BG25088A3 - Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли - Google Patents

Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли

Info

Publication number
BG25088A3
BG25088A3 BG030726A BG3072675A BG25088A3 BG 25088 A3 BG25088 A3 BG 25088A3 BG 030726 A BG030726 A BG 030726A BG 3072675 A BG3072675 A BG 3072675A BG 25088 A3 BG25088 A3 BG 25088A3
Authority
BG
Bulgaria
Prior art keywords
benzomorphanes
furfuryl
tetrahydro
salts
preparation
Prior art date
Application number
BG030726A
Other languages
Bulgarian (bg)
English (en)
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
C.H.Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn
Publication of BG25088A3 publication Critical patent/BG25088A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG030726A 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли BG25088A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
BG25088A3 true BG25088A3 (bg) 1978-07-12

Family

ID=5922448

Family Applications (3)

Application Number Title Priority Date Filing Date
BG030726A BG25088A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли
BG031842A BG25089A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли
BG031843A BG25090A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли

Family Applications After (2)

Application Number Title Priority Date Filing Date
BG031842A BG25089A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли
BG031843A BG25090A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли

Country Status (27)

Country Link
US (1) US3982005A (enExample)
JP (1) JPS60358B2 (enExample)
AT (1) AT348140B (enExample)
BE (1) BE832099R (enExample)
BG (3) BG25088A3 (enExample)
CA (1) CA1049008A (enExample)
CH (7) CH613963A5 (enExample)
CS (1) CS189717B2 (enExample)
DD (1) DD122685A5 (enExample)
DE (1) DE2437610A1 (enExample)
DK (1) DK138992C (enExample)
ES (6) ES452767A1 (enExample)
FI (1) FI63229C (enExample)
FR (1) FR2320096A2 (enExample)
GB (1) GB1513950A (enExample)
HU (1) HU177952B (enExample)
IE (1) IE42216B1 (enExample)
IL (1) IL47860A (enExample)
LU (1) LU73138A1 (enExample)
NL (1) NL7509249A (enExample)
NO (1) NO143460C (enExample)
PH (1) PH13687A (enExample)
PL (3) PL99819B1 (enExample)
RO (3) RO67390A (enExample)
SE (1) SE425392B (enExample)
SU (3) SU591147A3 (enExample)
ZA (1) ZA754997B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
US8575156B2 (en) 2007-07-26 2013-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
NZ588954A (en) 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200950780A (en) 2008-05-13 2009-12-16 Boehringer Ingelheim Int Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN104327062A (zh) 2008-07-25 2015-02-04 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体
KR20230112134A (ko) 2020-11-26 2023-07-26 신에쓰 가가꾸 고교 가부시끼가이샤 실온경화성 오르가노폴리실록산 조성물 및 물품 그리고 가수분해성 오르가노실란 화합물 및 그 제조 방법
EP4397695A4 (en) 2021-09-03 2025-09-10 Shinetsu Chemical Co ORGANOPOLYSILOXANE COMPOUND, ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION AND ARTICLE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (enExample) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (enExample) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
ES452765A1 (es) 1977-10-16
DD122685A5 (enExample) 1976-10-20
CA1049008A (en) 1979-02-20
IL47860A (en) 1979-01-31
CH615680A5 (enExample) 1980-02-15
PL99838B1 (pl) 1978-08-31
SU587859A3 (ru) 1978-01-05
GB1513950A (en) 1978-06-14
CS189717B2 (en) 1979-04-30
SE425392B (sv) 1982-09-27
CH615677A5 (enExample) 1980-02-15
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
IL47860A0 (en) 1975-11-25
SU587858A3 (ru) 1978-01-05
NO143460B (no) 1980-11-10
NO752731L (enExample) 1976-02-06
FI63229B (fi) 1983-01-31
FR2320096A2 (fr) 1977-03-04
FR2320096B2 (enExample) 1978-09-01
LU73138A1 (enExample) 1977-04-13
CH616421A5 (enExample) 1980-03-31
PL99819B1 (pl) 1978-08-31
ATA523775A (de) 1978-06-15
RO72736A (ro) 1982-09-09
BG25089A3 (bg) 1978-07-12
PL99816B1 (pl) 1978-08-31
CH615678A5 (enExample) 1980-02-15
US3982005A (en) 1976-09-21
AU8364675A (en) 1977-02-10
JPS60358B2 (ja) 1985-01-07
CH616420A5 (enExample) 1980-03-31
ES452764A1 (es) 1977-10-16
HU177952B (en) 1982-02-28
IE42216B1 (en) 1980-07-02
DK138992B (da) 1978-11-27
ES452768A1 (es) 1977-10-01
ES452767A1 (es) 1977-10-01
ES452766A1 (es) 1977-10-01
RO72735A (ro) 1982-09-09
ZA754997B (en) 1977-04-27
AT348140B (de) 1979-01-25
SU591147A3 (ru) 1978-01-30
IE42216L (en) 1976-02-05
BE832099R (fr) 1976-02-04
FI63229C (fi) 1983-05-10
CH613963A5 (enExample) 1979-10-31
NO143460C (no) 1981-02-18
FI752211A7 (enExample) 1976-02-06
SE7508789L (sv) 1976-02-10
DK138992C (da) 1979-04-30
BG25090A3 (bg) 1978-07-12
DK352875A (da) 1976-02-06
CH615679A5 (enExample) 1980-02-15
NL7509249A (nl) 1976-02-09
ES452763A1 (es) 1977-10-01
JPS5139673A (en) 1976-04-02
DE2437610A1 (de) 1976-02-26

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