FI852143L - Rekombinantti lymfotoksiini - Google Patents

Rekombinantti lymfotoksiini

Info

Publication number
FI852143L
FI852143L FI852143A FI852143A FI852143L FI 852143 L FI852143 L FI 852143L FI 852143 A FI852143 A FI 852143A FI 852143 A FI852143 A FI 852143A FI 852143 L FI852143 L FI 852143L
Authority
FI
Finland
Prior art keywords
recombinant lymphotoxin
lymphotoxin
recombinant
Prior art date
Application number
FI852143A
Other languages
English (en)
Swedish (sv)
Other versions
FI93025C (fi
FI93025B (fi
FI852143A0 (fi
Inventor
Bharat Bhushan Aggarwal
Timothy Scott Bringman
Patrick William Gray
Glenn Evan Nedwin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI852143A0 publication Critical patent/FI852143A0/fi
Publication of FI852143L publication Critical patent/FI852143L/fi
Application granted granted Critical
Publication of FI93025B publication Critical patent/FI93025B/fi
Publication of FI93025C publication Critical patent/FI93025C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI852143A 1984-05-31 1985-05-29 Rekombinantti lymfotoksiini FI93025C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US61650384 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US61650284 1984-05-31
US73231285A 1985-05-09 1985-05-09
US73231285 1985-05-09

Publications (4)

Publication Number Publication Date
FI852143A0 FI852143A0 (fi) 1985-05-29
FI852143L true FI852143L (fi) 1985-12-01
FI93025B FI93025B (fi) 1994-10-31
FI93025C FI93025C (fi) 1995-02-10

Family

ID=27417179

Family Applications (1)

Application Number Title Priority Date Filing Date
FI852143A FI93025C (fi) 1984-05-31 1985-05-29 Rekombinantti lymfotoksiini

Country Status (23)

Country Link
EP (2) EP0509553B1 (fi)
JP (3) JP2521703B2 (fi)
AR (1) AR245219A1 (fi)
AT (2) ATE195323T1 (fi)
AU (1) AU599303B2 (fi)
BG (1) BG60256B2 (fi)
CA (1) CA1340641C (fi)
CZ (1) CZ283148B6 (fi)
DE (2) DE3587597T2 (fi)
DK (1) DK171531B1 (fi)
ES (1) ES8802182A1 (fi)
FI (1) FI93025C (fi)
GR (1) GR851317B (fi)
HU (1) HU204085B (fi)
IE (1) IE63487B1 (fi)
IL (1) IL75318A (fi)
NO (1) NO179075C (fi)
NZ (1) NZ212207A (fi)
PL (1) PL155410B1 (fi)
PT (1) PT80573B (fi)
RO (1) RO100383A2 (fi)
SK (1) SK393085A3 (fi)
YU (1) YU47735B (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE57069B1 (en) 1980-04-03 1992-04-22 Biogen Inc Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0216786B1 (en) * 1984-12-21 1992-03-18 Biogen, Inc. Purification, production and use of tumor necrosis factors
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
EP0230781B1 (en) * 1985-12-24 1992-07-22 Denki Kagaku Kogyo Kabushiki Kaisha Lymphotoxin gene, method for its production, and lymphotoxin
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
EP0230574A3 (en) * 1986-01-31 1989-03-22 Yale University Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
JP2636862B2 (ja) * 1986-12-24 1997-07-30 武田薬品工業株式会社 組み換え型ヒトリンホトキシン
FI884798A (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (en) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispecific hybrid monoclonal antibody
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
JP4231106B2 (ja) * 1995-01-23 2009-02-25 ゼノテック インコーポレイティッド 骨溶解および転移を改善する方法
US5925351A (en) * 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
CA2318029C (en) 1998-01-15 2009-05-19 Genentech, Inc. Apo-2 ligand
WO2004047728A2 (en) * 2002-11-26 2004-06-10 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
NZ544924A (en) 2003-06-27 2009-03-31 Biogen Idec Inc Modified binding molecules comprising connecting peptides
US20050266004A1 (en) * 2003-12-08 2005-12-01 Jill Giles-Komar Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
EP1756162A1 (en) 2004-03-23 2007-02-28 Biogen Idec MA Inc. Receptor coupling agents and therapeutic uses thereof
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
KR20090078349A (ko) * 2006-10-12 2009-07-17 제넨테크, 인크. 림포톡신-알파에 대한 항체
KR20090071652A (ko) 2006-10-20 2009-07-01 바이오겐 아이덱 엠에이 인코포레이티드 가용성 림프독소-베타-수용체를 이용한 탈수초성 장애의 치료
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
KR20160144499A (ko) * 2014-04-25 2016-12-16 노렉스, 인크. 신경활성 펩타이드의 안정한 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD147855A5 (de) * 1978-12-22 1981-04-22 Biogen Nv Verfahren zur erzeugung mindestens eines hbv-antigenwirkung aufweisenden polypeptids
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production

Also Published As

Publication number Publication date
FI93025C (fi) 1995-02-10
GR851317B (fi) 1985-11-25
NO179075B (no) 1996-04-22
EP0509553B1 (en) 2000-08-09
PT80573A (en) 1985-06-01
CZ393085A3 (en) 1997-07-16
FI93025B (fi) 1994-10-31
SK278333B6 (en) 1996-11-06
RO100383A2 (ro) 1991-10-17
NO179075C (no) 1996-07-31
AU599303B2 (en) 1990-07-19
ATE95243T1 (de) 1993-10-15
AR245219A1 (es) 1993-12-30
DK171531B1 (da) 1996-12-23
JP2804237B2 (ja) 1998-09-24
PL155410B1 (en) 1991-11-29
ES8802182A1 (es) 1988-04-16
FI852143A0 (fi) 1985-05-29
EP0164965A3 (en) 1988-04-06
CA1340641C (en) 1999-07-13
EP0164965B1 (en) 1993-09-29
IL75318A (en) 1994-08-26
DE3587597D1 (de) 1993-11-04
ES543695A0 (es) 1988-04-16
SK393085A3 (en) 1996-11-06
PT80573B (pt) 1987-08-19
ATE195323T1 (de) 2000-08-15
IE851321L (en) 1985-11-30
NO852173L (no) 1985-12-02
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
DE3588225D1 (de) 2000-09-14
IE63487B1 (en) 1995-05-03
JPH07291995A (ja) 1995-11-07
EP0164965A2 (en) 1985-12-18
PL253739A1 (en) 1986-03-11
DK241385A (da) 1985-12-01
JP2521703B2 (ja) 1996-08-07
DE3588225T2 (de) 2001-04-05
IE930589L (en) 1985-11-30
YU47735B (sh) 1996-01-08
YU91985A (en) 1988-12-31
RO100383B1 (ro) 1991-03-01
HUT37814A (en) 1986-02-28
JPS6156197A (ja) 1986-03-20
CZ283148B6 (cs) 1998-01-14
JPH07250692A (ja) 1995-10-03
DK241385D0 (da) 1985-05-30
BG60256B2 (bg) 1994-03-24
EP0509553A1 (en) 1992-10-21
HU204085B (en) 1991-11-28
DE3587597T2 (de) 1994-06-01
IL75318A0 (en) 1985-09-29
NZ212207A (en) 1991-07-26

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: GENENTECH INC.

BB Publication of examined application
FG Patent granted

Owner name: GENENTECH, INC.

MA Patent expired