BG61420B2 - 3-метилов естер 5-етилов естер на 2,6-диметил-4-(2,3- дихлорофенил)-1,4-дихидропиридин-3,5-дикарбоксиловата киселина,притежаващ хипотензивни свойства,метод за неговото получаване и фармацевтични препарати, които ги съдържат - Google Patents
3-метилов естер 5-етилов естер на 2,6-диметил-4-(2,3- дихлорофенил)-1,4-дихидропиридин-3,5-дикарбоксиловата киселина,притежаващ хипотензивни свойства,метод за неговото получаване и фармацевтични препарати, които ги съдържат Download PDFInfo
- Publication number
- BG61420B2 BG61420B2 BG98595A BG9859594A BG61420B2 BG 61420 B2 BG61420 B2 BG 61420B2 BG 98595 A BG98595 A BG 98595A BG 9859594 A BG9859594 A BG 9859594A BG 61420 B2 BG61420 B2 BG 61420B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- compound
- formula
- dimethyl
- dihydropyridine
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7807404A SE429652B (sv) | 1978-06-30 | 1978-06-30 | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
Publications (1)
Publication Number | Publication Date |
---|---|
BG61420B2 true BG61420B2 (bg) | 1997-07-31 |
Family
ID=20335348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG98595A BG61420B2 (bg) | 1978-06-30 | 1994-02-25 | 3-метилов естер 5-етилов естер на 2,6-диметил-4-(2,3- дихлорофенил)-1,4-дихидропиридин-3,5-дикарбоксиловата киселина,притежаващ хипотензивни свойства,метод за неговото получаване и фармацевтични препарати, които ги съдържат |
Country Status (24)
Country | Link |
---|---|
US (1) | US4264611A (es) |
EP (1) | EP0007293B1 (es) |
JP (1) | JPS559083A (es) |
AT (1) | ATE1237T1 (es) |
AU (1) | AU529116B2 (es) |
BG (1) | BG61420B2 (es) |
CA (1) | CA1117530A (es) |
CS (1) | CS241021B2 (es) |
CY (1) | CY1299A (es) |
DD (1) | DD144667A5 (es) |
DE (1) | DE2963150D1 (es) |
DK (1) | DK148978C (es) |
FI (1) | FI70573C (es) |
HK (1) | HK60585A (es) |
HU (1) | HU178568B (es) |
IE (1) | IE48650B1 (es) |
LU (2) | LU88666I2 (es) |
NL (2) | NL930054I2 (es) |
NO (3) | NO151965C (es) |
NZ (1) | NZ190809A (es) |
SE (1) | SE429652B (es) |
SG (1) | SG26085G (es) |
SU (2) | SU856380A3 (es) |
ZA (1) | ZA792804B (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
IL68604A0 (en) * | 1982-05-21 | 1983-09-30 | Haessle Ab | Processes for preparing therapeutically active dihydropyridines and intermediates for the processes |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
DE3307422A1 (de) * | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
DE3339236A1 (de) * | 1983-10-28 | 1985-05-09 | Bayer Ag | Arzneimittelzubereitung |
DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
FI852359L (fi) * | 1984-06-27 | 1985-12-28 | Hoffmann La Roche | Dihydropyridinderivat. |
US4757071A (en) * | 1984-12-14 | 1988-07-12 | Nisshin Flour Milling Co., Ltd. | 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases |
DE3447169A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3447170A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
NZ220022A (en) * | 1986-04-22 | 1990-04-26 | Byk Gulden Lomberg Chem Fab | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
JPS63255071A (ja) * | 1987-04-14 | 1988-10-21 | 株式会社 岡田吾作郎商店 | 磁石内蔵健康棒 |
AT391269B (de) * | 1988-12-30 | 1990-09-10 | Burghart Kurt | Pharmazeutische zubereitung |
US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
JPH07501551A (ja) * | 1991-12-02 | 1995-02-16 | セプラコア,インコーポレーテッド | 光学的に純粋なs(−)フェロジピンを用いる,高血圧,狭心症および他の疾患を治療するための方法および組成物 |
US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
DE59410255D1 (de) * | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
SE9600086D0 (sv) * | 1996-01-10 | 1996-01-10 | Astra Ab | New manufacturing process |
IT1283793B1 (it) * | 1996-08-23 | 1998-04-30 | Lusochimica Spa | Processo per la preparazione di diidropiridine |
EP1108710A4 (en) * | 1998-07-23 | 2001-11-21 | Chen Ing Jun | GUAIACOXYPROPANOLAMINE WITH ALPHA / BETA ADRENERGIC INHIBIT ACTIVITY |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6569456B2 (en) | 2000-01-13 | 2003-05-27 | Osmotica Corp. | Osmotic device containing diltiazem and an ACE inhibitor or diuretic |
KR100756565B1 (ko) * | 2000-04-11 | 2007-09-07 | 상꾜 가부시키가이샤 | 칼슘 채널 블록커를 함유하는 안정화된 약제 조성물 |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
MXPA05001958A (es) | 2002-08-19 | 2005-04-28 | Pfizer Prod Inc | Terapia de combinacion para enfermedades hiperproliferativas. |
EA009646B1 (ru) * | 2003-05-30 | 2008-02-28 | Рэнбакси Лабораториз Лтд. | Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
CN101090714A (zh) * | 2004-07-26 | 2007-12-19 | 康泽里克斯公司 | 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症 |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
TW200744583A (en) * | 2006-03-14 | 2007-12-16 | Ranbaxy Lab Ltd | Statin stabilizing dosage formulations |
MX2009000439A (es) * | 2006-07-14 | 2009-02-04 | Ranbaxy Lab Ltd | Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas. |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
US8748648B2 (en) * | 2007-09-06 | 2014-06-10 | Nektar Therapeutics | Oligomer-calcium channel blocker conjugates |
US20090118258A1 (en) * | 2007-11-07 | 2009-05-07 | Bruce Damiano | Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists |
WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
CN102827068A (zh) * | 2011-06-17 | 2012-12-19 | 张锐豪 | 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法 |
MX2014002163A (es) | 2011-08-26 | 2014-09-25 | Wockhardt Ltd | Métodos para el tratamiento de desórdenes cardiovasculares. |
CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
CN104177286A (zh) * | 2014-08-11 | 2014-12-03 | 广东东阳光药业有限公司 | 一种地平类药物的制备方法 |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
KR101824982B1 (ko) | 2015-10-07 | 2018-02-02 | 엘지전자 주식회사 | 차량 및 그 제어방법 |
CN107952483B (zh) * | 2017-12-18 | 2020-07-28 | 万华化学集团股份有限公司 | 一种催化剂,使用该催化剂的反应器,以及一种制备β-苯乙醇的方法 |
CN108840819B (zh) * | 2018-04-02 | 2021-07-30 | 常州瑞明药业有限公司 | 一种非洛地平的制备方法 |
US11417416B2 (en) | 2018-06-14 | 2022-08-16 | Astrazeneca Uk Limited | Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition |
CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3441648A (en) * | 1967-02-07 | 1969-04-29 | Smithkline Corp | Compositions and methods for lowering blood pressure with 1,4-dihydropyridines |
DE1670824C3 (de) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridin-33-dicarbonsäurealkylester |
DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2117572C3 (de) * | 1971-04-10 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1978
- 1978-06-30 SE SE7807404A patent/SE429652B/sv unknown
-
1979
- 1979-06-06 ZA ZA792804A patent/ZA792804B/xx unknown
- 1979-06-12 EP EP79850057A patent/EP0007293B1/en not_active Expired
- 1979-06-12 AT AT79850057T patent/ATE1237T1/de active
- 1979-06-12 LU LU88666C patent/LU88666I2/fr unknown
- 1979-06-12 DE DE7979850057T patent/DE2963150D1/de not_active Expired
- 1979-06-12 CY CY1299A patent/CY1299A/xx unknown
- 1979-06-19 US US06/050,083 patent/US4264611A/en not_active Expired - Lifetime
- 1979-06-22 AU AU48316/79A patent/AU529116B2/en not_active Expired
- 1979-06-22 NO NO792112A patent/NO151965C/no unknown
- 1979-06-25 NZ NZ190809A patent/NZ190809A/xx unknown
- 1979-06-28 CA CA000330762A patent/CA1117530A/en not_active Expired
- 1979-06-28 DD DD79213967A patent/DD144667A5/de unknown
- 1979-06-29 HU HU79HE788A patent/HU178568B/hu unknown
- 1979-06-29 CS CS794585A patent/CS241021B2/cs unknown
- 1979-06-29 FI FI792058A patent/FI70573C/fi not_active IP Right Cessation
- 1979-06-29 DK DK275079A patent/DK148978C/da active
- 1979-06-29 SU SU792781817A patent/SU856380A3/ru active
- 1979-06-30 JP JP8206279A patent/JPS559083A/ja active Granted
- 1979-08-08 IE IE1217/79A patent/IE48650B1/en not_active IP Right Cessation
-
1980
- 1980-05-15 SU SU802921246A patent/SU915799A3/ru active
-
1985
- 1985-04-06 SG SG260/85A patent/SG26085G/en unknown
- 1985-08-15 HK HK605/85A patent/HK60585A/xx not_active IP Right Cessation
-
1993
- 1993-06-10 NL NL930054C patent/NL930054I2/nl unknown
- 1993-06-16 LU LU88306C patent/LU88306I2/fr unknown
-
1994
- 1994-02-25 BG BG98595A patent/BG61420B2/bg unknown
- 1994-06-29 NL NL940012C patent/NL940012I1/nl unknown
- 1994-12-21 NO NO1994026C patent/NO1994026I1/no unknown
-
1996
- 1996-06-24 NO NO1996006C patent/NO1996006I1/no unknown
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