DE3587597T2 - Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper. - Google Patents

Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.

Info

Publication number
DE3587597T2
DE3587597T2 DE3587597T DE3587597T DE3587597T2 DE 3587597 T2 DE3587597 T2 DE 3587597T2 DE 3587597 T DE3587597 T DE 3587597T DE 3587597 T DE3587597 T DE 3587597T DE 3587597 T2 DE3587597 T2 DE 3587597T2
Authority
DE
Germany
Prior art keywords
lymphotoxin
nucleic acid
obtaining
neutralizing antibodies
cells transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3587597T
Other languages
English (en)
Other versions
DE3587597D1 (de
Inventor
Bharat Bhushan Aggarwal
Patrick William Gray
Timothy Scott Bringman
Glenn Evan Nedwin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE3587597D1 publication Critical patent/DE3587597D1/de
Publication of DE3587597T2 publication Critical patent/DE3587597T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE3587597T 1984-05-31 1985-05-30 Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper. Expired - Lifetime DE3587597T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US73231285A 1985-05-09 1985-05-09

Publications (2)

Publication Number Publication Date
DE3587597D1 DE3587597D1 (de) 1993-11-04
DE3587597T2 true DE3587597T2 (de) 1994-06-01

Family

ID=27417179

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3588225T Expired - Lifetime DE3588225T2 (de) 1984-05-31 1985-05-30 Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung
DE3587597T Expired - Lifetime DE3587597T2 (de) 1984-05-31 1985-05-30 Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3588225T Expired - Lifetime DE3588225T2 (de) 1984-05-31 1985-05-30 Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung

Country Status (23)

Country Link
EP (2) EP0509553B1 (de)
JP (3) JP2521703B2 (de)
AR (1) AR245219A1 (de)
AT (2) ATE95243T1 (de)
AU (1) AU599303B2 (de)
BG (1) BG60256B1 (de)
CA (1) CA1340641C (de)
CZ (1) CZ283148B6 (de)
DE (2) DE3588225T2 (de)
DK (1) DK171531B1 (de)
ES (1) ES8802182A1 (de)
FI (1) FI93025C (de)
GR (1) GR851317B (de)
HU (1) HU204085B (de)
IE (1) IE63487B1 (de)
IL (1) IL75318A (de)
NO (1) NO179075C (de)
NZ (1) NZ212207A (de)
PL (1) PL155410B1 (de)
PT (1) PT80573B (de)
RO (1) RO100383A2 (de)
SK (1) SK278333B6 (de)
YU (1) YU47735B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62552A0 (en) 1980-04-03 1981-06-29 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
DE3585690D1 (de) * 1984-12-21 1992-04-23 Biogen Inc Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren.
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
EP0230781B1 (de) * 1985-12-24 1992-07-22 Denki Kagaku Kogyo Kabushiki Kaisha Lymphotoxin-Gen, Verfahren zu dessen Herstellung und Lymphotoxin
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
EP0230574A3 (de) * 1986-01-31 1989-03-22 Yale University Pharmazeutische Zusammensetzungen gegen durch LAV/HTLV-III-Virus verursachte Infektionen und ihre Verwendung
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
EP0272894A3 (de) * 1986-12-24 1989-06-14 Takeda Chemical Industries, Ltd. Rekombinantes menschliches Lymphotoxin
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
FI884798A (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (de) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispezifische hybride monoklonale Antikörper
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
EP0813423B1 (de) * 1995-01-23 2002-07-03 Xenotech Incorporated Zusammensetzung zur verhinderung von osteolyse und metastasen
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
EP1045906B1 (de) 1998-01-15 2008-10-15 Genentech, Inc. Apo-2 ligand
AU2003302386B2 (en) * 2002-11-26 2010-04-01 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2005000898A2 (en) 2003-06-27 2005-01-06 Biogen Idec Ma Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
EP1699486A4 (de) * 2003-12-08 2007-07-18 Centocor Inc Anti-humanlymphotoxin-alpha-antikörper, zusammensetzungen, verfahren und anwendungen
EP1756162A1 (de) 2004-03-23 2007-02-28 Biogen Idec MA Inc. Rezeptor-kupplungsmittel und ihre therapeutischen verwendungen
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
NZ576032A (en) * 2006-10-12 2012-03-30 Genentech Inc Antibodies to lymphotoxin-alpha
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
MX2009004134A (es) 2006-10-20 2009-08-12 Biogen Idec Inc Tratamiento de trastornos de desmielinizacion con el receptor de linfotoxina beta soluble.
EP3689362A1 (de) * 2014-04-25 2020-08-05 Naurex, Inc. Stabile zusammensetzungen von neuroaktiven peptiden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES487106A0 (es) * 1978-12-22 1981-05-16 Biogen Nv Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production

Also Published As

Publication number Publication date
PL155410B1 (en) 1991-11-29
NZ212207A (en) 1991-07-26
JP2804237B2 (ja) 1998-09-24
ATE95243T1 (de) 1993-10-15
DK171531B1 (da) 1996-12-23
EP0509553A1 (de) 1992-10-21
FI93025B (fi) 1994-10-31
RO100383B1 (ro) 1991-03-01
SK393085A3 (en) 1996-11-06
AU599303B2 (en) 1990-07-19
ES543695A0 (es) 1988-04-16
DE3588225D1 (de) 2000-09-14
AR245219A1 (es) 1993-12-30
YU47735B (sh) 1996-01-08
CA1340641C (en) 1999-07-13
JPH07250692A (ja) 1995-10-03
EP0164965A3 (en) 1988-04-06
FI852143L (fi) 1985-12-01
IL75318A0 (en) 1985-09-29
JPS6156197A (ja) 1986-03-20
BG60256B2 (bg) 1994-03-24
FI852143A0 (fi) 1985-05-29
CZ283148B6 (cs) 1998-01-14
IE63487B1 (en) 1995-05-03
JP2521703B2 (ja) 1996-08-07
JPH07291995A (ja) 1995-11-07
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
RO100383A2 (ro) 1991-10-17
DK241385D0 (da) 1985-05-30
DE3587597D1 (de) 1993-11-04
ATE195323T1 (de) 2000-08-15
PL253739A1 (en) 1986-03-11
CZ393085A3 (en) 1997-07-16
ES8802182A1 (es) 1988-04-16
NO852173L (no) 1985-12-02
NO179075C (no) 1996-07-31
EP0509553B1 (de) 2000-08-09
EP0164965A2 (de) 1985-12-18
DK241385A (da) 1985-12-01
PT80573B (pt) 1987-08-19
GR851317B (de) 1985-11-25
NO179075B (no) 1996-04-22
HU204085B (en) 1991-11-28
IE851321L (en) 1985-11-30
FI93025C (fi) 1995-02-10
YU91985A (en) 1988-12-31
SK278333B6 (en) 1996-11-06
HUT37814A (en) 1986-02-28
IE930589L (en) 1985-11-30
EP0164965B1 (de) 1993-09-29
DE3588225T2 (de) 2001-04-05
IL75318A (en) 1994-08-26
PT80573A (en) 1985-06-01

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition