FI69473C - Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av erytromycin - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av erytromycin Download PDFInfo
- Publication number
- FI69473C FI69473C FI810042A FI810042A FI69473C FI 69473 C FI69473 C FI 69473C FI 810042 A FI810042 A FI 810042A FI 810042 A FI810042 A FI 810042A FI 69473 C FI69473 C FI 69473C
- Authority
- FI
- Finland
- Prior art keywords
- group
- formula
- compound
- erythromycin
- oxime
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8000566A FR2473525A1 (fr) | 1980-01-11 | 1980-01-11 | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR8000566 | 1980-01-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI810042L FI810042L (fi) | 1981-07-12 |
FI69473B FI69473B (fi) | 1985-10-31 |
FI69473C true FI69473C (fi) | 1986-02-10 |
Family
ID=9237443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI810042A FI69473C (fi) | 1980-01-11 | 1981-01-08 | Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av erytromycin |
Country Status (25)
Country | Link |
---|---|
US (1) | US4349545A (da) |
EP (1) | EP0033255B1 (da) |
JP (1) | JPS56100799A (da) |
KR (1) | KR850000964B1 (da) |
AU (1) | AU537247B2 (da) |
BG (1) | BG61369B2 (da) |
CA (1) | CA1162535A (da) |
CY (1) | CY1319A (da) |
DE (1) | DE3165720D1 (da) |
DK (1) | DK157878C (da) |
ES (1) | ES498395A0 (da) |
FI (1) | FI69473C (da) |
FR (1) | FR2473525A1 (da) |
GR (1) | GR73103B (da) |
GT (1) | GT198500080A (da) |
HK (1) | HK586A (da) |
HU (1) | HU187760B (da) |
IE (1) | IE50680B1 (da) |
IL (1) | IL61808A (da) |
LU (1) | LU88283I2 (da) |
MY (1) | MY8500984A (da) |
NL (1) | NL930097I2 (da) |
OA (1) | OA06719A (da) |
PT (1) | PT72331B (da) |
ZA (1) | ZA808108B (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534588B2 (fr) * | 1982-10-15 | 1985-09-20 | Roussel Uclaf | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US4526889A (en) * | 1982-11-15 | 1985-07-02 | Pfizer Inc. | Epimeric azahomoerythromycin A derivative, intermediates and method of use |
DK149776C (da) * | 1984-01-06 | 1987-04-21 | Orion Yhtymae Oy | Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen |
JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシン類の製法 |
JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシンa誘導体 |
DE3668894D1 (en) | 1985-03-12 | 1990-03-15 | Beecham Group Plc | Erythromycin-derivate. |
JPS61229895A (ja) * | 1985-04-03 | 1986-10-14 | Nippon Zeon Co Ltd | 保護化デス−n−メチルエリスロマイシン誘導体 |
US4740502A (en) * | 1986-06-20 | 1988-04-26 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
DE3782994T2 (de) | 1986-09-18 | 1993-04-08 | Taisho Pharma Co Ltd | Erythromycin-a-derivate und verfahren zu ihrer herstellung. |
JP2751385B2 (ja) * | 1988-05-19 | 1998-05-18 | 大正製薬株式会社 | エリスロマイシンaオキシム及びその塩の製造方法 |
US5075289A (en) * | 1988-06-07 | 1991-12-24 | Abbott Laboratories | 9-r-azacyclic erythromycin antibiotics |
US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
EP0503932B1 (en) | 1991-03-15 | 1998-12-02 | Merck & Co. Inc. | 9-Deoxo-9(z)-hydroxy-iminoerythromycin A and O-derivatives thereof |
US5912331A (en) * | 1991-03-15 | 1999-06-15 | Merck & Co., Inc. | Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A |
US5985844A (en) * | 1992-03-26 | 1999-11-16 | Merck & Co., Inc. | Homoerythromycin A derivatives modified at the 4"-and 8A-positions |
US5189159A (en) * | 1992-04-02 | 1993-02-23 | Merck & Co., Inc. | 8a-AZA-8a-homoerythromycin cyclic iminoethers |
ES2036472B1 (es) * | 1991-10-01 | 1994-03-01 | Prodesfarma Sa | Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina). |
US5210235A (en) * | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
EP0758549A4 (en) * | 1994-04-26 | 1997-07-02 | Nobuhiro Narita | MEDICAL COMPOSITION AS A MEDICINE FOR NON-SMALL CELL CANCER |
IT1276901B1 (it) * | 1994-12-13 | 1997-11-03 | Zambon Spa | Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica |
US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
FR2760017B1 (fr) * | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
US5929219A (en) | 1997-09-10 | 1999-07-27 | Abbott Laboratories | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
PT102202B (pt) * | 1998-09-10 | 2001-04-30 | Hovione Sociedade Quimica S A | Processo para a purificacao de roxitromicina |
IN190782B (da) * | 1998-09-30 | 2003-08-23 | Max India Ltd | |
EP1004591B1 (en) * | 1998-11-24 | 2003-04-09 | Max India Limited | Process for preparing roxithromycin and derivatives thereof |
CZ20021999A3 (cs) | 1999-12-16 | 2003-02-12 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy klaritromycinových polymorfních forem a nového polymorfu IV |
PL356645A1 (en) | 2000-01-11 | 2004-06-28 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin polymorphs |
AU2578701A (en) * | 2000-02-29 | 2001-09-12 | Teva Pharma | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
HRP20020885B1 (en) | 2002-11-11 | 2007-05-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A |
HRP20020991A2 (en) | 2002-12-12 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de |
AU2003271408B2 (en) * | 2002-12-31 | 2008-07-17 | Alembic Limited | A process for the purification of roxithromycin |
JP2010501541A (ja) | 2006-08-24 | 2010-01-21 | ウォックハート リサーチ センター | 抗菌活性を有する新規マクロライド及びケトライド |
US20090005326A1 (en) * | 2007-06-26 | 2009-01-01 | Idexx Laboratories, Inc. | Single dose roxithromycin |
ES2642287T3 (es) | 2010-12-09 | 2017-11-16 | Wockhardt Limited | Compuestos cetólidos |
US9206214B2 (en) | 2011-03-01 | 2015-12-08 | Wockhardt Ltd. | Process for preparation of ketolide intermediates |
WO2012127351A1 (en) | 2011-03-22 | 2012-09-27 | Wockhardt Limited | Process for preparation of ketolide compounds |
CN102219816A (zh) * | 2011-05-12 | 2011-10-19 | 浙江国邦药业有限公司 | 一种罗红霉素的纯化方法 |
PL222631B1 (pl) | 2012-11-14 | 2016-08-31 | Gdański Univ Medyczny | Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję |
CN104163840A (zh) * | 2013-08-30 | 2014-11-26 | 郑州后羿制药有限公司 | 一种罗红霉素的精制方法 |
FR3049861A1 (fr) | 2016-04-07 | 2017-10-13 | Univ Claude Bernard Lyon | Nouvelles compositions antivirales pour le traitement de la grippe |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU31319B (en) * | 1967-08-03 | 1973-04-30 | Pliva Pharm & Chem Works | Postupak za dobijanje acil derivata eritromicin oksima |
US3869444A (en) * | 1972-10-10 | 1975-03-04 | Abbott Lab | Esters of erythromycin oxime |
ES434842A1 (es) * | 1975-02-19 | 1976-12-01 | Andreu Sa Dr | Procedimiento para la preparacion de esteres de la oxima deeritromicina. |
DE2515077A1 (de) * | 1975-04-07 | 1976-10-28 | Thomae Gmbh Dr K | Neue 9-alkylidenamino-erythromycine, ihre salze und verfahren zu ihrer herstellung |
DE2515076A1 (de) * | 1975-04-07 | 1976-10-28 | Thomae Gmbh Dr K | Neue erythromycinderivate, deren salze und verfahren zu ihrer herstellung |
DK139522C (da) * | 1975-04-07 | 1979-08-20 | Thomae Gmbh Dr K | Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf |
DE2750288A1 (de) * | 1977-11-10 | 1979-05-17 | Thomae Gmbh Dr K | Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1980
- 1980-01-11 FR FR8000566A patent/FR2473525A1/fr active Granted
- 1980-12-26 IL IL61808A patent/IL61808A/xx not_active IP Right Cessation
- 1980-12-30 ZA ZA00808108A patent/ZA808108B/xx unknown
-
1981
- 1981-01-08 FI FI810042A patent/FI69473C/fi not_active IP Right Cessation
- 1981-01-08 US US06/223,368 patent/US4349545A/en not_active Expired - Lifetime
- 1981-01-09 JP JP126481A patent/JPS56100799A/ja active Granted
- 1981-01-09 HU HU8155A patent/HU187760B/hu unknown
- 1981-01-09 PT PT72331A patent/PT72331B/pt unknown
- 1981-01-09 OA OA57295A patent/OA06719A/xx unknown
- 1981-01-09 IE IE46/81A patent/IE50680B1/en not_active IP Right Cessation
- 1981-01-09 CY CY1319A patent/CY1319A/xx unknown
- 1981-01-09 CA CA000368249A patent/CA1162535A/fr not_active Expired
- 1981-01-09 DE DE8181400026T patent/DE3165720D1/de not_active Expired
- 1981-01-09 AU AU66131/81A patent/AU537247B2/en not_active Expired
- 1981-01-09 EP EP81400026A patent/EP0033255B1/fr not_active Expired
- 1981-01-09 ES ES498395A patent/ES498395A0/es active Granted
- 1981-01-09 DK DK007881A patent/DK157878C/da active
- 1981-01-09 GR GR63831A patent/GR73103B/el unknown
- 1981-01-10 KR KR1019810000051A patent/KR850000964B1/ko active
-
1985
- 1985-09-12 GT GT198500080A patent/GT198500080A/es unknown
- 1985-12-30 MY MY984/85A patent/MY8500984A/xx unknown
-
1986
- 1986-01-02 HK HK5/86A patent/HK586A/xx not_active IP Right Cessation
-
1993
- 1993-06-03 LU LU88283C patent/LU88283I2/fr unknown
- 1993-06-25 NL NL930097C patent/NL930097I2/nl unknown
-
1994
- 1994-02-22 BG BG98506A patent/BG61369B2/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI69473C (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av erytromycin | |
DK172636B1 (en) | 6-o-methylerythromycin a derivative | |
DE69224765T2 (de) | An 4''- und 8A-Stellungen modifizierte 9-Deoxo-8a-Aza-8a-Homoerythromycin-A-Derivate | |
JP3130097B2 (ja) | 新規なエリスロマイシン誘導体、その製造法、得られる新規な中間体及びそれらの薬剤としての使用 | |
TW442490B (en) | Tricyclic erythromycin derivatives | |
US5202434A (en) | 8a-aza-8a-homoerythromycin lactams | |
EP0289030A2 (en) | Esperamicin derivatives, a process for preparing them and pharmaceutical compositions | |
NO860901L (no) | Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater. | |
GB2135670A (en) | C-20- and c-23-modified macrolide derivatives | |
EP0549040A1 (en) | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A | |
EP0099747B1 (en) | C-23-modified derivatives of 5-0-mycaminosyl tylonolide | |
EP0503932B1 (en) | 9-Deoxo-9(z)-hydroxy-iminoerythromycin A and O-derivatives thereof | |
JPS6360031B2 (da) | ||
AU616717B2 (en) | Epipodophyllotoxin glucoside 4'-acylderivative | |
KR100529980B1 (ko) | 신규 에리트로마이신 유도체, 그의 제조 방법 및 의약으로서의용도 | |
BG106173A (bg) | Халогенови производни на 9-дезоксо-9а-аза-9а-хомеритромицин а | |
KR850001179B1 (ko) | 에리트로마이신 a의 옥심 유도체류의 제조방법 | |
EP0507595A1 (en) | 8A-aza-8A-homoerythromycin lactams | |
JPS62190188A (ja) | セルビノマイシン系抗生物質誘導体およびその製造法 | |
EP0508795A1 (en) | 8a-aza-8a-homoerythromycin cyclic iminoethers | |
FI58502C (fi) | Foerfarande foer framstaellning av alkyl-7-deoxi-7-(acors)-alfa-tiolinkosaminider vilka aer mellanprodukter vid framstaellning av substituerade tioanaloger av linkomycin | |
EP0515141A1 (en) | Novel process for the preparation of 8A-aza-8A-homoerythromycin cyclic lactams | |
CN111662351A (zh) | 新奥克梯隆型皂苷元衍生物及制备抗耐药菌药物应用 | |
JPS61225194A (ja) | 新規化合物,その製法及びそれを含む医薬組成物 | |
CS199728B2 (en) | Method of producing derivatives of 4"-sulphonyl amino oleandomycin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: HOECHST MARION ROUSSEL |
|
MA | Patent expired |
Owner name: HOECHST MARION ROUSSEL |