BR112014031310A2 - anticorpos anti-pcsk9, formulações, dosagem e métodos de uso - Google Patents

anticorpos anti-pcsk9, formulações, dosagem e métodos de uso

Info

Publication number
BR112014031310A2
BR112014031310A2 BR112014031310A BR112014031310A BR112014031310A2 BR 112014031310 A2 BR112014031310 A2 BR 112014031310A2 BR 112014031310 A BR112014031310 A BR 112014031310A BR 112014031310 A BR112014031310 A BR 112014031310A BR 112014031310 A2 BR112014031310 A2 BR 112014031310A2
Authority
BR
Brazil
Prior art keywords
formulations
methods
dosage
pcsk9 antibodies
pcsk9
Prior art date
Application number
BR112014031310A
Other languages
English (en)
Inventor
Hui Ada
Peterson Andrew
Pui Chi Chiu Cecilia
K Kirchhofer Daniel
A Kolumam Ganesh
Douglas Davis John
Luis Lin
Kong Beltran Monica
R Budha Nageshwar
Moran Paul
Li Wei
Tingley Whittemore
Lam Xanthe
Wu Yan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112014031310A2 publication Critical patent/BR112014031310A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

resumo patente de invenção: "anticorpos anti-pcsk9, formulações, dosagem e métodos de uso". a presente invenção refere-se a anticorpos anti-pcsk9, formulações, regimes de dosagem, e métodos de uso dos mesmos.
BR112014031310A 2012-06-15 2013-06-14 anticorpos anti-pcsk9, formulações, dosagem e métodos de uso BR112014031310A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660605P 2012-06-15 2012-06-15
US201361786280P 2013-03-14 2013-03-14
PCT/US2013/046032 WO2013188855A1 (en) 2012-06-15 2013-06-14 Anti-pcsk9 antibodies, formulations, dosing, and methods of use

Publications (1)

Publication Number Publication Date
BR112014031310A2 true BR112014031310A2 (pt) 2017-07-25

Family

ID=48746111

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014031310A BR112014031310A2 (pt) 2012-06-15 2013-06-14 anticorpos anti-pcsk9, formulações, dosagem e métodos de uso

Country Status (13)

Country Link
US (2) US9266961B2 (pt)
EP (1) EP2861624A1 (pt)
JP (1) JP2015530867A (pt)
KR (1) KR20150023711A (pt)
CN (1) CN104364266A (pt)
AR (1) AR091462A1 (pt)
BR (1) BR112014031310A2 (pt)
CA (1) CA2875096A1 (pt)
HK (1) HK1205141A1 (pt)
MX (1) MX2014014830A (pt)
RU (1) RU2015101113A (pt)
TW (1) TW201410706A (pt)
WO (1) WO2013188855A1 (pt)

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WO2016010927A1 (en) * 2014-07-14 2016-01-21 Amgen Inc. Crystalline antibody formulations
CN105461809B (zh) * 2015-02-11 2018-10-12 康融东方（广东）医药有限公司 Pcsk9抗体、其药物组合物及其用途
CN106810609A (zh) 2015-11-27 2017-06-09 苏州君盟生物医药科技有限公司 抗pcsk9抗体及其应用
AU2016382932B2 (en) * 2015-12-31 2022-12-08 Jiangsu Hengrui Medicine Co., Ltd. PCSK9 antibody, antigen-binding fragment thereof, and medicinal application thereof
CN107531795B (zh) * 2016-01-05 2021-01-19 江苏恒瑞医药股份有限公司 Pcsk9抗体、其抗原结合片段及其医药用途
CN107266575B (zh) 2016-04-07 2021-12-24 天士力生物医药股份有限公司 前蛋白转化酶枯草溶菌素kexin 9型的结合蛋白及其应用
CN107474140B (zh) * 2016-06-08 2022-06-03 常州博嘉生物医药科技有限公司 Pcsk9特异性的结合蛋白mv072及其应用
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US20200165354A1 (en) * 2016-09-20 2020-05-28 WuXi Biologics Ireland Limited Novel Anti-PCSK9 Antibodies
CN107698680B (zh) * 2017-01-22 2019-03-01 北京东方百泰生物科技有限公司 抗pcsk9单克隆抗体
US11325945B2 (en) 2017-04-12 2022-05-10 Cadila Healthcare Limited Peptide based PCSK9 vaccine
CN107177003A (zh) * 2017-06-27 2017-09-19 上海海玫生物科技有限公司 一种特异性抗人pcsk9的抗体及其应用
TWI720325B (zh) 2017-06-30 2021-03-01 大陸商江蘇恒瑞醫藥股份有限公司 一種pcsk-9抗體醫藥組成物及其用途
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
CN109776680B (zh) * 2019-01-25 2020-05-12 浙江蓝盾药业有限公司 抗人pcsk9单克隆抗体及其用途
EP3969620A1 (en) 2019-05-17 2022-03-23 Regeneron Pharmaceuticals, Inc. Genome-based methods for reducing cardiovascular risk
US20230167188A1 (en) * 2020-07-02 2023-06-01 Biolojic Design Ltd. Anti-tumor necrosis factor receptor (tnfr2) antibodies and uses thereof

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CA2875096A1 (en) 2013-12-19
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TW201410706A (zh) 2014-03-16
US20160355606A1 (en) 2016-12-08
US20130344085A1 (en) 2013-12-26
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RU2015101113A (ru) 2016-08-10
CN104364266A (zh) 2015-02-18

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