EA201390796A1 - Применение ацилированного аналога глюкагона - Google Patents
Применение ацилированного аналога глюкагонаInfo
- Publication number
- EA201390796A1 EA201390796A1 EA201390796A EA201390796A EA201390796A1 EA 201390796 A1 EA201390796 A1 EA 201390796A1 EA 201390796 A EA201390796 A EA 201390796A EA 201390796 A EA201390796 A EA 201390796A EA 201390796 A1 EA201390796 A1 EA 201390796A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- application
- acylated glucagon
- glucagon analog
- analogue
- acylated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Abstract
Изобретение относится к способам лечения метаболических нарушений, включая диабет, путем применения комбинации ацилированного аналога глюкагона и аналога инсулина. Изобретение также относится к набору, включающему ацилированный аналог глюкагона и аналог инсулина.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161434698P | 2011-01-20 | 2011-01-20 | |
PCT/IB2012/000134 WO2012098462A1 (en) | 2011-01-20 | 2012-01-20 | Combination of acylated glucagon analogues with insulin analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201390796A1 true EA201390796A1 (ru) | 2014-07-30 |
Family
ID=45607302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390796A EA201390796A1 (ru) | 2011-01-20 | 2012-01-20 | Применение ацилированного аналога глюкагона |
Country Status (20)
Country | Link |
---|---|
US (2) | US20140011733A1 (ru) |
EP (1) | EP2665487A1 (ru) |
JP (1) | JP2014504597A (ru) |
KR (1) | KR20140043709A (ru) |
CN (1) | CN103491975B (ru) |
AR (1) | AR085086A1 (ru) |
AU (1) | AU2012208349A1 (ru) |
BR (1) | BR112013018269A2 (ru) |
CA (1) | CA2824397A1 (ru) |
CL (1) | CL2013002085A1 (ru) |
CO (1) | CO6761400A2 (ru) |
EA (1) | EA201390796A1 (ru) |
MA (1) | MA34913B1 (ru) |
MX (1) | MX2013008005A (ru) |
PE (1) | PE20140969A1 (ru) |
SG (1) | SG192038A1 (ru) |
TN (1) | TN2013000251A1 (ru) |
TW (1) | TW201247702A (ru) |
UY (1) | UY33872A (ru) |
WO (1) | WO2012098462A1 (ru) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA020520B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
EP2370459A1 (en) | 2008-12-15 | 2011-10-05 | Zealand Pharma A/S | Glucagon analogues |
DK2370462T3 (da) | 2008-12-15 | 2014-09-08 | Zealand Pharma As | Glucagon-analoger |
CN102282166B (zh) | 2008-12-15 | 2015-04-01 | 西兰制药公司 | 胰高血糖素类似物 |
SG177609A1 (en) | 2009-07-13 | 2012-02-28 | Zealand Pharma As | Acylated glucagon analogues |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
MX2012014961A (es) | 2010-06-24 | 2013-02-26 | Zealand Pharma As | Analogos de glucagon. |
TWI596110B (zh) | 2011-09-23 | 2017-08-21 | 諾佛 儂迪克股份有限公司 | 新穎升糖素類似物 |
IN2014MN02304A (ru) | 2012-05-03 | 2015-08-07 | Zealand Pharma As | |
AR091866A1 (es) | 2012-07-23 | 2015-03-04 | Zealand Pharma As | Analogos del glucagon |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
RU2678134C2 (ru) * | 2013-03-14 | 2019-01-23 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты инсулин-инкретин |
WO2014170496A1 (en) | 2013-04-18 | 2014-10-23 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
US9988429B2 (en) * | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
UA122767C2 (uk) * | 2013-10-17 | 2021-01-06 | Зіленд Фарма А/С | Ацильований аналог глюкагону |
CA2929459C (en) | 2013-11-06 | 2022-05-03 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
EA035688B1 (ru) | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
AR098616A1 (es) | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
MA46146A1 (fr) | 2014-01-20 | 2020-12-31 | Hanmi Pharm Ind Co Ltd | Insuline a action prolongée et utilisation associée |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
BR112017008659A2 (pt) | 2014-10-29 | 2018-01-30 | Zealand Pharma As | ?métodos e compostos de agonista de gip? |
AU2016247499B2 (en) | 2015-04-16 | 2020-09-03 | Zealand Pharma A/S | Acylated glucagon analogue |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
BR102015031283A2 (pt) * | 2015-12-14 | 2018-09-18 | Univ Rio De Janeiro | Bioconjugado de amilina humana ou de análogos de amilinanão agregantes, composição, métodos para a preparação deuma composição, para o tratamento de uma doença oucondição e para estabilizar um composto amilino-mimético, e,medicamento |
WO2017160669A1 (en) * | 2016-03-18 | 2017-09-21 | Merck Sharp & Dohme Corp. | Insulin-incretin conjugates |
US11058775B2 (en) | 2016-04-26 | 2021-07-13 | Merck Sharp & Dohme Corp. | Insulin dimer-incretin conjugates |
JP7158378B2 (ja) | 2016-09-23 | 2022-10-21 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン受容体との結合力が減少された、インスリンアナログ及びその用途 |
US11752216B2 (en) | 2017-03-23 | 2023-09-12 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
JP2022514835A (ja) * | 2018-12-21 | 2022-02-16 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン及びグルカゴンを含む薬学組成物 |
CA3186427A1 (en) * | 2020-06-11 | 2021-12-16 | Abvance Therapeutics Inc. | Systems, devices, compositions and methods for treating diabetes |
WO2023088140A1 (zh) * | 2021-11-19 | 2023-05-25 | 南京明德新药研发有限公司 | 订合肽及其应用 |
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US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
ATE204882T1 (de) | 1993-09-17 | 2001-09-15 | Novo Nordisk As | Acyliertes insulin |
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EA020520B1 (ru) * | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
DK2370462T3 (da) * | 2008-12-15 | 2014-09-08 | Zealand Pharma As | Glucagon-analoger |
EP2370459A1 (en) * | 2008-12-15 | 2011-10-05 | Zealand Pharma A/S | Glucagon analogues |
CN102282166B (zh) * | 2008-12-15 | 2015-04-01 | 西兰制药公司 | 胰高血糖素类似物 |
US8697632B2 (en) | 2008-12-19 | 2014-04-15 | Indiana University Research And Technology Corporation | Amide based insulin prodrugs |
CA2747490C (en) | 2008-12-19 | 2017-02-14 | Indiana University Research And Technology Corporation | Insulin analogs |
CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
SG177609A1 (en) * | 2009-07-13 | 2012-02-28 | Zealand Pharma As | Acylated glucagon analogues |
MX343360B (es) * | 2010-04-27 | 2016-11-03 | Zealand Pharma As | Conjugados peptidicos de agonistas del receptor de glp-1 y gastrina y su uso. |
UY33462A (es) * | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
-
2012
- 2012-01-20 UY UY0001033872A patent/UY33872A/es not_active Application Discontinuation
- 2012-01-20 WO PCT/IB2012/000134 patent/WO2012098462A1/en active Application Filing
- 2012-01-20 AR ARP120100195A patent/AR085086A1/es unknown
- 2012-01-20 EA EA201390796A patent/EA201390796A1/ru unknown
- 2012-01-20 PE PE2013001533A patent/PE20140969A1/es not_active Application Discontinuation
- 2012-01-20 KR KR1020137018388A patent/KR20140043709A/ko not_active Application Discontinuation
- 2012-01-20 MA MA36191A patent/MA34913B1/fr unknown
- 2012-01-20 JP JP2013549906A patent/JP2014504597A/ja active Pending
- 2012-01-20 BR BR112013018269A patent/BR112013018269A2/pt not_active IP Right Cessation
- 2012-01-20 AU AU2012208349A patent/AU2012208349A1/en not_active Abandoned
- 2012-01-20 SG SG2013055090A patent/SG192038A1/en unknown
- 2012-01-20 TW TW101102724A patent/TW201247702A/zh unknown
- 2012-01-20 MX MX2013008005A patent/MX2013008005A/es not_active Application Discontinuation
- 2012-01-20 US US13/980,087 patent/US20140011733A1/en not_active Abandoned
- 2012-01-20 CA CA2824397A patent/CA2824397A1/en not_active Abandoned
- 2012-01-20 CN CN201280005920.1A patent/CN103491975B/zh not_active Expired - Fee Related
- 2012-01-20 EP EP12704117.6A patent/EP2665487A1/en not_active Withdrawn
-
2013
- 2013-06-11 TN TNP2013000251A patent/TN2013000251A1/fr unknown
- 2013-07-11 CO CO13165262A patent/CO6761400A2/es unknown
- 2013-07-19 CL CL2013002085A patent/CL2013002085A1/es unknown
-
2015
- 2015-09-17 US US14/857,067 patent/US20160000883A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AR085086A1 (es) | 2013-09-11 |
NZ612719A (en) | 2015-05-29 |
CL2013002085A1 (es) | 2013-12-06 |
CA2824397A1 (en) | 2012-07-26 |
KR20140043709A (ko) | 2014-04-10 |
CO6761400A2 (es) | 2013-09-30 |
BR112013018269A2 (pt) | 2017-06-06 |
JP2014504597A (ja) | 2014-02-24 |
EP2665487A1 (en) | 2013-11-27 |
UY33872A (es) | 2012-08-31 |
SG192038A1 (en) | 2013-08-30 |
TW201247702A (en) | 2012-12-01 |
MX2013008005A (es) | 2013-08-21 |
WO2012098462A1 (en) | 2012-07-26 |
CN103491975A (zh) | 2014-01-01 |
TN2013000251A1 (en) | 2014-11-10 |
PE20140969A1 (es) | 2014-07-24 |
MA34913B1 (fr) | 2014-02-01 |
AU2012208349A1 (en) | 2013-07-18 |
US20140011733A1 (en) | 2014-01-09 |
CN103491975B (zh) | 2016-05-11 |
US20160000883A1 (en) | 2016-01-07 |
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