ATE55151T1 - Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. - Google Patents
Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen.Info
- Publication number
- ATE55151T1 ATE55151T1 AT84300091T AT84300091T ATE55151T1 AT E55151 T1 ATE55151 T1 AT E55151T1 AT 84300091 T AT84300091 T AT 84300091T AT 84300091 T AT84300091 T AT 84300091T AT E55151 T1 ATE55151 T1 AT E55151T1
- Authority
- AT
- Austria
- Prior art keywords
- yeast
- synthesis
- expression systems
- foreign proteins
- containing vectors
- Prior art date
Links
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 239000013612 plasmid Substances 0.000 abstract 3
- 210000005253 yeast cell Anatomy 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Toys (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46858983A | 1983-02-22 | 1983-02-22 | |
| EP84300091A EP0120551B1 (en) | 1983-02-22 | 1984-01-06 | Yeast expression systems with vectors having a gapdh promoter, and synthesis of foreign proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE55151T1 true ATE55151T1 (de) | 1990-08-15 |
Family
ID=23860419
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84300091T ATE55151T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. |
| AT91114001T ATE138975T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b |
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91114001T ATE138975T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b |
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
Country Status (7)
| Country | Link |
|---|---|
| EP (4) | EP0732403A1 (en:Method) |
| JP (2) | JPS59210888A (en:Method) |
| AT (3) | ATE55151T1 (en:Method) |
| CA (2) | CA1341116C (en:Method) |
| DE (3) | DE3486206T2 (en:Method) |
| DK (1) | DK173604B1 (en:Method) |
| SG (1) | SG48422A1 (en:Method) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
| JPS5936699A (ja) * | 1982-08-20 | 1984-02-28 | Chemo Sero Therapeut Res Inst | シヤトルベクタ− |
| US5422267A (en) * | 1984-05-22 | 1995-06-06 | Robert R. Yocum | Industrial yeast comprising an integrated glucoamylase gene |
| EP0173997A1 (en) * | 1984-09-06 | 1986-03-12 | Chiron Corporation | Feline leukemia virus protein vaccines and their preparation |
| US5336609A (en) * | 1984-12-06 | 1994-08-09 | Labofina, S.A. | Transformed yeasts for producing lysozyme, plasmids used for this transformation, method of producing lysozyme |
| EP0211767B1 (en) * | 1985-08-05 | 1991-03-06 | Merck & Co. Inc. | Method for increasing recombinant protein production in yeast species of the genus saccharomyces |
| ES2028779T3 (es) * | 1985-10-03 | 1992-07-16 | Green Cross Corporation | Promotor de levadura y procedimiento para preparar proteina heterologa. |
| JPH0655155B2 (ja) * | 1985-10-03 | 1994-07-27 | 株式会社ミドリ十字 | 蛋白質の製造方法 |
| DK162900C (da) * | 1985-10-24 | 1992-05-11 | Danisco | Fremgangsmaade til ekspression af gener i gaer samt dna-fragment, rekombineret dna-segment og plasmider, hvor disse indgaar til brug ved udoevelse af fremgangsmaaden |
| US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
| JPS62236496A (ja) * | 1986-04-07 | 1987-10-16 | Green Cross Corp:The | HBsAgの製造方法 |
| US4839283A (en) * | 1986-12-30 | 1989-06-13 | Zymogenetics, Inc. | Method of expressing alpha-1-antitrypsin in yeast |
| IL86832A (en) * | 1987-06-22 | 2002-09-12 | Medeva Holdings Bv | A recombinant DNA molecule containing a nucleotide sequence of part of the region encoding HBV pre-1s, an immunogenic particle containing multiple peptide monomers containing a pre-s1 epitope and pharmaceutical preparations containing it |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| AU644619B2 (en) | 1989-12-21 | 1993-12-16 | Advanced Technologies (Cambridge) Limited | Modification of plant metabolism |
| NZ236434A (en) * | 1990-01-29 | 1992-08-26 | Ciba Geigy Ag | Dna molecules comprising the a niger pyruvate kinase transcription promoter, vectors containing it and their use in transforming host cells |
| US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| ATE158816T1 (de) | 1990-11-26 | 1997-10-15 | Genetics Inst | Expression von pace in wirtszellen und verfahren zu dessen verwendung |
| EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
| ATE249838T1 (de) | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
| US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| JP2000507087A (ja) | 1995-12-22 | 2000-06-13 | ギスト ブロカデス ベスローテン ファンノートシャップ | ファフィア株を形質転換する改良法、そのようにして得られた形質転換したファフィア株及び前記方法における組換えdna |
| AU9363798A (en) | 1997-11-06 | 1999-05-31 | Chiron S.P.A. | Neisserial antigens |
| ES2333071T5 (es) | 1998-01-14 | 2015-08-17 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos de Neisseria meningitidis |
| US6087128A (en) * | 1998-02-12 | 2000-07-11 | Ndsu Research Foundation | DNA encoding an avian E. coli iss |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| ES2304065T3 (es) | 1998-05-01 | 2008-09-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos y composiciones de neisseria meningitidis. |
| ES2477194T3 (es) | 1999-04-30 | 2014-07-16 | Novartis Vaccines And Diagnostics S.R.L. | Ant�genos neisseriales conservados |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| CA2864069A1 (en) | 1999-10-29 | 2001-05-03 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigenic peptides |
| US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
| DK1248647T3 (da) | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Ydre membranvesikel (OMV) vaccine omfattende N. meningitidis serogruppe B ydre membranproteiner |
| AU1412702A (en) | 2000-10-27 | 2002-05-06 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a and b |
| DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| EP1572720A4 (en) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES |
| US20070059329A1 (en) | 2002-11-15 | 2007-03-15 | Nathalie Norais | Unexpected surface proteins in meningococcus |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| SI1704234T1 (sl) | 2003-11-21 | 2012-08-31 | Nps Pharma Inc | Proizvodnja glukagonu podobnih peptidov 2 in analogov |
| DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
| AU2005319099B2 (en) | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
| GB2426521A (en) | 2004-02-02 | 2006-11-29 | Ambrx Inc | Modified human four helical bundle polypeptides and their uses |
| MXPA06014684A (es) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novedosos polipeptidos de enlace antigeno y sus usos. |
| WO2006091231A2 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| WO2009100255A2 (en) | 2008-02-08 | 2009-08-13 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
| ZA200704927B (en) | 2004-12-22 | 2009-09-30 | Ambrx Inc | Compositions of aminoacyl-tRNA synthetase and uses thereof |
| CA2590590C (en) | 2004-12-22 | 2016-04-19 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| BRPI0610297A2 (pt) | 2005-04-18 | 2010-06-08 | Novartis Vaccines & Diagnostic | expressão de antìgeno de superfìcie de vìrus da hepatite b para a preparação de vacina |
| AU2005335491B2 (en) | 2005-08-18 | 2010-11-25 | Ambrx, Inc. | Compositions of tRNA and uses thereof |
| CA2621023C (en) | 2005-09-01 | 2019-07-02 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Multiple vaccination including serogroup c meningococcus |
| ES2547554T3 (es) | 2005-11-16 | 2015-10-07 | Ambrx, Inc. | Métodos y composiciones que comprenden aminoácidos no naturales |
| KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
| US20100015168A1 (en) | 2006-06-09 | 2010-01-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| KR20090060294A (ko) | 2006-09-08 | 2009-06-11 | 암브룩스, 인코포레이티드 | 변형된 인간 혈장 폴리펩티드 또는 Fc 스캐폴드 및 그의 용도 |
| MX2009002460A (es) | 2006-09-08 | 2009-03-20 | Ambrx Inc | Arnt supresor hibrido para celulas de vertebrados. |
| KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
| WO2008139591A1 (ja) * | 2007-05-11 | 2008-11-20 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 組換えアプロチニンの生産方法 |
| EP2217265B1 (en) | 2007-11-20 | 2017-05-10 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
| BRPI0916515B8 (pt) | 2008-07-23 | 2021-07-27 | Ambrx Inc | polipeptídeo de fator estimulante de colônias de granulócitos bovino (bg-csf), formulação farmacêutica e composição compreendendo o mesmo |
| DK2342223T3 (en) | 2008-09-26 | 2017-07-24 | Ambrx Inc | Modified animal erythropoietin polypeptides and their uses |
| MX2011003196A (es) | 2008-09-26 | 2011-04-27 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
| PE20121799A1 (es) | 2009-12-21 | 2013-01-02 | Ambrx Inc | Polipeptidos de somatotropina porcina modificados y sus usos |
| MX349301B (es) | 2009-12-21 | 2017-07-21 | Ambrx Inc | Polipéptidos de somatotropina bovina modificados y sus usos. |
| US9476082B2 (en) | 2010-05-20 | 2016-10-25 | Evolva Sa | Method of producing isoprenoid compounds in yeast |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| MX346786B (es) | 2010-08-17 | 2017-03-31 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos. |
| AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| JP6702962B2 (ja) | 2014-10-24 | 2020-06-03 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 改変fgf−21ポリペプチドおよびその使用 |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| GR76274B (en:Method) * | 1981-08-04 | 1984-08-04 | Univ California | |
| NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
| US4446235A (en) * | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
| BR8307525A (pt) * | 1982-05-19 | 1984-08-21 | Unilever Nv | Expressao de proteinas semelhantes a pretrotaumatina em leveduras kluyveromyces |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPH0716432B2 (ja) * | 1982-10-20 | 1995-03-01 | サントリー株式会社 | 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法 |
-
1983
- 1983-10-25 CA CA000524802A patent/CA1341116C/en not_active Expired - Lifetime
- 1983-10-25 CA CA000439701A patent/CA1341302C/en not_active Expired - Lifetime
- 1983-12-15 DK DK198305777A patent/DK173604B1/da not_active IP Right Cessation
-
1984
- 1984-01-06 EP EP96200286A patent/EP0732403A1/en not_active Withdrawn
- 1984-01-06 AT AT84300091T patent/ATE55151T1/de not_active IP Right Cessation
- 1984-01-06 AT AT91114001T patent/ATE138975T1/de not_active IP Right Cessation
- 1984-01-06 EP EP91114001A patent/EP0460716B2/en not_active Expired - Lifetime
- 1984-01-06 DE DE89106868T patent/DE3486206T2/de not_active Expired - Lifetime
- 1984-01-06 AT AT89106868T patent/ATE93894T1/de not_active IP Right Cessation
- 1984-01-06 SG SG1996009565A patent/SG48422A1/en unknown
- 1984-01-06 DE DE8484300091T patent/DE3482844D1/de not_active Expired - Lifetime
- 1984-01-06 EP EP89106868A patent/EP0329203B1/en not_active Expired - Lifetime
- 1984-01-06 DE DE3486431T patent/DE3486431T3/de not_active Expired - Lifetime
- 1984-01-06 EP EP84300091A patent/EP0120551B1/en not_active Expired - Lifetime
- 1984-02-16 JP JP59026172A patent/JPS59210888A/ja active Granted
-
1992
- 1992-06-17 JP JP4200091A patent/JPH0724594B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1341116C (en) | 2000-10-17 |
| JPS59210888A (ja) | 1984-11-29 |
| EP0120551A3 (en) | 1986-05-14 |
| DE3486206T2 (de) | 1994-02-03 |
| ATE138975T1 (de) | 1996-06-15 |
| DK173604B1 (da) | 2001-04-23 |
| EP0329203A1 (en) | 1989-08-23 |
| EP0460716B2 (en) | 1999-12-15 |
| SG48422A1 (en) | 1998-04-17 |
| DE3486431T2 (de) | 1996-10-10 |
| EP0120551A2 (en) | 1984-10-03 |
| EP0329203B1 (en) | 1993-09-01 |
| ATE93894T1 (de) | 1993-09-15 |
| DK577783A (da) | 1984-08-23 |
| DK577783D0 (da) | 1983-12-15 |
| EP0120551B1 (en) | 1990-08-01 |
| JPH05268984A (ja) | 1993-10-19 |
| EP0460716A1 (en) | 1991-12-11 |
| EP0732403A1 (en) | 1996-09-18 |
| DE3482844D1 (de) | 1990-09-06 |
| JPH0515431B2 (en:Method) | 1993-03-01 |
| DE3486206D1 (de) | 1993-10-07 |
| DE3486431T3 (de) | 2000-05-04 |
| CA1341302C (en) | 2001-10-09 |
| JPH0724594B2 (ja) | 1995-03-22 |
| EP0460716B1 (en) | 1996-06-05 |
| DE3486431D1 (de) | 1996-07-11 |
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