AU2013295035B2 - Glucagon analogues - Google Patents

Glucagon analogues Download PDF

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Publication number
AU2013295035B2
AU2013295035B2 AU2013295035A AU2013295035A AU2013295035B2 AU 2013295035 B2 AU2013295035 B2 AU 2013295035B2 AU 2013295035 A AU2013295035 A AU 2013295035A AU 2013295035 A AU2013295035 A AU 2013295035A AU 2013295035 B2 AU2013295035 B2 AU 2013295035B2
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Australia
Prior art keywords
aib
hypoglycaemia
glu
seq
compound
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AU2013295035A
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AU2013295035A1 (en
Inventor
Lise GIEHM
Ditte Riber
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Zealand Pharma AS
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Zealand Pharma AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2013295035A 2012-07-23 2013-07-23 Glucagon analogues Active AU2013295035B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261674706P 2012-07-23 2012-07-23
US61/674,706 2012-07-23
US201361785611P 2013-03-14 2013-03-14
US61/785,611 2013-03-14
DKPA201300360 2013-06-14
DKPA201300360 2013-06-14
PCT/EP2013/065519 WO2014016300A1 (en) 2012-07-23 2013-07-23 Glucagon analogues

Publications (2)

Publication Number Publication Date
AU2013295035A1 AU2013295035A1 (en) 2015-02-12
AU2013295035B2 true AU2013295035B2 (en) 2017-08-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013295035A Active AU2013295035B2 (en) 2012-07-23 2013-07-23 Glucagon analogues

Country Status (27)

Country Link
US (3) US10442847B2 (cg-RX-API-DMAC10.html)
EP (1) EP2875043B1 (cg-RX-API-DMAC10.html)
JP (3) JP6534927B2 (cg-RX-API-DMAC10.html)
KR (1) KR102129235B1 (cg-RX-API-DMAC10.html)
CN (2) CN104662038B (cg-RX-API-DMAC10.html)
AR (1) AR091866A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013295035B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015001451B1 (cg-RX-API-DMAC10.html)
CA (1) CA2878991C (cg-RX-API-DMAC10.html)
DK (1) DK2875043T3 (cg-RX-API-DMAC10.html)
EA (1) EA033399B1 (cg-RX-API-DMAC10.html)
ES (1) ES2620111T3 (cg-RX-API-DMAC10.html)
FI (1) FIC20240034I1 (cg-RX-API-DMAC10.html)
FR (1) FR24C1043I2 (cg-RX-API-DMAC10.html)
IL (1) IL236554B (cg-RX-API-DMAC10.html)
IN (1) IN2015DN00544A (cg-RX-API-DMAC10.html)
MX (1) MX356957B (cg-RX-API-DMAC10.html)
MY (1) MY170671A (cg-RX-API-DMAC10.html)
NL (1) NL301294I2 (cg-RX-API-DMAC10.html)
NZ (1) NZ704043A (cg-RX-API-DMAC10.html)
PH (1) PH12015500115A1 (cg-RX-API-DMAC10.html)
PL (1) PL2875043T3 (cg-RX-API-DMAC10.html)
SG (1) SG11201500375PA (cg-RX-API-DMAC10.html)
TW (1) TWI642682B (cg-RX-API-DMAC10.html)
UA (1) UA117103C2 (cg-RX-API-DMAC10.html)
WO (1) WO2014016300A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201702364B (cg-RX-API-DMAC10.html)

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CA2878991C (en) * 2012-07-23 2021-12-07 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
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US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
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EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
CN106536547A (zh) 2014-06-04 2017-03-22 诺和诺德股份有限公司 用于医疗用途的glp‑1/胰高血糖素受体共激动剂
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AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
WO2018229252A1 (en) 2017-06-16 2018-12-20 Zealand Pharma A/S Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues
GB201710822D0 (en) * 2017-07-05 2017-08-16 Zealand Pharma As Methods and medical uses relating to the treatment of hypoglycaemia
AU2018301715B2 (en) 2017-07-14 2024-11-21 Xeris Pharmaceuticals, Inc. Methods for treating congenital hyperinsulinism
US20210030847A1 (en) * 2018-01-23 2021-02-04 Xeris Pharmaceuticals, Inc. Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon
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JP2023553563A (ja) * 2020-12-16 2023-12-22 ジーランド ファーマ エー／エス Ｇｌｐ－１／ｇｌｐ－２デュアルアゴニストの医薬組成物
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