AU2020328511A1 - Methods and apparatuses for manufacturing for removing material from a therapeutic composition - Google Patents

Methods and apparatuses for manufacturing for removing material from a therapeutic composition Download PDF

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Publication number
AU2020328511A1
AU2020328511A1 AU2020328511A AU2020328511A AU2020328511A1 AU 2020328511 A1 AU2020328511 A1 AU 2020328511A1 AU 2020328511 A AU2020328511 A AU 2020328511A AU 2020328511 A AU2020328511 A AU 2020328511A AU 2020328511 A1 AU2020328511 A1 AU 2020328511A1
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AU
Australia
Prior art keywords
fluid
therapeutic
mrna
microfluidic path
template
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Pending
Application number
AU2020328511A
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English (en)
Inventor
Samuel Deutsch
Benjamin Eldridge
Robert Evans
Igor Khandros
Colin MCKINLAY
Sangeeta Nath
Ximiao WEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medici Therapeutics Inc
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Medici Therapeutics Inc
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Publication date
Application filed by Medici Therapeutics Inc filed Critical Medici Therapeutics Inc
Publication of AU2020328511A1 publication Critical patent/AU2020328511A1/en
Assigned to MEDICI THERAPEUTICS, INC. reassignment MEDICI THERAPEUTICS, INC. Request for Assignment Assignors: NUTCRACKER THERAPEUTICS, INC.
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • G—PHYSICS
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    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
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  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Hematology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2020328511A 2019-08-09 2020-08-10 Methods and apparatuses for manufacturing for removing material from a therapeutic composition Pending AU2020328511A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962885170P 2019-08-09 2019-08-09
US201962885159P 2019-08-09 2019-08-09
US62/885,170 2019-08-09
US62/885,159 2019-08-09
US201962914374P 2019-10-11 2019-10-11
US62/914,374 2019-10-11
PCT/US2020/045625 WO2021030271A2 (en) 2019-08-09 2020-08-10 Methods and apparatuses for manufacturing for removing material from a therapeutic composition

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Publication Number Publication Date
AU2020328511A1 true AU2020328511A1 (en) 2022-03-03

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AU2020328511A Pending AU2020328511A1 (en) 2019-08-09 2020-08-10 Methods and apparatuses for manufacturing for removing material from a therapeutic composition
AU2020329166A Pending AU2020329166A1 (en) 2019-08-09 2020-08-10 Microfluidic apparatus and methods of use thereof

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AU2020329166A Pending AU2020329166A1 (en) 2019-08-09 2020-08-10 Microfluidic apparatus and methods of use thereof

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US (6) US11926817B2 (https=)
EP (2) EP4010350A4 (https=)
JP (3) JP7773282B2 (https=)
KR (1) KR20220041211A (https=)
CN (3) CN214973877U (https=)
AU (2) AU2020328511A1 (https=)
BR (1) BR112022002365A2 (https=)
CA (2) CA3149642A1 (https=)
IL (2) IL290364A (https=)
MX (2) MX2022001664A (https=)
WO (2) WO2021030271A2 (https=)

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Publication number Priority date Publication date Assignee Title
WO2025022178A3 (en) * 2023-07-24 2025-06-05 Apte Zachary Schulz In-situ mrna vaccine production method and device

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GB201704769D0 (en) 2017-01-03 2017-05-10 Illumina Inc Flowcell cartridge with floating seal bracket
MX2022001664A (es) 2019-08-09 2022-07-19 Nutcracker Therapeutics Inc Aparato microfluídico y metodos de uso del mismo.
KR102377073B1 (ko) * 2019-12-10 2022-03-22 비엔엘바이오테크 주식회사 치과용 디지털 측정장치 및 이의 측정 방법
WO2021133765A1 (en) 2019-12-23 2021-07-01 Nutcracker Therapeutics, Inc. Microfluidic apparatus and methods of use thereof
CA3173131A1 (en) * 2020-04-16 2021-10-21 Michael Humbert In vitro manufacturing and purification of therapeutic mrna
NL2027654B1 (en) * 2021-02-08 2022-09-09 Nutcracker Therapeutics Inc Methods for manufacturing a syntetic template
JP2024517410A (ja) * 2021-04-16 2024-04-22 ナットクラッカー セラピューティクス， インコーポレイテッド 動的光散乱アセンブリを有する装置
NL2028164B1 (en) * 2021-04-16 2022-10-28 Nutcracker Therapeutics Inc Apparatus with dynamic light scattering assembly
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