 | 1990-06-26 | Dainippon Pharmaceutical Co. Ltd. | Quinolonecarboxylic acid derivatives, process for their preparation and medicinal composition containing same |
| JP2761566B2 (ja) | 1989-03-10 | 1998-06-04 | 吉富製薬株式会社 | ピリドンカルボン酸化合物 |
| WO1992009579A1 (en) | 1990-11-30 | 1992-06-11 | Yoshitomi Pharmaceutical Industries, Ltd. | Quinolonecarboxylic acid compound and its use |
| JPH05117238A (ja) | 1991-10-23 | 1993-05-14 | Chugai Pharmaceut Co Ltd | キノロンカルボン酸誘導体の製造方法及びその合成中間体 |
| TW209865B (es) | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| AU4022593A (en) | 1992-04-28 | 1993-11-29 | Chugai Seiyaku Kabushiki Kaisha | Process for producing quinolonecarboxylic acid derivative |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| DE4230804A1 (de) | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
| DE4232172A1 (de) | 1992-09-25 | 1994-03-31 | Bayer Ag | 7-(Aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)chinolon- und Naphthyridoncarbonsäure-Derivate |
| DE4234078A1 (de) | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| DE4234330A1 (de) | 1992-10-12 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| EP0677522A4 (en) * | 1992-12-28 | 1995-12-27 | Yoshitomi Pharmaceutical | 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE. |
| CA2114981A1 (en) * | 1993-02-09 | 1994-08-10 | Kazumi Ogata | Quinolonecarboxylic acid derivatives |
| AU4272793A (en) * | 1993-04-24 | 1994-11-21 | Korea Research Institute Of Chemical Technology | Novel quinolone carboxylic acid derivatives and process for preparing the same |
| US5631266A (en) * | 1993-04-26 | 1997-05-20 | Korea Research Institute Of Chemical Technology | Quinolone carboxylic acid derivatives and process for preparing the same |
| KR950018003A (ko) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | 신규한 퀴놀론 유도체 및 그의 제조 방법 |
| GB2289674A (en) | 1994-05-23 | 1995-11-29 | Pfizer | Antibacterial naphthyridine |
| DE4435479A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| DE19546249A1 (de) | 1995-12-12 | 1997-06-19 | Bayer Ag | Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| CZ238698A3 (cs) * | 1996-01-31 | 1998-12-16 | Sankyo Company, Limited | Prostředky pro léčení a prevenci AIDS |
-
1997
- 1997-11-24 DE DE19751948A patent/DE19751948A1/de not_active Withdrawn
-
1998
- 1998-11-12 SK SK748-2000A patent/SK285492B6/sk not_active IP Right Cessation
- 1998-11-12 KR KR1020007005597A patent/KR100589549B1/ko not_active IP Right Cessation
- 1998-11-12 DE DE59812758T patent/DE59812758D1/de not_active Expired - Lifetime
- 1998-11-12 JP JP2000522098A patent/JP4445667B2/ja not_active Expired - Lifetime
- 1998-11-12 AU AU15619/99A patent/AU732977B2/en not_active Expired
- 1998-11-12 ES ES98959874T patent/ES2241185T3/es not_active Expired - Lifetime
- 1998-11-12 AT AT98959874T patent/ATE294169T1/de active
- 1998-11-12 PL PL341088A patent/PL192461B1/pl unknown
- 1998-11-12 DK DK98959874T patent/DK1034173T3/da active
- 1998-11-12 RU RU2000116546/04A patent/RU2219175C2/ru active
- 1998-11-12 CN CNB988114445A patent/CN1151151C/zh not_active Expired - Lifetime
- 1998-11-12 EP EP98959874A patent/EP1034173B1/de not_active Expired - Lifetime
- 1998-11-12 SI SI9830772T patent/SI1034173T1/xx unknown
- 1998-11-12 HU HU0004337A patent/HU228337B1/hu active Protection Beyond IP Right Term
- 1998-11-12 IL IL13586698A patent/IL135866A0/xx not_active IP Right Cessation
- 1998-11-12 CZ CZ20001926A patent/CZ297212B6/cs not_active IP Right Cessation
- 1998-11-12 BR BRPI9814894-0 patent/BRPI9814894B8/pt not_active IP Right Cessation
- 1998-11-12 ID IDW20000981A patent/ID26840A/id unknown
- 1998-11-12 EE EEP200000241A patent/EE04281B1/xx unknown
- 1998-11-12 WO PCT/EP1998/007237 patent/WO1999026940A2/de active IP Right Grant
- 1998-11-12 CA CA2711645A patent/CA2711645C/en not_active Expired - Lifetime
- 1998-11-12 NZ NZ504657A patent/NZ504657A/en not_active IP Right Cessation
- 1998-11-12 CA CA2311540A patent/CA2311540C/en not_active Expired - Lifetime
- 1998-11-12 PT PT98959874T patent/PT1034173E/pt unknown
- 1998-11-12 TR TR2000/01472T patent/TR200001472T2/xx unknown
- 1998-11-18 IN IN3456DE1998 patent/IN189753B/en unknown
- 1998-11-20 MY MYPI98005283A patent/MY129324A/en unknown
- 1998-11-23 TW TW087119353A patent/TW513427B/zh not_active IP Right Cessation
- 1998-11-23 PE PE1998001139A patent/PE20000007A1/es not_active IP Right Cessation
- 1998-11-23 ZA ZA9810669A patent/ZA9810669B/xx unknown
- 1998-11-24 SV SV1998000139A patent/SV1998000139A/es not_active Application Discontinuation
- 1998-11-24 AR ARP980105947A patent/AR016694A1/es active IP Right Grant
- 1998-11-24 UY UY25265A patent/UY25265A1/es unknown
- 1998-11-24 CO CO98069225A patent/CO5011069A1/es unknown
- 1998-11-24 HN HN1998000179A patent/HN1998000179A/es unknown
- 1998-12-11 UA UA2000063686A patent/UA56286C2/uk unknown
-
2000
- 2000-05-22 BG BG104467A patent/BG64532B1/bg unknown
- 2000-05-23 NO NO20002637A patent/NO315748B1/no not_active IP Right Cessation
- 2000-05-23 HR HR20000332A patent/HRP20000332B1/xx not_active IP Right Cessation
- 2000-05-24 CU CU20000115A patent/CU22953A3/es unknown
-
2001
- 2001-07-03 HK HK01104581A patent/HK1034080A1/xx not_active IP Right Cessation
-
2002
- 2002-09-04 CN CNB021319626A patent/CN1200938C/zh not_active Expired - Lifetime
-
2003
- 2003-04-03 US US10/406,129 patent/US6897315B2/en not_active Expired - Lifetime
- 2003-11-18 HK HK03108394A patent/HK1056169A1/xx not_active IP Right Cessation
-
2005
- 2005-05-11 US US11/127,811 patent/US7115744B2/en not_active Expired - Lifetime
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