YU47735B - Postupak za sintezu biološki aktivnih polipeptida limfotoksina - Google Patents

Postupak za sintezu biološki aktivnih polipeptida limfotoksina

Info

Publication number
YU47735B
YU47735B YU91985A YU91985A YU47735B YU 47735 B YU47735 B YU 47735B YU 91985 A YU91985 A YU 91985A YU 91985 A YU91985 A YU 91985A YU 47735 B YU47735 B YU 47735B
Authority
YU
Yugoslavia
Prior art keywords
lymphotoxin
nucleic acid
polypeptides
synthesis
procedure
Prior art date
Application number
YU91985A
Other languages
English (en)
Other versions
YU91985A (en
Inventor
B.B. Aggarwal
T.S. Bringman
P.W. Gray
G.E. Nedwin
Original Assignee
Genentech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Genentech Inc. filed Critical Genentech Inc.
Publication of YU91985A publication Critical patent/YU91985A/xx
Publication of YU47735B publication Critical patent/YU47735B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • C07K16/242Lymphotoxin [LT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • C07K14/5255Lymphotoxin [LT]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

POSTUPAK ZA SINTEZU BIOLOŠKI AKTIVNIH POLIPEPTIDA LIMFOTOKSINA postupak ekspresije u rekombinatnoj ćeliji domaćina rekombinantne nukleinske kiseline kao konstrukta, naznačen eime, što obuhvata: i nukleinsku kiselinu koja kodira limfotoksin kao što je prikazano na sl. 2A, ili ii nukleinsku kiselinu kako se dobiva hibridizacijom sa onom datom na sl.2A i koja kodira limfotoksinski polipeptid, ili iii nukleinsku kiselinu koja kodira limfotoksinski polipeptid koji ima uglavnom strukturnu morfologiju sa bar delom limfotoksinske amino kiselinske sekvence date na sl.2A. Prijava sadrži još 2 nezavisna i 40 zavisnih zahteva.
YU91985A 1984-05-31 1985-05-31 Postupak za sintezu biološki aktivnih polipeptida limfotoksina YU47735B (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US73231285A 1985-05-09 1985-05-09

Publications (2)

Publication Number Publication Date
YU91985A YU91985A (en) 1988-12-31
YU47735B true YU47735B (sh) 1996-01-08

Family

ID=27417179

Family Applications (1)

Application Number Title Priority Date Filing Date
YU91985A YU47735B (sh) 1984-05-31 1985-05-31 Postupak za sintezu biološki aktivnih polipeptida limfotoksina

Country Status (23)

Country Link
EP (2) EP0164965B1 (sh)
JP (3) JP2521703B2 (sh)
AR (1) AR245219A1 (sh)
AT (2) ATE95243T1 (sh)
AU (1) AU599303B2 (sh)
BG (1) BG60256B2 (sh)
CA (1) CA1340641C (sh)
CZ (1) CZ283148B6 (sh)
DE (2) DE3588225T2 (sh)
DK (1) DK171531B1 (sh)
ES (1) ES8802182A1 (sh)
FI (1) FI93025C (sh)
GR (1) GR851317B (sh)
HU (1) HU204085B (sh)
IE (1) IE63487B1 (sh)
IL (1) IL75318A (sh)
NO (1) NO179075C (sh)
NZ (1) NZ212207A (sh)
PL (1) PL155410B1 (sh)
PT (1) PT80573B (sh)
RO (1) RO100383A2 (sh)
SK (1) SK278333B6 (sh)
YU (1) YU47735B (sh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR860001471B1 (ko) 1980-04-03 1986-09-26 비오겐 엔. 브이 인체의 섬유아세포 인터페론(IFN-β)폴리펩티드의 제조방법
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
DE3585690D1 (de) * 1984-12-21 1992-04-23 Biogen Inc Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren.
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
EP0230781B1 (en) * 1985-12-24 1992-07-22 Denki Kagaku Kogyo Kabushiki Kaisha Lymphotoxin gene, method for its production, and lymphotoxin
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
EP0230574A3 (en) * 1986-01-31 1989-03-22 Yale University Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
JP2636862B2 (ja) * 1986-12-24 1997-07-30 武田薬品工業株式会社 組み換え型ヒトリンホトキシン
FI884798A (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (en) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispecific hybrid monoclonal antibody
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
ES2179929T3 (es) * 1995-01-23 2003-02-01 Xenotech Inc Procedimiento que trata de inhibir la osteolisis y las metastasis.
US5925351A (en) * 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
EP1045906B1 (en) 1998-01-15 2008-10-15 Genentech, Inc. Apo-2 ligand
EP1572116A4 (en) * 2002-11-26 2007-12-12 Genentech Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE DISEASES
US20050163782A1 (en) 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
US20050266004A1 (en) * 2003-12-08 2005-12-01 Jill Giles-Komar Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
AU2005227322A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
TWI414531B (zh) * 2006-10-12 2013-11-11 Genentech Inc 淋巴毒素α之抗體
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
US8067375B2 (en) 2006-10-20 2011-11-29 Biogen Idec Ma Inc. Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor
UA122204C2 (uk) * 2014-04-25 2020-10-12 Наурекс, Інк. Стабільні композиції нейроактивних пептидів

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171727B1 (da) * 1978-12-22 1997-04-14 Biogen Inc Rekombinante hepatitis B virus DNA-molekyler, værtsorganismer transformeret hermed, HBV-antigenspecifikke polypeptider, DNA-sekvenser kodende for HBV-antigenspecifikke polypeptider, metoder til påvisning af hepatitis B virus-antistoffer, metoder til fremstilling af nævnte DNA-molekyler, fremgangsmåder til fremstilling af nævnte polypeptider og midler til påvisning af HBV-infektion
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin

Also Published As

Publication number Publication date
EP0509553A1 (en) 1992-10-21
JP2804237B2 (ja) 1998-09-24
FI852143A0 (fi) 1985-05-29
DK171531B1 (da) 1996-12-23
ES8802182A1 (es) 1988-04-16
NO852173L (no) 1985-12-02
YU91985A (en) 1988-12-31
CA1340641C (en) 1999-07-13
EP0164965A2 (en) 1985-12-18
JP2521703B2 (ja) 1996-08-07
JPH07291995A (ja) 1995-11-07
EP0164965B1 (en) 1993-09-29
FI93025B (fi) 1994-10-31
DK241385A (da) 1985-12-01
IE930589L (en) 1985-11-30
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
DE3587597D1 (de) 1993-11-04
HU204085B (en) 1991-11-28
RO100383B1 (ro) 1991-03-01
PL253739A1 (en) 1986-03-11
ATE195323T1 (de) 2000-08-15
BG60256B2 (bg) 1994-03-24
HUT37814A (en) 1986-02-28
AR245219A1 (es) 1993-12-30
PL155410B1 (en) 1991-11-29
IE63487B1 (en) 1995-05-03
CZ283148B6 (cs) 1998-01-14
EP0509553B1 (en) 2000-08-09
SK393085A3 (en) 1996-11-06
IE851321L (en) 1985-11-30
IL75318A (en) 1994-08-26
NZ212207A (en) 1991-07-26
RO100383A2 (ro) 1991-10-17
NO179075C (no) 1996-07-31
DE3587597T2 (de) 1994-06-01
DE3588225T2 (de) 2001-04-05
ATE95243T1 (de) 1993-10-15
PT80573A (en) 1985-06-01
CZ393085A3 (en) 1997-07-16
AU599303B2 (en) 1990-07-19
EP0164965A3 (en) 1988-04-06
FI852143L (fi) 1985-12-01
JPS6156197A (ja) 1986-03-20
IL75318A0 (en) 1985-09-29
DK241385D0 (da) 1985-05-30
SK278333B6 (en) 1996-11-06
PT80573B (pt) 1987-08-19
ES543695A0 (es) 1988-04-16
NO179075B (no) 1996-04-22
DE3588225D1 (de) 2000-09-14
JPH07250692A (ja) 1995-10-03
GR851317B (sh) 1985-11-25
FI93025C (fi) 1995-02-10

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