ATE404583T1 - Funktionelle antagonisten von hedgehog-aktivität - Google Patents

Funktionelle antagonisten von hedgehog-aktivität

Info

Publication number
ATE404583T1
ATE404583T1 AT99965744T AT99965744T ATE404583T1 AT E404583 T1 ATE404583 T1 AT E404583T1 AT 99965744 T AT99965744 T AT 99965744T AT 99965744 T AT99965744 T AT 99965744T AT E404583 T1 ATE404583 T1 AT E404583T1
Authority
AT
Austria
Prior art keywords
hedgehog
functional antagonists
variants
ability
hedgehog activity
Prior art date
Application number
AT99965744T
Other languages
English (en)
Inventor
Kevin Williams
Paul Rayhorn
Ellen Garber
Blake Pepinsky
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of ATE404583T1 publication Critical patent/ATE404583T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99965744T 1998-11-02 1999-11-02 Funktionelle antagonisten von hedgehog-aktivität ATE404583T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10670398P 1998-11-02 1998-11-02

Publications (1)

Publication Number Publication Date
ATE404583T1 true ATE404583T1 (de) 2008-08-15

Family

ID=22312815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965744T ATE404583T1 (de) 1998-11-02 1999-11-02 Funktionelle antagonisten von hedgehog-aktivität

Country Status (9)

Country Link
US (1) US8410061B2 (de)
EP (1) EP1133519B1 (de)
JP (1) JP4574012B2 (de)
AT (1) ATE404583T1 (de)
AU (1) AU765485B2 (de)
CA (1) CA2348773C (de)
DE (1) DE69939327D1 (de)
IL (2) IL142905A0 (de)
WO (1) WO2000025725A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035020A2 (en) 1997-02-10 1998-08-13 The Presidents And Fellows Of Harvard College Methods for modulating hematopoiesis and vascular growth
EP1034269A1 (de) * 1997-11-28 2000-09-13 Roche Diagnostics GmbH Aktive hedgehog-protein-mutante, verfahren zur herstellung und verwendung als arzneimittel
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
JP2003502292A (ja) * 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド ヘッジホッグタンパク質のポリマー結合体及び利用
CA2376210A1 (en) * 1999-06-08 2000-12-14 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
AU780693B2 (en) * 1999-11-05 2005-04-14 Curis, Inc. Hedgehog fusion proteins and uses
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
AU2001275495B2 (en) * 2000-06-16 2006-08-17 Curis, Inc. Angiogenesis-modulating compositions and uses
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2002011752A1 (fr) * 2000-08-04 2002-02-14 Takeda Chemical Industries, Ltd. Utilisation du gene glil
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
ES2623711T3 (es) * 2000-10-13 2017-07-12 Curis, Inc. Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DK1730280T3 (en) 2004-03-26 2019-02-04 Curis Inc RNA interference modulators for hedgehog signaling and applications thereof
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP5129149B2 (ja) 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
DK2500360T3 (en) 2005-10-31 2015-10-26 Oncomed Pharm Inc Compositions and methods for the diagnosis and treatment of cancer
US8026354B2 (en) 2005-11-23 2011-09-27 Institut Pasteur Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
PL2470173T3 (pl) 2009-08-25 2016-11-30 Leczenie skojarzone nanocząstkowymi kompozycjami taksanu i inhibitorów hedgehog
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610656B1 (en) 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6271363B1 (en) 1993-12-30 2001-08-07 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6165747A (en) 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6261786B1 (en) 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6884775B1 (en) 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
WO1995023223A1 (en) 1994-02-25 1995-08-31 The Trustees Of Columbia University In The City Of New York Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
US6514724B1 (en) 1996-09-20 2003-02-04 President And Fellows Of Harvard College Hedgehog interacting proteins and uses related thereto
US5759811A (en) * 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
WO1999000117A2 (en) * 1997-06-27 1999-01-07 Ontogeny, Inc. Neuroprotective methods and reagents
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
KR20010032753A (ko) * 1997-12-03 2001-04-25 온토제니, 인코오포레이티드 소수적으로 개질된 단백질 조성물 및 방법
US6897297B1 (en) 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
AU773044B2 (en) 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
JP2003502292A (ja) 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド ヘッジホッグタンパク質のポリマー結合体及び利用

Also Published As

Publication number Publication date
JP2002534060A (ja) 2002-10-15
CA2348773A1 (en) 2000-05-11
AU765485B2 (en) 2003-09-18
IL142905A (en) 2009-12-24
JP4574012B2 (ja) 2010-11-04
EP1133519B1 (de) 2008-08-13
DE69939327D1 (de) 2008-09-25
AU2144500A (en) 2000-05-22
US20030166543A1 (en) 2003-09-04
WO2000025725A3 (en) 2000-11-30
IL142905A0 (en) 2002-04-21
US8410061B2 (en) 2013-04-02
WO2000025725A2 (en) 2000-05-11
CA2348773C (en) 2010-04-13
EP1133519A2 (de) 2001-09-19

Similar Documents

Publication Publication Date Title
ATE404583T1 (de) Funktionelle antagonisten von hedgehog-aktivität
BG104149A (bg) Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение
DK0758383T3 (da) Oplöselige polypeptidfraktioner af LAG-3-proteinet; fremgangsmåde til fremstilling; terapeutisk sammensætning; antiidiotypisk antistof
AU4981101A (en) Subtilisin variants
CY1107821T1 (el) Πολυπεπτιδιο παραγοντα viii με ενεργοτητα παραγοντα viii:c
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
ATE175446T1 (de) Immunogene peptide, antikörper sowie deren verwendungen im zusammenhang mit der cd4- rezeptorbindung
SE9901379D0 (sv) Receptor structures
NZ236511A (en) Polypeptides containing sequences from residues 61 to 82 or 104 to 129 of human il-4 or subsequences thereof; antibodies and pharmaceutical compositions
NZ501767A (en) Cyclic integrin binding peptide with the amino acid sequence RKK
UA65561A (en) Therapeutic agent for lymphatic tumors
KR980002066A (ko) 변이형 인간 성장호르몬 및 그의 용도
WO2002044197A3 (en) Cytokine receptor binding peptides
DK258789D0 (da) Peptider, der blokerer bindingen af hiv-1 til cd4 receptorproteinet
PT1007559E (pt) Celulas geneticamente modificadas que expressam as proteinas morfogeneticas do osso
DK0990703T3 (da) Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf
NO984491L (no) SCF-analogpreparater og fremgangsmÕte for fremstilling av disse
ATE287952T1 (de) Humanes thymosin beta 15 gen,protein und dessen verwendungen
DK0939769T3 (da) Vertebrat-Smoothened-proteiner
ATE294816T1 (de) Neue, physiologisch aktive peptide und ihre verwendung.
DK0938555T3 (da) Konstruktioner og komplekser af cyclin E
EP1019500A4 (de) Neue ifn rezeptor 1 bindende proteine, dafür kodierende dna und verfahren zur regulierung der zellulären antwort auf interferone
DE69739525D1 (de) Neuer cxc chemokinrezeptor aus maus
WO2003044159A9 (en) Zinc finger proteins, polynucleotides encoding same and antibodies thereto

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties