ATE362985T1 - Apo-2 ligand - Google Patents
Apo-2 ligandInfo
- Publication number
- ATE362985T1 ATE362985T1 AT97903760T AT97903760T ATE362985T1 AT E362985 T1 ATE362985 T1 AT E362985T1 AT 97903760 T AT97903760 T AT 97903760T AT 97903760 T AT97903760 T AT 97903760T AT E362985 T1 ATE362985 T1 AT E362985T1
- Authority
- AT
- Austria
- Prior art keywords
- ligand
- apo
- cytokine
- antibodies
- induce
- Prior art date
Links
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 title abstract 7
- 108700012411 TNFSF10 Proteins 0.000 title abstract 7
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/144—Tumor necrosis factor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/584,031 US6030945A (en) | 1996-01-09 | 1996-01-09 | Apo-2 ligand |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE362985T1 true ATE362985T1 (de) | 2007-06-15 |
Family
ID=24335618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97903760T ATE362985T1 (de) | 1996-01-09 | 1997-01-08 | Apo-2 ligand |
Country Status (13)
Country | Link |
---|---|
US (1) | US6030945A (de) |
EP (3) | EP1734122A3 (de) |
JP (4) | JP2001510321A (de) |
AT (1) | ATE362985T1 (de) |
AU (1) | AU729279B2 (de) |
CA (2) | CA2241572C (de) |
DE (1) | DE69737747T2 (de) |
DK (1) | DK0873407T3 (de) |
ES (1) | ES2287948T3 (de) |
HK (1) | HK1018961A1 (de) |
IL (3) | IL125168A0 (de) |
PT (1) | PT873407E (de) |
WO (1) | WO1997025428A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284236B1 (en) | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
DE69635480T2 (de) * | 1995-06-29 | 2006-08-17 | Immunex Corp., Thousand Oaks | Apoptosis induzierendes cytokin |
US6998116B1 (en) | 1996-01-09 | 2006-02-14 | Genentech, Inc. | Apo-2 ligand |
US20050089958A1 (en) * | 1996-01-09 | 2005-04-28 | Genentech, Inc. | Apo-2 ligand |
US20040048340A1 (en) * | 1996-03-14 | 2004-03-11 | Human Genome Sciences, Inc. | Apoptosis inducing molecule I |
US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
CA2256464A1 (en) * | 1996-06-07 | 1997-12-11 | Amgen Inc. | Tumor necrosis factor-related polypeptide |
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
EP1032661A1 (de) * | 1997-06-18 | 2000-09-06 | Genentech, Inc. | Apo-2DcR |
US6346388B1 (en) | 1997-08-13 | 2002-02-12 | Smithkline Beecham Corporation | Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2 |
IL134578A0 (en) | 1997-09-18 | 2001-04-30 | Genentech Inc | DcR3 POLYPEPTIDE, A TNFR HOMOLOG |
ATE424459T1 (de) * | 1997-10-10 | 2009-03-15 | Genentech Inc | Apo-3 ligand |
JP2002508962A (ja) * | 1998-01-15 | 2002-03-26 | ジェネンテク・インコーポレイテッド | Apo−2リガンド |
CA2318405C (en) | 1998-01-26 | 2014-01-07 | Genentech, Inc. | Antibodies to death receptor 4(dr4) and uses thereof |
NZ525914A (en) | 1998-03-10 | 2004-03-26 | Genentech Inc | Novel polypeptides and nucleic acids encoding the same |
EP1941905A1 (de) | 1998-03-27 | 2008-07-09 | Genentech, Inc. | APO-2 Liganden-Anti-HER-2-Antikörper-Synergismus |
DE69938923D1 (de) * | 1998-03-27 | 2008-07-31 | Genentech Inc | Synergie zwischen apo-2 ligand und antikörper gegen her-2 |
US6252050B1 (en) * | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
JP2002517223A (ja) * | 1998-06-12 | 2002-06-18 | ジェネンテック・インコーポレーテッド | モノクローナル抗体、交叉反応性抗体およびそれを生成する方法 |
DE69933690T2 (de) * | 1998-11-23 | 2007-08-23 | Centre National De La Recherche Scientifique | Apoptosis induzierender faktor |
US6773911B1 (en) | 1998-11-23 | 2004-08-10 | Amgen Canada Inc. | Apoptosis-inducing factor |
ES2421720T3 (es) | 1999-04-12 | 2013-09-05 | Genentech Inc | Homólogos del factor de necrosis tumoral y ácidos nucleicos que los codifican |
EP1867719A3 (de) * | 1999-06-02 | 2008-03-19 | Genentech, Inc. | Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums |
ZA200002867B (en) * | 1999-06-09 | 2001-12-07 | Pfizer Prod Inc | Process for preparing sertraline from chiral tetralone. |
EP1658859A1 (de) * | 1999-06-09 | 2006-05-24 | Genentech, Inc. | APO-2L Rezeptor-Agonist und CPT-11 Synergie-Effekt |
WO2001000832A1 (en) * | 1999-06-28 | 2001-01-04 | Genentech, Inc. | Methods for making apo-2 ligand using divalent metal ions |
IL150755A0 (en) | 2000-02-16 | 2003-02-12 | Genentech Inc | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
CN100390288C (zh) | 2000-04-11 | 2008-05-28 | 杰南技术公司 | 多价抗体及其应用 |
US6900185B1 (en) * | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
ATE415978T1 (de) * | 2000-07-27 | 2008-12-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
CN1473055A (zh) * | 2000-11-02 | 2004-02-04 | ˹¡-�����ְ�֢�о��� | 通过使用hsp90抑制剂提高细胞毒剂效力的方法 |
JP2002306170A (ja) * | 2001-04-06 | 2002-10-22 | Jenokkusu Soyaku Kenkyusho:Kk | アレルギー性疾患の検査方法 |
US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
JP4509570B2 (ja) | 2001-07-03 | 2010-07-21 | ジェネンテック, インコーポレイテッド | ヒトdr4抗体及びその使用法 |
US20040186051A1 (en) | 2001-10-02 | 2004-09-23 | Kelley Robert F | Apo-2 ligand variants and uses thereof |
US7741285B2 (en) * | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
PT1450847E (pt) | 2001-11-13 | 2011-01-05 | Genentech Inc | Formulações de ligando de apo2/trail e suas utilizações |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
US20060141561A1 (en) | 2002-06-24 | 2006-06-29 | Kelley Robert F | Apo-2 ligand/trail variants and uses thereof |
EP1558631A4 (de) * | 2002-10-30 | 2006-10-04 | Pfizer Prod Inc | Verfahren und zusammensetzungen zur diagnose und behandlung von krebs bei haustieren |
EP1633317A4 (de) | 2003-05-16 | 2008-08-20 | Intermune Inc | Synthetische chemokin-rezeptor-liganden und anwendungsverfahren dafür |
EP1629001A2 (de) | 2003-06-05 | 2006-03-01 | Genentech, Inc. | Blys-antagonisten und deren verwendung |
PT1733037E (pt) | 2004-03-11 | 2015-02-05 | Genentech Inc | Processo para produzir polipéptidos |
US20080274955A1 (en) * | 2004-04-13 | 2008-11-06 | Kyungpook National University Industry Academic Cooperation Foundation | Novel Use of a Polypeptide Comprising Fas-1 Domain |
EP1778871B1 (de) | 2004-08-06 | 2011-05-04 | Genentech, Inc. | Tests und verfahren unter verwendung von biomarkern |
KR101235479B1 (ko) | 2004-08-06 | 2013-02-20 | 제넨테크, 인크. | 바이오마커를 사용한 분석 및 방법 |
AU2012200601B2 (en) * | 2004-08-06 | 2012-10-11 | Genentech, Inc. | Assays and methods using biomarkers |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
EP1791864A2 (de) * | 2004-09-08 | 2007-06-06 | Genentech, Inc. | Verfahren zur verwendung von todesrezeptorliganden und cd20-antikörpern |
JP2008512479A (ja) * | 2004-09-08 | 2008-04-24 | ジェネンテック・インコーポレーテッド | デスレセプターリガンド及びcd20抗体の使用方法 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
US20060188498A1 (en) | 2005-02-18 | 2006-08-24 | Genentech, Inc. | Methods of using death receptor agonists and EGFR inhibitors |
JP5744376B2 (ja) | 2005-03-22 | 2015-07-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | タンパク質分解障害の治療 |
ZA200800974B (en) * | 2005-08-16 | 2009-11-25 | Genentech Inc | Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues |
EP1952150B1 (de) | 2005-11-23 | 2016-12-14 | Genentech, Inc. | Verfahren und zusammensetzungen in verbindung mit b-zellen-testverfahren |
CN101400362B (zh) | 2006-02-14 | 2016-10-12 | 哈佛大学校长及研究员协会 | 双官能组蛋白去乙酰化酶抑制剂 |
JP5409015B2 (ja) | 2006-02-14 | 2014-02-05 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ヒストンデアセチラーゼ阻害剤 |
CN101484156B (zh) * | 2006-05-03 | 2015-11-25 | 哈佛大学校长及研究员协会 | 组蛋白脱乙酰基酶和微管蛋白脱乙酰基酶抑制剂 |
HUE030134T2 (en) | 2007-10-16 | 2017-04-28 | Zymogenetics Inc | Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for the treatment of autoimmune diseases |
GB0724532D0 (en) * | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
RU2515611C2 (ru) * | 2008-07-23 | 2014-05-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Ингибиторы деацетилазы и их применение |
WO2010062904A2 (en) | 2008-11-25 | 2010-06-03 | Biogen Idec Ma Inc. | Use of dr6 and p75 antagonists to promote survival of cells of the nervous system |
WO2010136443A1 (en) * | 2009-05-27 | 2010-12-02 | Glaxosmithkline Biologicals S.A. | Casb7439 constructs |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
KR20200111282A (ko) | 2009-08-11 | 2020-09-28 | 제넨테크, 인크. | 글루타민-비함유 세포 배양 배지에서의 단백질의 생성 |
ES2356880B8 (es) * | 2009-08-21 | 2012-10-30 | Universidad De Zaragoza | Liposomas recubiertos con el dominio extracelular de la proteína apo2l/trail. |
US20110086770A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial Libraries Based on C-type Lectin-like Domain |
CA2812057A1 (en) | 2010-09-28 | 2012-04-05 | Kahr Medical Ltd. | Compositions and methods for treatment of hematological malignancies |
CA2834776A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies |
WO2013037090A1 (zh) | 2011-09-16 | 2013-03-21 | 北京沙东生物技术有限公司 | 包含trail/apo2l环化变构体的融合蛋白及其编码基因与应用 |
BR112016017660B1 (pt) | 2014-02-27 | 2022-04-19 | F. Hoffmann-La Roche Ag | Método para a produção de uma glicoproteína recombinante |
US11279768B1 (en) | 2015-04-03 | 2022-03-22 | Precision Biologics, Inc. | Anti-cancer antibodies, combination therapies, and uses thereof |
CN115400220A (zh) | 2015-12-30 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 减少聚山梨酯降解的制剂 |
WO2021209512A1 (en) | 2020-04-15 | 2021-10-21 | Genentech, Inc. | Method for medium treatment before inoculation |
US20230265204A1 (en) | 2020-04-24 | 2023-08-24 | Hoffmann-La Roche Inc. | Enzyme and pathway modulation with sulfhydryl compounds and their derivatives |
JP2023549809A (ja) | 2020-11-16 | 2023-11-29 | エフ. ホフマン-ラ ロシュ アーゲー | Fab高マンノースグリコフォーム |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE266710C (de) * | ||||
US3691016A (en) * | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
CA1023287A (en) * | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4195128A (en) * | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
US4330440A (en) * | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) * | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
US4206226A (en) * | 1977-08-29 | 1980-06-03 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia |
FR2413974A1 (fr) * | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4229537A (en) * | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4342566A (en) * | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4419446A (en) * | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4601978A (en) * | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4713339A (en) * | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU2353384A (en) * | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
EP0206448B1 (de) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
EP0272253A4 (de) * | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | Verfahren zur verbesserung der glykoproteinstabilität. |
US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
GB8724885D0 (en) * | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
EP0321196A3 (de) * | 1987-12-18 | 1990-07-18 | Mycogen Plant Science, Inc. | Transkriptionsaktivator des 780 T-DNA-Gens |
KR0154872B1 (ko) * | 1987-12-21 | 1998-10-15 | 로버트 에이. 아미테이지 | 발아하는 식물종자의 아크로박테리움 매개된 형질전환 |
AU4005289A (en) * | 1988-08-25 | 1990-03-01 | Smithkline Beecham Corporation | Recombinant saccharomyces |
FR2646437B1 (fr) * | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
CA2062795A1 (en) * | 1989-06-29 | 1990-12-30 | Michael W. Fanger | Bispecific reagents for aids therapy |
DK168302B1 (da) * | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
DK0417563T3 (da) * | 1989-09-12 | 2000-11-06 | Hoffmann La Roche | TNF-bindende proteiner |
AU639047B2 (en) * | 1989-11-22 | 1993-07-15 | Genentech Inc. | Latency associated peptide and uses therefor |
US5206161A (en) * | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
WO1992020373A1 (en) * | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
WO1993008829A1 (en) * | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
CA2140280A1 (en) * | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
RU2139092C1 (ru) * | 1993-06-03 | 1999-10-10 | Терапьютик Антибодиз Инк. | Фрагменты антител в терапии |
WO1995010540A1 (en) * | 1993-10-14 | 1995-04-20 | Immunex Corporation | Fas antagonists and uses thereof |
AU7983294A (en) * | 1993-10-19 | 1995-05-08 | Regents Of The University Of Michigan, The | P53-mediated apoptosis |
IL111125A0 (en) * | 1994-05-11 | 1994-12-29 | Yeda Res & Dev | Soluble oligomeric tnf/ngf super family ligand receptors and their use |
DE69635480T2 (de) * | 1995-06-29 | 2006-08-17 | Immunex Corp., Thousand Oaks | Apoptosis induzierendes cytokin |
WO1997033899A1 (en) * | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
CA2256464A1 (en) * | 1996-06-07 | 1997-12-11 | Amgen Inc. | Tumor necrosis factor-related polypeptide |
-
1996
- 1996-01-09 US US08/584,031 patent/US6030945A/en not_active Expired - Lifetime
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1997
- 1997-01-08 IL IL12516897A patent/IL125168A0/xx unknown
- 1997-01-08 CA CA002241572A patent/CA2241572C/en not_active Expired - Lifetime
- 1997-01-08 JP JP52536997A patent/JP2001510321A/ja not_active Withdrawn
- 1997-01-08 WO PCT/US1997/000272 patent/WO1997025428A1/en active Application Filing
- 1997-01-08 EP EP06013720A patent/EP1734122A3/de not_active Withdrawn
- 1997-01-08 DK DK97903760T patent/DK0873407T3/da active
- 1997-01-08 AU AU18248/97A patent/AU729279B2/en not_active Expired
- 1997-01-08 ES ES97903760T patent/ES2287948T3/es not_active Expired - Lifetime
- 1997-01-08 CA CA002666263A patent/CA2666263A1/en not_active Abandoned
- 1997-01-08 EP EP07022045A patent/EP1889915A1/de not_active Withdrawn
- 1997-01-08 DE DE69737747T patent/DE69737747T2/de not_active Expired - Lifetime
- 1997-01-08 PT PT97903760T patent/PT873407E/pt unknown
- 1997-01-08 EP EP97903760A patent/EP0873407B1/de not_active Expired - Lifetime
- 1997-01-08 AT AT97903760T patent/ATE362985T1/de active
-
1998
- 1998-06-30 IL IL125168A patent/IL125168A/en not_active IP Right Cessation
-
1999
- 1999-04-20 HK HK99101694A patent/HK1018961A1/xx not_active IP Right Cessation
-
2004
- 2004-11-11 JP JP2004328142A patent/JP2005237370A/ja active Pending
-
2006
- 2006-12-20 JP JP2006343397A patent/JP2007169280A/ja not_active Withdrawn
-
2008
- 2008-07-01 JP JP2008172349A patent/JP2008308502A/ja active Pending
- 2008-08-28 IL IL193752A patent/IL193752A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0873407A1 (de) | 1998-10-28 |
IL193752A0 (en) | 2011-08-01 |
EP0873407B1 (de) | 2007-05-23 |
EP1734122A3 (de) | 2007-07-11 |
AU1824897A (en) | 1997-08-01 |
JP2008308502A (ja) | 2008-12-25 |
HK1018961A1 (en) | 2000-01-14 |
IL125168A (en) | 2011-04-28 |
DE69737747T2 (de) | 2008-02-14 |
ES2287948T3 (es) | 2007-12-16 |
US6030945A (en) | 2000-02-29 |
CA2241572C (en) | 2009-08-11 |
EP1889915A1 (de) | 2008-02-20 |
JP2007169280A (ja) | 2007-07-05 |
IL125168A0 (en) | 1999-01-26 |
DE69737747D1 (de) | 2007-07-05 |
DK0873407T3 (da) | 2007-09-24 |
WO1997025428A1 (en) | 1997-07-17 |
CA2666263A1 (en) | 1997-07-17 |
JP2001510321A (ja) | 2001-07-31 |
CA2241572A1 (en) | 1997-07-17 |
EP1734122A2 (de) | 2006-12-20 |
PT873407E (pt) | 2007-09-04 |
AU729279B2 (en) | 2001-02-01 |
JP2005237370A (ja) | 2005-09-08 |
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