DE3588225D1 - Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung - Google Patents

Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung

Info

Publication number
DE3588225D1
DE3588225D1 DE3588225T DE3588225T DE3588225D1 DE 3588225 D1 DE3588225 D1 DE 3588225D1 DE 3588225 T DE3588225 T DE 3588225T DE 3588225 T DE3588225 T DE 3588225T DE 3588225 D1 DE3588225 D1 DE 3588225D1
Authority
DE
Germany
Prior art keywords
production
lymphotoxin
antibodies
lymphotoxin antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3588225T
Other languages
English (en)
Other versions
DE3588225T2 (de
Inventor
Bharat Bhushan Aggarwal
Patrick William Gray
Timothy Scott Bringman
Glenn Evan Nedwin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE3588225D1 publication Critical patent/DE3588225D1/de
Application granted granted Critical
Publication of DE3588225T2 publication Critical patent/DE3588225T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE3588225T 1984-05-31 1985-05-30 Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung Expired - Lifetime DE3588225T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US73231285A 1985-05-09 1985-05-09

Publications (2)

Publication Number Publication Date
DE3588225D1 true DE3588225D1 (de) 2000-09-14
DE3588225T2 DE3588225T2 (de) 2001-04-05

Family

ID=27417179

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3587597T Expired - Lifetime DE3587597T2 (de) 1984-05-31 1985-05-30 Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.
DE3588225T Expired - Lifetime DE3588225T2 (de) 1984-05-31 1985-05-30 Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3587597T Expired - Lifetime DE3587597T2 (de) 1984-05-31 1985-05-30 Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.

Country Status (23)

Country Link
EP (2) EP0164965B1 (de)
JP (3) JP2521703B2 (de)
AR (1) AR245219A1 (de)
AT (2) ATE195323T1 (de)
AU (1) AU599303B2 (de)
BG (1) BG60256B2 (de)
CA (1) CA1340641C (de)
CZ (1) CZ283148B6 (de)
DE (2) DE3587597T2 (de)
DK (1) DK171531B1 (de)
ES (1) ES8802182A1 (de)
FI (1) FI93025C (de)
GR (1) GR851317B (de)
HU (1) HU204085B (de)
IE (1) IE63487B1 (de)
IL (1) IL75318A (de)
NO (1) NO179075C (de)
NZ (1) NZ212207A (de)
PL (1) PL155410B1 (de)
PT (1) PT80573B (de)
RO (1) RO100383A2 (de)
SK (1) SK278333B6 (de)
YU (1) YU47735B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES500966A0 (es) 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
JP2557053B2 (ja) * 1984-12-21 1996-11-27 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
EP0230781B1 (de) * 1985-12-24 1992-07-22 Denki Kagaku Kogyo Kabushiki Kaisha Lymphotoxin-Gen, Verfahren zu dessen Herstellung und Lymphotoxin
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
EP0230574A3 (de) * 1986-01-31 1989-03-22 Yale University Pharmazeutische Zusammensetzungen gegen durch LAV/HTLV-III-Virus verursachte Infektionen und ihre Verwendung
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
EP0272894A3 (de) * 1986-12-24 1989-06-14 Takeda Chemical Industries, Ltd. Rekombinantes menschliches Lymphotoxin
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
FI884798A (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (de) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispezifische hybride monoklonale Antikörper
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
ATE219945T1 (de) * 1995-01-23 2002-07-15 Xenotech Inc Zusammensetzung zur verhinderung von osteolyse und metastasen
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
EP1045906B1 (de) 1998-01-15 2008-10-15 Genentech, Inc. Apo-2 ligand
AU2003302386B2 (en) * 2002-11-26 2010-04-01 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP5091476B2 (ja) 2003-06-27 2012-12-05 バイオジェン・アイデック・エムエイ・インコーポレイテッド 均質な抗体溶液の生成のための疎水性相互作用クロマトグラフィーまたはヒンジ領域改変の使用
US20050266004A1 (en) * 2003-12-08 2005-12-01 Jill Giles-Komar Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
WO2005092927A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
CL2007002926A1 (es) * 2006-10-12 2008-05-16 Genentech Inc Anticuerpo antilinfotoxina alfa (lt-alfa); composicion con el anticuerpo; hibridoma pta-7538; acido nucleico codificante del anticuerpo; vector y celula huesped que comprenden el acido nucleico; metodo para inhibir la proliferacion celular activada p
US8067375B2 (en) 2006-10-20 2011-11-29 Biogen Idec Ma Inc. Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
BR112016024841A2 (pt) * 2014-04-25 2017-10-24 Naurex Inc composições estáveis de peptídeos neuroativos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU44186B (en) * 1978-12-22 1990-04-30 Biogen Nv Process for obtaining recombinant dnk molecules
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
IE56026B1 (en) 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production

Also Published As

Publication number Publication date
YU91985A (en) 1988-12-31
FI93025C (fi) 1995-02-10
GR851317B (de) 1985-11-25
YU47735B (sh) 1996-01-08
EP0164965A2 (de) 1985-12-18
SK393085A3 (en) 1996-11-06
JPH07250692A (ja) 1995-10-03
RO100383A2 (ro) 1991-10-17
IE63487B1 (en) 1995-05-03
IL75318A (en) 1994-08-26
FI93025B (fi) 1994-10-31
AR245219A1 (es) 1993-12-30
RO100383B1 (ro) 1991-03-01
FI852143A0 (fi) 1985-05-29
NO179075B (no) 1996-04-22
PT80573B (pt) 1987-08-19
HU204085B (en) 1991-11-28
IE930589L (en) 1985-11-30
DK171531B1 (da) 1996-12-23
ES543695A0 (es) 1988-04-16
IL75318A0 (en) 1985-09-29
AU599303B2 (en) 1990-07-19
JP2804237B2 (ja) 1998-09-24
IE851321L (en) 1985-11-30
NO179075C (no) 1996-07-31
JP2521703B2 (ja) 1996-08-07
ATE95243T1 (de) 1993-10-15
NO852173L (no) 1985-12-02
EP0509553B1 (de) 2000-08-09
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
PL155410B1 (en) 1991-11-29
HUT37814A (en) 1986-02-28
NZ212207A (en) 1991-07-26
DE3587597T2 (de) 1994-06-01
DK241385D0 (da) 1985-05-30
EP0164965A3 (en) 1988-04-06
FI852143L (fi) 1985-12-01
ES8802182A1 (es) 1988-04-16
BG60256B2 (bg) 1994-03-24
CZ283148B6 (cs) 1998-01-14
DK241385A (da) 1985-12-01
DE3588225T2 (de) 2001-04-05
JPH07291995A (ja) 1995-11-07
JPS6156197A (ja) 1986-03-20
CZ393085A3 (en) 1997-07-16
CA1340641C (en) 1999-07-13
DE3587597D1 (de) 1993-11-04
ATE195323T1 (de) 2000-08-15
PT80573A (en) 1985-06-01
SK278333B6 (en) 1996-11-06
PL253739A1 (en) 1986-03-11
EP0509553A1 (de) 1992-10-21
EP0164965B1 (de) 1993-09-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition