BG61369B2 - Нови оксими производни на еритромицин а, получаването им,приложението им като лекарствени средстваи съдържащите ги фармацевтични състави - Google Patents

Нови оксими производни на еритромицин а, получаването им,приложението им като лекарствени средстваи съдържащите ги фармацевтични състави Download PDF

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Publication number
BG61369B2
BG61369B2 BG98506A BG9850694A BG61369B2 BG 61369 B2 BG61369 B2 BG 61369B2 BG 98506 A BG98506 A BG 98506A BG 9850694 A BG9850694 A BG 9850694A BG 61369 B2 BG61369 B2 BG 61369B2
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BG
Bulgaria
Prior art keywords
radical
formula
product
products
erythromycin
Prior art date
Application number
BG98506A
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Bulgarian (bg)
English (en)
Inventor
D'ambrieres Solange Gouin
Andre Lutz
Jean-Claude Gasc
Original Assignee
Roussel Uclaf
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Publication date
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Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of BG61369B2 publication Critical patent/BG61369B2/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BG98506A 1980-01-11 1994-02-22 Нови оксими производни на еритромицин а, получаването им,приложението им като лекарствени средстваи съдържащите ги фармацевтични състави BG61369B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8000566A FR2473525A1 (fr) 1980-01-11 1980-01-11 Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
BG61369B2 true BG61369B2 (bg) 1997-06-30

Family

ID=9237443

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98506A BG61369B2 (bg) 1980-01-11 1994-02-22 Нови оксими производни на еритромицин а, получаването им,приложението им като лекарствени средстваи съдържащите ги фармацевтични състави

Country Status (25)

Country Link
US (1) US4349545A (da)
EP (1) EP0033255B1 (da)
JP (1) JPS56100799A (da)
KR (1) KR850000964B1 (da)
AU (1) AU537247B2 (da)
BG (1) BG61369B2 (da)
CA (1) CA1162535A (da)
CY (1) CY1319A (da)
DE (1) DE3165720D1 (da)
DK (1) DK157878C (da)
ES (1) ES8200702A1 (da)
FI (1) FI69473C (da)
FR (1) FR2473525A1 (da)
GR (1) GR73103B (da)
GT (1) GT198500080A (da)
HK (1) HK586A (da)
HU (1) HU187760B (da)
IE (1) IE50680B1 (da)
IL (1) IL61808A (da)
LU (1) LU88283I2 (da)
MY (1) MY8500984A (da)
NL (1) NL930097I2 (da)
OA (1) OA06719A (da)
PT (1) PT72331B (da)
ZA (1) ZA808108B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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FR2534588B2 (fr) * 1982-10-15 1985-09-20 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
DK149776C (da) * 1984-01-06 1987-04-21 Orion Yhtymae Oy Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
DE3668894D1 (en) 1985-03-12 1990-03-15 Beecham Group Plc Erythromycin-derivate.
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0260938B1 (en) 1986-09-18 1992-12-09 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for preparing the same
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
EP0503932B1 (en) 1991-03-15 1998-12-02 Merck & Co. Inc. 9-Deoxo-9(z)-hydroxy-iminoerythromycin A and O-derivatives thereof
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
ES2036472B1 (es) * 1991-10-01 1994-03-01 Prodesfarma Sa Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina).
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CA2189001A1 (en) * 1994-04-26 1995-11-02 Nobuhiro Narita Medicinal composition as a remedy for nonsmall cell lung cancer
IT1276901B1 (it) * 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5929219A (en) 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
PT102202B (pt) 1998-09-10 2001-04-30 Hovione Sociedade Quimica S A Processo para a purificacao de roxitromicina
IN190782B (da) * 1998-09-30 2003-08-23 Max India Ltd
DE69813244T2 (de) * 1998-11-24 2004-03-04 Jubilant Organosys Ltd. Verfahren zur Herstellung von Roxithromycin und Derivate davon
RU2002116232A (ru) * 1999-12-16 2004-01-10 Тева Фамэситикл Индастрис Лтд. (Il) Способ получения полиморфных модификаций кларитромицина и новой полиморфной модификации IV
DK1280535T3 (da) * 2000-01-11 2005-04-04 Teva Pharma Processer til fremstilling af clarithromycin polymorfer
WO2001064224A1 (en) * 2000-02-29 2001-09-07 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
EP1435359A1 (en) * 2002-12-31 2004-07-07 Alembic Limited A process for the purification of roxithromycin
KR20090042971A (ko) 2006-08-24 2009-05-04 욱크하르트 리서치 센터 항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
US20090005326A1 (en) * 2007-06-26 2009-01-01 Idexx Laboratories, Inc. Single dose roxithromycin
AU2011340204B2 (en) 2010-12-09 2016-04-14 Wockhardt Limited Ketolide compounds
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
ES2603227T3 (es) 2011-03-22 2017-02-24 Wockhardt Limited Proceso para la preparación de compuestos cetólidos
CN102219816A (zh) * 2011-05-12 2011-10-19 浙江国邦药业有限公司 一种罗红霉素的纯化方法
PL222631B1 (pl) 2012-11-14 2016-08-31 Gdański Univ Medyczny Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję
CN104163840A (zh) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 一种罗红霉素的精制方法
FR3049861A1 (fr) 2016-04-07 2017-10-13 Univ Claude Bernard Lyon Nouvelles compositions antivirales pour le traitement de la grippe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU31319B (en) * 1967-08-03 1973-04-30 Pliva Pharm & Chem Works Postupak za dobijanje acil derivata eritromicin oksima
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
ES434842A1 (es) * 1975-02-19 1976-12-01 Andreu Sa Dr Procedimiento para la preparacion de esteres de la oxima deeritromicina.
DE2515076A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue erythromycinderivate, deren salze und verfahren zu ihrer herstellung
DE2515077A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue 9-alkylidenamino-erythromycine, ihre salze und verfahren zu ihrer herstellung
DK139522C (da) * 1975-04-07 1979-08-20 Thomae Gmbh Dr K Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
DE3165720D1 (en) 1984-10-04
JPS6237639B2 (da) 1987-08-13
EP0033255B1 (fr) 1984-08-29
GR73103B (da) 1984-02-02
HU187760B (en) 1986-02-28
GT198500080A (es) 1987-03-06
AU537247B2 (en) 1984-06-14
IL61808A (en) 1986-12-31
ES498395A0 (es) 1981-11-01
AU6613181A (en) 1981-07-16
NL930097I2 (nl) 1995-04-03
IE810046L (en) 1981-07-11
KR830005258A (ko) 1983-08-03
PT72331A (fr) 1981-02-01
MY8500984A (en) 1985-12-31
PT72331B (fr) 1982-07-23
HK586A (en) 1986-01-10
LU88283I2 (fr) 1994-09-09
IE50680B1 (en) 1986-06-11
DK157878B (da) 1990-02-26
EP0033255A1 (fr) 1981-08-05
DK7881A (da) 1981-07-12
NL930097I1 (nl) 1993-10-01
FR2473525B1 (da) 1983-04-15
DK157878C (da) 1990-07-30
OA06719A (fr) 1982-06-30
CY1319A (en) 1986-03-28
JPS56100799A (en) 1981-08-12
FI69473C (fi) 1986-02-10
IL61808A0 (en) 1981-01-30
ZA808108B (en) 1982-01-27
FR2473525A1 (fr) 1981-07-17
KR850000964B1 (ko) 1985-07-02
US4349545A (en) 1982-09-14
ES8200702A1 (es) 1981-11-01
FI810042L (fi) 1981-07-12
FI69473B (fi) 1985-10-31
CA1162535A (fr) 1984-02-21

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