RO100383B1 - Metoda de obtinere a unui anticorp monoclonal - Google Patents

Metoda de obtinere a unui anticorp monoclonal

Info

Publication number
RO100383B1
RO100383B1 RO131846A RO13184688A RO100383B1 RO 100383 B1 RO100383 B1 RO 100383B1 RO 131846 A RO131846 A RO 131846A RO 13184688 A RO13184688 A RO 13184688A RO 100383 B1 RO100383 B1 RO 100383B1
Authority
RO
Romania
Prior art keywords
monoclonal antibody
immunized
antibody
cells
atilimphotoxin
Prior art date
Application number
RO131846A
Other languages
English (en)
Other versions
RO100383A2 (ro
Inventor
Bhushan Aggarwal Bharat
Scott Bringman Timothy
William Gray Partrick
Evan Nedwin Glenn
Original Assignee
Gennentech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/616,502 external-priority patent/US4959457A/en
Application filed by Gennentech Inc. filed Critical Gennentech Inc.
Publication of RO100383B1 publication Critical patent/RO100383B1/ro
Publication of RO100383A2 publication Critical patent/RO100383A2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Inventia se refera la o metoda de obtinere a unui anticorp specific antilimfotoxina. Se prepara o suspensie din limfotoxina si hidroxid de aluminiu cu care se imunizeaza soareci si apoi se recolteaza ser, plasma, fractiuni IgG sau imunoglobuline secretate de hibridoamele generate de celulele spenice sau de celulele limfatice de la animalele imunizate, care contin anticorpul atilimfotoxina lipsit de anticorpi antilimfotoxina.
RO131846A 1984-05-31 1988-01-19 Metoda de obtinere a unui anticorp monoclonal RO100383A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61650384A 1984-05-31 1984-05-31
US06/616,502 US4959457A (en) 1984-05-31 1984-05-31 Anti-lymphotoxin
US73231285A 1985-05-09 1985-05-09

Publications (2)

Publication Number Publication Date
RO100383B1 true RO100383B1 (ro) 1991-03-01
RO100383A2 RO100383A2 (ro) 1991-10-17

Family

ID=27417179

Family Applications (1)

Application Number Title Priority Date Filing Date
RO131846A RO100383A2 (ro) 1984-05-31 1988-01-19 Metoda de obtinere a unui anticorp monoclonal

Country Status (23)

Country Link
EP (2) EP0509553B1 (ro)
JP (3) JP2521703B2 (ro)
AR (1) AR245219A1 (ro)
AT (2) ATE95243T1 (ro)
AU (1) AU599303B2 (ro)
BG (1) BG60256B2 (ro)
CA (1) CA1340641C (ro)
CZ (1) CZ283148B6 (ro)
DE (2) DE3588225T2 (ro)
DK (1) DK171531B1 (ro)
ES (1) ES8802182A1 (ro)
FI (1) FI93025C (ro)
GR (1) GR851317B (ro)
HU (1) HU204085B (ro)
IE (1) IE63487B1 (ro)
IL (1) IL75318A (ro)
NO (1) NO179075C (ro)
NZ (1) NZ212207A (ro)
PL (1) PL155410B1 (ro)
PT (1) PT80573B (ro)
RO (1) RO100383A2 (ro)
SK (1) SK393085A3 (ro)
YU (1) YU47735B (ro)

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JP2687995B2 (ja) 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
ATE73856T1 (de) * 1984-12-21 1992-04-15 Biogen Inc Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren.
JPS62111928A (ja) * 1985-10-15 1987-05-22 Kanegafuchi Chem Ind Co Ltd 新規リンホトキシン
JPS62195285A (ja) * 1986-02-19 1987-08-28 Kanegafuchi Chem Ind Co Ltd リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
AU603768B2 (en) * 1985-07-04 1990-11-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
JP2548204B2 (ja) * 1987-06-27 1996-10-30 電気化学工業株式会社 新生理活性ポリペプチド
DE3686148T2 (de) * 1985-12-24 1993-01-14 Denki Kagaku Kogyo Kk Lymphotoxin-gen, verfahren zu dessen herstellung und lymphotoxin.
US5403725A (en) * 1985-12-24 1995-04-04 Denki Kagaku Kogyo Kabushiki Kaisha Method for production of lymphotoxin (TNFB) in cell line A-C5-8
EP0230574A3 (en) * 1986-01-31 1989-03-22 Yale University Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) * 1986-10-22 1988-05-10 Kanegafuchi Chem Ind Co Ltd ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
JP2636862B2 (ja) * 1986-12-24 1997-07-30 武田薬品工業株式会社 組み換え型ヒトリンホトキシン
US5175268A (en) * 1986-12-24 1992-12-29 Takeda Chemical Industries, Ltd. DNA encoding recombinant human lymphotoxin
FI884798A7 (fi) * 1987-10-28 1989-04-29 Eisai Co Ltd Rekombinantlymfotoxin.
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (en) * 1988-04-22 1990-05-16 Takeda Chemical Industries, Ltd. Bispecific hybrid monoclonal antibody
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) * 1988-10-31 1991-04-30 Seiichi Uesugi New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) * 1989-09-20 1991-05-07 Denki Kagaku Kogyo Kk 抗腫瘍剤
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
AU703222B2 (en) * 1995-01-23 1999-03-18 Xenotech Incorporated Composition to ameliorate osteolysis and metastasis
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
ATE411385T1 (de) 1998-01-15 2008-10-15 Genentech Inc Apo-2 ligand
WO2004047728A2 (en) * 2002-11-26 2004-06-10 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20050163782A1 (en) 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
US20050266004A1 (en) * 2003-12-08 2005-12-01 Jill Giles-Komar Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
SG151294A1 (en) 2004-03-23 2009-04-30 Biogen Idec Inc Receptor coupling agents and therapeutic uses thereof
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
EP2084188A2 (en) * 2006-10-12 2009-08-05 Genentech, Inc. Antibodies to lymphotoxin-alpha
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
JP2010506955A (ja) 2006-10-20 2010-03-04 バイオジェン・アイデック・エムエイ・インコーポレイテッド 可溶性リンホトキシンβレセプターによる脱髄障害の処置
RU2716164C2 (ru) * 2014-04-25 2020-03-06 Наурекс, Инк. Стабильные композиции нейроактивных пептидов

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53176B1 (en) * 1978-12-22 1988-08-17 Biogen Nv Recombinant dna molecules and their method of production
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) * 1982-07-30 1984-08-29 Genentech Inc Human lymphotoxin
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
DE3331108A1 (de) * 1983-08-30 1985-05-02 Boehringer Ingelheim International GmbH, 6507 Ingelheim Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
EP0135797A3 (de) * 1983-08-30 1987-11-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin

Also Published As

Publication number Publication date
IE930589L (en) 1985-11-30
DE3588225T2 (de) 2001-04-05
CA1340641C (en) 1999-07-13
EP0509553B1 (en) 2000-08-09
ATE95243T1 (de) 1993-10-15
AR245219A1 (es) 1993-12-30
IE851321L (en) 1985-11-30
ES543695A0 (es) 1988-04-16
NZ212207A (en) 1991-07-26
AU4320385A (en) 1985-12-05
BG60256B1 (bg) 1994-03-24
CZ393085A3 (en) 1997-07-16
ES8802182A1 (es) 1988-04-16
IL75318A0 (en) 1985-09-29
DK241385D0 (da) 1985-05-30
EP0164965A2 (en) 1985-12-18
NO852173L (no) 1985-12-02
CZ283148B6 (cs) 1998-01-14
DK171531B1 (da) 1996-12-23
JPH07291995A (ja) 1995-11-07
PL155410B1 (en) 1991-11-29
IE63487B1 (en) 1995-05-03
HUT37814A (en) 1986-02-28
EP0164965B1 (en) 1993-09-29
BG60256B2 (bg) 1994-03-24
DK241385A (da) 1985-12-01
FI93025C (fi) 1995-02-10
JPS6156197A (ja) 1986-03-20
IL75318A (en) 1994-08-26
AU599303B2 (en) 1990-07-19
DE3588225D1 (de) 2000-09-14
FI93025B (fi) 1994-10-31
JPH07250692A (ja) 1995-10-03
PT80573B (pt) 1987-08-19
EP0509553A1 (en) 1992-10-21
YU47735B (sh) 1996-01-08
RO100383A2 (ro) 1991-10-17
YU91985A (en) 1988-12-31
DE3587597D1 (de) 1993-11-04
JP2804237B2 (ja) 1998-09-24
HU204085B (en) 1991-11-28
GR851317B (ro) 1985-11-25
SK278333B6 (en) 1996-11-06
PT80573A (en) 1985-06-01
JP2521703B2 (ja) 1996-08-07
NO179075B (no) 1996-04-22
NO179075C (no) 1996-07-31
SK393085A3 (en) 1996-11-06
EP0164965A3 (en) 1988-04-06
FI852143L (fi) 1985-12-01
FI852143A0 (fi) 1985-05-29
DE3587597T2 (de) 1994-06-01
PL253739A1 (en) 1986-03-11
ATE195323T1 (de) 2000-08-15

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