BE901665A - Composition pharmaceutique a biodisponibilite elevee et procede pour la preparer. - Google Patents

Composition pharmaceutique a biodisponibilite elevee et procede pour la preparer.

Info

Publication number
BE901665A
BE901665A BE0/214459A BE214459A BE901665A BE 901665 A BE901665 A BE 901665A BE 0/214459 A BE0/214459 A BE 0/214459A BE 214459 A BE214459 A BE 214459A BE 901665 A BE901665 A BE 901665A
Authority
BE
Belgium
Prior art keywords
pharmaceutical composition
preparing
same
water
substance
Prior art date
Application number
BE0/214459A
Other languages
English (en)
Inventor
F Carli
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE901665A publication Critical patent/BE901665A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un polymère gonflable à l'eau insoluble dans l'eau est chargé d'une substance biologiquement active ou d'une substance qui est convertie in vivo en substance biologiquement active, par exemple un médicament ou un précurseur de médicament, par préparation et broyage d'un mélange de ladite substance avec un polymère gonflable à l'eau insoluble dans l'eau dans un rapport des poids substance : polymère de 1 : 0,1 à 1 : 100 ; le polymère ainsi chargé est utilisable comme composition pharmaceutique.
BE0/214459A 1984-02-08 1985-02-06 Composition pharmaceutique a biodisponibilite elevee et procede pour la preparer. BE901665A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848403359A GB8403359D0 (en) 1984-02-08 1984-02-08 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BE901665A true BE901665A (fr) 1985-08-06

Family

ID=10556299

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214459A BE901665A (fr) 1984-02-08 1985-02-06 Composition pharmaceutique a biodisponibilite elevee et procede pour la preparer.

Country Status (7)

Country Link
US (1) US4639370A (fr)
JP (1) JPH0717496B2 (fr)
BE (1) BE901665A (fr)
DE (1) DE3503681A1 (fr)
FR (1) FR2559064B1 (fr)
GB (2) GB8403359D0 (fr)
IT (1) IT1221012B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0215027A (ja) * 1988-07-01 1990-01-18 Takada Seiyaku Kk 新規なプロブコール固形製剤
JPH0215026A (ja) * 1988-07-01 1990-01-18 Takada Seiyaku Kk 新規なプロブコール固形製剤
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
IT1241417B (it) 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1246188B (it) * 1990-07-27 1994-11-16 Resa Farma Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute.
JP2516524B2 (ja) * 1992-04-27 1996-07-24 大洋薬品工業株式会社 持続性製剤
US5252611A (en) * 1992-07-20 1993-10-12 Isp Investments Inc. Controlled release tablets including strongly swellable, moderately crosslinked polyvinylpyrrolidone
IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
CA2218486A1 (fr) * 1995-04-20 1996-10-24 Vectorpharma - Eon N.A. Compose contenant du glycolate d'amidon de sodium en tant que materiau support et produits a base de ce compose
CN1215339A (zh) * 1996-02-05 1999-04-28 三共株式会社 5α－还原酶抑制剂的口服制剂及其制备方法和应用
DE19608750A1 (de) * 1996-03-06 1997-09-11 Durachemie Gmbh & Co Kg Verfahren zur Herstellung von Fenofibrat-Präparaten
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
US20020132839A1 (en) * 2000-06-22 2002-09-19 Ganter Sabina Maria Tablet formulations comprising valsartan
BR0113357A (pt) 2000-08-21 2003-07-29 Unilever Nv Composição oral
DE10125509A1 (de) * 2001-05-23 2002-12-12 Hexal Ag Lösungsmittelfreie Homogenisatherstellung
ES2295379T3 (es) * 2001-06-29 2008-04-16 Eurand Pharmaceuticals Ltd. Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
GB2398221B (en) * 2001-10-26 2006-04-12 John Kohnke Dosage system & dosage vehicle therefor
ITMI20021074A1 (it) * 2002-05-20 2003-11-20 Actimex S R L Composizione ternaria comprendente una sostanza attiva e processo di comacinazione per la sua preparazione
AUPS244002A0 (en) * 2002-05-20 2002-06-13 John Kohnke Products Pty Ltd Agent delivery system
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20070099996A1 (en) * 2003-05-20 2007-05-03 Shashikanth Isloor Pharmaceutical compositions of acitretin
WO2005000273A1 (fr) * 2003-06-27 2005-01-06 Bioprogress S.P.A. Produit composite obtenu par broyage d'un principe actif avec un copolymere n-vinyle-2-pyrrolidone/vinyle-acetate
RU2261095C1 (ru) * 2004-01-09 2005-09-27 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственная форма, обладающая нестероидным противовоспалительным действием, и способ ее изготовления
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
US7611630B2 (en) * 2004-03-30 2009-11-03 Bend Research, Inc. Method and device for evaluation of pharmaceutical compositions
WO2008065502A1 (fr) * 2006-11-29 2008-06-05 Pfizer Products Inc. Compositions pharmaceutiques constituées a) de nanoparticules comprenant des polymères entériques et b) de la caséine
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
WO2008135855A2 (fr) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticules contenant un inhibiteur de la protéine de transfert d'ester de cholestéryle et un polymère non ionisable
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
WO2008135828A2 (fr) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticules comprenant un médicament, de l'éthylcellulose et un sel biliaire
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US8974827B2 (en) * 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US20100215747A1 (en) * 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
WO2009073216A1 (fr) * 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticules comprenant un polymère non ionisable et un copolymère de méthacrylate fonctionnalisé par amine
EP2231169B1 (fr) * 2007-12-06 2016-05-04 Bend Research, Inc. Compositions pharmaceutiques comprenant des nanoparticules et une matière de remise en suspension
AP3628A (en) * 2009-04-24 2016-03-08 Iceutica Pty Ltd A novel formulation of indomethacin
JP5530716B2 (ja) * 2009-12-28 2014-06-25 ライオン株式会社 生薬含有錠剤、生薬含有錠剤用の生薬担持粒子の製造方法
ITMI20120092A1 (it) 2012-01-26 2013-07-27 Micro Macinazione S A Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB426290A (en) * 1933-03-08 1935-04-01 Heyden Chem Fab Manufacture of preparations having an anti-emetic action
DE2200778B2 (de) * 1971-01-13 1974-04-18 Sandoz Ag, Basel (Schweiz) Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen
JPS5132719A (en) * 1974-09-13 1976-03-19 Yoshinobu Nakai Iyakuhinnoshorihoho
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
CA1098443A (fr) * 1977-05-20 1981-03-31 Namassivaya Doddi Composes medicinal absorbable contenant des polymeres de p-dioxanone
JPS603783B2 (ja) * 1977-08-10 1985-01-30 株式会社日立製作所 共通リードフレームから小リード数のリードフレームを製造する方法
GB1601833A (en) * 1978-02-06 1981-11-04 Wellcome Found Antacid formulation
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
IT1131833B (it) * 1980-06-20 1986-06-25 Crinos Industria Farmaco Eccipienti per sostanze spermicide
JPS6029682B2 (ja) * 1980-07-11 1985-07-12 山之内製薬株式会社 苦味のない製剤用組成物およびその製造法
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
DE3270785D1 (en) * 1981-10-29 1986-05-28 Bayer Ag Process for preparing solid fast-releasing drug formulations of dihydropyridines
JPS59101422A (ja) * 1982-12-02 1984-06-12 Takada Seiyaku Kk 溶出性の優れたニフエジピン固形製剤
EP0129893B1 (fr) * 1983-06-28 1991-09-04 Takeda Chemical Industries, Ltd. Mélange broyé
US4555399A (en) * 1983-11-18 1985-11-26 Key Pharmaceuticals, Inc. Aspirin tablet
JP5429565B2 (ja) 2010-03-31 2014-02-26 マツダ株式会社 車高検出装置

Also Published As

Publication number Publication date
IT8519433A0 (it) 1985-02-07
GB8503034D0 (en) 1985-03-06
GB2153678B (en) 1988-04-13
FR2559064A1 (fr) 1985-08-09
GB2153678A (en) 1985-08-29
FR2559064B1 (fr) 1990-09-07
JPS60181030A (ja) 1985-09-14
JPH0717496B2 (ja) 1995-03-01
DE3503681C2 (fr) 1991-09-19
GB8403359D0 (en) 1984-03-14
US4639370A (en) 1987-01-27
DE3503681A1 (de) 1985-08-08
IT1221012B (it) 1990-06-21

Similar Documents

Publication Publication Date Title
BE901665A (fr) Composition pharmaceutique a biodisponibilite elevee et procede pour la preparer.
MY101553A (en) New pharmaceutical preparations with extended release.
BE901994A (fr) Comprimes de principes actifs pharmaceutiques a delitement rapide, stables au stockage.
EA199700110A1 (ru) Композиция с высоким содержанием ацетаминофена для прямого прессования
ES8800041A1 (es) Un procedimiento para la produccion de una composicion farmaceutica de liberacion controlada de unidades individuales
BE901007A (fr) Comprimes pharmaceutiques a liberation etalee et procede pour les preparer.
FR2355035A1 (fr) Procede de preparation de copolymeres solubles, comprenant des groupes hydroxyle, durcissables avec des polyisocyanates organiques
Fowler et al. Substrate-selective activation of rat liver mitochondrial mono amine oxidase by oxygen
MA27123A1 (fr) Forme solide d'administration d'acide diphosphonique ou de sel de celui-ci, utilisant l'acide stearique comme lubrifiant, et procede pour la preparer
BE1000355A3 (fr) Composition pharmaceutique hydrosoluble contenant de la n-acetyl-cysteine et de l'acide citrique.
BE904368A (fr) Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant.
BE901664A (fr) Composition pharmaceutique a biodisponibilite elevee a base d'acetate de medroxyprogesterone et procede pour la preparer.
FR2392031A1 (fr) Procede de preparation d'une poudre contenant du lactulose non hygroscopique
FR2712809B1 (fr) Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide.
BE902796A (fr) Ester d'acetyl carnitine, sa preparation et son utilisation.
FR2427794A1 (fr) Poudre de jus de fruit stable de faible hygroscopicite et son procede de preparation
BE901663A (fr) Composition pharmaceutique a base de polymere gonflable insoluble et procede pour la preparer.
DK161564C (da) Fremgangsmaade til fremstilling af et farmaceutisk praeparat indeholdende det fibrinolytiske middel urokinase og diffusionsfaktoren hyaluronidase
MY106405A (en) Composition based on a finely divided active principle of low water solubility.
IL70124A (en) 5,14-dihydrobenz(5,6)isoindolo(2,1-b)isoquinoline-8,13-dione,its preparation and pharmaceutical compositions containing it
JPS54126723A (en) Preparation of specific hcg and specific anti-hcg-beta-subunit antibody
FR2445832A1 (fr) Oxyamino eburnanes epimeres, procede pour les preparer et leur utilisation dans une composition pharmaceutique et pour la preparation de derives ester de l'acide apovincaminique
BE1002121A4 (fr) Derives de la 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine (ou -1,4-benzoxazonine), procede pour leur preparation et medicaments les contenant.
Perlman et al. Differential agar‐diffusion bioassay for cytotoxic substances
Bray et al. Some observations on the source of cysteine for mercapturic acid formation

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *FARMITALIA CARLO ERBA S.R.L.

Effective date: 20050206

RE20 Patent expired

Owner name: *FARMITALIA CARLO ERBA S.R.L.

Effective date: 20050206