BR112016021004A2 - biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula - Google Patents

biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula

Info

Publication number
BR112016021004A2
BR112016021004A2 BR112016021004-2A BR112016021004A BR112016021004A2 BR 112016021004 A2 BR112016021004 A2 BR 112016021004A2 BR 112016021004 A BR112016021004 A BR 112016021004A BR 112016021004 A2 BR112016021004 A2 BR 112016021004A2
Authority
BR
Brazil
Prior art keywords
library
cell receptor
particle
obtaining
specifically binds
Prior art date
Application number
BR112016021004-2A
Other languages
English (en)
Inventor
Karsten Jakobsen Bent
Eamon Molloy Peter
Brigitte Vuidepot Annelise
Ross Liddy Nathaniel
Original Assignee
Immunocore Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54070975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016021004(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB201404536A external-priority patent/GB201404536D0/en
Priority claimed from GBGB1421336.7A external-priority patent/GB201421336D0/en
Application filed by Immunocore Limited filed Critical Immunocore Limited
Publication of BR112016021004A2 publication Critical patent/BR112016021004A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Abstract

a presente invenção se refere a uma biblioteca de partículas, exibindo a biblioteca uma pluralidade de diferentes receptores de células t (tcrs), em que a pluralidade de tcrs consiste essencialmente em tcrs compreendendo um domínio variável de cadeia alfa de um repertório natural e um domínio variável de cadeia beta de um repertório natural, em que o domínio variável10 de cadeia alfa compreende um produto de gene trav12-2 ou trav21 e o domínio variável de cadeia beta compreende um produto de gene trbv6.
BR112016021004-2A 2014-03-14 2015-03-13 biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula BR112016021004A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461953114P 2014-03-14 2014-03-14
GB201404536A GB201404536D0 (en) 2014-03-14 2014-03-14 TCR libraries
GB1404536.3 2014-03-14
US61/953,114 2014-03-14
GB1421336.7 2014-12-02
GBGB1421336.7A GB201421336D0 (en) 2014-12-02 2014-12-02 TCR libraries
PCT/EP2015/055293 WO2015136072A1 (en) 2014-03-14 2015-03-13 Tcr libraries

Publications (1)

Publication Number Publication Date
BR112016021004A2 true BR112016021004A2 (pt) 2018-01-23

Family

ID=54070975

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016021004-2A BR112016021004A2 (pt) 2014-03-14 2015-03-13 biblioteca de partículas; receptor de células t (tcr) isolado não natural; uso de uma biblioteca; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; ácido nucleico; método de construção de uma biblioteca de partículas; método de obtenção de um receptor de células t que se liga especificamente a um antígeno de peptídeo; e partícula

Country Status (14)

Country Link
US (3) US20170051036A1 (pt)
EP (2) EP3116901B1 (pt)
JP (3) JP2017511151A (pt)
KR (1) KR102290829B1 (pt)
CN (1) CN106164091A (pt)
AU (1) AU2015228751B2 (pt)
BR (1) BR112016021004A2 (pt)
CA (1) CA2942433C (pt)
ES (1) ES2740930T3 (pt)
MX (1) MX2016011817A (pt)
NZ (1) NZ724320A (pt)
RU (1) RU2722696C2 (pt)
SG (1) SG11201607181WA (pt)
WO (1) WO2015136072A1 (pt)

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Also Published As

Publication number Publication date
AU2015228751A1 (en) 2016-09-15
EP3116901B1 (en) 2019-06-12
JP2020114212A (ja) 2020-07-30
MX2016011817A (es) 2017-05-12
KR20170005795A (ko) 2017-01-16
SG11201607181WA (en) 2016-09-29
JP2017511151A (ja) 2017-04-20
JP2022109972A (ja) 2022-07-28
EP3590958A1 (en) 2020-01-08
JP7471867B2 (ja) 2024-04-22
ES2740930T3 (es) 2020-02-07
EP3116901A1 (en) 2017-01-18
CN106164091A (zh) 2016-11-23
WO2015136072A1 (en) 2015-09-17
RU2016140189A3 (pt) 2018-09-04
US20210371493A1 (en) 2021-12-02
NZ724320A (en) 2022-05-27
RU2722696C2 (ru) 2020-06-03
RU2016140189A (ru) 2018-04-16
CA2942433A1 (en) 2015-09-17
CA2942433C (en) 2023-08-01
US20220235113A1 (en) 2022-07-28
KR102290829B1 (ko) 2021-08-18
US20170051036A1 (en) 2017-02-23
AU2015228751B2 (en) 2019-06-20

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