EA201792660A1 - Библиотека т-клеточных рецепторов - Google Patents

Библиотека т-клеточных рецепторов

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Publication number
EA201792660A1
EA201792660A1 EA201792660A EA201792660A EA201792660A1 EA 201792660 A1 EA201792660 A1 EA 201792660A1 EA 201792660 A EA201792660 A EA 201792660A EA 201792660 A EA201792660 A EA 201792660A EA 201792660 A1 EA201792660 A1 EA 201792660A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tcr
chains
constructs
different
cell receptor
Prior art date
Application number
EA201792660A
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English (en)
Inventor
Долорес Шендель
Славолюб Милошевич
Кристиан Эллингер
Original Assignee
Медиджин Иммьюнотерапиз Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Медиджин Иммьюнотерапиз Гмбх filed Critical Медиджин Иммьюнотерапиз Гмбх
Publication of EA201792660A1 publication Critical patent/EA201792660A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение относится к библиотеке для экспрессии всех типов функциональных TCR, включающей 45 конструкций TCR, причем каждая кодирует одну из 45 различных TCR α цепей, и 47 конструкций TCR, причем каждая кодирует одну из 47 различных TCR β цепей, причем каждая из 45 конструкций TCR, кодирующая одну из 45 различных TCR α цепей, включает следующие строительные блоки: один из вариабельных AV сегментов AVseg1-AVseg45 и константный АС сегмент, и причем каждая из 47 конструкций TCR, кодирующая одну из 47 различных TCR β цепей, включает один из вариабельных BV сегментов BVseg1-BVseg47 и константный ВС сегмент.
EA201792660A 2015-06-01 2016-06-01 Библиотека т-клеточных рецепторов EA201792660A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15170157 2015-06-01
PCT/EP2016/062366 WO2016193299A1 (en) 2015-06-01 2016-06-01 T cell receptor library

Publications (1)

Publication Number Publication Date
EA201792660A1 true EA201792660A1 (ru) 2018-05-31

Family

ID=53365825

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792660A EA201792660A1 (ru) 2015-06-01 2016-06-01 Библиотека т-клеточных рецепторов

Country Status (10)

Country Link
US (1) US10858760B2 (ru)
EP (1) EP3303591B1 (ru)
JP (1) JP6568239B2 (ru)
CN (1) CN107922950B (ru)
AU (1) AU2016273213B2 (ru)
CA (1) CA2987857A1 (ru)
EA (1) EA201792660A1 (ru)
HK (1) HK1253694A1 (ru)
NZ (1) NZ737400A (ru)
WO (1) WO2016193299A1 (ru)

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CN110023497B (zh) 2016-11-07 2021-07-13 杰诺维有限公司 用于t细胞受体合成和向tcr呈递细胞进行稳定的基因组整合的两部分装置
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CN110945120A (zh) * 2017-04-07 2020-03-31 优迪有限合伙公司 测量纳米药物中受体-配体相互作用的效力的测定
EP3655532B1 (en) * 2017-07-18 2021-08-18 Genovie AB A two-component vector library system for rapid assembly and diversification of full-length t-cell receptor open reading frames
CN111655280A (zh) 2017-09-01 2020-09-11 达纳-法伯癌症研究所股份有限公司 用于治疗癌症的bcma和taci抗原特异的免疫原性肽
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Also Published As

Publication number Publication date
AU2016273213B2 (en) 2019-03-14
EP3303591B1 (en) 2019-04-03
CA2987857A1 (en) 2016-12-08
NZ737400A (en) 2019-09-27
CN107922950A (zh) 2018-04-17
HK1253694A1 (zh) 2019-06-28
JP2018517713A (ja) 2018-07-05
AU2016273213A1 (en) 2017-12-07
CN107922950B (zh) 2021-12-31
US10858760B2 (en) 2020-12-08
EP3303591A1 (en) 2018-04-11
JP6568239B2 (ja) 2019-08-28
US20180245242A1 (en) 2018-08-30
WO2016193299A1 (en) 2016-12-08

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