DE3578557D1 - Substituierte thiophen-2-sulfonamide und ihre herstellung. - Google Patents

Substituierte thiophen-2-sulfonamide und ihre herstellung.

Info

Publication number
DE3578557D1
DE3578557D1 DE8585402081T DE3578557T DE3578557D1 DE 3578557 D1 DE3578557 D1 DE 3578557D1 DE 8585402081 T DE8585402081 T DE 8585402081T DE 3578557 T DE3578557 T DE 3578557T DE 3578557 D1 DE3578557 D1 DE 3578557D1
Authority
DE
Germany
Prior art keywords
sulfonamides
production
substituted thiophen
thiophen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585402081T
Other languages
English (en)
Inventor
Kenneth L Shepard
Samuel L Graham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3578557D1 publication Critical patent/DE3578557D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
DE8585402081T 1984-11-02 1985-10-28 Substituierte thiophen-2-sulfonamide und ihre herstellung. Expired - Fee Related DE3578557D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66766684A 1984-11-02 1984-11-02

Publications (1)

Publication Number Publication Date
DE3578557D1 true DE3578557D1 (de) 1990-08-09

Family

ID=24679132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585402081T Expired - Fee Related DE3578557D1 (de) 1984-11-02 1985-10-28 Substituierte thiophen-2-sulfonamide und ihre herstellung.

Country Status (3)

Country Link
EP (1) EP0182691B1 (de)
JP (1) JPH06104664B2 (de)
DE (1) DE3578557D1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4665090A (en) * 1985-10-09 1987-05-12 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
DE3667056D1 (en) * 1985-12-24 1989-12-28 Merck & Co Inc Substituted thiophene-2-sulfonamide antiglaucoma agents
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459571A (en) * 1974-09-12 1976-12-22 Pfizer Ltd Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus
ZA813332B (en) * 1980-06-21 1982-05-26 Pfizer Larvicides and isecticides
US4477466A (en) * 1983-05-23 1984-10-16 Merck & Co., Inc. Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure
ES8600752A1 (es) * 1983-06-20 1985-10-16 Merck & Co Inc Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida.

Also Published As

Publication number Publication date
JPH06104664B2 (ja) 1994-12-21
EP0182691A1 (de) 1986-05-28
EP0182691B1 (de) 1990-07-04
JPS61109787A (ja) 1986-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee