ES8200702A1 - Procedimiento para preparar derivados de la eritromicina - Google Patents

Procedimiento para preparar derivados de la eritromicina

Info

Publication number
ES8200702A1
ES8200702A1 ES498395A ES498395A ES8200702A1 ES 8200702 A1 ES8200702 A1 ES 8200702A1 ES 498395 A ES498395 A ES 498395A ES 498395 A ES498395 A ES 498395A ES 8200702 A1 ES8200702 A1 ES 8200702A1
Authority
ES
Spain
Prior art keywords
optionally substituted
carbon atoms
group
optionally
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498395A
Other languages
English (en)
Other versions
ES498395A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9237443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8200702(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES498395A0 publication Critical patent/ES498395A0/es
Publication of ES8200702A1 publication Critical patent/ES8200702A1/es
Priority to GT198500080A priority Critical patent/GT198500080A/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE ERITROMICINA DE FORMULA (I), EN QUE A ES UN RADICAL ALCOHILENO Y R ES ALCOHILOXI, ALQUENILOXI, ALQUINILOXI, ALCOHILTIO, ARILOXI, ARILTIO U OTROS Y RA HIDROGENO O ACILO. SE BASA EN LA REACCION DE UNA ERITROMICINA DE FORMUA (II), CON UN COMPUESTO D FORMULA (III) O CON UN HALOHIDRATO DE DICHO COMPUESTO, EN PRESENCIA DE UNA BASE ORGANICA AMINADA, EN EXCESO, O DE UNA MEZCLA DE ACIDO ORGANICO-SAL ALCALINA DEL ACIDO. LA REACCION SE EFECTUA EN UN DISOLVENTE ALCOHOLICO Y EN MEDIO ANHIDRO. OPCIONALMENTE, SE OBTIENE TAMBIEN EL PRODUCTO POR REACCION DE UNA 9-OXIMA DE ERITROMICINA CON UN COMPUESTO DE FORMULA (IV). DE APLICACION COMO ANTIBIOTICO CONTRA LAS BACTERIAS GRAM-POSITIVAS.
ES498395A 1980-01-11 1981-01-09 Procedimiento para preparar derivados de la eritromicina Expired ES8200702A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GT198500080A GT198500080A (es) 1980-01-11 1985-09-12 Procedimiento para preparar derivados de la eritromicina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8000566A FR2473525A1 (fr) 1980-01-11 1980-01-11 Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
ES498395A0 ES498395A0 (es) 1981-11-01
ES8200702A1 true ES8200702A1 (es) 1981-11-01

Family

ID=9237443

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498395A Expired ES8200702A1 (es) 1980-01-11 1981-01-09 Procedimiento para preparar derivados de la eritromicina

Country Status (25)

Country Link
US (1) US4349545A (es)
EP (1) EP0033255B1 (es)
JP (1) JPS56100799A (es)
KR (1) KR850000964B1 (es)
AU (1) AU537247B2 (es)
BG (1) BG61369B2 (es)
CA (1) CA1162535A (es)
CY (1) CY1319A (es)
DE (1) DE3165720D1 (es)
DK (1) DK157878C (es)
ES (1) ES8200702A1 (es)
FI (1) FI69473C (es)
FR (1) FR2473525A1 (es)
GR (1) GR73103B (es)
GT (1) GT198500080A (es)
HK (1) HK586A (es)
HU (1) HU187760B (es)
IE (1) IE50680B1 (es)
IL (1) IL61808A (es)
LU (1) LU88283I2 (es)
MY (1) MY8500984A (es)
NL (1) NL930097I2 (es)
OA (1) OA06719A (es)
PT (1) PT72331B (es)
ZA (1) ZA808108B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036472A1 (es) * 1991-10-01 1993-05-16 Prodesfarma Sa Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina).

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534588B2 (fr) * 1982-10-15 1985-09-20 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
DK149776C (da) * 1984-01-06 1987-04-21 Orion Yhtymae Oy Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
NO860901L (no) 1985-03-12 1986-09-15 Beecham Group Plc Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater.
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
DE3782994T2 (de) 1986-09-18 1993-04-08 Taisho Pharmaceutical Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
DE69227713D1 (de) 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5795871A (en) * 1994-04-26 1998-08-18 Nobuhiro Narita Pharmaceutical composition for treatment of non-small cell lung cancer
IT1276901B1 (it) * 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5929219A (en) 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
PT102202B (pt) * 1998-09-10 2001-04-30 Hovione Sociedade Quimica S A Processo para a purificacao de roxitromicina
IN190782B (es) * 1998-09-30 2003-08-23 Max India Ltd
EP1004591B1 (en) * 1998-11-24 2003-04-09 Max India Limited Process for preparing roxithromycin and derivatives thereof
AU783055B2 (en) 1999-12-16 2005-09-22 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph IV
PT1280535E (pt) 2000-01-11 2005-04-29 Teva Pharma Processos para a preparacao de polimorfos de claritromicina
EP1313486A1 (en) 2000-02-29 2003-05-28 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
EP1435359A1 (en) * 2002-12-31 2004-07-07 Alembic Limited A process for the purification of roxithromycin
CA2661538A1 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
US20090005326A1 (en) * 2007-06-26 2009-01-01 Idexx Laboratories, Inc. Single dose roxithromycin
DK2673285T3 (en) 2010-12-09 2017-10-16 Wockhardt Ltd Ketolide compounds
CN103619849B (zh) 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
CA2830861C (en) 2011-03-22 2017-01-24 Wockhardt Limited Process for preparation of ketolide compounds
CN102219816A (zh) * 2011-05-12 2011-10-19 浙江国邦药业有限公司 一种罗红霉素的纯化方法
PL222631B1 (pl) 2012-11-14 2016-08-31 Gdański Univ Medyczny Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję
CN104163840A (zh) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 一种罗红霉素的精制方法
FR3049861A1 (fr) 2016-04-07 2017-10-13 Univ Claude Bernard Lyon Nouvelles compositions antivirales pour le traitement de la grippe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU31319B (en) * 1967-08-03 1973-04-30 Pliva Pharm & Chem Works Postupak za dobijanje acil derivata eritromicin oksima
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
ES434842A1 (es) * 1975-02-19 1976-12-01 Andreu Sa Dr Procedimiento para la preparacion de esteres de la oxima deeritromicina.
DE2515077A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue 9-alkylidenamino-erythromycine, ihre salze und verfahren zu ihrer herstellung
DK139522C (da) * 1975-04-07 1979-08-20 Thomae Gmbh Dr K Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DE2515076A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue erythromycinderivate, deren salze und verfahren zu ihrer herstellung
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036472A1 (es) * 1991-10-01 1993-05-16 Prodesfarma Sa Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina).

Also Published As

Publication number Publication date
ES498395A0 (es) 1981-11-01
AU537247B2 (en) 1984-06-14
FI69473C (fi) 1986-02-10
AU6613181A (en) 1981-07-16
EP0033255B1 (fr) 1984-08-29
DK7881A (da) 1981-07-12
FI810042L (fi) 1981-07-12
ZA808108B (en) 1982-01-27
LU88283I2 (fr) 1994-09-09
JPS6237639B2 (es) 1987-08-13
KR850000964B1 (ko) 1985-07-02
HK586A (en) 1986-01-10
MY8500984A (en) 1985-12-31
EP0033255A1 (fr) 1981-08-05
HU187760B (en) 1986-02-28
FR2473525B1 (es) 1983-04-15
NL930097I1 (nl) 1993-10-01
IL61808A (en) 1986-12-31
JPS56100799A (en) 1981-08-12
US4349545A (en) 1982-09-14
KR830005258A (ko) 1983-08-03
DE3165720D1 (en) 1984-10-04
GT198500080A (es) 1987-03-06
IE50680B1 (en) 1986-06-11
DK157878C (da) 1990-07-30
PT72331B (fr) 1982-07-23
IL61808A0 (en) 1981-01-30
FR2473525A1 (fr) 1981-07-17
GR73103B (es) 1984-02-02
CA1162535A (fr) 1984-02-21
OA06719A (fr) 1982-06-30
BG61369B2 (bg) 1997-06-30
CY1319A (en) 1986-03-28
IE810046L (en) 1981-07-11
NL930097I2 (nl) 1995-04-03
DK157878B (da) 1990-02-26
FI69473B (fi) 1985-10-31
PT72331A (fr) 1981-02-01

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