ATE55151T1 - Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. - Google Patents
Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen.Info
- Publication number
- ATE55151T1 ATE55151T1 AT84300091T AT84300091T ATE55151T1 AT E55151 T1 ATE55151 T1 AT E55151T1 AT 84300091 T AT84300091 T AT 84300091T AT 84300091 T AT84300091 T AT 84300091T AT E55151 T1 ATE55151 T1 AT E55151T1
- Authority
- AT
- Austria
- Prior art keywords
- yeast
- synthesis
- expression systems
- foreign proteins
- containing vectors
- Prior art date
Links
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 239000013612 plasmid Substances 0.000 abstract 3
- 210000005253 yeast cell Anatomy 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Toys (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46858983A | 1983-02-22 | 1983-02-22 | |
| EP84300091A EP0120551B1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für Hefe mit einen GAPDH Promotor enthaltenden Vektoren und Synthese von Fremdproteinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE55151T1 true ATE55151T1 (de) | 1990-08-15 |
Family
ID=23860419
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84300091T ATE55151T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. |
| AT91114001T ATE138975T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b |
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91114001T ATE138975T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b |
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
Country Status (7)
| Country | Link |
|---|---|
| EP (4) | EP0460716B2 (de) |
| JP (2) | JPS59210888A (de) |
| AT (3) | ATE55151T1 (de) |
| CA (2) | CA1341302C (de) |
| DE (3) | DE3486431T3 (de) |
| DK (1) | DK173604B1 (de) |
| SG (1) | SG48422A1 (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
| JPS5936699A (ja) * | 1982-08-20 | 1984-02-28 | Chemo Sero Therapeut Res Inst | シヤトルベクタ− |
| US5422267A (en) * | 1984-05-22 | 1995-06-06 | Robert R. Yocum | Industrial yeast comprising an integrated glucoamylase gene |
| EP0173997A1 (de) * | 1984-09-06 | 1986-03-12 | Chiron Corporation | Katzenleukämievirusproteinimpfstoffe und ihre Herstellung |
| CA1339912C (en) * | 1984-12-06 | 1998-06-16 | Jacques Oberto | Transformed yeasts producing lysozyme, plasmids used for this transformation, and uses thereof |
| EP0211767B1 (de) * | 1985-08-05 | 1991-03-06 | Merck & Co. Inc. | Verfahren zur Steigerung der Produktion von rekombinantem Protein in Hefearten der Gattung Saccharomyces |
| ES2028779T3 (es) * | 1985-10-03 | 1992-07-16 | Green Cross Corporation | Promotor de levadura y procedimiento para preparar proteina heterologa. |
| JPH0655155B2 (ja) * | 1985-10-03 | 1994-07-27 | 株式会社ミドリ十字 | 蛋白質の製造方法 |
| DK162900C (da) * | 1985-10-24 | 1992-05-11 | Danisco | Fremgangsmaade til ekspression af gener i gaer samt dna-fragment, rekombineret dna-segment og plasmider, hvor disse indgaar til brug ved udoevelse af fremgangsmaaden |
| US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
| JPS62236496A (ja) * | 1986-04-07 | 1987-10-16 | Green Cross Corp:The | HBsAgの製造方法 |
| US4839283A (en) * | 1986-12-30 | 1989-06-13 | Zymogenetics, Inc. | Method of expressing alpha-1-antitrypsin in yeast |
| ATE207535T1 (de) * | 1987-06-22 | 2001-11-15 | Medeva Holdings Bv | Hepatitis-b-oberflächenantigen enthaltendes peptid |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| AU644619B2 (en) | 1989-12-21 | 1993-12-16 | Advanced Technologies (Cambridge) Limited | Modification of plant metabolism |
| NZ236434A (en) * | 1990-01-29 | 1992-08-26 | Ciba Geigy Ag | Dna molecules comprising the a niger pyruvate kinase transcription promoter, vectors containing it and their use in transforming host cells |
| US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| EP0785273A1 (de) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz |
| EP0491077A1 (de) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten |
| WO1994026306A1 (en) | 1993-05-12 | 1994-11-24 | Chiron Corporation | Conserved motif of hepatitis c virus e2/ns1 region |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
| US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| ES2229288T3 (es) | 1995-12-22 | 2005-04-16 | Dsm Ip Assets B.V. | Metodos mejorados para transformar cepas de phaffia, cepas de phaffia transformadas asi obtenidas y dna recombinante en dichos metodos. |
| JP4472866B2 (ja) | 1997-11-06 | 2010-06-02 | カイロン ソチエタ ア レスポンサビリタ リミタータ | ナイセリア抗原 |
| SG152917A1 (en) | 1998-01-14 | 2009-06-29 | Chiron Srl | Neisseria meningitidis antigens |
| US6087128A (en) * | 1998-02-12 | 2000-07-11 | Ndsu Research Foundation | DNA encoding an avian E. coli iss |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| DK1093517T3 (da) | 1998-05-01 | 2008-06-23 | Novartis Vaccines & Diagnostic | Neisseria-meningitidis-antigener og præparater |
| NZ530640A (en) | 1999-04-30 | 2006-06-30 | Chiron S | Conserved neisserial antigens |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| EP2275553B1 (de) | 1999-10-29 | 2015-05-13 | Novartis Vaccines and Diagnostics S.r.l. | Antigenpeptide aus Neisseria |
| US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
| CA2871789C (en) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
| ES2330083T3 (es) | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| US7838287B2 (en) | 2001-01-25 | 2010-11-23 | Evolva Sa | Library of a collection of cells |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| CN100515494C (zh) | 2001-12-12 | 2009-07-22 | 启龙有限公司 | 抗沙眼衣原体的免疫 |
| EP1572720A4 (de) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden |
| ATE466875T1 (de) | 2002-11-15 | 2010-05-15 | Novartis Vaccines & Diagnostic | Unerwartete oberflächenproteine in neisseria meningitidis |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| CA2546319A1 (en) | 2003-11-21 | 2005-07-28 | Nps Allelix Corp. | Production of glucagon like peptide 2 and analogs |
| DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
| WO2005074546A2 (en) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| NZ582684A (en) | 2004-06-18 | 2011-05-27 | Ambrx Inc | Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| ATE541934T1 (de) | 2004-12-22 | 2012-02-15 | Ambrx Inc | Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon |
| CA2590590C (en) | 2004-12-22 | 2016-04-19 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| KR20070090023A (ko) | 2004-12-22 | 2007-09-04 | 암브룩스, 인코포레이티드 | 변형 인간 성장 호르몬 |
| SG175456A1 (en) | 2005-04-18 | 2011-11-28 | Novartis Vaccines & Diagnostic | Expressing hepatitis b virus surface antigen for vaccine preparation |
| WO2007021297A1 (en) | 2005-08-18 | 2007-02-22 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| ES2443529T3 (es) | 2005-09-01 | 2014-02-19 | Novartis Vaccines And Diagnostics Gmbh | Vacunación múltiple incluyendo meningococo del serogrupo C |
| EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| JP2009519942A (ja) | 2005-12-14 | 2009-05-21 | アンブルックス,インコーポレイテッド | 非天然アミノ酸およびポリペプチドを含んでいる組成物、それらに関する方法、ならびに、それらの使用 |
| PT2054431E (pt) | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| CN104193815A (zh) | 2006-09-08 | 2014-12-10 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
| ES2457527T3 (es) | 2006-09-08 | 2014-04-28 | Ambrx, Inc. | ARNt Supresor hibrido en células de vertebrados |
| KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
| WO2008139591A1 (ja) * | 2007-05-11 | 2008-11-20 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 組換えアプロチニンの生産方法 |
| EP2930182A1 (de) | 2007-11-20 | 2015-10-14 | Ambrx, Inc. | Modifizierte insulinpolypeptide und deren verwendungen |
| EP3103880A1 (de) | 2008-02-08 | 2016-12-14 | Ambrx, Inc. | Modifizierte leptinpolypeptide und deren verwendungen |
| AU2009274076C1 (en) | 2008-07-23 | 2014-04-17 | Ambrx, Inc. | Modified bovine G-CSF polypeptides and their uses |
| US9121024B2 (en) | 2008-09-26 | 2015-09-01 | Ambrx, Inc. | Non-natural amino acid replication-dependent microorganisms and vaccines |
| PL2342223T3 (pl) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
| BR112012015461A2 (pt) | 2009-12-21 | 2017-01-10 | Ambrx Inc | polipeptídeos de somatotropina boviina modificados e seus usos |
| WO2011087810A1 (en) | 2009-12-21 | 2011-07-21 | Ambrx, Inc. | Modified porcine somatotropin polypeptides and their uses |
| US9476082B2 (en) | 2010-05-20 | 2016-10-25 | Evolva Sa | Method of producing isoprenoid compounds in yeast |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| ES2742296T3 (es) | 2010-08-17 | 2020-02-13 | Ambrx Inc | Polipéptidos de relaxina modificados y sus usos |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| CN107108710B (zh) | 2014-10-24 | 2022-02-15 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| KR102670432B1 (ko) | 2017-02-08 | 2024-05-28 | 브리스톨-마이어스 스큅 컴퍼니 | 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| GR76274B (de) * | 1981-08-04 | 1984-08-04 | Univ California | |
| NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
| US4446235A (en) * | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
| CA1224735A (en) * | 1982-05-19 | 1987-07-28 | Cornelius P. Hollenberg | Cloning system for kluyveromyces species |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPH0716432B2 (ja) * | 1982-10-20 | 1995-03-01 | サントリー株式会社 | 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法 |
-
1983
- 1983-10-25 CA CA000439701A patent/CA1341302C/en not_active Expired - Lifetime
- 1983-10-25 CA CA000524802A patent/CA1341116C/en not_active Expired - Lifetime
- 1983-12-15 DK DK198305777A patent/DK173604B1/da not_active IP Right Cessation
-
1984
- 1984-01-06 AT AT84300091T patent/ATE55151T1/de not_active IP Right Cessation
- 1984-01-06 EP EP91114001A patent/EP0460716B2/de not_active Expired - Lifetime
- 1984-01-06 AT AT91114001T patent/ATE138975T1/de not_active IP Right Cessation
- 1984-01-06 EP EP84300091A patent/EP0120551B1/de not_active Expired - Lifetime
- 1984-01-06 EP EP89106868A patent/EP0329203B1/de not_active Expired - Lifetime
- 1984-01-06 DE DE3486431T patent/DE3486431T3/de not_active Expired - Lifetime
- 1984-01-06 DE DE8484300091T patent/DE3482844D1/de not_active Expired - Lifetime
- 1984-01-06 DE DE89106868T patent/DE3486206T2/de not_active Expired - Lifetime
- 1984-01-06 EP EP96200286A patent/EP0732403A1/de not_active Withdrawn
- 1984-01-06 AT AT89106868T patent/ATE93894T1/de not_active IP Right Cessation
- 1984-01-06 SG SG1996009565A patent/SG48422A1/en unknown
- 1984-02-16 JP JP59026172A patent/JPS59210888A/ja active Granted
-
1992
- 1992-06-17 JP JP4200091A patent/JPH0724594B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0120551A2 (de) | 1984-10-03 |
| EP0329203B1 (de) | 1993-09-01 |
| EP0329203A1 (de) | 1989-08-23 |
| DE3486206T2 (de) | 1994-02-03 |
| EP0120551B1 (de) | 1990-08-01 |
| DK173604B1 (da) | 2001-04-23 |
| DE3486431T3 (de) | 2000-05-04 |
| EP0460716A1 (de) | 1991-12-11 |
| EP0120551A3 (en) | 1986-05-14 |
| DE3486206D1 (de) | 1993-10-07 |
| EP0460716B1 (de) | 1996-06-05 |
| CA1341302C (en) | 2001-10-09 |
| DE3486431T2 (de) | 1996-10-10 |
| SG48422A1 (en) | 1998-04-17 |
| JPH0724594B2 (ja) | 1995-03-22 |
| EP0732403A1 (de) | 1996-09-18 |
| EP0460716B2 (de) | 1999-12-15 |
| ATE138975T1 (de) | 1996-06-15 |
| JPH05268984A (ja) | 1993-10-19 |
| CA1341116C (en) | 2000-10-17 |
| DK577783A (da) | 1984-08-23 |
| DE3486431D1 (de) | 1996-07-11 |
| JPH0515431B2 (de) | 1993-03-01 |
| DE3482844D1 (de) | 1990-09-06 |
| DK577783D0 (da) | 1983-12-15 |
| ATE93894T1 (de) | 1993-09-15 |
| JPS59210888A (ja) | 1984-11-29 |
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