DE3579754D1 - 16 alpha-methyl-steroide und ihre herstellung. - Google Patents

16 alpha-methyl-steroide und ihre herstellung.

Info

Publication number
DE3579754D1
DE3579754D1 DE8585304101T DE3579754T DE3579754D1 DE 3579754 D1 DE3579754 D1 DE 3579754D1 DE 8585304101 T DE8585304101 T DE 8585304101T DE 3579754 T DE3579754 T DE 3579754T DE 3579754 D1 DE3579754 D1 DE 3579754D1
Authority
DE
Germany
Prior art keywords
production
alpha methyl
methyl steroids
steroids
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585304101T
Other languages
English (en)
Inventor
Verlan Henry Vanrheenen
Joel Edward Huber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE3579754D1 publication Critical patent/DE3579754D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE8585304101T 1984-06-11 1985-06-10 16 alpha-methyl-steroide und ihre herstellung. Expired - Fee Related DE3579754D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61898684A 1984-06-11 1984-06-11
US06/724,380 US4704455A (en) 1984-06-11 1985-04-18 16α-methylatedΔ17(20)-corticoids

Publications (1)

Publication Number Publication Date
DE3579754D1 true DE3579754D1 (de) 1990-10-25

Family

ID=27088379

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8888101102T Expired - Fee Related DE3586745T2 (de) 1984-06-11 1985-06-10 9,11-epoxy-21-hydroxypregnan-derivate.
DE8585304101T Expired - Fee Related DE3579754D1 (de) 1984-06-11 1985-06-10 16 alpha-methyl-steroide und ihre herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8888101102T Expired - Fee Related DE3586745T2 (de) 1984-06-11 1985-06-10 9,11-epoxy-21-hydroxypregnan-derivate.

Country Status (5)

Country Link
US (1) US4704455A (de)
EP (2) EP0165037B1 (de)
DE (2) DE3586745T2 (de)
HK (2) HK96993A (de)
HU (1) HU207340B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990612A (en) * 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
AU7480187A (en) * 1986-06-04 1988-01-11 Upjohn Company, The 16alpha-methylation process
US4975536A (en) * 1989-06-02 1990-12-04 The Upjohn Company Conversion of a delta16-steroid to a delta17(20)-20-silyl ether
FR2700548B1 (fr) * 1993-01-20 1995-03-03 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.
US6040468A (en) * 1996-10-25 2000-03-21 Alcon Laboratories, Inc. Method of preparing 16α, 17α-dialkylated steroids
EP2386634A4 (de) 2009-01-07 2012-07-18 Mitsubishi Chem Corp Sterolseitenketten spaltendes enzymprotein und verwendung davon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2864834A (en) * 1957-10-08 1958-12-16 American Cyanamid Co Pregnatetraenes and method of preparing the same
US3072686A (en) * 1958-10-10 1963-01-08 Ciba Geigy Corp 16alpha-alkyl-pregnane compounds and process for their manufacture
US3210341A (en) * 1963-03-29 1965-10-05 Upjohn Co 9, 11-epoxy-6-fluoro-delta4, 16-pregnadienes and products produced therefrom
US3231568A (en) * 1964-02-26 1966-01-25 Smith Kline French Lab Processes and intermediates for preparing 16alpha-methyl corticoids
US3513163A (en) * 1968-02-12 1970-05-19 Searle & Co 21-tri(lower alkyl)-siloxypregnane-3,20-diones
CH529119A (de) * 1968-10-02 1972-10-15 Schering Ag Verfahren zur Herstellung von 17a-Acyloxy-20-keto-steroiden
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
US3876633A (en) * 1973-02-21 1975-04-08 Omni Research Processes and intermediates for 16-substituted corticoid synthesis
GB1536691A (en) * 1975-02-01 1978-12-20 Lark Spa 16-methyl-17-bromo-1,4-pregnadien-21-ol-3,20-dione compounds
NL7607283A (nl) * 1975-07-23 1977-01-25 Merck & Co Inc Werkwijze voor het bereiden van nieuwe pregnaansteroiden.
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
US4277409A (en) * 1977-03-18 1981-07-07 Roussel Uclaf Preparation of 9α-fluoro-16α-methyl-21-acetoxy-Δ1,4 -pregnadiene-11β-ol-3,20-dione
GB2001990B (en) * 1977-07-16 1982-01-13 Lark Spa Process for the preparation of prednisolone derivatives
US4568492A (en) * 1984-09-14 1986-02-04 The Upjohn Company Δ16-20-Keto steroid conversion to 17α-hydroxy-20-keto steroids

Also Published As

Publication number Publication date
DE3586745T2 (de) 1993-03-18
EP0165037A3 (en) 1987-01-21
EP0278319B1 (de) 1992-10-07
US4704455A (en) 1987-11-03
HUT38952A (en) 1986-07-28
EP0165037A2 (de) 1985-12-18
EP0165037B1 (de) 1990-09-19
HK96993A (en) 1993-09-24
HU207340B (en) 1993-03-29
EP0278319A1 (de) 1988-08-17
HK185395A (en) 1995-12-15
DE3586745D1 (de) 1992-11-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US

8339 Ceased/non-payment of the annual fee