BG60256B1 - Рекомбинантен метод за получаване на лимфотоксин - Google Patents
Рекомбинантен метод за получаване на лимфотоксинInfo
- Publication number
- BG60256B1 BG60256B1 BG070460A BG7046085A BG60256B1 BG 60256 B1 BG60256 B1 BG 60256B1 BG 070460 A BG070460 A BG 070460A BG 7046085 A BG7046085 A BG 7046085A BG 60256 B1 BG60256 B1 BG 60256B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- lymphotoxin
- new
- recombinant method
- lymphotoxins
- immobilized
- Prior art date
Links
- 102000004083 Lymphotoxin-alpha Human genes 0.000 title abstract 5
- 108090000542 Lymphotoxin-alpha Proteins 0.000 title abstract 5
- 238000010188 recombinant method Methods 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C07K16/242—Lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61650384A | 1984-05-31 | 1984-05-31 | |
| US06/616,502 US4959457A (en) | 1984-05-31 | 1984-05-31 | Anti-lymphotoxin |
| US73231285A | 1985-05-09 | 1985-05-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG60256B2 BG60256B2 (bg) | 1994-03-24 |
| BG60256B1 true BG60256B1 (bg) | 1994-03-24 |
Family
ID=27417179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG070460A BG60256B1 (bg) | 1984-05-31 | 1985-05-30 | Рекомбинантен метод за получаване на лимфотоксин |
Country Status (23)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU564690B2 (en) | 1980-04-03 | 1987-08-20 | Biogen Idec Ma Inc. | Process for producing human fibroblast interferon-like polypeptides using recombinant dna |
| US5683688A (en) | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
| NZ212207A (en) | 1984-05-31 | 1991-07-26 | Genentech Inc | Recombinant lymphotoxin |
| IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
| WO1986003751A2 (en) * | 1984-12-21 | 1986-07-03 | Biogen N.V. | Purification, production and use of tumor necrosis factors |
| JPS62111928A (ja) * | 1985-10-15 | 1987-05-22 | Kanegafuchi Chem Ind Co Ltd | 新規リンホトキシン |
| JPS62195285A (ja) * | 1986-02-19 | 1987-08-28 | Kanegafuchi Chem Ind Co Ltd | リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法 |
| AU603768B2 (en) * | 1985-07-04 | 1990-11-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin |
| DE3686148T2 (de) * | 1985-12-24 | 1993-01-14 | Denki Kagaku Kogyo Kk | Lymphotoxin-gen, verfahren zu dessen herstellung und lymphotoxin. |
| JP2548204B2 (ja) * | 1987-06-27 | 1996-10-30 | 電気化学工業株式会社 | 新生理活性ポリペプチド |
| US5403725A (en) * | 1985-12-24 | 1995-04-04 | Denki Kagaku Kogyo Kabushiki Kaisha | Method for production of lymphotoxin (TNFB) in cell line A-C5-8 |
| EP0230574A3 (en) * | 1986-01-31 | 1989-03-22 | Yale University | Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof |
| JPS62181298A (ja) * | 1986-02-05 | 1987-08-08 | Kyowa Hakko Kogyo Co Ltd | ヒトリンホトキシンポリペプチド誘導体 |
| DE3620656A1 (de) * | 1986-06-20 | 1987-12-23 | Basf Ag | Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung |
| JPS63105680A (ja) * | 1986-10-22 | 1988-05-10 | Kanegafuchi Chem Ind Co Ltd | ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法 |
| EP0272894A3 (en) * | 1986-12-24 | 1989-06-14 | Takeda Chemical Industries, Ltd. | Recombinant human lymphotoxin |
| US5175268A (en) * | 1986-12-24 | 1992-12-29 | Takeda Chemical Industries, Ltd. | DNA encoding recombinant human lymphotoxin |
| FI884798A7 (fi) * | 1987-10-28 | 1989-04-29 | Eisai Co Ltd | Rekombinantlymfotoxin. |
| DE3837012A1 (de) * | 1988-01-15 | 1989-07-27 | Knoll Ag | Verwendung von tnf und lt zur herstellung von arzneimitteln |
| GB2217326B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene encoding human tumour necrosis factor beta. |
| EP0338497A3 (en) * | 1988-04-22 | 1990-05-16 | Takeda Chemical Industries, Ltd. | Bispecific hybrid monoclonal antibody |
| JPH023698A (ja) * | 1988-06-20 | 1990-01-09 | Denki Kagaku Kogyo Kk | ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬 |
| CA2001756A1 (en) * | 1988-10-31 | 1991-04-30 | Seiichi Uesugi | New human lymphotoxin n-end deletion mutant |
| JPH03106821A (ja) * | 1989-09-20 | 1991-05-07 | Denki Kagaku Kogyo Kk | 抗腫瘍剤 |
| US5200176A (en) * | 1989-10-06 | 1993-04-06 | Genentech, Inc. | Method for protection of ischemic tissues using tumor nerosis factor |
| US5370870A (en) * | 1989-10-06 | 1994-12-06 | Genentech, Inc. | Method for protection against reactive oxygen species |
| IL97779A (en) * | 1990-04-10 | 2000-01-31 | Genentech Inc | Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof |
| US5747023A (en) * | 1994-07-01 | 1998-05-05 | Genentech, Inc. | Cancer therapy using lymphotoxin |
| JP4231106B2 (ja) * | 1995-01-23 | 2009-02-25 | ゼノテック インコーポレイティッド | 骨溶解および転移を改善する方法 |
| US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US6998116B1 (en) | 1996-01-09 | 2006-02-14 | Genentech, Inc. | Apo-2 ligand |
| ES2316182T3 (es) | 1998-01-15 | 2009-04-01 | Genentech, Inc. | Ligando apo-2. |
| EP2314676A1 (en) * | 2002-11-26 | 2011-04-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP1641826A2 (en) | 2003-06-27 | 2006-04-05 | Biogen Idec MA Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| EP1699486A4 (en) * | 2003-12-08 | 2007-07-18 | Centocor Inc | ANTI-LYMPHOTOXIN HUMAN ALPHA ANTIBODIES, COMPOSITIONS, METHODS AND USES |
| BRPI0509201A (pt) | 2004-03-23 | 2007-08-28 | Biogen Idec Inc | agentes de acoplamento de receptor e usos terapêuticos destes |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| CL2007002926A1 (es) * | 2006-10-12 | 2008-05-16 | Genentech Inc | Anticuerpo antilinfotoxina alfa (lt-alfa); composicion con el anticuerpo; hibridoma pta-7538; acido nucleico codificante del anticuerpo; vector y celula huesped que comprenden el acido nucleico; metodo para inhibir la proliferacion celular activada p |
| EP2311481A3 (en) | 2006-10-20 | 2013-10-16 | Biogen Idec MA Inc. | Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor |
| US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| UA122204C2 (uk) * | 2014-04-25 | 2020-10-12 | Наурекс, Інк. | Стабільні композиції нейроактивних пептидів |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN151589B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1978-12-22 | 1983-05-28 | Biogen Nv | |
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| ZA834976B (en) * | 1982-07-30 | 1984-08-29 | Genentech Inc | Human lymphotoxin |
| IE56026B1 (en) | 1982-10-19 | 1991-03-27 | Cetus Corp | Cysteine-depleted muteins of biologically active proteins |
| EP0135797A3 (de) * | 1983-08-30 | 1987-11-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA |
| DE3331108A1 (de) * | 1983-08-30 | 1985-05-02 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna |
| NZ212207A (en) | 1984-05-31 | 1991-07-26 | Genentech Inc | Recombinant lymphotoxin |
-
1985
- 1985-05-27 NZ NZ212207A patent/NZ212207A/en unknown
- 1985-05-27 IL IL7531885A patent/IL75318A/en unknown
- 1985-05-28 IE IE132185A patent/IE63487B1/en not_active IP Right Cessation
- 1985-05-29 FI FI852143A patent/FI93025C/fi not_active IP Right Cessation
- 1985-05-29 GR GR851317A patent/GR851317B/el unknown
- 1985-05-30 EP EP92110196A patent/EP0509553B1/en not_active Expired - Lifetime
- 1985-05-30 HU HU852076A patent/HU204085B/hu unknown
- 1985-05-30 BG BG070460A patent/BG60256B1/bg unknown
- 1985-05-30 ES ES543695A patent/ES8802182A1/es not_active Expired
- 1985-05-30 AT AT92110196T patent/ATE195323T1/de not_active IP Right Cessation
- 1985-05-30 DE DE3587597T patent/DE3587597T2/de not_active Expired - Lifetime
- 1985-05-30 DE DE3588225T patent/DE3588225T2/de not_active Expired - Lifetime
- 1985-05-30 NO NO852173A patent/NO179075C/no unknown
- 1985-05-30 DK DK241385A patent/DK171531B1/da not_active IP Right Cessation
- 1985-05-30 AT AT85303818T patent/ATE95243T1/de not_active IP Right Cessation
- 1985-05-30 EP EP85303818A patent/EP0164965B1/en not_active Expired - Lifetime
- 1985-05-31 SK SK3930-85A patent/SK278333B6/sk unknown
- 1985-05-31 AU AU43203/85A patent/AU599303B2/en not_active Expired
- 1985-05-31 JP JP60119648A patent/JP2521703B2/ja not_active Expired - Lifetime
- 1985-05-31 PT PT80573A patent/PT80573B/pt unknown
- 1985-05-31 YU YU91985A patent/YU47735B/sh unknown
- 1985-05-31 CZ CS853930A patent/CZ283148B6/cs not_active IP Right Cessation
- 1985-05-31 CA CA000482995A patent/CA1340641C/en not_active Expired - Lifetime
- 1985-05-31 PL PL1985253739A patent/PL155410B1/pl unknown
-
1986
- 1986-10-14 AR AR86305572A patent/AR245219A1/es active
-
1988
- 1988-01-19 RO RO131846A patent/RO100383A2/ro unknown
-
1995
- 1995-01-19 JP JP7006657A patent/JPH07291995A/ja active Pending
- 1995-01-19 JP JP7006665A patent/JP2804237B2/ja not_active Expired - Lifetime
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