SG11201607181WA - Tcr libraries - Google Patents
Tcr librariesInfo
- Publication number
- SG11201607181WA SG11201607181WA SG11201607181WA SG11201607181WA SG11201607181WA SG 11201607181W A SG11201607181W A SG 11201607181WA SG 11201607181W A SG11201607181W A SG 11201607181WA SG 11201607181W A SG11201607181W A SG 11201607181WA SG 11201607181W A SG11201607181W A SG 11201607181WA
- Authority
- SG
- Singapore
- Prior art keywords
- tcr libraries
- tcr
- libraries
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461953114P | 2014-03-14 | 2014-03-14 | |
GB201404536A GB201404536D0 (en) | 2014-03-14 | 2014-03-14 | TCR libraries |
GBGB1421336.7A GB201421336D0 (en) | 2014-12-02 | 2014-12-02 | TCR libraries |
PCT/EP2015/055293 WO2015136072A1 (en) | 2014-03-14 | 2015-03-13 | Tcr libraries |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201607181WA true SG11201607181WA (en) | 2016-09-29 |
Family
ID=54070975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201607181WA SG11201607181WA (en) | 2014-03-14 | 2015-03-13 | Tcr libraries |
Country Status (14)
Country | Link |
---|---|
US (3) | US20170051036A1 (en) |
EP (2) | EP3116901B1 (en) |
JP (3) | JP2017511151A (en) |
KR (1) | KR102290829B1 (en) |
CN (1) | CN106164091A (en) |
AU (1) | AU2015228751B2 (en) |
BR (1) | BR112016021004A2 (en) |
CA (1) | CA2942433C (en) |
ES (1) | ES2740930T3 (en) |
MX (1) | MX2016011817A (en) |
NZ (1) | NZ724320A (en) |
RU (1) | RU2722696C2 (en) |
SG (1) | SG11201607181WA (en) |
WO (1) | WO2015136072A1 (en) |
Families Citing this family (78)
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DK3030682T3 (en) | 2013-08-05 | 2020-09-14 | Twist Bioscience Corp | DE NOVO SYNTHESIZED GENE LIBRARIES |
WO2015153969A1 (en) | 2014-04-04 | 2015-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Ligand discovery for t cell receptors |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
HUE057014T2 (en) | 2014-12-23 | 2022-04-28 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers |
WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
NZ737423A (en) | 2015-06-01 | 2019-08-30 | Medigene Immunotherapies Gmbh | Method for generating antibodies against t cell receptor |
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GB201607534D0 (en) | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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GB201520536D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520563D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520592D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520539D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520603D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520562D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520589D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201607535D0 (en) | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
GB201520559D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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EA201891459A1 (en) | 2015-12-23 | 2018-11-30 | Медиджин Иммьюнотерапиз Гмбх | NEW GENERATION OF ANTIGENSPECIFIC TCR |
CN107345242A (en) * | 2016-05-12 | 2017-11-14 | 眭维国 | The processing method of TCR β chain complementary determining regions |
US10222369B2 (en) * | 2016-05-17 | 2019-03-05 | Chimera Bioengineering, Inc. | Methods for making novel antigen binding domains |
JP6854340B2 (en) | 2016-08-22 | 2021-04-07 | ツイスト バイオサイエンス コーポレーション | Denovo Synthesized Nucleic Acid Library |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
EP4039800B1 (en) | 2016-11-07 | 2023-10-25 | Genovie AB | An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens |
ES2900151T3 (en) * | 2016-11-07 | 2022-03-16 | Genovie Ab | A two-part device for T0 cell receptor synthesis and stable genomic integration in TCR-presenting cells |
US10907274B2 (en) * | 2016-12-16 | 2021-02-02 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
CN118116478A (en) | 2017-02-22 | 2024-05-31 | 特韦斯特生物科学公司 | Nucleic acid-based data storage |
CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
GB201709866D0 (en) * | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
CN111315883B (en) * | 2017-07-18 | 2024-06-18 | 杰诺维有限公司 | Two-component vector library system for rapid assembly and diversification of open reading frames of full-length T cell receptors |
US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
CA3079613A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
JP2021503885A (en) | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Expanded culture of peripheral blood lymphocytes (PBL) from peripheral blood |
WO2019136175A1 (en) | 2018-01-04 | 2019-07-11 | Twist Bioscience Corporation | Dna-based digital information storage |
JP2021516049A (en) * | 2018-03-01 | 2021-07-01 | ザ ユニバーシティ オブ カンザス | Techniques for Producing Cell-Based Therapeutics Using Recombinant T Cell Receptor Genes |
AU2019270243A1 (en) | 2018-05-18 | 2021-01-07 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
MX2021001763A (en) * | 2018-08-13 | 2021-04-19 | Rootpath Genomics Inc | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof. |
WO2020176680A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
AU2020233284A1 (en) | 2019-03-01 | 2021-09-16 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
WO2021026266A1 (en) * | 2019-08-05 | 2021-02-11 | Distributed Bio, Inc. | Antigen binding molecules and methods of screening thereof |
US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
CA3161321A1 (en) | 2019-12-11 | 2021-06-17 | Victor LEVITSKY | Recombinant peptide-mhc complex binding proteins and their generation and use |
GB202010329D0 (en) | 2020-07-06 | 2020-08-19 | Immunocore Ltd | Specific binding molecules |
WO2024038193A1 (en) | 2022-08-18 | 2024-02-22 | Immunocore Limited | Multi-domain binding molecules |
WO2024098024A1 (en) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
WO2024146951A1 (en) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Binding molecules against a prame peptide-hla complex |
WO2024146936A1 (en) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Binding molecules against a piwil1 peptide-hla complex |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9718455D0 (en) | 1997-09-02 | 1997-11-05 | Mcgregor Duncan P | Chimeric binding peptide library screening method |
JP2002515244A (en) | 1998-05-19 | 2002-05-28 | アヴィデックス リミテッド | Soluble T cell receptor |
PT1144607E (en) | 1999-07-20 | 2009-04-22 | Morphosys Ag | Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds |
EP1247095B1 (en) | 1999-12-06 | 2008-10-15 | Board Of Trustees Of The University Of Illinois | High affinity tcr proteins and methods |
PL208712B1 (en) | 2001-08-31 | 2011-05-31 | Avidex Ltd | Soluble t cell receptor |
AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
JP4975324B2 (en) | 2002-11-09 | 2012-07-11 | イムノコア リミテッド | T cell receptor display |
JP4972549B2 (en) | 2004-05-19 | 2012-07-11 | イムノコア リミテッド | Methods for improving T cell receptors |
ATE417065T1 (en) * | 2004-05-19 | 2008-12-15 | Medigene Ltd | HIGH-AFFINITY NY-ESO T-CELL RECEPTOR |
GB0411773D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex |
GB0411771D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Nucleoproteins displaying native T cell receptor libraries |
JP5563194B2 (en) * | 2004-06-29 | 2014-07-30 | イムノコア リミテッド | Cells expressing modified T cell receptors |
AU2008304555A1 (en) | 2007-09-25 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified T cell receptors and related materials and methods |
GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
EA201390011A1 (en) | 2010-07-28 | 2013-07-30 | Иммьюнокор Лтд. | T-CELL RECEPTORS |
AU2013259544B9 (en) * | 2012-05-08 | 2017-09-28 | Adaptive Biotechnologies Corporation | Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions |
GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
-
2015
- 2015-03-13 CA CA2942433A patent/CA2942433C/en active Active
- 2015-03-13 CN CN201580013862.0A patent/CN106164091A/en active Pending
- 2015-03-13 ES ES15709505T patent/ES2740930T3/en active Active
- 2015-03-13 KR KR1020167028338A patent/KR102290829B1/en active IP Right Grant
- 2015-03-13 MX MX2016011817A patent/MX2016011817A/en active IP Right Grant
- 2015-03-13 NZ NZ724320A patent/NZ724320A/en unknown
- 2015-03-13 SG SG11201607181WA patent/SG11201607181WA/en unknown
- 2015-03-13 AU AU2015228751A patent/AU2015228751B2/en active Active
- 2015-03-13 RU RU2016140189A patent/RU2722696C2/en active
- 2015-03-13 JP JP2016574488A patent/JP2017511151A/en not_active Withdrawn
- 2015-03-13 EP EP15709505.0A patent/EP3116901B1/en active Active
- 2015-03-13 BR BR112016021004-2A patent/BR112016021004A2/en not_active Application Discontinuation
- 2015-03-13 WO PCT/EP2015/055293 patent/WO2015136072A1/en active Application Filing
- 2015-03-13 EP EP19178872.8A patent/EP3590958A1/en active Pending
-
2016
- 2016-09-12 US US15/262,160 patent/US20170051036A1/en not_active Abandoned
-
2020
- 2020-03-03 JP JP2020035872A patent/JP7471867B2/en active Active
-
2021
- 2021-05-28 US US17/334,469 patent/US20210371493A1/en not_active Abandoned
-
2022
- 2022-04-12 US US17/719,299 patent/US20220235113A1/en active Pending
- 2022-04-21 JP JP2022070332A patent/JP2022109972A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020114212A (en) | 2020-07-30 |
MX2016011817A (en) | 2017-05-12 |
JP2017511151A (en) | 2017-04-20 |
AU2015228751A1 (en) | 2016-09-15 |
AU2015228751B2 (en) | 2019-06-20 |
CA2942433C (en) | 2023-08-01 |
KR20170005795A (en) | 2017-01-16 |
RU2016140189A (en) | 2018-04-16 |
JP7471867B2 (en) | 2024-04-22 |
EP3590958A1 (en) | 2020-01-08 |
US20220235113A1 (en) | 2022-07-28 |
US20210371493A1 (en) | 2021-12-02 |
WO2015136072A1 (en) | 2015-09-17 |
RU2016140189A3 (en) | 2018-09-04 |
RU2722696C2 (en) | 2020-06-03 |
BR112016021004A2 (en) | 2018-01-23 |
NZ724320A (en) | 2022-05-27 |
CN106164091A (en) | 2016-11-23 |
EP3116901B1 (en) | 2019-06-12 |
ES2740930T3 (en) | 2020-02-07 |
KR102290829B1 (en) | 2021-08-18 |
CA2942433A1 (en) | 2015-09-17 |
US20170051036A1 (en) | 2017-02-23 |
EP3116901A1 (en) | 2017-01-18 |
JP2022109972A (en) | 2022-07-28 |
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