BG45700A3 - Method for preparing of alpha- heterocyclic substituted tolunitriles - Google Patents

Method for preparing of alpha- heterocyclic substituted tolunitriles

Info

Publication number
BG45700A3
BG45700A3 BG081514A BG8151487A BG45700A3 BG 45700 A3 BG45700 A3 BG 45700A3 BG 081514 A BG081514 A BG 081514A BG 8151487 A BG8151487 A BG 8151487A BG 45700 A3 BG45700 A3 BG 45700A3
Authority
BG
Bulgaria
Prior art keywords
alpha
preparing
heterocyclic substituted
tolunitriles
substituted tolunitriles
Prior art date
Application number
BG081514A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Bowman
Ronald Steele
Leslie Browne
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG45700(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG45700A3 publication Critical patent/BG45700A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BG081514A 1986-03-07 1987-03-05 Method for preparing of alpha- heterocyclic substituted tolunitriles BG45700A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
BG45700A3 true BG45700A3 (en) 1989-07-14

Family

ID=25274596

Family Applications (4)

Application Number Title Priority Date Filing Date
BG081514A BG45700A3 (en) 1986-03-07 1987-03-05 Method for preparing of alpha- heterocyclic substituted tolunitriles
BG081515A BG45701A3 (en) 1986-03-07 1987-03-05 Method for preparing of alpha- heterocyclic substituted tolunitriles
BG078756A BG46598A3 (en) 1986-03-07 1987-03-05 Method for preparation of alpha- heterocyclic substituted tolunitriles
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Family Applications After (3)

Application Number Title Priority Date Filing Date
BG081515A BG45701A3 (en) 1986-03-07 1987-03-05 Method for preparing of alpha- heterocyclic substituted tolunitriles
BG078756A BG46598A3 (en) 1986-03-07 1987-03-05 Method for preparation of alpha- heterocyclic substituted tolunitriles
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Country Status (36)

Country Link
US (1) US4749713A (sk)
EP (1) EP0236940B3 (sk)
JP (1) JPH0755930B2 (sk)
KR (1) KR910000482B1 (sk)
AT (1) ATE94873T1 (sk)
BG (4) BG45700A3 (sk)
CA (1) CA1316928C (sk)
CY (1) CY1905A (sk)
CZ (3) CZ279028B6 (sk)
DD (1) DD264432A5 (sk)
DE (2) DE19775016I2 (sk)
DK (1) DK172190B1 (sk)
DZ (1) DZ1055A1 (sk)
ES (1) ES2059317T3 (sk)
FI (1) FI91857C (sk)
HK (1) HK50296A (sk)
HU (1) HU202843B (sk)
IE (1) IE61101B1 (sk)
IL (1) IL81746A (sk)
LU (1) LU90128I2 (sk)
LV (1) LV5769B4 (sk)
MA (1) MA20888A1 (sk)
MC (1) MC1805A1 (sk)
MT (1) MTP998B (sk)
MX (1) MX5496A (sk)
MY (1) MY102428A (sk)
NL (1) NL970011I2 (sk)
NO (2) NO170277C (sk)
PH (1) PH24159A (sk)
PL (2) PL151490B1 (sk)
PT (1) PT84410B (sk)
RO (2) RO101532B1 (sk)
SK (3) SK279103B6 (sk)
SU (3) SU1470184A3 (sk)
TN (1) TNSN87033A1 (sk)
ZA (1) ZA871637B (sk)

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US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
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US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
DK117687A (da) 1987-09-08
PT84410B (pt) 1989-10-04
CY1905A (en) 1987-03-05
MY102428A (en) 1992-06-30
MX5496A (es) 1993-12-01
EP0236940B1 (en) 1993-09-22
SU1577695A3 (ru) 1990-07-07
SK279102B6 (sk) 1998-06-03
EP0236940B3 (en) 2011-03-23
DE3787480D1 (de) 1993-10-28
FI870903A0 (fi) 1987-03-02
MTP998B (en) 1987-08-21
FI870903A (fi) 1987-09-08
LU90128I2 (fr) 1997-10-06
MC1805A1 (fr) 1987-12-22
CS8707368A2 (en) 1991-02-12
SK736787A3 (en) 1998-06-03
CS8707367A2 (en) 1991-02-12
IL81746A (en) 1992-02-16
BG45701A3 (en) 1989-07-14
US4749713A (en) 1988-06-07
LV5769B4 (lv) 1997-04-20
IE870575L (en) 1987-09-07
IL81746A0 (en) 1987-10-20
NO170277C (no) 1992-09-30
NL970011I1 (nl) 1997-05-01
PL151490B1 (en) 1990-09-28
NO1998010I1 (no) 1998-03-04
RO101532B1 (en) 1992-11-03
NL970011I2 (nl) 1997-09-01
DK117687D0 (da) 1987-03-06
KR870008851A (ko) 1987-10-21
FI91857B (fi) 1994-05-13
KR910000482B1 (ko) 1991-01-25
HK50296A (en) 1996-03-29
TNSN87033A1 (fr) 1990-01-01
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
NO170277B (no) 1992-06-22
ZA871637B (en) 1987-10-28
DE19775016I2 (de) 2002-02-21
SU1549478A3 (ru) 1990-03-07
NO870937L (no) 1987-09-08
DK172190B1 (da) 1997-12-22
CA1316928C (en) 1993-04-27
ATE94873T1 (de) 1993-10-15
MA20888A1 (fr) 1987-10-01
JPS62212369A (ja) 1987-09-18
AU6976887A (en) 1987-09-10
RO101533B1 (en) 1992-06-25
PL264460A1 (en) 1988-07-21
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
CZ279027B6 (en) 1994-11-16
DZ1055A1 (fr) 2004-09-13
JPH0755930B2 (ja) 1995-06-14
SK736887A3 (en) 1998-06-03
DE3787480T2 (de) 1994-02-24
SK279101B6 (sk) 1998-06-03
AU604011B2 (en) 1990-12-06
CS8701512A2 (en) 1991-02-12
EP0236940A2 (en) 1987-09-16
FI91857C (fi) 1994-08-25
CZ279026B6 (en) 1994-11-16
EP0236940A3 (en) 1989-10-18
CZ279028B6 (en) 1994-11-16
SK279103B6 (sk) 1998-06-03
SK151287A3 (en) 1998-06-03
BG46598A3 (en) 1990-01-15
BG61204B2 (bg) 1997-02-28
DD264432A5 (de) 1989-02-01
PH24159A (en) 1990-03-22
IE61101B1 (en) 1994-10-05
PT84410A (en) 1987-04-01
ES2059317T3 (es) 1994-11-16
LV5769A4 (lv) 1996-12-20
PL152025B1 (en) 1990-10-31

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