DE3579399D1 - Cephalosporinverbindungen und ihre herstellung. - Google Patents

Cephalosporinverbindungen und ihre herstellung.

Info

Publication number
DE3579399D1
DE3579399D1 DE8585401741T DE3579399T DE3579399D1 DE 3579399 D1 DE3579399 D1 DE 3579399D1 DE 8585401741 T DE8585401741 T DE 8585401741T DE 3579399 T DE3579399 T DE 3579399T DE 3579399 D1 DE3579399 D1 DE 3579399D1
Authority
DE
Germany
Prior art keywords
production
cephalosporine compounds
cephalosporine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585401741T
Other languages
English (en)
Inventor
Kunio Atsumi
Kenji Sakagami
Yuichi Yamamoto
Takashi Yoshida
Ken Nishihata
Shinichi Kondo
Shunzo Fukatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59186464A external-priority patent/JPS61178991A/ja
Priority claimed from JP60157005A external-priority patent/JPS6219593A/ja
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of DE3579399D1 publication Critical patent/DE3579399D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8585401741T 1984-09-07 1985-09-06 Cephalosporinverbindungen und ihre herstellung. Expired - Lifetime DE3579399D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59186464A JPS61178991A (ja) 1984-09-07 1984-09-07 新規セフアロスポリン化合物
JP60157005A JPS6219593A (ja) 1985-07-18 1985-07-18 新規セフエム化合物

Publications (1)

Publication Number Publication Date
DE3579399D1 true DE3579399D1 (de) 1990-10-04

Family

ID=26484598

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585401741T Expired - Lifetime DE3579399D1 (de) 1984-09-07 1985-09-06 Cephalosporinverbindungen und ihre herstellung.

Country Status (7)

Country Link
US (1) US4839350A (de)
EP (1) EP0175610B1 (de)
KR (1) KR890001196B1 (de)
CA (1) CA1272714A (de)
DE (1) DE3579399D1 (de)
ES (1) ES8704955A1 (de)
IE (1) IE58487B1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205088A (ja) * 1986-03-03 1987-09-09 Meiji Seika Kaisha Ltd 新規セフエム化合物
US5073551A (en) * 1988-03-30 1991-12-17 Sagami Chemical Research Center Cephalosporin compounds
JPH0678234B2 (ja) 1988-04-19 1994-10-05 明治製菓株式会社 経口投与用抗菌組成物
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
JPH0635464B2 (ja) * 1988-09-02 1994-05-11 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
IL94946A0 (en) * 1989-07-13 1991-06-10 Eisai Co Ltd 3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
DE69427365T2 (de) * 1993-09-29 2002-02-28 Meiji Seika Kaisha Neue cephalosporinderivate
ATE198892T1 (de) * 1993-11-17 2001-02-15 Biochemie Gmbh Trennung von cephalosporinisomeren
JPH0840907A (ja) 1994-08-03 1996-02-13 Meiji Seika Kaisha Ltd セファロスポリン注射剤
AR004014A1 (es) * 1995-10-13 1998-09-30 Meiji Seika Kaisha Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion
EP0937083B1 (de) * 1996-09-20 2003-04-23 Meiji Seika Kaisha Ltd. Kristalline substanz von pivoxilcefditoren und verfahren zu ihrer herstellung
PT1016665E (pt) * 1997-06-24 2002-12-31 Meiji Seika Kaisha Processo para a preparacao selectiva de isomeros z de 3-(2-vinil-substituido) cefalosporinas
EP1325923B1 (de) * 2000-09-22 2006-12-06 Zenyaku Kogyo Kabushiki Kaisha Cephem verbindungen und diese enthaltende esbl nachweisreagenzien
JP5051865B2 (ja) 2001-05-29 2012-10-17 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド レシチンでのプロドラッグエステル非乳化調合物の経口バイオアベイラビリティの向上
US20030060451A1 (en) * 2001-05-29 2003-03-27 Rajneesh Taneja Enhancement of oral bioavailability of non-emulsified formulations of prodrug esters with lecithin
KR20030066204A (ko) * 2002-02-05 2003-08-09 씨제이 주식회사 세프디토렌 중간체의 제조방법
US7459550B2 (en) 2003-07-04 2008-12-02 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of Cefditoren
WO2005016936A2 (en) * 2003-08-14 2005-02-24 Ranbaxy Laboratories Limited Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof
EP1671635B1 (de) * 2003-10-08 2012-01-04 Meiji Seika Pharma Co., Ltd. Nichtkristalline antibakterielle zusammensetzung mit cefditoren-pivoxil
WO2005100367A1 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins
JP4064948B2 (ja) * 2004-06-04 2008-03-19 明治製菓株式会社 ３−アルケニルセフェム化合物及び製造方法
DE112006001606T5 (de) 2005-06-08 2009-07-09 Elan Pharma International Ltd., Athlone Nanopartikuläre und eine kontrollierte Freisetzung aufweisende Zusammensetzung, die Cefditoren umfassen
US20080069879A1 (en) * 2006-05-02 2008-03-20 Ravishekhar Bhiwgade Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof
CA2935651A1 (en) 2007-10-09 2009-04-16 Gladius Pharmaceuticals Corporation Broad spectrum beta-lactamase inhibitors
WO2011139251A1 (en) 2010-05-04 2011-11-10 Mahmut Bilgic Pharmaceutical compositions comprising cefditoren pivoxil
EP2520578A1 (de) 2011-05-06 2012-11-07 Lupin Limited Verfahren zur Reinigung von Cephalosporinen
WO2013109203A1 (en) 2012-01-18 2013-07-25 Mahmut Bilgic Tablet formulations comprising cefditoren pivoxil
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas
WO2016114727A1 (en) 2015-01-16 2016-07-21 Öğün Yusuf Toktamiş Cefditoren pivoxil compositions with improved stability and production methods thereof
CN105622636B (zh) * 2016-02-05 2017-08-25 河南理工大学 一种头孢妥仑匹酯中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
NO801501L (no) * 1979-05-23 1980-11-24 Rhone Poulenc Ind Fremgangsmaate for fremstilling av 3-tiovinylcefalosporiner
US4482551A (en) * 1980-06-26 1984-11-13 Hoffmann-La Roche Inc. Cephalosporin derivatives
FR2494280A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation
US4546101A (en) * 1982-09-10 1985-10-08 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof

Also Published As

Publication number Publication date
US4839350A (en) 1989-06-13
EP0175610A2 (de) 1986-03-26
ES8704955A1 (es) 1987-04-16
IE852071L (en) 1986-03-07
IE58487B1 (en) 1993-09-22
KR890001196B1 (ko) 1989-04-27
EP0175610B1 (de) 1990-08-29
CA1272714A (en) 1990-08-14
KR860002511A (ko) 1986-04-26
ES546749A0 (es) 1987-04-16
EP0175610A3 (en) 1987-06-03

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: STREHL, P., DIPL.-ING. DIPL.-WIRTSCH.-ING. SCHUEBEL-HOPF, U., DIPL.-CHEM. DR.RER.NAT. GROENING, H., DIPL.-ING., PAT.-ANWAELTE, 8000 MUENCHEN

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MEIJI SEIKA KAISHA LTD., TOKIO/TOKYO, JP