ATE138975T1 - Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b - Google Patents
Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis bInfo
- Publication number
- ATE138975T1 ATE138975T1 AT91114001T AT91114001T ATE138975T1 AT E138975 T1 ATE138975 T1 AT E138975T1 AT 91114001 T AT91114001 T AT 91114001T AT 91114001 T AT91114001 T AT 91114001T AT E138975 T1 ATE138975 T1 AT E138975T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- surface antigen
- expression systems
- vectors containing
- yeast expression
- Prior art date
Links
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 239000013612 plasmid Substances 0.000 abstract 3
- 210000005253 yeast cell Anatomy 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Toys (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46858983A | 1983-02-22 | 1983-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE138975T1 true ATE138975T1 (de) | 1996-06-15 |
Family
ID=23860419
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91114001T ATE138975T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme für hefe mit vektoren, die einen gapdh-promotor enthalten und oberflächenantigensynthese von hepatitis b |
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
| AT84300091T ATE55151T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89106868T ATE93894T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit pyk-promotoren enthaltenden vektoren und synthese von fremdproteinen. |
| AT84300091T ATE55151T1 (de) | 1983-02-22 | 1984-01-06 | Expressionssysteme fuer hefe mit einen gapdh promotor enthaltenden vektoren und synthese von fremdproteinen. |
Country Status (7)
| Country | Link |
|---|---|
| EP (4) | EP0732403A1 (de) |
| JP (2) | JPS59210888A (de) |
| AT (3) | ATE138975T1 (de) |
| CA (2) | CA1341116C (de) |
| DE (3) | DE3486206T2 (de) |
| DK (1) | DK173604B1 (de) |
| SG (1) | SG48422A1 (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPS5936699A (ja) * | 1982-08-20 | 1984-02-28 | Chemo Sero Therapeut Res Inst | シヤトルベクタ− |
| JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
| US5422267A (en) * | 1984-05-22 | 1995-06-06 | Robert R. Yocum | Industrial yeast comprising an integrated glucoamylase gene |
| EP0173997A1 (de) * | 1984-09-06 | 1986-03-12 | Chiron Corporation | Katzenleukämievirusproteinimpfstoffe und ihre Herstellung |
| ATE88754T1 (de) * | 1984-12-06 | 1993-05-15 | Fina Research | Transformierte hefen die lysozym produzieren, fuer diese transformation zu verwendende plasmide und deren verwendung. |
| DE3677851D1 (de) * | 1985-08-05 | 1991-04-11 | Merck & Co Inc | Verfahren zur steigerung der produktion von rekombinantem protein in hefearten der gattung saccharomyces. |
| JPH0655155B2 (ja) * | 1985-10-03 | 1994-07-27 | 株式会社ミドリ十字 | 蛋白質の製造方法 |
| ES2028779T3 (es) * | 1985-10-03 | 1992-07-16 | Green Cross Corporation | Promotor de levadura y procedimiento para preparar proteina heterologa. |
| DK162900C (da) * | 1985-10-24 | 1992-05-11 | Danisco | Fremgangsmaade til ekspression af gener i gaer samt dna-fragment, rekombineret dna-segment og plasmider, hvor disse indgaar til brug ved udoevelse af fremgangsmaaden |
| US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
| JPS62236496A (ja) * | 1986-04-07 | 1987-10-16 | Green Cross Corp:The | HBsAgの製造方法 |
| US4839283A (en) * | 1986-12-30 | 1989-06-13 | Zymogenetics, Inc. | Method of expressing alpha-1-antitrypsin in yeast |
| DE10299017I2 (de) * | 1987-06-22 | 2005-05-25 | Medeva Holdings Bv | Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| AU644619B2 (en) | 1989-12-21 | 1993-12-16 | Advanced Technologies (Cambridge) Limited | Modification of plant metabolism |
| ZA909987B (en) * | 1990-01-29 | 1991-09-25 | Ciba Geigy | Novel fungal expression system |
| US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| JP4236698B2 (ja) | 1990-11-26 | 2009-03-11 | ジェネティックス インスティチュート,リミテッド ライアビリティ カンパニー | 宿主細胞でのpaceの発現およびその使用法 |
| EP0491077A1 (de) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten |
| EP1421951A3 (de) | 1993-05-12 | 2005-10-05 | Chiron Corporation | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
| US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
| US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| CA2241267C (en) | 1995-12-22 | 2012-12-04 | Gist-Brocades B.V. | Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods |
| DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| DE69941567D1 (de) | 1998-01-14 | 2009-12-03 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| US6087128A (en) | 1998-02-12 | 2000-07-11 | Ndsu Research Foundation | DNA encoding an avian E. coli iss |
| GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| DE69937419T2 (de) | 1998-05-01 | 2008-07-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria Meningitidis Antigene und Zusammenstellungen |
| US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275554E (pt) | 1999-10-29 | 2015-06-26 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
| EP2275129A3 (de) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Ergänzter Außenmembranvesikel-Impfstoff gegen Meningokokken |
| AU1412702A (en) | 2000-10-27 | 2002-05-06 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a and b |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| DK1356037T3 (da) | 2001-01-25 | 2011-06-27 | Evolva Ltd | Bibliotek med en samling af celler |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| EP1572720A4 (de) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden |
| PT2279746E (pt) | 2002-11-15 | 2013-12-09 | Novartis Vaccines & Diagnostic | Proteínas de superfície de neisseria meningitidis |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| CA2546319A1 (en) | 2003-11-21 | 2005-07-28 | Nps Allelix Corp. | Production of glucagon like peptide 2 and analogs |
| DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| MXPA06014684A (es) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novedosos polipeptidos de enlace antigeno y sus usos. |
| WO2006091231A2 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| US7736872B2 (en) | 2004-12-22 | 2010-06-15 | Ambrx, Inc. | Compositions of aminoacyl-TRNA synthetase and uses thereof |
| ATE542920T1 (de) | 2004-12-22 | 2012-02-15 | Ambrx Inc | Modifiziertes menschliches wachstumshormon |
| US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
| WO2006113528A2 (en) | 2005-04-18 | 2006-10-26 | Novartis Vaccines And Diagnostics Inc. | Expressing hepatitis b virus surface antigen for vaccine preparation |
| NZ565294A (en) | 2005-08-18 | 2010-06-25 | Ambrx Inc | Compositions of tRNA and uses thereof |
| WO2007026249A2 (en) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Multiple vaccination including serogroup c meningococcus |
| EP2339014B1 (de) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Verfahren und Zusammensetzungen mit nichtnatürlichen Aminosäuren |
| CN105384807A (zh) | 2005-12-14 | 2016-03-09 | Ambrx公司 | 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途 |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| CA2663083A1 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
| CN106190983B (zh) | 2006-09-08 | 2019-05-28 | Ambrx公司 | 用于脊椎动物细胞的杂合抑制tRNA |
| ES2385114T3 (es) | 2007-03-30 | 2012-07-18 | Ambrx, Inc. | Polipéptidos de FGF-21 modificados y sus usos |
| WO2008139591A1 (ja) * | 2007-05-11 | 2008-11-20 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 組換えアプロチニンの生産方法 |
| KR101656107B1 (ko) | 2007-11-20 | 2016-09-08 | 암브룩스, 인코포레이티드 | 변형된 인슐린 폴리펩티드 및 이의 용도 |
| MX2010008632A (es) | 2008-02-08 | 2010-08-30 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
| EP2318029B1 (de) | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modifizierte bovine g-csf-polypeptide und ihre verwendung |
| EP2342223B1 (de) | 2008-09-26 | 2017-04-26 | Ambrx, Inc. | Modifizierte tiererythropoietinpolypeptide und anwendungen davon |
| NZ592249A (en) | 2008-09-26 | 2013-03-28 | Ambrx Inc | Non-natural amino acid replication-dependent microorganisms and vaccines |
| SG181769A1 (en) | 2009-12-21 | 2012-07-30 | Ambrx Inc | Modified porcine somatotropin polypeptides and their uses |
| CN107674121A (zh) | 2009-12-21 | 2018-02-09 | Ambrx 公司 | 经过修饰的牛促生长素多肽和其用途 |
| US9476082B2 (en) | 2010-05-20 | 2016-10-25 | Evolva Sa | Method of producing isoprenoid compounds in yeast |
| EP3572091B1 (de) | 2010-08-17 | 2023-12-13 | Ambrx, Inc. | Modifizierte relaxinpolypeptide und deren verwendungen |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| SG11201702824UA (en) | 2014-10-24 | 2017-05-30 | Bristol Myers Squibb Co | Modified fgf-21 polypeptides and uses thereof |
| WO2018148419A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| GR76274B (de) * | 1981-08-04 | 1984-08-04 | Univ California | |
| NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
| US4446235A (en) * | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
| WO1983004050A1 (en) * | 1982-05-19 | 1983-11-24 | Gist-Brocades N.V. | Cloning system for kluyveromyces species |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPH0716432B2 (ja) * | 1982-10-20 | 1995-03-01 | サントリー株式会社 | 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法 |
-
1983
- 1983-10-25 CA CA000524802A patent/CA1341116C/en not_active Expired - Lifetime
- 1983-10-25 CA CA000439701A patent/CA1341302C/en not_active Expired - Lifetime
- 1983-12-15 DK DK198305777A patent/DK173604B1/da not_active IP Right Cessation
-
1984
- 1984-01-06 AT AT91114001T patent/ATE138975T1/de not_active IP Right Cessation
- 1984-01-06 AT AT89106868T patent/ATE93894T1/de not_active IP Right Cessation
- 1984-01-06 DE DE89106868T patent/DE3486206T2/de not_active Expired - Lifetime
- 1984-01-06 DE DE3486431T patent/DE3486431T3/de not_active Expired - Lifetime
- 1984-01-06 AT AT84300091T patent/ATE55151T1/de not_active IP Right Cessation
- 1984-01-06 EP EP96200286A patent/EP0732403A1/de not_active Withdrawn
- 1984-01-06 DE DE8484300091T patent/DE3482844D1/de not_active Expired - Lifetime
- 1984-01-06 EP EP84300091A patent/EP0120551B1/de not_active Expired - Lifetime
- 1984-01-06 SG SG1996009565A patent/SG48422A1/en unknown
- 1984-01-06 EP EP89106868A patent/EP0329203B1/de not_active Expired - Lifetime
- 1984-01-06 EP EP91114001A patent/EP0460716B2/de not_active Expired - Lifetime
- 1984-02-16 JP JP59026172A patent/JPS59210888A/ja active Granted
-
1992
- 1992-06-17 JP JP4200091A patent/JPH0724594B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE55151T1 (de) | 1990-08-15 |
| ATE93894T1 (de) | 1993-09-15 |
| JPH05268984A (ja) | 1993-10-19 |
| DK577783D0 (da) | 1983-12-15 |
| CA1341302C (en) | 2001-10-09 |
| DE3486431T2 (de) | 1996-10-10 |
| DK577783A (da) | 1984-08-23 |
| EP0329203B1 (de) | 1993-09-01 |
| DE3486431T3 (de) | 2000-05-04 |
| JPH0515431B2 (de) | 1993-03-01 |
| EP0460716B2 (de) | 1999-12-15 |
| JPH0724594B2 (ja) | 1995-03-22 |
| DE3486206D1 (de) | 1993-10-07 |
| CA1341116C (en) | 2000-10-17 |
| EP0732403A1 (de) | 1996-09-18 |
| EP0120551B1 (de) | 1990-08-01 |
| EP0120551A2 (de) | 1984-10-03 |
| EP0460716B1 (de) | 1996-06-05 |
| SG48422A1 (en) | 1998-04-17 |
| DK173604B1 (da) | 2001-04-23 |
| DE3486431D1 (de) | 1996-07-11 |
| DE3482844D1 (de) | 1990-09-06 |
| EP0120551A3 (en) | 1986-05-14 |
| EP0329203A1 (de) | 1989-08-23 |
| EP0460716A1 (de) | 1991-12-11 |
| DE3486206T2 (de) | 1994-02-03 |
| JPS59210888A (ja) | 1984-11-29 |
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