AU2014274840B2 - RNA-guided gene editing and gene regulation - Google Patents

RNA-guided gene editing and gene regulation Download PDF

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Publication number
AU2014274840B2
AU2014274840B2 AU2014274840A AU2014274840A AU2014274840B2 AU 2014274840 B2 AU2014274840 B2 AU 2014274840B2 AU 2014274840 A AU2014274840 A AU 2014274840A AU 2014274840 A AU2014274840 A AU 2014274840A AU 2014274840 B2 AU2014274840 B2 AU 2014274840B2
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gene
cell
cas9
grna
dna
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AU2014274840A2 (en
AU2014274840A1 (en
Inventor
Joshua B. Black
Charles A. Gersbach
Isaac B. Hilton
Ami M. Kabadi
David G. Ousterout
Pablo Perez-Pinera
Pratiksha I. Thakore
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Duke University
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Duke University
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Priority to AU2022250450A priority patent/AU2022250450B2/en
Priority to AU2022250572A priority patent/AU2022250572B2/en
Priority to AU2025213563A priority patent/AU2025213563A1/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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AU2014274840A 2013-06-05 2014-06-05 RNA-guided gene editing and gene regulation Active AU2014274840B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2020203924A AU2020203924A1 (en) 2013-06-05 2020-06-12 RNA-guided gene editing and gene regulation
AU2022250450A AU2022250450B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2022250572A AU2022250572B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2025213563A AU2025213563A1 (en) 2013-06-05 2025-08-05 RNA-guided gene editing and gene regulation

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361831481P 2013-06-05 2013-06-05
US61/831,481 2013-06-05
US201361839127P 2013-06-25 2013-06-25
US61/839,127 2013-06-25
US201361904911P 2013-11-15 2013-11-15
US61/904,911 2013-11-15
US201461967466P 2014-03-19 2014-03-19
US61/967,466 2014-03-19
US201461981575P 2014-04-18 2014-04-18
US61/981,575 2014-04-18
PCT/US2014/041190 WO2014197748A2 (en) 2013-06-05 2014-06-05 Rna-guided gene editing and gene regulation

Related Child Applications (1)

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AU2020203924A Division AU2020203924A1 (en) 2013-06-05 2020-06-12 RNA-guided gene editing and gene regulation

Publications (3)

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AU2014274840A2 AU2014274840A2 (en) 2016-01-21
AU2014274840A1 AU2014274840A1 (en) 2016-01-21
AU2014274840B2 true AU2014274840B2 (en) 2020-03-12

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AU2014274840A Active AU2014274840B2 (en) 2013-06-05 2014-06-05 RNA-guided gene editing and gene regulation
AU2020203924A Abandoned AU2020203924A1 (en) 2013-06-05 2020-06-12 RNA-guided gene editing and gene regulation
AU2022250572A Active AU2022250572B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2022250450A Active AU2022250450B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2025213563A Pending AU2025213563A1 (en) 2013-06-05 2025-08-05 RNA-guided gene editing and gene regulation

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AU2020203924A Abandoned AU2020203924A1 (en) 2013-06-05 2020-06-12 RNA-guided gene editing and gene regulation
AU2022250572A Active AU2022250572B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2022250450A Active AU2022250450B2 (en) 2013-06-05 2022-10-10 RNA-guided gene editing and gene regulation
AU2025213563A Pending AU2025213563A1 (en) 2013-06-05 2025-08-05 RNA-guided gene editing and gene regulation

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US (4) US10704060B2 (https=)
EP (5) EP3004370B1 (https=)
JP (6) JP7085716B2 (https=)
KR (4) KR102733409B1 (https=)
CN (3) CN114230675B (https=)
AU (5) AU2014274840B2 (https=)
CA (1) CA2914519A1 (https=)
ES (3) ES3029138T3 (https=)
WO (1) WO2014197748A2 (https=)

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