AU601905B2 - Substituted benzthiazol-2-yl compounds as antitumor agents - Google Patents

Substituted benzthiazol-2-yl compounds as antitumor agents Download PDF

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Publication number
AU601905B2
AU601905B2 AU35098/89A AU3509889A AU601905B2 AU 601905 B2 AU601905 B2 AU 601905B2 AU 35098/89 A AU35098/89 A AU 35098/89A AU 3509889 A AU3509889 A AU 3509889A AU 601905 B2 AU601905 B2 AU 601905B2
Authority
AU
Australia
Prior art keywords
hydrogen
compound
fluoro
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35098/89A
Other languages
English (en)
Other versions
AU3509889A (en
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of AU3509889A publication Critical patent/AU3509889A/en
Application granted granted Critical
Publication of AU601905B2 publication Critical patent/AU601905B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Graft Or Block Polymers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU35098/89A 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents Ceased AU601905B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198034 1988-05-24

Publications (2)

Publication Number Publication Date
AU3509889A AU3509889A (en) 1989-11-30
AU601905B2 true AU601905B2 (en) 1990-09-20

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35098/89A Ceased AU601905B2 (en) 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents

Country Status (25)

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EP (1) EP0343893B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0678331B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR910006864B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1023700C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE79114T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU601905B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1328871C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD283815A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE68902358T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK249389A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2043012T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI892498A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3005844T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU202507B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE891667L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL90337A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX173140B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY106035A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO172389C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ229234A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL154875B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT90622B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1681728A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU47019B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA893862B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

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US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US6028223A (en) 1995-08-30 2000-02-22 G. D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
DE69833224T2 (de) 1997-11-10 2006-09-28 Bristol-Myers Squibb Co. Benzothiazole als protein tyrosin-kinase inhibitoren
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
DK1303272T3 (da) 2000-06-21 2008-05-26 Hoffmann La Roche Benzothiazolderivater til behandling af Alzheimers sygdom og Parkinsons sygdom
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
ES2301991T3 (es) * 2003-05-19 2008-07-01 F. Hoffmann-La Roche Ag Derivados de benzotiazol como ligandos del receptor de adenosina.
BRPI0410754A (pt) * 2003-05-21 2006-06-27 Hoffmann La Roche derivados de benzotiazol e uso desses derivados no tratamento de doenças relacionadas com o receptor de adenosina a2a
ES2307015T3 (es) * 2003-05-30 2008-11-16 F. Hoffmann-La Roche Ag Derivados de benzotiazol y su empleo en el tratamiento de enfermedades relacionadas con el receptor de la adenosina a2a.
CN100591679C (zh) * 2003-07-28 2010-02-24 詹森药业有限公司 苯并咪唑、苯并噻唑和苯并唑衍生物及其作为lta4h调节剂的应用
ATE382619T1 (de) 2004-05-24 2008-01-15 Hoffmann La Roche 4-hydroxy-4-methylpiperidin-1-carbonsäure-(4- methoxy-7-morpholin-4-ylbenzothiazol-2-yl)-amid
KR100818028B1 (ko) * 2004-07-22 2008-03-31 에프. 호프만-라 로슈 아게 치환된 벤조티아졸
EP1773827B1 (en) * 2004-07-22 2010-02-17 F.Hoffmann-La Roche Ag Benzothiazole derivatives
ATE400557T1 (de) 2004-11-05 2008-07-15 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
CN101180299B (zh) 2005-03-23 2010-12-15 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的乙炔基-吡唑并嘧啶衍生物
AU2006298829B2 (en) 2005-09-27 2011-03-03 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists
CN101405278A (zh) * 2006-03-15 2009-04-08 4Sc股份公司 新颖的杂环NF-κB抑制剂
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
BR112014007599A2 (pt) * 2011-09-30 2017-04-11 Kineta Inc compostos anti-virais
US9587220B2 (en) 2012-01-27 2017-03-07 Kyoto University Method for inducing cardiac differentiation of pluripotent stem cell
EP2966166B1 (en) 2013-03-08 2019-04-03 Kyoto University Promoter of differentiation of pluripotent stem cell into myocardium, which comprises egf receptor inhibitor
JP6333830B2 (ja) * 2013-09-13 2018-05-30 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
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KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

Also Published As

Publication number Publication date
NO172389B (no) 1993-04-05
ZA893862B (en) 1991-01-30
CN1023700C (zh) 1994-02-09
SU1681728A3 (ru) 1991-09-30
YU105989A (en) 1990-08-31
JPH0678331B2 (ja) 1994-10-05
FI892498A0 (fi) 1989-05-23
CN1037898A (zh) 1989-12-13
CA1328871C (en) 1994-04-26
IL90337A0 (en) 1989-12-15
YU47019B (sh) 1994-11-15
EP0343893B1 (en) 1992-08-05
DE68902358D1 (de) 1992-09-10
HUT51606A (en) 1990-05-28
HU202507B (en) 1991-03-28
PL154875B1 (en) 1991-09-30
DE68902358T2 (de) 1992-12-10
DK249389D0 (da) 1989-05-23
NO892059L (no) 1989-11-27
MX16158A (es) 1993-06-01
KR890017248A (ko) 1989-12-15
PL279613A1 (en) 1989-11-27
EP0343893A1 (en) 1989-11-29
JPH0217181A (ja) 1990-01-22
MX173140B (es) 1994-02-02
IE891667L (en) 1989-11-24
NO892059D0 (no) 1989-05-23
MY106035A (en) 1995-03-31
PT90622B (pt) 1994-10-31
FI892498A7 (fi) 1989-11-25
ES2043012T3 (es) 1993-12-16
NZ229234A (en) 1990-09-26
DK249389A (da) 1989-11-27
ATE79114T1 (de) 1992-08-15
PT90622A (pt) 1989-11-30
NO172389C (no) 1993-07-14
DD283815A5 (de) 1990-10-24
AU3509889A (en) 1989-11-30
GR3005844T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-07
KR910006864B1 (ko) 1991-09-09

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