AU2010202125B1 - A method to produce an immunoglobulin preparation with improved yield - Google Patents

A method to produce an immunoglobulin preparation with improved yield Download PDF

Info

Publication number
AU2010202125B1
AU2010202125B1 AU2010202125A AU2010202125A AU2010202125B1 AU 2010202125 B1 AU2010202125 B1 AU 2010202125B1 AU 2010202125 A AU2010202125 A AU 2010202125A AU 2010202125 A AU2010202125 A AU 2010202125A AU 2010202125 B1 AU2010202125 B1 AU 2010202125B1
Authority
AU
Australia
Prior art keywords
igg
composition
alcohol
precipitation
precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2010202125A
Other languages
English (en)
Inventor
Leopold Bruckshwaiger
Harald Arno Butterweck
Reinhard Grausenburger
Thomas Gundinger
Bernhard Koelbl
Julia Nuernberger
Arza Pljevljakovic
Hans-Peter Schwarz
Sonja Svatos
Wolfgang Teschner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42727304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010202125(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to AU2010202125A priority Critical patent/AU2010202125B1/en
Priority to ES14176511T priority patent/ES2959234T3/es
Priority to SG10201505161SA priority patent/SG10201505161SA/en
Priority to HK12110936.2A priority patent/HK1170168B/en
Priority to CN201510158213.1A priority patent/CN104958761B/zh
Priority to ARP100101844A priority patent/AR076800A1/es
Priority to KR1020127033758A priority patent/KR101593265B1/ko
Priority to PL10727539T priority patent/PL2445482T3/pl
Priority to PCT/US2010/036470 priority patent/WO2011149472A1/en
Priority to CA2800155A priority patent/CA2800155A1/en
Priority to US12/789,365 priority patent/US8993734B2/en
Priority to ES12190138.3T priority patent/ES2536093T3/es
Priority to EA201500848A priority patent/EA034602B1/ru
Priority to DK10727539.8T priority patent/DK2445482T3/da
Priority to EA201291355A priority patent/EA023446B1/ru
Priority to CN201080067929.6A priority patent/CN102970975B/zh
Priority to MX2014006981A priority patent/MX364252B/es
Priority to MX2012013682A priority patent/MX349815B/es
Priority to TW099117123A priority patent/TWI531577B/zh
Priority to PT121901383T priority patent/PT2554160E/pt
Priority to EP10727539.8A priority patent/EP2445482B1/en
Priority to BR112012029893-3A priority patent/BR112012029893B1/pt
Priority to DK12190138T priority patent/DK2554160T3/da
Priority to SG2012086245A priority patent/SG185724A1/en
Priority to PL12190138T priority patent/PL2554160T3/pl
Priority to ES10727539.8T priority patent/ES2525492T3/es
Priority to PT107275398T priority patent/PT2445482E/pt
Priority to EP12190138.3A priority patent/EP2554160B1/en
Priority to MYPI2015002952A priority patent/MY173299A/en
Priority to JP2013512585A priority patent/JP5876474B2/ja
Priority to HRP20141109AT priority patent/HRP20141109T1/hr
Priority to KR1020167002347A priority patent/KR101647617B1/ko
Priority to MYPI2012005077A priority patent/MY160551A/en
Priority to HUE14176511A priority patent/HUE064400T2/hu
Priority to EP14176511.5A priority patent/EP2803349B1/en
Priority to PL14176511.5T priority patent/PL2803349T3/pl
Publication of AU2010202125B1 publication Critical patent/AU2010202125B1/en
Priority to AU2010224461A priority patent/AU2010224461B2/en
Priority to US13/085,056 priority patent/US8796430B2/en
Priority to MX2012013689A priority patent/MX337028B/es
Priority to TW100118581A priority patent/TWI504607B/zh
Priority to PL11729200T priority patent/PL2575762T3/pl
Priority to EP20140166189 priority patent/EP2796128A1/en
Priority to ES11729200.3T priority patent/ES2505465T3/es
Priority to JP2013512262A priority patent/JP5866345B2/ja
Priority to DK22164436.2T priority patent/DK4039249T3/da
Priority to MYPI2012005078A priority patent/MY161617A/en
Priority to DK11729200.3T priority patent/DK2575762T3/da
Priority to CN201180036374.3A priority patent/CN103068365B/zh
Priority to AU2011258111A priority patent/AU2011258111B2/en
Priority to HK13110932.5A priority patent/HK1183449B/en
Priority to PT117292003T priority patent/PT2575762E/pt
Priority to HRP20260340TT priority patent/HRP20260340T1/hr
Priority to US13/117,028 priority patent/US8772462B2/en
Priority to PCT/US2011/038247 priority patent/WO2011150284A2/en
Priority to EA201291367A priority patent/EA025826B1/ru
Priority to ARP110101811A priority patent/AR082093A1/es
Priority to HRP20140944AT priority patent/HRP20140944T1/hr
Priority to CA2800272A priority patent/CA2800272A1/en
Priority to EP22164436.2A priority patent/EP4039249B1/en
Priority to TW104127086A priority patent/TWI543989B/zh
Priority to SG2012086252A priority patent/SG185725A1/en
Priority to EP11729200.3A priority patent/EP2575762B1/en
Priority to BR112012029897A priority patent/BR112012029897A2/pt
Priority to EA201691558A priority patent/EA034530B1/ru
Priority to CN201510171065.7A priority patent/CN104840946A/zh
Priority to CN201810967589.0A priority patent/CN109180776B/zh
Priority to FIEP22164436.2T priority patent/FI4039249T3/fi
Priority to KR1020127033759A priority patent/KR101716534B1/ko
Priority to US13/633,697 priority patent/US8921520B2/en
Priority to US13/653,332 priority patent/US8940877B2/en
Priority to IL223150A priority patent/IL223150A0/en
Priority to IL223149A priority patent/IL223149A/en
Priority to CL2012003290A priority patent/CL2012003290A1/es
Priority to CO12212751A priority patent/CO6660438A2/es
Priority to CL2012003291A priority patent/CL2012003291A1/es
Priority to CO12212759A priority patent/CO6660439A2/es
Priority to MX2019004482A priority patent/MX2019004482A/es
Priority to US13/830,862 priority patent/US20130224184A1/en
Priority to US13/830,815 priority patent/US8889838B2/en
Priority to HK13109199.5A priority patent/HK1181682B/en
Priority to US14/296,319 priority patent/US9468675B2/en
Priority to US14/309,668 priority patent/US20150133644A1/en
Priority to CL2014003430A priority patent/CL2014003430A1/es
Priority to HRP20150484TT priority patent/HRP20150484T1/hr
Priority to HK15104607.0A priority patent/HK1203838B/en
Priority to JP2015160018A priority patent/JP2016053016A/ja
Assigned to Baxalta GmbH, BAXALTA INCORPORATED reassignment Baxalta GmbH Request for Assignment Assignors: BAXTER HEALTHCARE S. A., BAXTER INTERNATIONAL INC
Priority to JP2016000025A priority patent/JP2016155798A/ja
Priority to HK16101817.1A priority patent/HK1213790A1/zh
Priority to HK16103905.0A priority patent/HK1215931B/zh
Priority to AU2016202973A priority patent/AU2016202973B2/en
Priority to US15/151,302 priority patent/US9708391B2/en
Priority to JP2016210160A priority patent/JP6363676B2/ja
Priority to US15/619,346 priority patent/US10208106B2/en
Priority to US15/807,512 priority patent/US11136350B2/en
Priority to JP2018016073A priority patent/JP6592120B2/ja
Priority to AU2018201371A priority patent/AU2018201371B2/en
Priority to US16/241,551 priority patent/US10875906B2/en
Priority to ARP190100147A priority patent/AR114228A2/es
Priority to CL2019003179A priority patent/CL2019003179A1/es
Priority to AU2020200373A priority patent/AU2020200373B2/en
Priority to US17/103,618 priority patent/US11891431B2/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: Baxalta GmbH, BAXALTA INCORPORATED
Priority to ARP210101010A priority patent/AR121861A2/es
Priority to US17/473,910 priority patent/US12545703B2/en
Priority to AU2021286395A priority patent/AU2021286395B2/en
Priority to US18/545,528 priority patent/US20240117009A1/en
Priority to AU2024204779A priority patent/AU2024204779A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
AU2010202125A 2010-05-26 2010-05-26 A method to produce an immunoglobulin preparation with improved yield Active AU2010202125B1 (en)

Priority Applications (106)

Application Number Priority Date Filing Date Title
AU2010202125A AU2010202125B1 (en) 2010-05-26 2010-05-26 A method to produce an immunoglobulin preparation with improved yield
ES14176511T ES2959234T3 (es) 2010-05-26 2010-05-27 Procedimiento para preparar una composición de IgG enriquecida a partir de plasma
SG10201505161SA SG10201505161SA (en) 2010-05-26 2010-05-27 Method For Preparing An Enriched IGG Composition From Plasma
HK12110936.2A HK1170168B (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
CN201510158213.1A CN104958761B (zh) 2010-05-26 2010-05-27 从血浆制备富含IgG的组合物的方法
ARP100101844A AR076800A1 (es) 2010-05-26 2010-05-27 Metodo para producir una preparacion de inmunoglobulina con un alto rendimiento
KR1020127033758A KR101593265B1 (ko) 2010-05-26 2010-05-27 혈장으로부터 IgG가 풍부한 조성물을 준비하는 방법
PL10727539T PL2445482T3 (pl) 2010-05-26 2010-05-27 Sposób wytwarzania z osocza kompozycji wzbogaconej IgG
PCT/US2010/036470 WO2011149472A1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
CA2800155A CA2800155A1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
US12/789,365 US8993734B2 (en) 2010-05-26 2010-05-27 Method to produce an immunoglobulin preparation with improved yield
ES12190138.3T ES2536093T3 (es) 2010-05-26 2010-05-27 Procedimiento para preparar una composición de IgG enriquecida a partir de plasma
EA201500848A EA034602B1 (ru) 2010-05-26 2010-05-27 Способ получения обогащенной igg-композиции из криосупернатантной плазмы
DK10727539.8T DK2445482T3 (da) 2010-05-26 2010-05-27 Fremgangsmåde til fremstilling af beriget IgG sammensætning af plasma
EA201291355A EA023446B1 (ru) 2010-05-26 2010-05-27 СПОСОБ ПОЛУЧЕНИЯ ОБОГАЩЕННОЙ IgG-КОМПОЗИЦИИ ИЗ ПЛАЗМЫ
CN201080067929.6A CN102970975B (zh) 2010-05-26 2010-05-27 从血浆制备富含IgG的组合物的方法
MX2014006981A MX364252B (es) 2010-05-26 2010-05-27 Método para producir una preparación de inmunoglobulina con un rendimiento mejorado.
MX2012013682A MX349815B (es) 2010-05-26 2010-05-27 Metodo para producir una preparacion de inmunoglobulina con un rendimiento mejorado.
TW099117123A TWI531577B (zh) 2010-05-26 2010-05-27 具有高產率之產製免疫球蛋白製備物的方法
PT121901383T PT2554160E (pt) 2010-05-26 2010-05-27 Método para preparar uma composição de igg enriquecida a partir do plasma
EP10727539.8A EP2445482B1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
BR112012029893-3A BR112012029893B1 (pt) 2010-05-26 2010-05-27 Método para preparar uma composição de igg enriquecida a partir de plasma
DK12190138T DK2554160T3 (da) 2010-05-26 2010-05-27 Fremgangsmåde til fremstilling af en beriget IgG-sammensætning fra plasma
SG2012086245A SG185724A1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
PL12190138T PL2554160T3 (pl) 2010-05-26 2010-05-27 Sposób wytwarzania z osocza kompozycji wzbogaconej w IgG
ES10727539.8T ES2525492T3 (es) 2010-05-26 2010-05-27 Procedimiento para preparar una composiciónde IgG enriquecida a partir de plasma
PT107275398T PT2445482E (pt) 2010-05-26 2010-05-27 Método para preparar uma composição de igg enriquecida a partir do plasma
EP12190138.3A EP2554160B1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched IgG composition from plasma
MYPI2015002952A MY173299A (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
JP2013512585A JP5876474B2 (ja) 2010-05-26 2010-05-27 血漿由来の富化ＩｇＧ組成物を調製する方法
HRP20141109AT HRP20141109T1 (hr) 2010-05-26 2010-05-27 Postupak za pripravu obogaä†enog sastava igg iz plazme
KR1020167002347A KR101647617B1 (ko) 2010-05-26 2010-05-27 혈장으로부터 IgG가 풍부한 조성물을 준비하는 방법
MYPI2012005077A MY160551A (en) 2010-05-26 2010-05-27 Method for preparing an enriched igg composition from plasma
HUE14176511A HUE064400T2 (hu) 2010-05-26 2010-05-27 Eljárás dúsított IgG-készítmény elõállítására plazmából
EP14176511.5A EP2803349B1 (en) 2010-05-26 2010-05-27 Method for preparing an enriched IgG composition from plasma
PL14176511.5T PL2803349T3 (pl) 2010-05-26 2010-05-27 Sposób wytwarzania wzbogaconej kompozycji IgG z osocza
AU2010224461A AU2010224461B2 (en) 2010-05-26 2010-09-29 A method to produce an immunoglobulin preparation with improved yield
US13/085,056 US8796430B2 (en) 2010-05-26 2011-04-12 Method to produce an immunoglobulin preparation with improved yield
PCT/US2011/038247 WO2011150284A2 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
TW100118581A TWI504607B (zh) 2010-05-26 2011-05-26 以微細分之二氧化矽處理移除絲胺酸蛋白酶
PL11729200T PL2575762T3 (pl) 2010-05-26 2011-05-26 Usuwanie proteazy serynowej przez traktowanie subtelnie rozdrobnionym dwutlenkiem krzemu
EP20140166189 EP2796128A1 (en) 2010-05-26 2011-05-26 Enrichment of factor H out of plasma
ES11729200.3T ES2505465T3 (es) 2010-05-26 2011-05-26 Retirada de serina proteasas por tratamiento con dióxido de silicio finamente dividido
JP2013512262A JP5866345B2 (ja) 2010-05-26 2011-05-26 微細二酸化シリコンを用いた処理によるセリンプロテアーゼ除去法
DK22164436.2T DK4039249T3 (da) 2010-05-26 2011-05-26 Fjernelse af serinproteaser ved behandling med findelt siliciumdioxid
MYPI2012005078A MY161617A (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
DK11729200.3T DK2575762T3 (da) 2010-05-26 2011-05-26 Fjernelse af serinproteaser ved behandling med findelt silicium-dioxid
CN201180036374.3A CN103068365B (zh) 2010-05-26 2011-05-26 通过用微细分的二氧化硅处理去除丝氨酸蛋白酶
AU2011258111A AU2011258111B2 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
HK13110932.5A HK1183449B (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
PT117292003T PT2575762E (pt) 2010-05-26 2011-05-26 Remoção de serina proteases por tratamento com dióxido de silício finamente dividido
HRP20260340TT HRP20260340T1 (hr) 2010-05-26 2011-05-26 Uklanjanje serinskih proteaza tretiranjem sitno podijeljenim silicijevim dioksidom
US13/117,028 US8772462B2 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
MX2012013689A MX337028B (es) 2010-05-26 2011-05-26 Eliminacion de serina proteasas por tratamiento con dioxido de silicona finamente dividido.
EA201291367A EA025826B1 (ru) 2010-05-26 2011-05-26 Удаление сериновых протеаз путем обработки тонкоизмельченным диоксидом кремния
ARP110101811A AR082093A1 (es) 2010-05-26 2011-05-26 Eliminacion de serina proteasas por tratamiento con dioxido de silicona finamente dividido
HRP20140944AT HRP20140944T1 (hr) 2010-05-26 2011-05-26 Odstranjivanje proteaza serina pomoä†u tretmana s fino podijeljenim silicijevim dioksidom
CA2800272A CA2800272A1 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
EP22164436.2A EP4039249B1 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
TW104127086A TWI543989B (zh) 2010-05-26 2011-05-26 以微細分之二氧化矽處理移除絲胺酸蛋白酶
SG2012086252A SG185725A1 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
EP11729200.3A EP2575762B1 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
BR112012029897A BR112012029897A2 (pt) 2010-05-26 2011-05-26 método para reduzir a quantidade de uma serina protease ou um zimogênio de serina protease em uma composição, método para preparar uma composição, composição de proteína derivada de plasma, e, método para tratamento de uma doença
EA201691558A EA034530B1 (ru) 2010-05-26 2011-05-26 Удаление сериновых протеаз путем обработки тонкоизмельченным диоксидом кремния
CN201510171065.7A CN104840946A (zh) 2010-05-26 2011-05-26 通过用微细分的二氧化硅处理去除丝氨酸蛋白酶
CN201810967589.0A CN109180776B (zh) 2010-05-26 2011-05-26 通过用微细分的二氧化硅处理去除丝氨酸蛋白酶
FIEP22164436.2T FI4039249T3 (fi) 2010-05-26 2011-05-26 Seriiniproteaasien poistaminen hienojakoisella piidioksidilla tehtävällä käsittelyllä
KR1020127033759A KR101716534B1 (ko) 2010-05-26 2011-05-26 미분된 이산화규소로의 처리에 의한 세린 프로테아제의 제거
US13/633,697 US8921520B2 (en) 2010-05-26 2012-10-02 Removal of serine proteases by treatment with finely divided silicon dioxide
US13/653,332 US8940877B2 (en) 2010-05-26 2012-10-16 Method to produce an immunoglobulin preparation with improved yield
IL223150A IL223150A0 (en) 2010-05-26 2012-11-20 Method for preparing an enriched igg composition from plasma
IL223149A IL223149A (en) 2010-05-26 2012-11-20 Removal of serine proteases by treatment with finely divided silicon dioxide
CO12212751A CO6660438A2 (es) 2010-05-26 2012-11-23 Método para producir una preparación de inmunoglobina con rendimiento mejorado
CL2012003290A CL2012003290A1 (es) 2010-05-26 2012-11-23 Metodo para preparar una composicion enriquecida en igg a partir de plasma; composicion acuosa de igg; composicion farmaceutica que comprende dicha composicion acuosa; uso de dicha composicion para tratar enfermedad autoinmune o infeccion aguda
CL2012003291A CL2012003291A1 (es) 2010-05-26 2012-11-23 Metodo para reducir la cantidad de una serina proteasa o de un zimógeno de serina proteasa en una composicion de proteinas derivadas de plasma de interés; metodo para preparar una composicion del factor h con una cantidad reducida de una serina proteasa o de un zimógeno de serina proteasa; metodo para preparar composicion de un inhibidor de inter-alfa-tripsina.
CO12212759A CO6660439A2 (es) 2010-05-26 2012-11-23 Eliminación de serina proteasa por tratamiento con dióxido de silicona finamente dividido
MX2019004482A MX2019004482A (es) 2010-05-26 2012-11-26 Metodo para producir una preparacion de inmunoglobulina con un rendimiento mejorado.
US13/830,862 US20130224184A1 (en) 2010-05-26 2013-03-14 Method to produce an immunoglobulin preparation with improved yield
US13/830,815 US8889838B2 (en) 2010-05-26 2013-03-14 Removal of serine proteases by treatment with finely divided silicon dioxide
HK13109199.5A HK1181682B (en) 2010-05-26 2013-08-06 Method for preparing an enriched igg composition from plasma
US14/296,319 US9468675B2 (en) 2010-05-26 2014-06-04 Removal of serine proteases by treatment with finely divided silicon dioxide
US14/309,668 US20150133644A1 (en) 2010-05-26 2014-06-19 Method to produce an immunoglobulin preparation with improved yield
CL2014003430A CL2014003430A1 (es) 2010-05-26 2014-12-17 Método para producir una preparacion de inmunoglobulina con un rendimiento mejorado
HRP20150484TT HRP20150484T1 (hr) 2010-05-26 2015-05-04 Postupak za proizvodnju obogaä†enog igg-sastava iz plazme
HK15104607.0A HK1203838B (en) 2010-05-26 2015-05-15 Method for preparing an enriched igg composition from plasma
JP2015160018A JP2016053016A (ja) 2010-05-26 2015-08-14 血漿由来の富化ＩｇＧ組成物を調製する方法
JP2016000025A JP2016155798A (ja) 2010-05-26 2016-01-04 微細二酸化シリコンを用いた処理によるセリンプロテアーゼ除去法
HK16101817.1A HK1213790A1 (zh) 2010-05-26 2016-02-18 通过用微细分的二氧化矽处理去除丝氨酸蛋白酶
HK16103905.0A HK1215931B (zh) 2010-05-26 2016-04-06 从血浆制备富含igg的组合物的方法
AU2016202973A AU2016202973B2 (en) 2010-05-26 2016-05-09 Removal of serine proteases by treatment with finely divided silicon dioxide
US15/151,302 US9708391B2 (en) 2010-05-26 2016-05-10 Removal of serine proteases by treatment with finely divided silicon dioxide
JP2016210160A JP6363676B2 (ja) 2010-05-26 2016-10-27 血漿由来の富化ＩｇＧ組成物を調製する方法
US15/619,346 US10208106B2 (en) 2010-05-26 2017-06-09 Removal of serine proteases by treatment with finely divided silicon dioxide
US15/807,512 US11136350B2 (en) 2010-05-26 2017-11-08 Method to produce an immunoglobulin preparation with improved yield
JP2018016073A JP6592120B2 (ja) 2010-05-26 2018-02-01 微細二酸化シリコンを用いた処理によるセリンプロテアーゼ除去法
AU2018201371A AU2018201371B2 (en) 2010-05-26 2018-02-26 Removal of serine proteases by treatment with finely divided silicon dioxide
US16/241,551 US10875906B2 (en) 2010-05-26 2019-01-07 Removal of serine proteases by treatment with finely divided silicon dioxide
ARP190100147A AR114228A2 (es) 2010-05-26 2019-01-23 Método para producir una preparación de inmunoglobulina con un rendimiento mejorado
CL2019003179A CL2019003179A1 (es) 2010-05-26 2019-11-06 Eliminación de serina proteasas por tratamiento con dióxido de silicio finamente dividido. (divisional solicitud 201203291)
AU2020200373A AU2020200373B2 (en) 2010-05-26 2020-01-19 Removal of serine proteases by treatment with finely divided silicon dioxide
US17/103,618 US11891431B2 (en) 2010-05-26 2020-11-24 Removal of serine proteases by treatment with finely divided silicon dioxide
ARP210101010A AR121861A2 (es) 2010-05-26 2021-04-16 MÉTODO PARA PREPARAR UNA COMPOSICIÓN DE IgG ENRIQUECIDA A PARTIR DE PLASMA
US17/473,910 US12545703B2 (en) 2010-05-26 2021-09-13 Method to produce an immunoglobulin preparation with improved yield
AU2021286395A AU2021286395B2 (en) 2010-05-26 2021-12-16 Removal of serine proteases by treatment with finely divided silicon dioxide
US18/545,528 US20240117009A1 (en) 2010-05-26 2023-12-19 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2024204779A AU2024204779A1 (en) 2010-05-26 2024-07-11 Removal of serine proteases by treatment with finely divided silicon dioxide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2010202125A AU2010202125B1 (en) 2010-05-26 2010-05-26 A method to produce an immunoglobulin preparation with improved yield

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010224461A Division AU2010224461B2 (en) 2010-05-26 2010-09-29 A method to produce an immunoglobulin preparation with improved yield

Publications (1)

Publication Number Publication Date
AU2010202125B1 true AU2010202125B1 (en) 2010-09-02

Family

ID=42727304

Family Applications (8)

Application Number Title Priority Date Filing Date
AU2010202125A Active AU2010202125B1 (en) 2010-05-26 2010-05-26 A method to produce an immunoglobulin preparation with improved yield
AU2010224461A Active AU2010224461B2 (en) 2010-05-26 2010-09-29 A method to produce an immunoglobulin preparation with improved yield
AU2011258111A Active AU2011258111B2 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2016202973A Active AU2016202973B2 (en) 2010-05-26 2016-05-09 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2018201371A Active AU2018201371B2 (en) 2010-05-26 2018-02-26 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2020200373A Active AU2020200373B2 (en) 2010-05-26 2020-01-19 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2021286395A Active AU2021286395B2 (en) 2010-05-26 2021-12-16 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2024204779A Pending AU2024204779A1 (en) 2010-05-26 2024-07-11 Removal of serine proteases by treatment with finely divided silicon dioxide

Family Applications After (7)

Application Number Title Priority Date Filing Date
AU2010224461A Active AU2010224461B2 (en) 2010-05-26 2010-09-29 A method to produce an immunoglobulin preparation with improved yield
AU2011258111A Active AU2011258111B2 (en) 2010-05-26 2011-05-26 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2016202973A Active AU2016202973B2 (en) 2010-05-26 2016-05-09 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2018201371A Active AU2018201371B2 (en) 2010-05-26 2018-02-26 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2020200373A Active AU2020200373B2 (en) 2010-05-26 2020-01-19 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2021286395A Active AU2021286395B2 (en) 2010-05-26 2021-12-16 Removal of serine proteases by treatment with finely divided silicon dioxide
AU2024204779A Pending AU2024204779A1 (en) 2010-05-26 2024-07-11 Removal of serine proteases by treatment with finely divided silicon dioxide

Country Status (26)

Country Link
US (6) US8993734B2 (https=)
EP (6) EP2445482B1 (https=)
JP (6) JP5876474B2 (https=)
KR (3) KR101593265B1 (https=)
CN (5) CN104958761B (https=)
AR (4) AR076800A1 (https=)
AU (8) AU2010202125B1 (https=)
BR (2) BR112012029893B1 (https=)
CA (2) CA2800155A1 (https=)
CL (3) CL2012003291A1 (https=)
CO (2) CO6660438A2 (https=)
DK (4) DK2554160T3 (https=)
EA (4) EA034602B1 (https=)
ES (4) ES2525492T3 (https=)
FI (1) FI4039249T3 (https=)
HK (1) HK1213790A1 (https=)
HR (4) HRP20141109T1 (https=)
HU (1) HUE064400T2 (https=)
IL (2) IL223150A0 (https=)
MX (4) MX364252B (https=)
MY (3) MY160551A (https=)
PL (4) PL2803349T3 (https=)
PT (3) PT2554160E (https=)
SG (3) SG185724A1 (https=)
TW (3) TWI531577B (https=)
WO (1) WO2011149472A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103476786A (zh) * 2011-04-08 2013-12-25 哥斯达黎加大学 一种生产血液来源蛋白质注射制剂的方法，以及使用上述方法获得的蛋白质物料
EP2575762B1 (en) 2010-05-26 2014-07-09 Baxter International Inc Removal of serine proteases by treatment with finely divided silicon dioxide
US9468675B2 (en) 2010-05-26 2016-10-18 Baxalta Incorporated Removal of serine proteases by treatment with finely divided silicon dioxide

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
HUE028832T2 (en) * 2009-09-17 2017-01-30 Baxalta Inc Stable co-formulation of hyaluronidase and immunoglobulin, as well as a process for its preparation
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
ES2717177T3 (es) * 2010-07-23 2019-06-19 Baxalta GmbH Fabricación de proteínas inhibidoras inter-alfa (IaIp) a partir de plasma
US9075069B2 (en) 2011-12-13 2015-07-07 Baxter International Inc. Measurement of autoantibodies at low conductivity with increased sensitivity
TWI629283B (zh) * 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
RU2487725C1 (ru) * 2012-03-15 2013-07-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации (ФГУП "НПО "Микроген" Минздрава России) Способ получения концентрированного иммуноглобулинового препарата для подкожного введения
CN103197053B (zh) * 2013-03-15 2015-02-18 上海市血液中心 一种抗IgA抗体检测试剂盒
AU2013203043B2 (en) 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
CN104086646B (zh) * 2014-07-03 2018-10-09 成都蓉生药业有限责任公司 血液制品中fv沉淀的制备方法
CN104072601A (zh) * 2014-07-03 2014-10-01 成都蓉生药业有限责任公司 血液制品中fii沉淀的制备方法
CN104086642A (zh) * 2014-07-03 2014-10-08 成都蓉生药业有限责任公司 血液制品中fi+iii上清的制备方法
GB201413227D0 (en) * 2014-07-25 2014-09-10 Bioproducts Lab Ltd Process
WO2016064955A1 (en) 2014-10-21 2016-04-28 The General Hospital Corporation Methods of diagnosis and treatment of tuberculosis and infection
CN204424090U (zh) 2014-11-28 2015-06-24 比亚迪股份有限公司 薄膜电容器
US10583179B2 (en) * 2015-04-02 2020-03-10 Kieu Hoang Method of manufacturing and purifying prothrombin complex concentrate from Fraction III for intravenous injection and a method of curing and preventing Hemophilia A with inhibitors or Hemophilia B in patients infected with HIV-1 and HIV-2
US20160289301A1 (en) * 2015-04-02 2016-10-06 Kieu Hoang Process of cloning and further purification to make a recombinant intravenous immunoglobulin
CN107921079A (zh) * 2015-04-02 2018-04-17 K·黄 由组分iii制造静脉注射免疫球蛋白的方法
CN108495860A (zh) * 2015-09-29 2018-09-04 K·黄 一种从组分iii制备静脉注射免疫球蛋白的方法
US20170232079A1 (en) * 2015-10-06 2017-08-17 Kieu Hoang Method of manufacturing prothrombin complex concentrate from fraction iii and non-prothrombin complex concentrate from fraction iv
CN106800583A (zh) * 2015-11-26 2017-06-06 上海洲跃生物科技有限公司 一种速溶无析出的冻干人纤维蛋白原制备工艺
EP3275897A1 (en) * 2016-07-27 2018-01-31 Biotest AG Process for preparing immunoglobulin compositions
KR20190053908A (ko) * 2016-09-16 2019-05-20 로이코케어 아게 가공 동안 바이오 의약품의 안정화를 위한 신규한 방법
US11166915B2 (en) 2016-09-16 2021-11-09 Leukocare Ag Method for obtaining efficient viral vector-based compositions for vaccination or gene therapy
US11510871B2 (en) 2016-09-16 2022-11-29 Leukocare Ag Method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
EP3612221A1 (en) * 2017-04-21 2020-02-26 CSL Behring AG Immunoglobulin products for use in the treatment of chronic inflammatory demyelinating polyneuropathy
ES2991988T3 (es) 2017-10-30 2024-12-05 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica
DK3728287T3 (da) * 2017-12-19 2024-06-10 CSL Behring Lengnau AG Proteinoprensning og virusinaktivering med alkylglycosider
MX2020010724A (es) * 2018-04-12 2020-11-06 Amgen Inc Metodos para preparar composiciones proteicas estables.
CN108733099B (zh) * 2018-05-31 2020-08-11 上海药明生物技术有限公司 低pH孵育和中和的自动调节系统及方法
JP2022551566A (ja) * 2019-10-11 2022-12-12 武田薬品工業株式会社 第ＸＩａ因子のヘパリン非感受性アッセイ
AU2020378245A1 (en) 2019-11-04 2022-04-07 Alkahest, Inc. Blood plasma fractions for use in muscle regeneration
EP4061826A1 (en) 2019-11-20 2022-09-28 CSL Behring AG Method for extracting a protein from a precipitate and method for precipitating impurities
WO2021202373A1 (en) * 2020-03-31 2021-10-07 Baxalta Incorporated A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma
US11732004B2 (en) 2020-04-10 2023-08-22 Plasma Technologies, Llc Compositions and methods for simplified high efficiency isolation of proteins
CN111961130B (zh) * 2020-08-31 2021-09-10 华兰生物工程重庆有限公司 一种从血浆中提取并分离IgM和IgG的方法
JP2023545948A (ja) * 2020-10-01 2023-11-01 武田薬品工業株式会社 噴霧乾燥ヒト血漿を利用した血漿分画プロセス
US11884702B2 (en) 2020-12-28 2024-01-30 Plasma Technologies, Llc Systems and methods for process scale isolation of immunoglobulin G
CN112574296B (zh) * 2020-12-30 2023-05-19 中国医学科学院输血研究所 一种模拟IVIg的多人份混合人血浆IgG样品的分离纯化方法
CA3223881A1 (en) 2021-07-29 2023-02-02 Roopsee ANAND Method of purifying immunoglobulin g and uses thereof
EP4423109A4 (en) 2021-10-27 2025-12-24 Plasma Tech Llc COMPOSITIONS AND METHODS FOR ISOLATING PROTEINS
KR102779378B1 (ko) * 2022-01-05 2025-03-12 한양대학교 에리카산학협력단 1-알릴이소크로만 유도체와 이의 제조방법
KR20230121373A (ko) * 2022-02-11 2023-08-18 주식회사 녹십자 인자 xiii의 정제방법
MX2024010855A (es) 2022-03-07 2024-09-11 Takeda Pharmaceuticals Co Produccion cromatografica de afinidad de productos clinicos de inmunoglobulina g (igg) humana.
CN119173446A (zh) 2022-03-08 2024-12-20 赤盾医疗有限公司 机器人药物制备系统中的流体转移站
CN119300842A (zh) 2022-05-02 2025-01-10 武田药品工业株式会社 通过超滤从血浆制备科恩池浓缩物的方法
US20260028390A1 (en) 2022-06-22 2026-01-29 Ageronix SA Alpha1-antitrypsin for use in the treatment of diseases or disorders of the nervous system such as chronic inflammatory demyelinating polyneuropathy
EP4689667A1 (en) 2023-03-29 2026-02-11 CSL Behring AG Methods of identifying immunoglobulin associated with adverse reactions
CN121712573A (zh) 2023-07-04 2026-03-20 瑞士杰特贝林生物制品有限公司 纯化方法
WO2025068923A2 (en) 2023-09-26 2025-04-03 Takeda Pharmaceutical Company Limited IMMUNOGLOBULIN FORMULATIONS DEPLETED IN IgA
WO2025085544A1 (en) * 2023-10-17 2025-04-24 Plasma Technologies, Llc Integrated process for isolation of plasma proteins
PL448469A1 (pl) * 2024-04-30 2025-11-03 Deveris Polska Spółka Z Ograniczoną Odpowiedzialnością Przedmiotem wynalazku jest sposób wzbogacania preparatów plazmy krwi drobiowej w immunoglobulinę G (IgG)
WO2025229607A1 (en) 2024-05-03 2025-11-06 Csl Behring Ag Systems and methods for solid-liquid separation
WO2026074476A1 (en) 2024-10-02 2026-04-09 Csl Behring Ag Method of detecting autoantibodies against fc epsilon receptor i
WO2026078636A1 (en) 2024-10-11 2026-04-16 Csl Behring Ag Methods of monitoring chromatographic purification of proteins

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2390074A (en) * 1942-02-09 1945-12-04 Research Corp Protein product and process
SE348942B (https=) 1970-06-02 1972-09-18 Statens Bakteriologiska Labor
US4056614A (en) 1972-09-22 1977-11-01 Marc Bonneau Immunity depressant medicine
US3998946A (en) * 1975-04-23 1976-12-21 The Regents Of The University Of Minnesota Fibrinogen-free plasminogen-plasmin-free plasma and method of preparing and using same
DE2801123C2 (de) * 1977-01-26 1986-01-02 Armour Pharma GmbH & Co KG, 3440 Eschwege Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates
US4136094A (en) 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
US4296027A (en) 1977-08-31 1981-10-20 The Regents Of The University Of Minnesota Pure intravenous human and animal gamma globulins
US4357272A (en) * 1978-03-22 1982-11-02 The South African Inventions Development Corporation Recovering purified antibodies from egg yolk
US4550019A (en) * 1978-03-22 1985-10-29 South Africa Inventions Development Corporation Manufacture and use of fowl egg antibodies
DE2901822A1 (de) * 1979-01-18 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung einer fuer die intravenoese applikation geeigneten immunglobulinloesung, die igm in ankonzentrierter form enthaelt
DE2902158A1 (de) 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen
US4228154A (en) 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
US4378346A (en) * 1979-08-15 1983-03-29 Tankersley Donald L Intravenously injectable solution of plasma protein fraction free from bradykinin, kininogen and prekallikrein activators and processes for its production
US4499073A (en) * 1981-08-24 1985-02-12 Cutter Laboratories, Inc. Intravenously injectable immune serum globulin
JPS5855432A (ja) 1981-09-29 1983-04-01 Fujirebio Inc 静脈注射用免疫グロブリンの製法
US4439358A (en) 1982-06-17 1984-03-27 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4624780A (en) 1982-06-28 1986-11-25 Alpha Therapeutic Corporation Fractionation of blood plasma
DE3247150A1 (de) 1982-12-21 1984-06-28 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Gerinnungsaktive plasmaproteinloesung, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von stoerungen des haemostasesystems
DK166763C (da) 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
US5061237A (en) 1985-07-02 1991-10-29 Cytomed Medizintechnik Gmbh Method of purifying whole blood
DE3523615A1 (de) 1985-07-02 1987-01-15 Cytomed Medizintechnik Medizinisches geraet, insbesondere kanuele, katheter oder implantat
JPH0742235B2 (ja) 1985-11-08 1995-05-10 三共株式会社 自己免疫性疾病の予防・治療剤
US5136094A (en) 1988-03-10 1992-08-04 Air Products And Chemicals, Inc. Process for the synthesis of secondary formamides
US5055447A (en) 1988-07-28 1991-10-08 Genentech, Inc. Method and compositions for the treatment and prevention of septic shock
US4897465A (en) 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
JP2871709B2 (ja) 1988-11-21 1999-03-17 住友製薬株式会社 免疫グロブリンｇ結合活性を有する新規な蛋白質プロテインｈ、該蛋白質をコードする遺伝子及び該蛋白質の製造法
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
EP0440509A3 (en) * 1990-02-02 1991-12-18 Common Services Agency Novel cell growth medium components and process for producing same
ES2074490T5 (es) * 1990-03-22 2004-02-16 Biotest Pharma Gmbh Procedimiento para la elaboracion de un preparado de inmunoglobulina g tolerable por via intravenosa.
US5130451A (en) * 1991-03-28 1992-07-14 Amoco Corporation Process for preparing carboxyaryl phosphates
US5324425A (en) * 1992-08-26 1994-06-28 Ellison Billy L Method and apparatus for removing solids from aqueous wash solutions
FR2706466B1 (fr) 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
FR2711371B1 (fr) 1993-10-18 1995-12-29 Aetsrn Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
GB9418092D0 (en) 1994-09-08 1994-10-26 Red Cross Found Cent Lab Blood Organic compounds
DE4435485C1 (de) 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AUPN858596A0 (en) 1996-03-08 1996-04-04 Csl Limited Filtration of plasma precipitates using cellulose filter aid
TW491855B (en) * 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
US5783640A (en) * 1997-03-04 1998-07-21 The Goodyear Tire & Rubber Company Rubber compositions containing a disodium salt of 2, 2'-dithiosalicyclic acid
TW541179B (en) 1997-03-19 2003-07-11 Green Cross Corp Process for preparing immunoglobulin preparation
GB9705810D0 (en) 1997-03-20 1997-05-07 Common Services Agency Intravenous immune globulin
AT407114B (de) 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
CN1149100C (zh) 1997-10-23 2004-05-12 三菱制药株式会社 可室温贮存的免疫球蛋白静脉注射制剂
US20020114802A1 (en) 1998-02-10 2002-08-22 Tjellstrom Bo Arthur Einar Oral immunoglobulin treatment for inflammatory bowel disease
AT406873B (de) 1998-02-25 2000-10-25 Immuno Ag Verfahren zur abreicherung von pathogenen aus proteinhaltigen lösungen
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
IL140155A (en) 1998-06-09 2005-12-18 Statens Seruminstitut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
AUPQ026799A0 (en) 1999-05-10 1999-06-03 Csl Limited Method of increasing protein stability by removing immunoglobulin aggregates
DE19932782A1 (de) * 1999-07-14 2001-01-18 Biotest Pharma Gmbh Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
JP2003511204A (ja) 1999-10-21 2003-03-25 アルコン，インコーポレイティド テノン下薬剤送出
DE10008519C1 (de) 2000-02-21 2001-07-12 Dica Technologies Ag Verfahren und Kommunikationseinrichtungen zum Aufbau von gesicherten E-Mail-Verkehr zwischen Mail-Domains des Internet
DE10008619A1 (de) * 2000-02-24 2001-09-06 Immuno Vet As Lynge Mikroorganismenfreies IgG-Präparat, Verfahren zu seiner Herstellung und seine Verwendung in der Tieraufzucht und in der Tiermast
SE0001128D0 (sv) 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US20020098182A1 (en) 2000-09-28 2002-07-25 Richard Weisbart Treatment of immune-mediated diseases by oral administration of plasma fractions enriched in immunoglobulin G
AU2002216968A1 (en) 2000-10-13 2002-04-22 Octapharma Ag Plasma fraction containing bikunin, method for the production thereof and use of the same
FR2824568B1 (fr) 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
EP1463527A4 (en) 2001-10-04 2005-05-11 Protein Therapeutics Inc USE OF GAMMAGLOBULIN FOR THE TREATMENT OF IMMUNE-MEDIATED DISEASES
US6893639B2 (en) 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
US7777006B2 (en) * 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
RU2364609C2 (ru) * 2003-05-23 2009-08-20 Ново Нордиск Хелт Кэр Аг Стабилизация белка в растворе
WO2005012354A1 (en) 2003-07-31 2005-02-10 Zlb Behring Gmbh Method for extending the half-life of fviii
WO2005023867A1 (en) 2003-09-08 2005-03-17 Medical Research Council Method for the treatment or prophylaxis of tuberculosis
US20050054003A1 (en) 2003-09-10 2005-03-10 Stenland Christopher J. Prion clearance using particulate metal oxides
EP1691820A4 (en) 2003-11-08 2010-03-03 Prothera Biolog PREPARATION AND COMPOSITION OF INTER ALPHA HEMMER PROTEINS FROM HUMAN PLASMA FOR THERAPEUTIC USE
US20070244305A1 (en) 2004-01-30 2007-10-18 Suomen Punainen Risti Veripalvelu Process for The Manufacture of Virus Safe Immunoglobulin
CA2557229C (en) 2004-02-27 2012-07-10 Octapharma Ag A method of providing a purified, virus safe antibody preparation
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
US7745389B2 (en) 2005-02-14 2010-06-29 University Of Iowa Research Foundation Methods for treatment of age-related macular degeneration
US8715649B2 (en) 2005-06-07 2014-05-06 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity
US7807435B2 (en) 2005-08-11 2010-10-05 Baxter International Inc. Method for the purification of alpha-1 proteinase inhibitor (a1PI)
US20090118163A1 (en) 2005-09-19 2009-05-07 Peter Gronski Factor H for the Treatment of Chronic Nephropathies and Production thereof
FR2894145B1 (fr) 2005-12-07 2008-10-17 Lab Francais Du Fractionnement Utilisation de facteur h du complement a titre de medicament
RU2520817C2 (ru) 2006-01-25 2014-06-27 Октафарма Аг Очистка и применение фактора, способствующего заживлению ран
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
EP1852443A1 (en) * 2006-05-05 2007-11-07 Leukocare AG Biocompatible three dimensional matrix for the immobilization of biological substances
DE102007001521A1 (de) * 2007-01-10 2008-07-17 Matthias, Torsten, Dr. Verwendung von Cohn-Oncley-Fraktionen II und II/III zur Behandlung des systemischen Lupus erythematodes
WO2008113589A1 (en) * 2007-03-20 2008-09-25 Csl Behring Gmbh Methods for industrial scale production of therapeutic complement factor h preparations from human plasma
DE202007004346U1 (de) 2007-03-21 2007-10-31 Rehau Ag + Co Rohranordnung
EP2148693A4 (en) * 2007-04-20 2010-06-02 Univ Colorado ALPHA-I-ANTITRYPINE WITHOUT SIGNIFICANT SERINE PROTEASE INHIBITOR ACTIVITY
JP2010529155A (ja) 2007-06-13 2010-08-26 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用
EP2522754B1 (en) 2007-08-13 2014-04-02 Baxter International Inc. IVIG modulation of chemokines for treatment of Multiple Sclerosis, Alzheimer's disease, and Parkinson's disease
US8466265B2 (en) * 2007-10-02 2013-06-18 Csl Limited Therapeutic antibody purification method and method of use
CN101279246B (zh) 2007-12-28 2011-07-27 华侨大学 一种嗜硫性磁性复合微球的制备方法和用此复合微球分离免疫球蛋白g的方法
SG187410A1 (en) 2007-12-28 2013-02-28 Baxter Int Recombinant vwf formulations
CN101249265B (zh) * 2008-04-11 2010-10-27 三九集团湛江开发区双林药业有限公司 静脉注射用人乙肝免疫球蛋白及其制备方法
AU2009236305B2 (en) 2008-04-15 2014-04-10 Grifols Therapeutics Inc. Two-stage ultrafiltration/diafiltration
CN106928346B (zh) 2008-05-28 2021-09-07 普罗瑟拉生物公司 来自血液的间-α抑制物蛋白的制备和组合物
PL2291523T3 (pl) 2008-06-24 2015-05-29 Csl Behring Gmbh Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo
CN201169579Y (zh) * 2008-06-30 2008-12-24 山东泰邦生物制品有限公司 一种人血白蛋白分离用乙醇雾化扩散装置
EP2349314B1 (en) 2008-10-21 2013-02-27 Baxter International Inc. Lyophilized recombinant vwf formulations
CA2742994A1 (en) 2008-11-12 2010-05-20 Baxter International Inc. Purification of butyrylcholinesterase using membrane adsorption
TWI445714B (zh) 2009-05-27 2014-07-21 Baxter Int 產製用於皮下使用之高濃度免疫球蛋白製備物之方法
AT516600B1 (de) 2009-07-23 2016-07-15 Baxter Int Herstellung von faktor h (fh) und fh-derivaten aus plasma
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2011150284A2 (en) * 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
WO2012006594A1 (en) 2010-07-08 2012-01-12 Baxter International Inc. Method of producing recombinant adamts13 in cell culture
ES2717177T3 (es) * 2010-07-23 2019-06-19 Baxalta GmbH Fabricación de proteínas inhibidoras inter-alfa (IaIp) a partir de plasma

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2575762B1 (en) 2010-05-26 2014-07-09 Baxter International Inc Removal of serine proteases by treatment with finely divided silicon dioxide
US9468675B2 (en) 2010-05-26 2016-10-18 Baxalta Incorporated Removal of serine proteases by treatment with finely divided silicon dioxide
US9708391B2 (en) 2010-05-26 2017-07-18 Baxalta Incorporated Removal of serine proteases by treatment with finely divided silicon dioxide
US10208106B2 (en) 2010-05-26 2019-02-19 Baxalta Incorporated Removal of serine proteases by treatment with finely divided silicon dioxide
US10875906B2 (en) 2010-05-26 2020-12-29 Baxalta Incorporated Removal of serine proteases by treatment with finely divided silicon dioxide
US11136350B2 (en) 2010-05-26 2021-10-05 Takeda Pharmaceutical Company Limited Method to produce an immunoglobulin preparation with improved yield
US11891431B2 (en) 2010-05-26 2024-02-06 Takeda Pharm Limited ceutical Company Limited Removal of serine proteases by treatment with finely divided silicon dioxide
US12545703B2 (en) 2010-05-26 2026-02-10 Takeda Pharmaceutical Company Limited Method to produce an immunoglobulin preparation with improved yield
CN103476786A (zh) * 2011-04-08 2013-12-25 哥斯达黎加大学 一种生产血液来源蛋白质注射制剂的方法，以及使用上述方法获得的蛋白质物料

Also Published As

Publication number Publication date
EP2445482B1 (en) 2014-08-27
PL2803349T3 (pl) 2024-02-26
AU2024204779A1 (en) 2024-08-01
US12545703B2 (en) 2026-02-10
EA201291367A1 (ru) 2013-09-30
TW201202263A (en) 2012-01-16
MX2012013682A (es) 2013-01-28
HRP20150484T1 (hr) 2015-08-14
AU2011258111B2 (en) 2016-02-11
EA023446B1 (ru) 2016-06-30
TWI504607B (zh) 2015-10-21
AR076800A1 (es) 2011-07-06
EA201691558A1 (ru) 2017-05-31
EP2796128A1 (en) 2014-10-29
EP2575762A2 (en) 2013-04-10
EA201500848A1 (ru) 2016-06-30
JP6363676B2 (ja) 2018-07-25
JP6592120B2 (ja) 2019-10-16
US8993734B2 (en) 2015-03-31
EP2803349C0 (en) 2023-09-27
KR20130109016A (ko) 2013-10-07
CN102970975A (zh) 2013-03-13
ES2525492T3 (es) 2014-12-23
MX2019004482A (es) 2019-08-30
TW201141879A (en) 2011-12-01
AR121861A2 (es) 2022-07-20
AU2020200373A1 (en) 2020-02-13
AR082093A1 (es) 2012-11-14
JP2016053016A (ja) 2016-04-14
JP2017014297A (ja) 2017-01-19
JP5876474B2 (ja) 2016-03-02
ES2536093T3 (es) 2015-05-20
KR20130080450A (ko) 2013-07-12
PT2554160E (pt) 2015-06-11
CO6660438A2 (es) 2013-04-30
HRP20260340T1 (hr) 2026-04-24
HUE064400T2 (hu) 2024-03-28
AU2021286395B2 (en) 2024-04-11
AU2016202973B2 (en) 2017-12-07
KR101647617B1 (ko) 2016-08-10
JP2013528183A (ja) 2013-07-08
EA034530B1 (ru) 2020-02-18
CN102970975B (zh) 2015-05-06
KR101716534B1 (ko) 2017-03-14
AR114228A2 (es) 2020-08-05
US20240117009A1 (en) 2024-04-11
IL223149A (en) 2017-02-28
CN104958761B (zh) 2021-01-01
DK2445482T3 (da) 2014-09-22
CN104958761A (zh) 2015-10-07
MX2012013689A (es) 2013-01-28
MY160551A (en) 2017-03-15
EP2554160B1 (en) 2015-02-25
EP4039249B1 (en) 2026-02-11
SG185725A1 (en) 2012-12-28
AU2010224461A1 (en) 2010-10-21
AU2018201371A1 (en) 2018-03-22
PT2575762E (pt) 2014-07-28
MX349815B (es) 2017-08-09
HK1183449A1 (en) 2013-12-27
CN103068365A (zh) 2013-04-24
CN104840946A (zh) 2015-08-19
FI4039249T3 (fi) 2026-03-20
EP2575762B1 (en) 2014-07-09
JP2016155798A (ja) 2016-09-01
CL2012003291A1 (es) 2013-10-04
SG185724A1 (en) 2013-01-30
DK2554160T3 (da) 2015-04-27
BR112012029897A2 (pt) 2016-08-16
ES2959234T3 (es) 2024-02-22
BR112012029893A2 (pt) 2019-05-28
TW201542584A (zh) 2015-11-16
CN109180776A (zh) 2019-01-11
JP2013527201A (ja) 2013-06-27
PL2554160T3 (pl) 2015-07-31
US20210403504A1 (en) 2021-12-30
HK1215931A1 (zh) 2016-09-30
PL2575762T3 (pl) 2015-01-30
EP4039249A1 (en) 2022-08-10
HRP20140944T1 (hr) 2014-12-05
IL223149A0 (en) 2013-02-03
CA2800272A1 (en) 2011-12-01
PL2445482T3 (pl) 2015-01-30
EP2554160A1 (en) 2013-02-06
US20150133644A1 (en) 2015-05-14
EA201291355A1 (ru) 2013-04-30
CO6660439A2 (es) 2013-04-30
AU2020200373B2 (en) 2022-01-13
HK1181682A1 (en) 2013-11-15
CN103068365B (zh) 2015-07-08
BR112012029893B1 (pt) 2022-09-06
HK1203838A1 (en) 2015-11-06
HK1213790A1 (zh) 2016-07-15
JP2018080207A (ja) 2018-05-24
CL2012003290A1 (es) 2013-10-18
US8940877B2 (en) 2015-01-27
PT2445482E (pt) 2014-11-03
TWI531577B (zh) 2016-05-01
US20130101579A1 (en) 2013-04-25
DK2575762T3 (da) 2014-10-13
AU2021286395A1 (en) 2022-01-20
CA2800155A1 (en) 2011-12-01
JP5866345B2 (ja) 2016-02-17
MY161617A (en) 2017-04-28
AU2016202973A1 (en) 2016-05-26
US20180118782A1 (en) 2018-05-03
MY173299A (en) 2020-01-14
AU2011258111A1 (en) 2012-12-13
KR101593265B1 (ko) 2016-02-11
MX337028B (es) 2016-02-09
EA034602B1 (ru) 2020-02-25
KR20160014119A (ko) 2016-02-05
EP2803349A1 (en) 2014-11-19
CL2014003430A1 (es) 2015-05-04
HRP20141109T1 (hr) 2014-12-19
SG10201505161SA (en) 2015-08-28
EP2445482A1 (en) 2012-05-02
CN109180776B (zh) 2022-12-13
ES2505465T3 (es) 2014-10-10
TWI543989B (zh) 2016-08-01
HK1170168A1 (en) 2013-02-22
EP2803349B1 (en) 2023-09-27
IL223150A0 (en) 2013-02-03
WO2011149472A1 (en) 2011-12-01
EA025826B1 (ru) 2017-02-28
DK4039249T3 (da) 2026-03-16
US11136350B2 (en) 2021-10-05
AU2010224461B2 (en) 2011-08-04
AU2018201371B2 (en) 2019-10-31
MX364252B (es) 2019-04-17
US20110293638A1 (en) 2011-12-01

Similar Documents

Publication Publication Date Title
US12545703B2 (en) Method to produce an immunoglobulin preparation with improved yield
US8796430B2 (en) Method to produce an immunoglobulin preparation with improved yield
AU2024204995A1 (en) A method to produce an immunoglobulin preparation with improved yield
HK1203838B (en) Method for preparing an enriched igg composition from plasma
HK1170168B (en) Method for preparing an enriched igg composition from plasma
HK1181682B (en) Method for preparing an enriched igg composition from plasma

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ BRUCKSHWAIGER, LEOPOLD; SVATOS, SONJA; TESCHNER, WOLFGANG; BUTTERWECK, HARALD ARNO; SCHWARZ, HANS-PETER; GUNDINGER, THOMAS; KOELBL, BERNHARD; GRAUSENBURGER, REINHARD; PLJEVLJAKOVIC, ARZA AND NUERNBERGER, JULIA .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ BRUCKSHWAIGER, LEOPOLD; SVATOS, SONJA; TESCHNER, WOLFGANG; BUTTERWECK, HARALD ARNO; SCHWARZ, HANS-PETER; GUNDINGER, THOMAS; KOELBL, BERNHARD; GRAUSENBURGER, REINHARD; PLJEVLJAKOVIC, ARZA AND NUERNBERGER, JULIA

PC Assignment registered

Owner name: BAXALTA GMBH; BAXALTA INCORPORATED

Free format text: FORMER OWNER WAS: BAXTER HEALTHCARE S. A.; BAXTER INTERNATIONAL INC

PC Assignment registered

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Free format text: FORMER OWNER(S): BAXALTA INCORPORATED; BAXALTA GMBH