DE3165720D1 - Oximes derived from erythromycin a, their preparation, their application in pharmaceuticals and pharmaceutical compositions containing them - Google Patents

Oximes derived from erythromycin a, their preparation, their application in pharmaceuticals and pharmaceutical compositions containing them

Info

Publication number
DE3165720D1
DE3165720D1 DE8181400026T DE3165720T DE3165720D1 DE 3165720 D1 DE3165720 D1 DE 3165720D1 DE 8181400026 T DE8181400026 T DE 8181400026T DE 3165720 T DE3165720 T DE 3165720T DE 3165720 D1 DE3165720 D1 DE 3165720D1
Authority
DE
Germany
Prior art keywords
erythromycin
pharmaceuticals
preparation
application
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181400026T
Other languages
English (en)
Inventor
D Ambrieres Solange Gouin
Andre Lutz
Jean-Claude Gasc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9237443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3165720(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3165720D1 publication Critical patent/DE3165720D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8181400026T 1980-01-11 1981-01-09 Oximes derived from erythromycin a, their preparation, their application in pharmaceuticals and pharmaceutical compositions containing them Expired DE3165720D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8000566A FR2473525A1 (fr) 1980-01-11 1980-01-11 Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
DE3165720D1 true DE3165720D1 (en) 1984-10-04

Family

ID=9237443

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181400026T Expired DE3165720D1 (en) 1980-01-11 1981-01-09 Oximes derived from erythromycin a, their preparation, their application in pharmaceuticals and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4349545A (de)
EP (1) EP0033255B1 (de)
JP (1) JPS56100799A (de)
KR (1) KR850000964B1 (de)
AU (1) AU537247B2 (de)
BG (1) BG61369B2 (de)
CA (1) CA1162535A (de)
CY (1) CY1319A (de)
DE (1) DE3165720D1 (de)
DK (1) DK157878C (de)
ES (1) ES8200702A1 (de)
FI (1) FI69473C (de)
FR (1) FR2473525A1 (de)
GR (1) GR73103B (de)
GT (1) GT198500080A (de)
HK (1) HK586A (de)
HU (1) HU187760B (de)
IE (1) IE50680B1 (de)
IL (1) IL61808A (de)
LU (1) LU88283I2 (de)
MY (1) MY8500984A (de)
NL (1) NL930097I2 (de)
OA (1) OA06719A (de)
PT (1) PT72331B (de)
ZA (1) ZA808108B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534588B2 (fr) * 1982-10-15 1985-09-20 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
DK149776C (da) * 1984-01-06 1987-04-21 Orion Yhtymae Oy Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
DE3668894D1 (en) 1985-03-12 1990-03-15 Beecham Group Plc Erythromycin-derivate.
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0260938B1 (de) 1986-09-18 1992-12-09 Taisho Pharmaceutical Co. Ltd Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
CA2062932A1 (en) 1991-03-15 1992-09-16 Robert R. Wilkening 9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
ES2036472B1 (es) * 1991-10-01 1994-03-01 Prodesfarma Sa Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina).
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5795871A (en) * 1994-04-26 1998-08-18 Nobuhiro Narita Pharmaceutical composition for treatment of non-small cell lung cancer
IT1276901B1 (it) * 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5929219A (en) 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
PT102202B (pt) 1998-09-10 2001-04-30 Hovione Sociedade Quimica S A Processo para a purificacao de roxitromicina
IN190782B (de) * 1998-09-30 2003-08-23 Max India Ltd
EP1004591B1 (de) * 1998-11-24 2003-04-09 Max India Limited Verfahren zur Herstellung von Roxithromycin und Derivate davon
IL150227A0 (en) * 1999-12-16 2002-12-01 Teva Pharma Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2261901A (en) * 2000-01-11 2001-07-24 Teva Pharma Processes for preparing clarithromycin polymorphs
EP1313486A1 (de) 2000-02-29 2003-05-28 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung des clarithromycins und eines clarithromycin-zwischenprodukt; clarithromycin wesentlich frei von oxime; und pharmazeutische zusammensetzung die sie enthalten
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
AU2003271408B2 (en) * 2002-12-31 2008-07-17 Alembic Limited A process for the purification of roxithromycin
EP2056844A4 (de) 2006-08-24 2010-11-24 Wockhardt Research Center Neue makrolide und ketolide mit antimikrobieller wirkung
US20090005326A1 (en) * 2007-06-26 2009-01-01 Idexx Laboratories, Inc. Single dose roxithromycin
NZ623574A (en) 2010-12-09 2015-07-31 Wockhardt Ltd Ketolide compounds
WO2012117357A2 (en) 2011-03-01 2012-09-07 Wockhardt Limited Process for preparation of ketolide intermediates
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
CN102219816A (zh) * 2011-05-12 2011-10-19 浙江国邦药业有限公司 一种罗红霉素的纯化方法
PL222631B1 (pl) 2012-11-14 2016-08-31 Gdański Univ Medyczny Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję
CN104163840A (zh) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 一种罗红霉素的精制方法
FR3049861A1 (fr) 2016-04-07 2017-10-13 Univ Claude Bernard Lyon Nouvelles compositions antivirales pour le traitement de la grippe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU31319B (en) * 1967-08-03 1973-04-30 Pliva Pharm & Chem Works Postupak za dobijanje acil derivata eritromicin oksima
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
ES434842A1 (es) * 1975-02-19 1976-12-01 Andreu Sa Dr Procedimiento para la preparacion de esteres de la oxima deeritromicina.
DE2515076A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue erythromycinderivate, deren salze und verfahren zu ihrer herstellung
DE2515077A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue 9-alkylidenamino-erythromycine, ihre salze und verfahren zu ihrer herstellung
DK139522C (da) * 1975-04-07 1979-08-20 Thomae Gmbh Dr K Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
PT72331B (fr) 1982-07-23
NL930097I1 (nl) 1993-10-01
JPS6237639B2 (de) 1987-08-13
FI810042L (fi) 1981-07-12
MY8500984A (en) 1985-12-31
FI69473B (fi) 1985-10-31
GR73103B (de) 1984-02-02
EP0033255B1 (de) 1984-08-29
KR850000964B1 (ko) 1985-07-02
HK586A (en) 1986-01-10
DK157878B (da) 1990-02-26
CY1319A (en) 1986-03-28
PT72331A (fr) 1981-02-01
KR830005258A (ko) 1983-08-03
IL61808A0 (en) 1981-01-30
NL930097I2 (nl) 1995-04-03
AU6613181A (en) 1981-07-16
EP0033255A1 (de) 1981-08-05
LU88283I2 (fr) 1994-09-09
CA1162535A (fr) 1984-02-21
FR2473525B1 (de) 1983-04-15
FI69473C (fi) 1986-02-10
ES498395A0 (es) 1981-11-01
GT198500080A (es) 1987-03-06
BG61369B2 (bg) 1997-06-30
DK7881A (da) 1981-07-12
ES8200702A1 (es) 1981-11-01
ZA808108B (en) 1982-01-27
AU537247B2 (en) 1984-06-14
DK157878C (da) 1990-07-30
HU187760B (en) 1986-02-28
US4349545A (en) 1982-09-14
OA06719A (fr) 1982-06-30
IL61808A (en) 1986-12-31
IE810046L (en) 1981-07-11
FR2473525A1 (fr) 1981-07-17
JPS56100799A (en) 1981-08-12
IE50680B1 (en) 1986-06-11

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR