ES2146243T3 - Inhibidores de tnf. - Google Patents

Inhibidores de tnf.

Info

Publication number
ES2146243T3
ES2146243T3 ES94116015T ES94116015T ES2146243T3 ES 2146243 T3 ES2146243 T3 ES 2146243T3 ES 94116015 T ES94116015 T ES 94116015T ES 94116015 T ES94116015 T ES 94116015T ES 2146243 T3 ES2146243 T3 ES 2146243T3
Authority
ES
Spain
Prior art keywords
tnf
tnf inhibitors
ligands
receptors
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94116015T
Other languages
English (en)
Inventor
David Wallach
Jacek Bigda
Igor Beletsky
Igor Mett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2146243T3 publication Critical patent/ES2146243T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

SE PRESENTAN LIGANDOS A LOS RECEPTORES DEL FACTOR DE LA NECROSIS DE TUMORES (TNF-RS) QUE INHIBEN EL EFECTO DEL TNF PERO NO SU ENLACE A LOS TNF-RS Y LIGANDOS QUE INTERACTUAN CON OTROS RECEPTORES DE LA FAMILIA TNF/NGF, ASI COMO LOS METODOS PARA LA PRODUCCION DE LOS MISMOS.
ES94116015T 1993-10-12 1994-10-11 Inhibidores de tnf. Expired - Lifetime ES2146243T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL107267A IL107267A (en) 1993-10-12 1993-10-12 Ligand to a member of the tnf/ngf receptor family

Publications (1)

Publication Number Publication Date
ES2146243T3 true ES2146243T3 (es) 2000-08-01

Family

ID=11065339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94116015T Expired - Lifetime ES2146243T3 (es) 1993-10-12 1994-10-11 Inhibidores de tnf.

Country Status (12)

Country Link
EP (1) EP0648783B1 (es)
JP (1) JPH07188298A (es)
AT (1) ATE191224T1 (es)
AU (1) AU683298B2 (es)
CA (1) CA2133873C (es)
DE (1) DE69423697T2 (es)
DK (1) DK0648783T3 (es)
ES (1) ES2146243T3 (es)
GR (1) GR3033468T3 (es)
IL (1) IL107267A (es)
PT (1) PT648783E (es)
ZA (1) ZA947961B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262239B1 (en) * 1989-05-18 2001-07-17 Yeda Research And Development Co., Ltd. TNF receptor-specific antibodies
US6232446B1 (en) 1989-05-18 2001-05-15 Yeda Research And Development Co. Ltd. TNF ligands
CA2328509A1 (en) * 1998-05-18 1999-11-25 Applied Research Systems Ars Holding N.V Methods and use of compositions comprising tnf-rii(p75) agonists for treating asthma and other allergic conditions
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
CA2381284A1 (en) 1999-08-04 2001-02-15 Amgen Inc. Fhm, a novel member of the tnf ligand supergene family
WO2001010908A1 (en) 1999-08-04 2001-02-15 Amgen Inc. Ntr3, a member of the tnf-receptor supergene family
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
CN103232539B (zh) 2001-06-26 2015-06-03 安姆根弗里蒙特公司 抗opgl抗体
WO2003009864A1 (en) * 2001-07-23 2003-02-06 Genset S.A. Agonists and antagonists of disomet for the treatment of metabolic disorders
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
PL378879A1 (pl) 2002-12-30 2006-05-29 Amgen Inc. Terapia skojarzona z czynnikami kostymulującymi

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94039A (en) * 1989-08-06 2006-09-05 Yeda Res & Dev Antibodies to tbp - 1 and their use
DE69017753T3 (de) * 1989-05-18 2013-06-20 Yeda Research And Development Co., Ltd. Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper
IL106271A (en) * 1992-09-03 2008-03-20 Yeda Res & Dev Ligand to TNF 75P receptor and its preparation

Also Published As

Publication number Publication date
EP0648783A1 (en) 1995-04-19
DE69423697D1 (de) 2000-05-04
ZA947961B (en) 1995-05-24
CA2133873C (en) 2010-08-03
IL107267A (en) 2009-07-20
DE69423697T2 (de) 2000-11-09
JPH07188298A (ja) 1995-07-25
PT648783E (pt) 2000-08-31
GR3033468T3 (en) 2000-09-29
ATE191224T1 (de) 2000-04-15
DK0648783T3 (da) 2000-08-14
AU7574394A (en) 1995-05-04
IL107267A0 (en) 1994-01-25
EP0648783B1 (en) 2000-03-29
CA2133873A1 (en) 1995-04-13
AU683298B2 (en) 1997-11-06

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