BG45700A3 - Метод за получаване на алфа-хетероциклично заместени толунитрили - Google Patents

Метод за получаване на алфа-хетероциклично заместени толунитрили

Info

Publication number
BG45700A3
BG45700A3 BG081514A BG8151487A BG45700A3 BG 45700 A3 BG45700 A3 BG 45700A3 BG 081514 A BG081514 A BG 081514A BG 8151487 A BG8151487 A BG 8151487A BG 45700 A3 BG45700 A3 BG 45700A3
Authority
BG
Bulgaria
Prior art keywords
tolunitrile
heterocyclic substituted
obtaining alpha
alpha
compounds
Prior art date
Application number
BG081514A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Bowman
Ronald Steele
Leslie Browne
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG45700(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG45700A3 publication Critical patent/BG45700A3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG081514A 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили BG45700A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
BG45700A3 true BG45700A3 (bg) 1989-07-14

Family

ID=25274596

Family Applications (4)

Application Number Title Priority Date Filing Date
BG081515A BG45701A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG078756A BG46598A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG081514A BG45700A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BG081515A BG45701A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG078756A BG46598A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Country Status (36)

Country Link
US (1) US4749713A (cs)
EP (1) EP0236940B3 (cs)
JP (1) JPH0755930B2 (cs)
KR (1) KR910000482B1 (cs)
AT (1) ATE94873T1 (cs)
BG (4) BG45701A3 (cs)
CA (1) CA1316928C (cs)
CY (1) CY1905A (cs)
CZ (3) CZ279027B6 (cs)
DD (1) DD264432A5 (cs)
DE (2) DE19775016I2 (cs)
DK (1) DK172190B1 (cs)
DZ (1) DZ1055A1 (cs)
ES (1) ES2059317T3 (cs)
FI (1) FI91857C (cs)
HK (1) HK50296A (cs)
HU (1) HU202843B (cs)
IE (1) IE61101B1 (cs)
IL (1) IL81746A (cs)
LU (1) LU90128I2 (cs)
LV (1) LV5769B4 (cs)
MA (1) MA20888A1 (cs)
MC (1) MC1805A1 (cs)
MT (1) MTP998B (cs)
MX (1) MX5496A (cs)
MY (1) MY102428A (cs)
NL (1) NL970011I2 (cs)
NO (2) NO170277C (cs)
PH (1) PH24159A (cs)
PL (2) PL151490B1 (cs)
PT (1) PT84410B (cs)
RO (2) RO101532B1 (cs)
SK (3) SK279102B6 (cs)
SU (3) SU1470184A3 (cs)
TN (1) TNSN87033A1 (cs)
ZA (1) ZA871637B (cs)

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US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
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DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
ES2084687T3 (es) * 1989-07-14 1996-05-16 Ciba Geigy Ag Benzonitrilos substituidos.
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
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DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
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CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
JP4477303B2 (ja) 2001-05-16 2010-06-09 ノバルティス アーゲー N−{5−[4−(4−メチル−ピペラジノ−メチル)−ベンゾイルアミド]−2−メチルフェニル}−4−(3−ピリジル)−2−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤
WO2003050093A1 (en) * 2001-12-11 2003-06-19 Emory University Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer
BR0313081A (pt) * 2002-07-30 2005-07-12 Novartis Ag Combinação de um inibidor de aromatase com um bisfosfanato
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのn−フェニル−3−シクロプロピルピラゾール−4−カルボニトリル
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
JP4834557B2 (ja) * 2003-12-15 2011-12-14 ラボラトワール テラメックス 1−n−フェニルアミノ−1h−イミダゾール誘導体及びこれを含む医薬組成物
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US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
RU2425038C2 (ru) * 2009-11-27 2011-07-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Способ получения 1-[ди(4-цианфенил)метил]-1,2,4-триазола
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
WO2012025762A2 (en) 2010-08-27 2012-03-01 Generics [Uk] Limited Pure intermediate
MX360315B (es) * 2011-09-08 2018-10-29 Novartis Ag Composiciones farmaceuticas que comprenden un inhibidor de aromatasa.
RU2665949C2 (ru) 2012-06-08 2018-09-05 Ф.Хоффманн-Ля Рош Аг Селективность в отношении мутантных форм и комбинации соединения, представляющего собой ингибитор фосфоинозитид-3-киназы, и химиотерапевтических агентов для лечения рака
HUE057061T2 (hu) 2013-08-14 2022-04-28 Novartis Ag Kombinációs terápia rák kezelésére
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
EP3826622A1 (en) 2018-07-23 2021-06-02 F. Hoffmann-La Roche AG Methods of treating cancer with pi3k inhibitor, gdc-0077
EP3863618A1 (en) 2018-10-08 2021-08-18 F. Hoffmann-La Roche AG Methods of treating cancer with pi3k alpha inhibitors and metformin
CA3156205A1 (en) 2019-12-03 2021-06-10 Jennifer O'hara Lauchle Combination therapies for treatment of breast cancer
TW202237136A (zh) 2020-12-11 2022-10-01 美商建南德克公司 用於治療her2癌症的組合療法
CN116925001B (zh) * 2023-07-26 2025-09-30 陕西师范大学 一种抗乳腺癌药物来曲唑类似物的合成方法
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Also Published As

Publication number Publication date
SU1577695A3 (ru) 1990-07-07
PL152025B1 (en) 1990-10-31
SK736787A3 (en) 1998-06-03
MC1805A1 (fr) 1987-12-22
KR910000482B1 (ko) 1991-01-25
AU6976887A (en) 1987-09-10
CZ279027B6 (en) 1994-11-16
LV5769A4 (lv) 1996-12-20
SK736887A3 (en) 1998-06-03
BG46598A3 (bg) 1990-01-15
FI91857B (fi) 1994-05-13
LU90128I2 (fr) 1997-10-06
PT84410A (en) 1987-04-01
IE61101B1 (en) 1994-10-05
DK117687A (da) 1987-09-08
DK117687D0 (da) 1987-03-06
SK279101B6 (sk) 1998-06-03
SK279103B6 (sk) 1998-06-03
SK151287A3 (en) 1998-06-03
SK279102B6 (sk) 1998-06-03
SU1549478A3 (ru) 1990-03-07
EP0236940B3 (en) 2011-03-23
FI91857C (fi) 1994-08-25
BG61204B2 (bg) 1997-02-28
CA1316928C (en) 1993-04-27
CS8707368A2 (en) 1991-02-12
MY102428A (en) 1992-06-30
LV5769B4 (lv) 1997-04-20
ES2059317T3 (es) 1994-11-16
NO870937L (no) 1987-09-08
NO1998010I1 (no) 1998-03-04
EP0236940A2 (en) 1987-09-16
RO101533B1 (en) 1992-06-25
DE19775016I2 (de) 2002-02-21
JPS62212369A (ja) 1987-09-18
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
RO101532B1 (en) 1992-11-03
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
CZ279028B6 (en) 1994-11-16
PT84410B (pt) 1989-10-04
ZA871637B (en) 1987-10-28
US4749713A (en) 1988-06-07
JPH0755930B2 (ja) 1995-06-14
HK50296A (en) 1996-03-29
IL81746A0 (en) 1987-10-20
CS8701512A2 (en) 1991-02-12
EP0236940B1 (en) 1993-09-22
NO170277B (no) 1992-06-22
ATE94873T1 (de) 1993-10-15
EP0236940A3 (en) 1989-10-18
IL81746A (en) 1992-02-16
CZ279026B6 (en) 1994-11-16
DE3787480D1 (de) 1993-10-28
PL151490B1 (en) 1990-09-28
TNSN87033A1 (fr) 1990-01-01
AU604011B2 (en) 1990-12-06
FI870903L (fi) 1987-09-08
DD264432A5 (de) 1989-02-01
NL970011I2 (nl) 1997-09-01
PL264460A1 (en) 1988-07-21
DK172190B1 (da) 1997-12-22
PH24159A (en) 1990-03-22
BG45701A3 (bg) 1989-07-14
MTP998B (en) 1987-08-21
DE3787480T2 (de) 1994-02-24
NL970011I1 (nl) 1997-05-01
IE870575L (en) 1987-09-07
MX5496A (es) 1993-12-01
CS8707367A2 (en) 1991-02-12
MA20888A1 (fr) 1987-10-01
NO170277C (no) 1992-09-30
KR870008851A (ko) 1987-10-21
DZ1055A1 (fr) 2004-09-13
FI870903A0 (fi) 1987-03-02
CY1905A (en) 1987-03-05

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