DK1045906T3 - APO-2-ligand - Google Patents

APO-2-ligand

Info

Publication number
DK1045906T3
DK1045906T3 DK99903166T DK99903166T DK1045906T3 DK 1045906 T3 DK1045906 T3 DK 1045906T3 DK 99903166 T DK99903166 T DK 99903166T DK 99903166 T DK99903166 T DK 99903166T DK 1045906 T3 DK1045906 T3 DK 1045906T3
Authority
DK
Denmark
Prior art keywords
ligand
apo
antibodies
believed
nucleic acid
Prior art date
Application number
DK99903166T
Other languages
English (en)
Inventor
Avi J Ashkenazi
Robert F Kelley
Robert M Pitti
Ralph H Schwall
Mark T O'connel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK1045906T3 publication Critical patent/DK1045906T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99903166T 1998-01-15 1999-01-15 APO-2-ligand DK1045906T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US788698A 1998-01-15 1998-01-15
US6053398A 1998-04-15 1998-04-15
PCT/US1999/001039 WO1999036535A1 (en) 1998-01-15 1999-01-15 Apo-2 ligand

Publications (1)

Publication Number Publication Date
DK1045906T3 true DK1045906T3 (da) 2009-02-16

Family

ID=26677483

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99903166T DK1045906T3 (da) 1998-01-15 1999-01-15 APO-2-ligand

Country Status (13)

Country Link
US (1) US6740739B1 (da)
EP (2) EP1045906B1 (da)
JP (2) JP2002508962A (da)
AT (1) ATE411385T1 (da)
AU (1) AU2325199A (da)
CA (1) CA2318029C (da)
CY (1) CY1108681T1 (da)
DE (1) DE69939732D1 (da)
DK (1) DK1045906T3 (da)
ES (1) ES2316182T3 (da)
HK (1) HK1032603A1 (da)
PT (1) PT1045906E (da)
WO (1) WO1999036535A1 (da)

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IL147029A0 (en) * 1999-06-28 2002-08-14 Genentech Inc Method for making apo-2 ligand using divalent metal ions
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PT1450847E (pt) 2001-11-13 2011-01-05 Genentech Inc Formulações de ligando de apo2/trail e suas utilizações
US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
CN1313611C (zh) * 2002-02-22 2007-05-02 中国人民解放军第二军医大学 新型肿瘤凋亡素2配体基因、其表达的肿瘤凋亡素及其制法
AU2003247609A1 (en) * 2002-06-24 2004-01-06 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof
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US20080242603A1 (en) * 2004-02-20 2008-10-02 Yan Wang Novel Apo2L and IL-24 Polypeptides, Polynucleotides, and Methods of Their Use
CA2575152A1 (en) * 2004-08-06 2006-02-16 Genentech, Inc. Method for predicting sensitivity of mammalian cells to apo2l/trail comprising deletion of biomarker expression
AU2012200601B2 (en) * 2004-08-06 2012-10-11 Genentech, Inc. Assays and methods using biomarkers
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
WO2008061377A1 (en) * 2006-11-22 2008-05-29 Centre Hospitalier De L'universite De Montreal Novel receptor for cd40l and uses thereof
GB0724532D0 (en) * 2007-12-17 2008-01-30 Nat Univ Ireland Trail variants for treating cancer
WO2011043835A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that bind il-23r
CA2812057A1 (en) 2010-09-28 2012-04-05 Kahr Medical Ltd. Compositions and methods for treatment of hematological malignancies
US20140178398A1 (en) 2011-05-03 2014-06-26 Genentech, Inc Vascular disruption agents and uses thereof
CN103534273B (zh) 2011-09-16 2020-05-12 北京沙东生物技术有限公司 环化变构trail/apo2l及其编码基因与应用
EP2684896A1 (en) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
US20160067337A1 (en) 2013-03-14 2016-03-10 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
US9914761B2 (en) 2014-07-10 2018-03-13 Washington University Oligomers for TNF superfamily inhibition
CA3007031A1 (en) 2015-12-01 2017-06-08 Genmab B.V. Anti-death receptor antibodies and methods of use thereof
RU2769513C2 (ru) 2017-01-05 2022-04-01 Кахр Медикал Лтд. Слитый белок pd1-4-1bbl и способы его применения
WO2018127918A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A sirp alpha-cd70 fusion protein and methods of use thereof
SI3565828T1 (sl) 2017-01-05 2022-04-29 Kahr Medical Ltd. SIRP1 alfa-41BBL fuzijski protein in postopki za njegovo uporabo
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof

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Also Published As

Publication number Publication date
EP2017341A3 (en) 2009-04-08
US6740739B1 (en) 2004-05-25
PT1045906E (pt) 2009-01-27
EP2017341A2 (en) 2009-01-21
EP1045906B1 (en) 2008-10-15
DE69939732D1 (de) 2008-11-27
CA2318029A1 (en) 1999-07-22
WO1999036535A9 (en) 2000-03-02
JP2002508962A (ja) 2002-03-26
ATE411385T1 (de) 2008-10-15
ES2316182T3 (es) 2009-04-01
WO1999036535A1 (en) 1999-07-22
JP2010246560A (ja) 2010-11-04
AU2325199A (en) 1999-08-02
EP1045906A1 (en) 2000-10-25
HK1032603A1 (en) 2001-07-27
CY1108681T1 (el) 2014-04-09
CA2318029C (en) 2009-05-19

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