BG45700A3 - Метод за получаване на алфа-хетероциклично заместени толунитрили - Google Patents
Метод за получаване на алфа-хетероциклично заместени толунитрилиInfo
- Publication number
- BG45700A3 BG45700A3 BG081514A BG8151487A BG45700A3 BG 45700 A3 BG45700 A3 BG 45700A3 BG 081514 A BG081514 A BG 081514A BG 8151487 A BG8151487 A BG 8151487A BG 45700 A3 BG45700 A3 BG 45700A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- tolunitrile
- heterocyclic substituted
- obtaining alpha
- alpha
- compounds
- Prior art date
Links
- NWPNXBQSRGKSJB-UHFFFAOYSA-N 2-methylbenzonitrile Chemical class CC1=CC=CC=C1C#N NWPNXBQSRGKSJB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003886 aromatase inhibitor Substances 0.000 abstract 1
- 229940046844 aromatase inhibitors Drugs 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Fats And Perfumes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/837,489 US4749713A (en) | 1986-03-07 | 1986-03-07 | Alpha-heterocycle substituted tolunitriles |
Publications (1)
Publication Number | Publication Date |
---|---|
BG45700A3 true BG45700A3 (bg) | 1989-07-14 |
Family
ID=25274596
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG081515A BG45701A3 (bg) | 1986-03-07 | 1987-03-05 | Метод за получаване на алфа-хетероциклично заместени толунитрили |
BG078756A BG46598A3 (bg) | 1986-03-07 | 1987-03-05 | Метод за получаване на алфа-хетероциклично заместени толунитрили |
BG081514A BG45700A3 (bg) | 1986-03-07 | 1987-03-05 | Метод за получаване на алфа-хетероциклично заместени толунитрили |
BG098212A BG61204B2 (bg) | 1986-03-07 | 1993-11-11 | Алфа-хетероциклени заместени толунитрили |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG081515A BG45701A3 (bg) | 1986-03-07 | 1987-03-05 | Метод за получаване на алфа-хетероциклично заместени толунитрили |
BG078756A BG46598A3 (bg) | 1986-03-07 | 1987-03-05 | Метод за получаване на алфа-хетероциклично заместени толунитрили |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG098212A BG61204B2 (bg) | 1986-03-07 | 1993-11-11 | Алфа-хетероциклени заместени толунитрили |
Country Status (36)
Country | Link |
---|---|
US (1) | US4749713A (cs) |
EP (1) | EP0236940B3 (cs) |
JP (1) | JPH0755930B2 (cs) |
KR (1) | KR910000482B1 (cs) |
AT (1) | ATE94873T1 (cs) |
BG (4) | BG45701A3 (cs) |
CA (1) | CA1316928C (cs) |
CY (1) | CY1905A (cs) |
CZ (3) | CZ279027B6 (cs) |
DD (1) | DD264432A5 (cs) |
DE (2) | DE19775016I2 (cs) |
DK (1) | DK172190B1 (cs) |
DZ (1) | DZ1055A1 (cs) |
ES (1) | ES2059317T3 (cs) |
FI (1) | FI91857C (cs) |
HK (1) | HK50296A (cs) |
HU (1) | HU202843B (cs) |
IE (1) | IE61101B1 (cs) |
IL (1) | IL81746A (cs) |
LU (1) | LU90128I2 (cs) |
LV (1) | LV5769B4 (cs) |
MA (1) | MA20888A1 (cs) |
MC (1) | MC1805A1 (cs) |
MT (1) | MTP998B (cs) |
MX (1) | MX5496A (cs) |
MY (1) | MY102428A (cs) |
NL (1) | NL970011I2 (cs) |
NO (2) | NO170277C (cs) |
PH (1) | PH24159A (cs) |
PL (2) | PL151490B1 (cs) |
PT (1) | PT84410B (cs) |
RO (2) | RO101532B1 (cs) |
SK (3) | SK279102B6 (cs) |
SU (3) | SU1470184A3 (cs) |
TN (1) | TNSN87033A1 (cs) |
ZA (1) | ZA871637B (cs) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5112845A (en) * | 1986-03-07 | 1992-05-12 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US5352795A (en) * | 1986-03-07 | 1994-10-04 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
GB8714013D0 (en) * | 1987-06-16 | 1987-07-22 | Ici Plc | (substituted-aralkyl)heterocyclic compounds |
DE3811574A1 (de) * | 1988-03-31 | 1989-10-19 | Schering Ag | N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
ES2084687T3 (es) * | 1989-07-14 | 1996-05-16 | Ciba Geigy Ag | Benzonitrilos substituidos. |
DE3926365A1 (de) * | 1989-08-04 | 1991-02-07 | Schering Ag | Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln |
JP2602456B2 (ja) * | 1990-04-12 | 1997-04-23 | 雪印乳業株式会社 | 子宮内膜症治療剤 |
EP0457716A1 (de) * | 1990-04-20 | 1991-11-21 | Ciba-Geigy Ag | Naphthalinderivate |
DE4039559A1 (de) * | 1990-12-07 | 1992-06-11 | Schering Ag | Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln |
TW210334B (cs) * | 1990-12-12 | 1993-08-01 | Ciba Geigy Ag | |
CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
DE4120107A1 (de) * | 1991-06-14 | 1992-12-17 | Schering Ag | Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole |
TW225526B (cs) | 1991-09-02 | 1994-06-21 | Yamanouchi Pharma Co Ltd | |
US5223539A (en) * | 1991-11-22 | 1993-06-29 | G. D. Searle & Co. | N,n-di-alkyl(phenoxy)benzamide derivatives |
AU5285593A (en) * | 1992-10-21 | 1994-05-09 | Sankyo Company Limited | Azole compound |
GB2273704B (en) * | 1992-12-16 | 1997-01-22 | Orion Yhtymae Oy | Triazolyl diaryl selective aromatase inhibiting compounds |
US5426196A (en) * | 1993-12-22 | 1995-06-20 | Glaxo Inc. | Synthesis of diaryl methanes |
WO1997027852A1 (en) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997027853A1 (en) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
US6063930A (en) * | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
AU715658B2 (en) * | 1996-04-03 | 2000-02-10 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2250353A1 (en) * | 1996-04-03 | 1997-10-09 | Christopher J. Dinsmore | Inhibitors of farnesyl-protein transferase |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
JP4477303B2 (ja) | 2001-05-16 | 2010-06-09 | ノバルティス アーゲー | N−{5−[4−(4−メチル−ピペラジノ−メチル)−ベンゾイルアミド]−2−メチルフェニル}−4−(3−ピリジル)−2−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤 |
WO2003050093A1 (en) * | 2001-12-11 | 2003-06-19 | Emory University | Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer |
BR0313081A (pt) * | 2002-07-30 | 2005-07-12 | Novartis Ag | Combinação de um inibidor de aromatase com um bisfosfanato |
GB0217636D0 (en) * | 2002-07-30 | 2002-09-11 | Novartis Ag | Organic compounds |
JP2004196795A (ja) * | 2002-12-16 | 2004-07-15 | Wyeth | 外部寄生虫駆除剤としてのn−フェニル−3−シクロプロピルピラゾール−4−カルボニトリル |
AU2003282380A1 (en) * | 2003-11-14 | 2004-06-06 | ADIBHATLA, KALI,SATYA, Bhujanga,rao | A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer |
JP4834557B2 (ja) * | 2003-12-15 | 2011-12-14 | ラボラトワール テラメックス | 1−n−フェニルアミノ−1h−イミダゾール誘導体及びこれを含む医薬組成物 |
US7705159B2 (en) * | 2005-07-06 | 2010-04-27 | Sicor, Inc. | Process for the preparation of letrozole |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US20090082413A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched letrozole |
RU2425038C2 (ru) * | 2009-11-27 | 2011-07-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Способ получения 1-[ди(4-цианфенил)метил]-1,2,4-триазола |
EP2558098A2 (en) | 2010-04-16 | 2013-02-20 | Novartis AG | Treatment of endocrine resistant breast cancer |
WO2012025762A2 (en) | 2010-08-27 | 2012-03-01 | Generics [Uk] Limited | Pure intermediate |
MX360315B (es) * | 2011-09-08 | 2018-10-29 | Novartis Ag | Composiciones farmaceuticas que comprenden un inhibidor de aromatasa. |
RU2665949C2 (ru) | 2012-06-08 | 2018-09-05 | Ф.Хоффманн-Ля Рош Аг | Селективность в отношении мутантных форм и комбинации соединения, представляющего собой ингибитор фосфоинозитид-3-киназы, и химиотерапевтических агентов для лечения рака |
HUE057061T2 (hu) | 2013-08-14 | 2022-04-28 | Novartis Ag | Kombinációs terápia rák kezelésére |
AR104068A1 (es) | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
GB201614179D0 (en) | 2016-08-19 | 2016-10-05 | Mereo Biopharma 2 Ltd | Dosage regimen for the treatment of endometriosis |
EP3826622A1 (en) | 2018-07-23 | 2021-06-02 | F. Hoffmann-La Roche AG | Methods of treating cancer with pi3k inhibitor, gdc-0077 |
EP3863618A1 (en) | 2018-10-08 | 2021-08-18 | F. Hoffmann-La Roche AG | Methods of treating cancer with pi3k alpha inhibitors and metformin |
CA3156205A1 (en) | 2019-12-03 | 2021-06-10 | Jennifer O'hara Lauchle | Combination therapies for treatment of breast cancer |
TW202237136A (zh) | 2020-12-11 | 2022-10-01 | 美商建南德克公司 | 用於治療her2癌症的組合療法 |
CN116925001B (zh) * | 2023-07-26 | 2025-09-30 | 陕西师范大学 | 一种抗乳腺癌药物来曲唑类似物的合成方法 |
WO2025122745A1 (en) | 2023-12-05 | 2025-06-12 | Genentech, Inc. | Combination therapies for treatment of her2 cancer |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3290281A (en) * | 1963-07-18 | 1966-12-06 | Weinstein Julius | Photochromic nitrobenzylpyridines |
US3397273A (en) * | 1966-02-18 | 1968-08-13 | Lilly Co Eli | Controlling phytopathogenic fungi on plants with 3-pyridyl methane derivatives |
GB1170188A (en) * | 1967-09-15 | 1969-11-12 | Bayer Ag | N-trityl-imidazoles and salts and uses thereof |
DE1670976B2 (de) * | 1968-01-29 | 1976-07-22 | N-trityl-imidazole | |
DE1908991B2 (de) * | 1969-02-22 | 1977-05-26 | Bayer Ag, 5090 Leverkusen | Alpha, alpha-disubstituierte n- benzylimidazole und deren salze |
BR6915465D0 (pt) * | 1969-03-07 | 1973-01-04 | Bayer Ag | Processo para preparar n-benzimidazois substituidos na posicao alfa por heterociclos penta-membrados com atividade antimicotica |
DE2007794A1 (de) * | 1970-02-20 | 1971-09-02 | Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen | Fungizide Mittel |
DE2009020C3 (de) * | 1970-02-26 | 1979-09-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von N-(l,l,l-trisubstituierten)-Methylazolen |
US3764690A (en) * | 1972-03-03 | 1973-10-09 | Bayer Ag | Substituted n-benzylimidazoles as antimycotic agents |
US3927017A (en) * | 1974-06-27 | 1975-12-16 | Janssen Pharmaceutica Nv | 1-({62 -Aryl-{62 -R-ethyl)imidazoles |
DE2628152C2 (de) * | 1976-06-23 | 1985-03-28 | Bayer Ag, 5090 Leverkusen | Fungizide und nematizide Mittel |
DE2732531A1 (de) * | 1977-07-19 | 1979-02-01 | Hoechst Ag | Imidazolcarbonsaeuren und deren derivate |
DE2735314A1 (de) * | 1977-08-05 | 1979-02-22 | Basf Ag | Alpha-azolylsulfide und deren derivate |
US4431815A (en) * | 1977-08-26 | 1984-02-14 | Burroughs Wellcome Co. | 1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof |
DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
DE2808086A1 (de) * | 1978-02-24 | 1979-08-30 | Bayer Ag | Substituierte diphenyl-imidazolyl- methane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2821829A1 (de) * | 1978-05-19 | 1979-11-22 | Basf Ag | Mittel zur regulierung des pflanzenwachstums |
JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
DE2847441A1 (de) | 1978-11-02 | 1980-05-22 | Basf Ag | Imidazol-kupferkomplexverbindungen |
DK157860C (da) * | 1979-06-07 | 1990-07-30 | Shionogi & Co | Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf |
US4281141A (en) * | 1980-05-30 | 1981-07-28 | Eli Lilly And Company | 3-(Imidazol-4-yl)-2-phenylpropanenitriles |
US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
US4562199A (en) * | 1983-08-11 | 1985-12-31 | Thorogood Peter B | Imidazole derivatives, compositions and use |
EP0149976A3 (de) * | 1983-12-30 | 1986-12-10 | Ciba-Geigy Ag | Substituierte Imidazole |
US4605661A (en) * | 1984-06-18 | 1986-08-12 | Eli Lilly And Company | Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles |
US4801594A (en) * | 1984-06-18 | 1989-01-31 | Eli Lilly And Company | Aromatase inhibitors |
US4755526A (en) * | 1984-06-18 | 1988-07-05 | Eli Lilly And Company | Method of inhibiting aromatase |
US4766140A (en) * | 1984-06-18 | 1988-08-23 | Eli Lilly And Company | Method of inhibiting aromatase |
US4602025A (en) * | 1984-06-18 | 1986-07-22 | Eli Lilly And Company | Aromatase inhibitors |
-
1986
- 1986-03-07 US US06/837,489 patent/US4749713A/en not_active Expired - Lifetime
-
1987
- 1987-03-02 FI FI870903A patent/FI91857C/fi not_active IP Right Cessation
- 1987-03-03 IL IL81746A patent/IL81746A/xx not_active IP Right Cessation
- 1987-03-03 DD DD87300415A patent/DD264432A5/de not_active IP Right Cessation
- 1987-03-04 DZ DZ870031A patent/DZ1055A1/fr active
- 1987-03-05 AT AT87103099T patent/ATE94873T1/de active
- 1987-03-05 MC MC871874A patent/MC1805A1/xx unknown
- 1987-03-05 RO RO1987134373A patent/RO101532B1/ro unknown
- 1987-03-05 BG BG081515A patent/BG45701A3/xx unknown
- 1987-03-05 BG BG078756A patent/BG46598A3/xx unknown
- 1987-03-05 PL PL1987264460A patent/PL151490B1/pl unknown
- 1987-03-05 EP EP87103099A patent/EP0236940B3/en not_active Expired - Lifetime
- 1987-03-05 DE DE1997175016 patent/DE19775016I2/de active Active
- 1987-03-05 HU HU87952A patent/HU202843B/hu unknown
- 1987-03-05 DE DE87103099T patent/DE3787480T2/de not_active Expired - Lifetime
- 1987-03-05 CA CA000531185A patent/CA1316928C/en not_active Expired - Lifetime
- 1987-03-05 RO RO1987134372A patent/RO101533B1/ro unknown
- 1987-03-05 MA MA21124A patent/MA20888A1/fr unknown
- 1987-03-05 PL PL1987280247A patent/PL152025B1/pl unknown
- 1987-03-05 PT PT84410A patent/PT84410B/pt unknown
- 1987-03-05 BG BG081514A patent/BG45700A3/xx unknown
- 1987-03-05 CY CY190587A patent/CY1905A/xx unknown
- 1987-03-05 ES ES87103099T patent/ES2059317T3/es not_active Expired - Lifetime
- 1987-03-06 SU SU874202145A patent/SU1470184A3/ru active
- 1987-03-06 ZA ZA871637A patent/ZA871637B/xx unknown
- 1987-03-06 TN TNTNSN87033A patent/TNSN87033A1/fr unknown
- 1987-03-06 CZ CS877367A patent/CZ279027B6/cs not_active IP Right Cessation
- 1987-03-06 MY MYPI87000247A patent/MY102428A/en unknown
- 1987-03-06 CZ CS877368A patent/CZ279028B6/cs not_active IP Right Cessation
- 1987-03-06 MT MT998A patent/MTP998B/xx unknown
- 1987-03-06 SK SK7367-87A patent/SK279102B6/sk unknown
- 1987-03-06 SK SK7368-87A patent/SK279103B6/sk unknown
- 1987-03-06 PH PH34986A patent/PH24159A/en unknown
- 1987-03-06 SK SK1512-87A patent/SK151287A3/sk unknown
- 1987-03-06 NO NO870937A patent/NO170277C/no not_active IP Right Cessation
- 1987-03-06 JP JP62050446A patent/JPH0755930B2/ja not_active Expired - Lifetime
- 1987-03-06 KR KR1019870002004A patent/KR910000482B1/ko not_active Expired
- 1987-03-06 MX MX549687A patent/MX5496A/es unknown
- 1987-03-06 IE IE57587A patent/IE61101B1/en not_active IP Right Cessation
- 1987-03-06 CZ CS871512A patent/CZ279026B6/cs not_active IP Right Cessation
- 1987-03-06 DK DK117687A patent/DK172190B1/da not_active IP Right Cessation
-
1988
- 1988-01-18 SU SU884203999A patent/SU1577695A3/ru active
- 1988-01-18 SU SU884203990A patent/SU1549478A3/ru active
-
1993
- 1993-11-11 BG BG098212A patent/BG61204B2/bg unknown
-
1996
- 1996-03-21 HK HK50296A patent/HK50296A/en not_active IP Right Cessation
- 1996-07-18 LV LV960274A patent/LV5769B4/xx unknown
-
1997
- 1997-03-03 NL NL970011C patent/NL970011I2/nl unknown
- 1997-08-20 LU LU90128C patent/LU90128I2/fr unknown
-
1998
- 1998-03-04 NO NO1998010C patent/NO1998010I1/no unknown
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