EA201491300A1 - Композиция для назального применения с улучшенной стабильностью - Google Patents

Композиция для назального применения с улучшенной стабильностью

Info

Publication number
EA201491300A1
EA201491300A1 EA201491300A EA201491300A EA201491300A1 EA 201491300 A1 EA201491300 A1 EA 201491300A1 EA 201491300 A EA201491300 A EA 201491300A EA 201491300 A EA201491300 A EA 201491300A EA 201491300 A1 EA201491300 A1 EA 201491300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
improved stability
composition
body application
pharmaceutical composition
application
Prior art date
Application number
EA201491300A
Other languages
English (en)
Other versions
EA024618B1 (ru
Inventor
Харальд Греве
Original Assignee
Мария Клементине Мартин Клостерфрау Фертрибсгезелльшафт Мбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47665594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мария Клементине Мартин Клостерфрау Фертрибсгезелльшафт Мбх filed Critical Мария Клементине Мартин Клостерфрау Фертрибсгезелльшафт Мбх
Publication of EA201491300A1 publication Critical patent/EA201491300A1/ru
Publication of EA024618B1 publication Critical patent/EA024618B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтической композиции с улучшенной стабильностью, предназначенной для местного, преимущественно для назального, предпочтительно для интраназального применения, а также к ее применению и устройству для применения, содержащему эту фармацевтическую композицию.
EA201491300A 2011-12-30 2012-09-25 Композиция для назального применения с улучшенной стабильностью EA024618B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011122588 2011-12-30
DE102012005452A DE102012005452A1 (de) 2011-12-30 2012-03-20 Zusammensetzung für die nasale Applikation mit verbesserter Stabilität
PCT/EP2012/003995 WO2013097911A1 (de) 2011-12-30 2012-09-25 Zusammensetzung für die nasale applikation mit verbesserter stabilität

Publications (2)

Publication Number Publication Date
EA201491300A1 true EA201491300A1 (ru) 2014-10-30
EA024618B1 EA024618B1 (ru) 2016-10-31

Family

ID=47665594

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491300A EA024618B1 (ru) 2011-12-30 2012-09-25 Композиция для назального применения с улучшенной стабильностью

Country Status (9)

Country Link
EP (2) EP2766008B1 (ru)
DE (2) DE102012005452A1 (ru)
DK (1) DK2766008T3 (ru)
EA (1) EA024618B1 (ru)
ES (1) ES2612652T3 (ru)
GE (1) GEP201706609B (ru)
PL (1) PL2766008T3 (ru)
UA (1) UA113749C2 (ru)
WO (1) WO2013097911A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202012005650U1 (de) * 2012-05-14 2013-05-15 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Kombinationstherapeutikum für die Behandlung von Rhinitis
DE202014105553U1 (de) * 2014-08-18 2015-08-20 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Cineolhaltige Zusammensetzung für die nasale Applikation
DE202017104738U1 (de) * 2017-07-31 2018-08-01 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Neue Zusammensetzung für die nasale Applikation
WO2019125330A2 (en) * 2017-08-10 2019-06-27 Eli̇xi̇r İlaç Araştirma Ve Geli̇şti̇rme A.Ş. Nasal decongestant compositions comprising dexpanthenol and sodium hyaluronate
EP3827818A1 (en) * 2019-11-26 2021-06-02 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic composition
WO2023046590A1 (en) * 2021-09-22 2023-03-30 Jadran - Galenski Laboratorij D.D. An improved pharmaceutical composition for nasal use, preparation, and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346886A (en) 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
DE19549421C2 (de) * 1995-11-10 1999-11-18 Klosterfrau Mcm Vetrieb Gmbh Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden
DE19541919C2 (de) 1995-11-10 1997-11-20 Klosterfrau Mcm Vetrieb Gmbh Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden
DE10000612A1 (de) * 2000-01-10 2001-07-19 Min Becker Flüssigkeitspräparate für Augen- und Nasen-Tropfen bzw. Nasenspray ohne Konservierungsmittel
DE10337186A1 (de) 2003-08-13 2005-03-17 Merck Patent Gmbh Wässrige Wirkstoff-Lösung
DE20318634U1 (de) 2003-11-13 2004-02-26 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Pharmazeutische Zusammensetzung zur Behandlung von Rhinitiden
CN101175479A (zh) 2005-03-16 2008-05-07 霍尼韦尔国际公司 药物递送制剂、装置和方法
DE102008036725B4 (de) * 2008-08-07 2021-01-28 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Pharmazeutische Zusammensetzung für die nasale Applikation
CN101756964A (zh) 2008-11-20 2010-06-30 北京利乐生制药科技有限公司 一种含有盐酸赛洛唑啉的复方药用鼻腔喷雾剂
CN102361552A (zh) 2009-03-23 2012-02-22 莱拉制药用品私营有限责任公司 用于治疗过敏性眼/鼻疾病的姜黄色素及其代谢物

Also Published As

Publication number Publication date
DE202012002792U1 (de) 2013-01-03
EA024618B1 (ru) 2016-10-31
ES2612652T3 (es) 2017-05-18
EP2818163A1 (de) 2014-12-31
DE102012005452A1 (de) 2013-07-04
UA113749C2 (xx) 2017-03-10
EP2766008A1 (de) 2014-08-20
WO2013097911A1 (de) 2013-07-04
EP2766008B1 (de) 2016-11-02
PL2766008T3 (pl) 2017-05-31
DK2766008T3 (en) 2017-02-13
GEP201706609B (en) 2017-01-25

Similar Documents

Publication Publication Date Title
EA201491811A1 (ru) АНТИ-LgR5 АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ
CL2014003370A1 (es) Composición acuosa estable de anticuerpos anti-baffr; y dispositivo de suministro de la composición.
EA201300388A1 (ru) Соединения замещенного бензамида
EA202190619A1 (ru) Противовирусные соединения
EA201491947A1 (ru) Антитела и иммуноконъюгаты к ly6e и способы применения
PH12015500850A1 (en) Stable preservative-free mydriatic and anti-inflammatory solutions for injection
EA201490420A1 (ru) ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С α-СУБЪЕДИНИЦАМИ ПОТЕНЦИАЛЗАВИСИМЫХ НАТРИЕВЫХ КАНАЛОВ (SCNxA), С ПОМОЩЬЮ МАЛЫХ МОЛЕКУЛ
EA201590173A1 (ru) Иммуноконъюгаты, содержащие антитела к cd22
BR112014031310A2 (pt) anticorpos anti-pcsk9, formulações, dosagem e métodos de uso
EA201490559A1 (ru) Композиция для лечения свища
EA201590731A1 (ru) Антитела к гемагглютинину и способы применения
BR112013031493A2 (pt) composto, composição farmacêutica, uso de um composto, combinação de um composto, dispositivo e processo de preparação de um composto.
BR112013023056A2 (pt) derivados de oxaespiro [2,5] octano e análogos
UY34582A (es) Anticuerpos anti-cxcr3
EA201491357A1 (ru) Анти-lrp5 антитела и способы их применения
EA201490037A1 (ru) Антагонисты trpv4
CR20130147A (es) Combinaciones que contienen n-(2-arilamino)arilsulfonamida sustituida
EA201590617A1 (ru) Композиции алкилированного циклодекстрина и способы их получения и применения
EA201491300A1 (ru) Композиция для назального применения с улучшенной стабильностью
EA201790410A1 (ru) Содержащая цинеол композиция для назального применения
CO6920289A2 (es) Composición farmacéutica oftalmológica tópica que contiene regorafenib.
CL2012001192S1 (es) Botella.
TR201100148A2 (tr) Stabil akarboz förmülasyonları.
EA201500313A1 (ru) Стабилизированная аморфная форма агомелатина, способ ее изготовления и фармацевтические композиции, ее содержащие
EA201400444A1 (ru) Производные 2-оксопиперидинила

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM