DE3486431T2 - Expressionssysteme für Hefe mit Vektoren, die einen GAPDH-Promotor enthalten und Oberflächenantigensynthese von Hepatitis B - Google Patents

Expressionssysteme für Hefe mit Vektoren, die einen GAPDH-Promotor enthalten und Oberflächenantigensynthese von Hepatitis B

Info

Publication number
DE3486431T2
DE3486431T2 DE3486431T DE3486431T DE3486431T2 DE 3486431 T2 DE3486431 T2 DE 3486431T2 DE 3486431 T DE3486431 T DE 3486431T DE 3486431 T DE3486431 T DE 3486431T DE 3486431 T2 DE3486431 T2 DE 3486431T2
Authority
DE
Germany
Prior art keywords
yeast
hepatitis
surface antigen
expression systems
vectors containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3486431T
Other languages
English (en)
Other versions
DE3486431D1 (de
DE3486431T3 (de
Inventor
Rae Lyn Burke
Patricia Tekamp-Olson
Steven Rosenberg
Pablo D T Valenzuela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23860419&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3486431(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE3486431D1 publication Critical patent/DE3486431D1/de
Application granted granted Critical
Publication of DE3486431T2 publication Critical patent/DE3486431T2/de
Publication of DE3486431T3 publication Critical patent/DE3486431T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Toys (AREA)
  • Peptides Or Proteins (AREA)
DE3486431T 1983-02-22 1984-01-06 Expressionssysteme für Hefe mit Vektoren, die einen GAPDH-Promotor enthalten und Oberflächenantigensynthese von Hepatitis B Expired - Lifetime DE3486431T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46858983A 1983-02-22 1983-02-22

Publications (3)

Publication Number Publication Date
DE3486431D1 DE3486431D1 (de) 1996-07-11
DE3486431T2 true DE3486431T2 (de) 1996-10-10
DE3486431T3 DE3486431T3 (de) 2000-05-04

Family

ID=23860419

Family Applications (3)

Application Number Title Priority Date Filing Date
DE89106868T Expired - Lifetime DE3486206T2 (de) 1983-02-22 1984-01-06 Expressionssysteme für Hefe mit PyK-Promotoren enthaltenden Vektoren und Synthese von Fremdproteinen.
DE3486431T Expired - Lifetime DE3486431T3 (de) 1983-02-22 1984-01-06 Expressionssysteme für Hefe mit Vektoren, die einen GAPDH-Promotor enthalten und Oberflächenantigensynthese von Hepatitis B
DE8484300091T Expired - Lifetime DE3482844D1 (de) 1983-02-22 1984-01-06 Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE89106868T Expired - Lifetime DE3486206T2 (de) 1983-02-22 1984-01-06 Expressionssysteme für Hefe mit PyK-Promotoren enthaltenden Vektoren und Synthese von Fremdproteinen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8484300091T Expired - Lifetime DE3482844D1 (de) 1983-02-22 1984-01-06 Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen.

Country Status (7)

Country Link
EP (4) EP0732403A1 (de)
JP (2) JPS59210888A (de)
AT (3) ATE138975T1 (de)
CA (2) CA1341302C (de)
DE (3) DE3486206T2 (de)
DK (1) DK173604B1 (de)
SG (1) SG48422A1 (de)

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EP0173997A1 (de) * 1984-09-06 1986-03-12 Chiron Corporation Katzenleukämievirusproteinimpfstoffe und ihre Herstellung
DE3587307T2 (de) * 1984-12-06 1993-09-02 Fina Research Transformierte hefen die lysozym produzieren, fuer diese transformation zu verwendende plasmide und deren verwendung.
EP0211767B1 (de) * 1985-08-05 1991-03-06 Merck & Co. Inc. Verfahren zur Steigerung der Produktion von rekombinantem Protein in Hefearten der Gattung Saccharomyces
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JPH0655155B2 (ja) * 1985-10-03 1994-07-27 株式会社ミドリ十字 蛋白質の製造方法
DK162900C (da) * 1985-10-24 1992-05-11 Danisco Fremgangsmaade til ekspression af gener i gaer samt dna-fragment, rekombineret dna-segment og plasmider, hvor disse indgaar til brug ved udoevelse af fremgangsmaaden
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JPS62236496A (ja) * 1986-04-07 1987-10-16 Green Cross Corp:The ＨＢｓＡｇの製造方法
US4839283A (en) * 1986-12-30 1989-06-13 Zymogenetics, Inc. Method of expressing alpha-1-antitrypsin in yeast
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US6194140B1 (en) 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
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EP0491077A1 (de) * 1990-12-19 1992-06-24 Medeva Holdings B.V. Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten
WO1994026306A1 (en) 1993-05-12 1994-11-24 Chiron Corporation Conserved motif of hepatitis c virus e2/ns1 region
US5629167A (en) 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
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ES2229288T3 (es) 1995-12-22 2005-04-16 Dsm Ip Assets B.V. Metodos mejorados para transformar cepas de phaffia, cepas de phaffia transformadas asi obtenidas y dna recombinante en dichos metodos.
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Also Published As

Publication number Publication date
ATE138975T1 (de) 1996-06-15
EP0460716B2 (de) 1999-12-15
DE3486206D1 (de) 1993-10-07
JPH05268984A (ja) 1993-10-19
EP0120551A3 (en) 1986-05-14
DK173604B1 (da) 2001-04-23
EP0329203B1 (de) 1993-09-01
DE3486206T2 (de) 1994-02-03
JPH0724594B2 (ja) 1995-03-22
DK577783D0 (da) 1983-12-15
EP0329203A1 (de) 1989-08-23
EP0460716A1 (de) 1991-12-11
ATE55151T1 (de) 1990-08-15
DE3486431D1 (de) 1996-07-11
CA1341116C (en) 2000-10-17
EP0460716B1 (de) 1996-06-05
DE3482844D1 (de) 1990-09-06
CA1341302C (en) 2001-10-09
EP0120551B1 (de) 1990-08-01
JPH0515431B2 (de) 1993-03-01
JPS59210888A (ja) 1984-11-29
DK577783A (da) 1984-08-23
ATE93894T1 (de) 1993-09-15
EP0732403A1 (de) 1996-09-18
DE3486431T3 (de) 2000-05-04
SG48422A1 (en) 1998-04-17
EP0120551A2 (de) 1984-10-03

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