BE901994A - Comprimes de principes actifs pharmaceutiques a delitement rapide, stables au stockage. - Google Patents

Comprimes de principes actifs pharmaceutiques a delitement rapide, stables au stockage.

Info

Publication number
BE901994A
BE901994A BE0/214685A BE214685A BE901994A BE 901994 A BE901994 A BE 901994A BE 0/214685 A BE0/214685 A BE 0/214685A BE 214685 A BE214685 A BE 214685A BE 901994 A BE901994 A BE 901994A
Authority
BE
Belgium
Prior art keywords
pharmaceutical active
tablets
fast
active ingredients
delitting
Prior art date
Application number
BE0/214685A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of BE901994A publication Critical patent/BE901994A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Comprimés de principes actifs pharmaceutiques à délitement rapide qui sont constitués pour l'essentiel d'un mélange comprimé de : a) une quantité efficace d'un principe actif pharmaceutique sous forme de grains, qui est recouvert d'un produit d'enrobage qui consiste en un mélange homogène d'un poly-(acrylate + méthacrylate) de (méthyle + éthyle) insoluble dans l'eau, et d'une éthylcellulose insoluble dans l'eau b) talc, c) dioxyde de silicium colloidal et polyvinylpolypyrrolydone réticulée, comme agent de délitement à pouvoir de délitement et propriétés liantes élevées.
BE0/214685A 1984-03-23 1985-03-22 Comprimes de principes actifs pharmaceutiques a delitement rapide, stables au stockage. BE901994A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1465/84A CH658188A5 (de) 1984-03-23 1984-03-23 Lagerstabile schnellzerfallende pharmazeutische presslinge.

Publications (1)

Publication Number Publication Date
BE901994A true BE901994A (fr) 1985-09-23

Family

ID=4211107

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214685A BE901994A (fr) 1984-03-23 1985-03-22 Comprimes de principes actifs pharmaceutiques a delitement rapide, stables au stockage.

Country Status (26)

Country Link
US (1) US4666703A (fr)
JP (1) JPS60209518A (fr)
AT (1) AT394310B (fr)
AU (1) AU579355B2 (fr)
BE (1) BE901994A (fr)
CA (1) CA1239348A (fr)
CH (1) CH658188A5 (fr)
DE (1) DE3510129A1 (fr)
DK (1) DK162375C (fr)
ES (1) ES8702786A1 (fr)
FI (1) FI82187C (fr)
FR (1) FR2561524B1 (fr)
GB (1) GB2157170B (fr)
GR (1) GR850717B (fr)
HK (1) HK73090A (fr)
IE (1) IE57954B1 (fr)
IL (1) IL74666A (fr)
IT (1) IT1182723B (fr)
LU (1) LU85817A1 (fr)
NL (1) NL8500856A (fr)
NO (1) NO170125C (fr)
NZ (1) NZ211537A (fr)
PT (1) PT80147B (fr)
SE (1) SE8501370L (fr)
SG (1) SG46890G (fr)
ZA (1) ZA852160B (fr)

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CA1270765A (fr) * 1985-02-19 1990-06-26 Charles Hsiao Chlorure de potassium a liberation controlee
IE59066B1 (en) * 1985-02-19 1993-12-15 Key Pharma Controlled release potassium chloride
GB8519310D0 (en) * 1985-07-31 1985-09-04 Zyma Sa Granular active substances
US4971791A (en) * 1985-08-26 1990-11-20 The Procter & Gamble Company Taste masking compositions
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
US5624683A (en) * 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
IT1197316B (it) * 1986-10-01 1988-11-30 Proter Spa Formulazione galenica ad uso orale di derivati della reina a lento rilascio per impiego terapeutico
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
EP0273209B1 (fr) * 1986-12-30 1992-01-15 American Cyanamid Company Composition contenant un polycarbophile
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US4789547A (en) * 1987-06-17 1988-12-06 Warner-Lambert Company Transdermal matrix system
US4904477A (en) * 1987-07-08 1990-02-27 American Home Products Corporation Spray dried ibuprofen compositions
US4927639A (en) * 1989-02-02 1990-05-22 Warner-Lambert Company Modified release gemfibrozil composition
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
DE3937455A1 (de) * 1989-11-10 1991-05-16 Nordmark Arzneimittel Gmbh Antacidatabletten
EP0462066A1 (fr) * 1990-06-15 1991-12-18 Warner-Lambert Company Gemfibrozil amorphe
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
DK0522128T3 (da) * 1991-01-30 1996-02-26 Wellcome Found Vanddispergerbare tabletter indeholdende acyclovir
ES2059260B1 (es) * 1992-10-06 1995-04-16 Espanola Prod Quimicos Procedimiento de preparacion de comprimidos conteniendo diclofenaco; dispersables en agua.
DE4317172A1 (de) * 1993-05-22 1995-01-05 Rhone Poulenc Rorer Gmbh Geschmacksneutrale und schnellfreisetzende Buflomedil-Hydrochlorid-Arzneiform und Herstellungsverfahren desselben
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
ES2082723B1 (es) * 1994-07-20 1996-10-01 Lilly Sa Formulacion farmaceutica de fluoxetina en forma dispersable.
US5674529A (en) * 1995-06-06 1997-10-07 Church & Dwight Co., Inc. Alkalinizing potassium salt controlled release preparations
AU712217B2 (en) * 1995-11-14 1999-11-04 Abbott Gmbh & Co. Kg Stabilized thyroid hormone preparations and methods of making same
US5773031A (en) * 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
WO1997040828A1 (fr) * 1996-04-26 1997-11-06 Shionogi & Co., Ltd. Comprimes de s1452 a liberation rapide
FR2766089B1 (fr) * 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
HU221435B (en) * 1998-02-20 2002-10-28 Egyt Gyogyszervegyeszeti Gyar Pellet-based pharmaceutical composition of controlled release with high content of potassium-chloride, and process for it's production
FR2781793B1 (fr) 1998-08-03 2001-07-20 Prographarm Lab Procede de fabrication de granules de gabapentine enrobes
US6432448B1 (en) 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6500462B1 (en) * 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
AU2001257107A1 (en) 2000-04-20 2001-11-07 Bristol-Myers Squibb Company Taste masking coating composition
EP1339395A2 (fr) 2000-11-28 2003-09-03 Fmc Corporation Composition d'enrobage comestible en alginate de propylene glycol
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
KR20040100835A (ko) * 2001-02-15 2004-12-02 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030175337A1 (en) * 2001-10-29 2003-09-18 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
US20030099699A1 (en) 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
WO2003074085A1 (fr) * 2002-03-06 2003-09-12 Kyowa Hakko Kogyo Co., Ltd. Comprimes a desintegration rapide dans la cavite buccale
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
EP2026768B1 (fr) * 2006-06-01 2018-02-28 Dexcel Pharma Technologies Ltd. Formulation pharmaceutique comprenant des unités multiples
US20100092564A1 (en) * 2006-12-21 2010-04-15 Jae Han Park Composition of and Method for Preparing Orally Disintegrating Tablets
EP2101739A2 (fr) * 2006-12-21 2009-09-23 Mallinckrodt Inc. Comprimés à désintégration par voie orale contenant une dose élevée de principes actifs: composition utilisée et méthodes de fabrication
CN101380474B (zh) * 2007-09-06 2012-07-25 北京大学 用于口服制剂的pH敏感性固体药物组合物及制备方法
CA3018328A1 (fr) 2014-10-31 2016-04-30 Purdue Pharma Methodes et compositions destinees au traitement du trouble de deficit d'attention
EP3288556A4 (fr) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

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DE2200778B2 (de) * 1971-01-13 1974-04-18 Sandoz Ag, Basel (Schweiz) Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen
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US4505896A (en) * 1979-04-19 1985-03-19 Elorac, Ltd. Method of treating acne vulgaris and composition
CH642809B (fr) * 1980-11-07 Longines Montres Comp D Montre avec un mecanisme de quantieme perpetuel.
DE3170764D1 (en) * 1980-11-12 1985-07-04 Ciba Geigy Ag Fast disaggregating pharmaceutical tablet
EP0052075A1 (fr) * 1980-11-12 1982-05-19 Ciba-Geigy Ag Granule pharmaceutique à action retardée
IT1168014B (it) * 1981-08-05 1987-05-20 Erba Farmitalia Forme farmaceutiche a cessione protratta

Also Published As

Publication number Publication date
SE8501370D0 (sv) 1985-03-20
AT394310B (de) 1992-03-10
DK162375B (da) 1991-10-21
AU4028785A (en) 1985-09-26
ATA86885A (de) 1991-09-15
JPH0574568B2 (fr) 1993-10-18
IT8547844A0 (it) 1985-03-21
DK162375C (da) 1992-03-09
SG46890G (en) 1990-08-17
ES541513A0 (es) 1987-01-16
IE57954B1 (en) 1993-05-19
GB2157170B (en) 1988-01-20
HK73090A (en) 1990-09-21
NL8500856A (nl) 1985-10-16
NO170125B (no) 1992-06-09
DK130685D0 (da) 1985-03-22
PT80147A (en) 1985-04-01
JPS60209518A (ja) 1985-10-22
GB8506758D0 (en) 1985-04-17
GB2157170A (en) 1985-10-23
SE8501370L (sv) 1985-09-24
CA1239348A (fr) 1988-07-19
DK130685A (da) 1985-09-24
FI82187B (fi) 1990-10-31
NO851170L (no) 1985-09-24
GR850717B (fr) 1985-07-19
NZ211537A (en) 1988-03-30
ES8702786A1 (es) 1987-01-16
FI82187C (fi) 1991-02-11
FR2561524B1 (fr) 1990-01-12
IT8547844A1 (it) 1986-09-21
CH658188A5 (de) 1986-10-31
DE3510129A1 (de) 1985-10-03
ZA852160B (en) 1985-11-27
IL74666A (en) 1988-11-30
US4666703A (en) 1987-05-19
IT1182723B (it) 1987-10-05
AU579355B2 (en) 1988-11-24
FI851114A0 (fi) 1985-03-20
IL74666A0 (en) 1985-06-30
FI851114L (fi) 1985-09-24
LU85817A1 (de) 1985-12-12
PT80147B (pt) 1987-10-20
FR2561524A1 (fr) 1985-09-27
IE850744L (en) 1985-09-23
NO170125C (no) 1992-09-16

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: CIBA-GEIGY A.G.

Effective date: 19950331