BG64448B1 - 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them - Google Patents

1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them Download PDF

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Publication number
BG64448B1
BG64448B1 BG104112A BG10411200A BG64448B1 BG 64448 B1 BG64448 B1 BG 64448B1 BG 104112 A BG104112 A BG 104112A BG 10411200 A BG10411200 A BG 10411200A BG 64448 B1 BG64448 B1 BG 64448B1
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BG
Bulgaria
Prior art keywords
group
alkyl
phenyl
pyrido
formula
Prior art date
Application number
BG104112A
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Bulgarian (bg)
English (en)
Other versions
BG104112A (en
Inventor
Ferrer Jordi Gracia
Crespo Ma Isabel Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of BG104112A publication Critical patent/BG104112A/xx
Publication of BG64448B1 publication Critical patent/BG64448B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG104112A 1997-07-29 2000-01-27 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them BG64448B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.

Publications (2)

Publication Number Publication Date
BG104112A BG104112A (en) 2001-01-31
BG64448B1 true BG64448B1 (en) 2005-02-28

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104112A BG64448B1 (en) 1997-07-29 2000-01-27 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Country Status (36)

Country Link
US (2) US6407108B1 (zh)
EP (1) EP1001955B1 (zh)
JP (1) JP4320118B2 (zh)
KR (1) KR20010022353A (zh)
CN (1) CN1135231C (zh)
AR (1) AR015927A1 (zh)
AT (1) ATE207069T1 (zh)
AU (1) AU737709B2 (zh)
BG (1) BG64448B1 (zh)
BR (1) BR9810829B1 (zh)
CA (1) CA2298935A1 (zh)
CO (1) CO4970780A1 (zh)
CZ (1) CZ290208B6 (zh)
DE (1) DE69802100T2 (zh)
DK (1) DK1001955T3 (zh)
EE (1) EE04313B1 (zh)
EG (1) EG24041A (zh)
ES (2) ES2137113B1 (zh)
HK (1) HK1024914A1 (zh)
HU (1) HUP0004708A3 (zh)
ID (1) ID24506A (zh)
IL (1) IL134081A (zh)
MY (1) MY118796A (zh)
NO (1) NO315118B1 (zh)
NZ (1) NZ502356A (zh)
PE (1) PE111099A1 (zh)
PL (1) PL191031B1 (zh)
PT (1) PT1001955E (zh)
RU (1) RU2202552C2 (zh)
SI (1) SI1001955T1 (zh)
SK (1) SK284046B6 (zh)
TR (1) TR200000243T2 (zh)
TW (1) TW542837B (zh)
UA (1) UA60339C2 (zh)
WO (1) WO1999006404A1 (zh)
ZA (1) ZA986248B (zh)

Families Citing this family (37)

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FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
MXPA02001830A (es) 1999-08-21 2002-08-12 Byk Gulden Lomberg Chem Fab Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor.
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
ES2282469T3 (es) * 2001-09-19 2007-10-16 Nycomed Gmbh Combinacion de un nsaid y un inhibidor de pde-4.
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
CA2504820C (en) * 2002-11-06 2011-08-23 Grelan Pharmaceutical Co., Ltd. Pyrazolonaphthyridine derivatives
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP5055494B2 (ja) * 2005-06-10 2012-10-24 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性阻害剤
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006289838B2 (en) 2005-09-15 2011-08-18 Aska Pharmaceutical Co., Ltd. Heterocyclic compound, and production process and use thereof
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
US7683060B2 (en) 2006-08-07 2010-03-23 Incyte Corporation Triazolotriazines as kinase inhibitors
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
LT3034075T (lt) 2006-11-22 2018-11-26 Incyte Holdings Corporation Imidazotriazinai ir imidazopirimidinai kaip kinazės inhibitoriai
EP2231669A1 (en) * 2008-01-09 2010-09-29 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Phosphodiesterase inhibitors
NZ589622A (en) 2008-05-21 2012-10-26 Incyte Corp Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
SG182297A1 (en) 2009-12-31 2012-08-30 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
AU2011269788B2 (en) 2010-02-03 2015-12-10 Incyte Holdings Corporation Imidazo[1,2-b][1,2,4]triazines as c-Met inhibitors
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085840A1 (en) * 1982-01-18 1983-08-17 Gruppo Lepetit S.P.A. New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives

Family Cites Families (4)

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DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
AU7238191A (en) * 1990-02-19 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
JP3245165B2 (ja) * 1991-10-09 2002-01-07 シンテックス（ユー・エス・エイ）・インコーポレイテッド ピリドピリダジノンおよびピリダジンチオン化合物
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0085840A1 (en) * 1982-01-18 1983-08-17 Gruppo Lepetit S.P.A. New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives

Also Published As

Publication number Publication date
SK284046B6 (sk) 2004-08-03
MY118796A (en) 2005-01-31
CZ290208B6 (cs) 2002-06-12
HK1024914A1 (en) 2000-10-27
JP4320118B2 (ja) 2009-08-26
WO1999006404A1 (en) 1999-02-11
BG104112A (en) 2001-01-31
IL134081A0 (en) 2001-04-30
EP1001955B1 (en) 2001-10-17
EE200000052A (et) 2000-10-16
CZ2000333A3 (cs) 2000-05-17
SK862000A3 (en) 2000-07-11
AU8861298A (en) 1999-02-22
US20020183326A1 (en) 2002-12-05
ES2137113B1 (es) 2000-09-16
IL134081A (en) 2004-02-08
SI1001955T1 (en) 2002-02-28
BR9810829B1 (pt) 2009-08-11
HUP0004708A2 (hu) 2001-07-30
PL191031B1 (pl) 2006-03-31
PT1001955E (pt) 2002-02-28
ID24506A (id) 2000-07-20
NO20000394L (no) 2000-03-27
NZ502356A (en) 2001-03-30
EG24041A (en) 2008-04-03
AR015927A1 (es) 2001-05-30
JP2001512121A (ja) 2001-08-21
ES2162466T3 (es) 2001-12-16
HUP0004708A3 (en) 2002-11-28
KR20010022353A (ko) 2001-03-15
ES2137113A1 (es) 1999-12-01
NO20000394D0 (no) 2000-01-26
RU2202552C2 (ru) 2003-04-20
CO4970780A1 (es) 2000-11-07
DE69802100D1 (de) 2001-11-22
NO315118B1 (no) 2003-07-14
EP1001955A1 (en) 2000-05-24
CN1266434A (zh) 2000-09-13
ZA986248B (en) 1999-02-05
BR9810829A (pt) 2000-07-25
CN1135231C (zh) 2004-01-21
UA60339C2 (uk) 2003-10-15
ATE207069T1 (de) 2001-11-15
EE04313B1 (et) 2004-06-15
TW542837B (en) 2003-07-21
DK1001955T3 (da) 2001-11-19
AU737709B2 (en) 2001-08-30
PE111099A1 (es) 1999-11-18
CA2298935A1 (en) 1999-02-11
DE69802100T2 (de) 2002-03-14
US6407108B1 (en) 2002-06-18
TR200000243T2 (tr) 2000-07-21
PL338214A1 (en) 2000-10-09

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