ATE411385T1 - Apo-2 ligand - Google Patents
Apo-2 ligandInfo
- Publication number
- ATE411385T1 ATE411385T1 AT99903166T AT99903166T ATE411385T1 AT E411385 T1 ATE411385 T1 AT E411385T1 AT 99903166 T AT99903166 T AT 99903166T AT 99903166 T AT99903166 T AT 99903166T AT E411385 T1 ATE411385 T1 AT E411385T1
- Authority
- AT
- Austria
- Prior art keywords
- ligand
- apo
- antibodies
- believed
- nucleic acid
- Prior art date
Links
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 title abstract 7
- 108700012411 TNFSF10 Proteins 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US788698A | 1998-01-15 | 1998-01-15 | |
US6053398A | 1998-04-15 | 1998-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE411385T1 true ATE411385T1 (de) | 2008-10-15 |
Family
ID=26677483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99903166T ATE411385T1 (de) | 1998-01-15 | 1999-01-15 | Apo-2 ligand |
Country Status (13)
Country | Link |
---|---|
US (1) | US6740739B1 (de) |
EP (2) | EP1045906B1 (de) |
JP (2) | JP2002508962A (de) |
AT (1) | ATE411385T1 (de) |
AU (1) | AU2325199A (de) |
CA (1) | CA2318029C (de) |
CY (1) | CY1108681T1 (de) |
DE (1) | DE69939732D1 (de) |
DK (1) | DK1045906T3 (de) |
ES (1) | ES2316182T3 (de) |
HK (1) | HK1032603A1 (de) |
PT (1) | PT1045906E (de) |
WO (1) | WO1999036535A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
US20040048340A1 (en) * | 1996-03-14 | 2004-03-11 | Human Genome Sciences, Inc. | Apoptosis inducing molecule I |
EP1820860A3 (de) * | 1999-06-02 | 2008-03-19 | Genentech, Inc. | Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums |
KR100674528B1 (ko) * | 1999-06-28 | 2007-01-29 | 제넨테크, 인크. | 2가 금속 이온을 사용한 Apo-2 리간드 제조 방법 |
CA2461292A1 (en) * | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
EP2322165A1 (de) | 2001-11-13 | 2011-05-18 | Genentech, Inc. | Apo2-Ligand/TRAIL-Formulierungen |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
CN1313611C (zh) * | 2002-02-22 | 2007-05-02 | 中国人民解放军第二军医大学 | 新型肿瘤凋亡素2配体基因、其表达的肿瘤凋亡素及其制法 |
EP1556076A4 (de) * | 2002-06-24 | 2009-07-08 | Genentech Inc | Apo-2 ligand/trail-varianten und ihre verwendungszwecke |
GB0328261D0 (en) | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
WO2005082934A2 (en) * | 2004-02-20 | 2005-09-09 | Five Prime Therapeutics, Inc. | Novel apo2l and il-24 polypeptides, polynucleotides, and methods of their use |
AU2012200601B2 (en) * | 2004-08-06 | 2012-10-11 | Genentech, Inc. | Assays and methods using biomarkers |
CN101035912A (zh) * | 2004-08-06 | 2007-09-12 | 健泰科生物技术公司 | 使用生物标志的测定法和方法 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
US20100150931A1 (en) * | 2006-11-22 | 2010-06-17 | Centre Hospitalier De L'universite De Montreal | Novel receptor for cd40l and uses thereof |
GB0724532D0 (en) * | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
US20110086770A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial Libraries Based on C-type Lectin-like Domain |
CA2812057A1 (en) | 2010-09-28 | 2012-04-05 | Kahr Medical Ltd. | Compositions and methods for treatment of hematological malignancies |
JP2014513128A (ja) | 2011-05-03 | 2014-05-29 | ジェネンテック, インコーポレイテッド | 血管破壊剤とその使用 |
JP5956580B2 (ja) | 2011-09-16 | 2016-07-27 | 北京沙▲東▼生物技▲術▼有限公司Beijing Sunbio Biotech Co., Ltd. | Trail/apo2lの円順列変異形を含む融合タンパク質、コーディング遺伝子およびそれらの使用 |
EP2684896A1 (de) | 2012-07-09 | 2014-01-15 | International-Drug-Development-Biotech | Antikörper gegen die DR5-Familie, bispezifische oder multivalente Antikörper gegen die DR5-Familie und Verfahren zu deren Verwendung |
PT2970473T (pt) | 2013-03-14 | 2017-10-26 | Bristol Myers Squibb Co | Combinação de agonista de dr5 e antagonista anti-pd-1 e métodos de utilização |
US9914761B2 (en) | 2014-07-10 | 2018-03-13 | Washington University | Oligomers for TNF superfamily inhibition |
CN109476737A (zh) | 2015-12-01 | 2019-03-15 | 根马布有限公司 | 抗dr5抗体及其使用方法 |
US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
DK3565579T3 (da) | 2017-01-05 | 2023-09-04 | Kahr Medical Ltd | Pd1-41bbl-fusionsprotein og fremgangsmåder til anvendelse deraf |
CA3047708A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirpalpha-41bbl fusion protein and methods of use thereof |
WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
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US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
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US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
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DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
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EP0397687B1 (de) | 1987-12-21 | 1994-05-11 | The University Of Toledo | Transformation von keimenden pflanzensamen mit hilfe von agrobacterium |
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US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
DE69635480T2 (de) | 1995-06-29 | 2006-08-17 | Immunex Corp., Thousand Oaks | Apoptosis induzierendes cytokin |
US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
AU5711196A (en) | 1996-03-14 | 1997-10-01 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
AU3381097A (en) | 1996-06-07 | 1998-01-05 | Amgen, Inc. | Tumor necrosis factor-related polypeptide |
KR20020056565A (ko) | 2000-12-29 | 2002-07-10 | 황규언 | 인간유래 세포 소멸 인자와 그 수용체의 결합체인TRAIL-sDR5 결합체의 결정화에 의한 3차원 구조및 TRAIL 결실 돌연변이 단백질 |
AU2002258399A1 (en) | 2001-02-16 | 2002-09-19 | Medical College Of Georgia Research Institute, Inc. | Use of trail and antiprogestins for treating cancer |
-
1999
- 1999-01-15 DK DK99903166T patent/DK1045906T3/da active
- 1999-01-15 CA CA002318029A patent/CA2318029C/en not_active Expired - Lifetime
- 1999-01-15 AT AT99903166T patent/ATE411385T1/de active
- 1999-01-15 US US09/582,450 patent/US6740739B1/en not_active Expired - Lifetime
- 1999-01-15 JP JP2000540237A patent/JP2002508962A/ja not_active Withdrawn
- 1999-01-15 EP EP99903166A patent/EP1045906B1/de not_active Expired - Lifetime
- 1999-01-15 ES ES99903166T patent/ES2316182T3/es not_active Expired - Lifetime
- 1999-01-15 WO PCT/US1999/001039 patent/WO1999036535A1/en active Application Filing
- 1999-01-15 EP EP08012755A patent/EP2017341A3/de not_active Withdrawn
- 1999-01-15 PT PT99903166T patent/PT1045906E/pt unknown
- 1999-01-15 AU AU23251/99A patent/AU2325199A/en not_active Abandoned
- 1999-01-15 DE DE69939732T patent/DE69939732D1/de not_active Expired - Lifetime
-
2001
- 2001-03-31 HK HK01102353.6A patent/HK1032603A1/xx not_active IP Right Cessation
-
2008
- 2008-12-17 CY CY20081101467T patent/CY1108681T1/el unknown
-
2010
- 2010-07-02 JP JP2010151519A patent/JP2010246560A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2002508962A (ja) | 2002-03-26 |
WO1999036535A9 (en) | 2000-03-02 |
EP2017341A3 (de) | 2009-04-08 |
EP1045906B1 (de) | 2008-10-15 |
CA2318029C (en) | 2009-05-19 |
US6740739B1 (en) | 2004-05-25 |
EP1045906A1 (de) | 2000-10-25 |
PT1045906E (pt) | 2009-01-27 |
WO1999036535A1 (en) | 1999-07-22 |
ES2316182T3 (es) | 2009-04-01 |
AU2325199A (en) | 1999-08-02 |
DK1045906T3 (da) | 2009-02-16 |
EP2017341A2 (de) | 2009-01-21 |
JP2010246560A (ja) | 2010-11-04 |
CA2318029A1 (en) | 1999-07-22 |
HK1032603A1 (en) | 2001-07-27 |
DE69939732D1 (de) | 2008-11-27 |
CY1108681T1 (el) | 2014-04-09 |
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Legal Events
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