DE69227116D1 - Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen - Google Patents

Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Info

Publication number
DE69227116D1
DE69227116D1 DE69227116T DE69227116T DE69227116D1 DE 69227116 D1 DE69227116 D1 DE 69227116D1 DE 69227116 T DE69227116 T DE 69227116T DE 69227116 T DE69227116 T DE 69227116T DE 69227116 D1 DE69227116 D1 DE 69227116D1
Authority
DE
Germany
Prior art keywords
recombinant
highly stable
years
production
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69227116T
Other languages
English (en)
Other versions
DE69227116T2 (de
Inventor
Reinhard Fleer
Alain Fournier
Patrice Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of DE69227116D1 publication Critical patent/DE69227116D1/de
Application granted granted Critical
Publication of DE69227116T2 publication Critical patent/DE69227116T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69227116T 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen Expired - Lifetime DE69227116T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9109854A FR2679920A1 (fr) 1991-08-02 1991-08-02 Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.
PCT/FR1992/000769 WO1993003159A1 (fr) 1991-08-02 1992-08-03 Levures recombinantes hautement stables pour la production de proteines recombinantes

Publications (2)

Publication Number Publication Date
DE69227116D1 true DE69227116D1 (de) 1998-10-29
DE69227116T2 DE69227116T2 (de) 1999-03-25

Family

ID=9415866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227116T Expired - Lifetime DE69227116T2 (de) 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Country Status (13)

Country Link
US (2) US5593858A (de)
EP (2) EP0597035B1 (de)
JP (1) JPH06509234A (de)
AT (1) ATE171474T1 (de)
AU (1) AU2474892A (de)
CA (1) CA2113551A1 (de)
DE (1) DE69227116T2 (de)
DK (1) DK0597035T3 (de)
ES (1) ES2123006T3 (de)
FR (1) FR2679920A1 (de)
NZ (1) NZ243782A (de)
WO (1) WO1993003159A1 (de)
ZA (1) ZA925735B (de)

Families Citing this family (43)

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US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
WO2000051623A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
AU2003298816C1 (en) * 2002-12-02 2010-12-16 Amgen Fremont, Inc. Antibodies directed to Tumor Necrosis Factor and uses thereof
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
DE102008057451A1 (de) * 2008-11-14 2010-05-20 Martin-Luther-Universität Halle-Wittenberg Verfahren zur oralen Vakzinierung mittels rekombinanter Hefen
DK2367928T3 (en) 2008-12-24 2018-06-14 Dsm Ip Assets Bv XYLOSE ISOMERAS SIGNS AND THEIR USE IN THE FERMENTATION OF PENTOSET SUGAR
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
MX341905B (es) 2010-04-21 2016-09-06 Dsm Ip Assets B V * Celula apropiada para la fermentacion de una composicion de azucares mixtos.
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
WO2011150313A1 (en) 2010-05-28 2011-12-01 Codexis, Inc. Pentose fermentation by a recombinant microorganism
MX2013004127A (es) 2010-10-13 2013-05-20 Dsm Ip Assets Bv Polipeptidos con actividad permeasa.
WO2012067510A1 (en) 2010-11-18 2012-05-24 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from glycerol
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
EP2691517A4 (de) 2011-03-30 2015-04-22 Codexis Inc Pentosefermentierung durch einen rekombinanten mikroorganismus
MX2013012269A (es) 2011-04-22 2013-11-22 Dsm Ip Assets Bv Celula de levadura capaz de convertir azucares que incluyen arabinosa y xilosa.
WO2013003219A1 (en) 2011-06-30 2013-01-03 Codexis, Inc. Pentose fermentation by a recombinant microorganism
EP2546336A1 (de) 2011-07-11 2013-01-16 DSM IP Assets B.V. Hefestränge, die Uronsäure verbrauchen und Fermentierungsprodukte wie Ethanol herstellen
EP2554668A1 (de) 2011-08-04 2013-02-06 DSM IP Assets B.V. Zelle zur Fermentierung von Pentosezucker
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
BR112014012963B8 (pt) 2011-11-30 2022-04-26 Dsm Ip Assets Bv Processo para a produção de etanol e célula de levedura
IN2014DN11163A (de) 2012-07-19 2015-10-02 Dsm Ip Assets Bv
IN2015DN01042A (de) 2012-08-28 2015-06-26 Dsm Ip Assets Bv
WO2014033018A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
DK2909305T3 (en) 2012-10-16 2019-04-15 Dsm Ip Assets Bv CELLS WITH IMPROVED PENTOSE CONVERSION
AU2013348272A1 (en) 2012-11-20 2015-05-14 Shell Internationale Research Maatschappij B.V. Pentose fermentation by a recombinant microorganism
ES2802807T3 (es) 2013-02-04 2021-01-21 Dsm Ip Assets Bv Polipéptido degradador de carbohidratos y sus usos
WO2014202620A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202624A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202622A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202621A1 (en) 2013-06-20 2014-12-24 Dsm Ip Assets B.V. Carbohydrate degrading polypeptide and uses thereof
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US20180030482A1 (en) 2014-04-18 2018-02-01 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
DE102014210308A1 (de) 2014-05-30 2015-12-03 Wacker Chemie Ag Hefestamm zur Produktion von Carotinoiden
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
KR20180097745A (ko) 2015-12-30 2018-08-31 디에스엠 아이피 어셋츠 비.브이. 트라이아실글리세롤의 부분 효소적 가수 분해
KR20180098386A (ko) 2015-12-30 2018-09-03 디에스엠 아이피 어셋츠 비.브이. 트라이아실글리세롤의 부분 효소적 가수 분해
WO2017211930A1 (en) 2016-06-10 2017-12-14 Dsm Ip Assets B.V. Mutant lipase and use thereof
BR112019012949A2 (pt) 2016-12-21 2019-11-26 Globalyeast N V isomerases de xilose que conferem capacidade de fermentação eficiente de xilose em levedura
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CA3235083A1 (en) * 2021-10-15 2023-04-20 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating skin conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
FR2635115B1 (fr) * 1988-08-05 1992-04-03 Rhone Poulenc Sante Procede de preparation de la serum albumine humaine a partir d'une levure
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces

Also Published As

Publication number Publication date
FR2679920B1 (de) 1994-08-19
DK0597035T3 (da) 1999-02-15
WO1993003159A1 (fr) 1993-02-18
US5593858A (en) 1997-01-14
ES2123006T3 (es) 1999-01-01
EP0597035A1 (de) 1994-05-18
EP0597035B1 (de) 1998-09-23
CA2113551A1 (fr) 1993-02-18
FR2679920A1 (fr) 1993-02-05
NZ243782A (en) 1994-07-26
JPH06509234A (ja) 1994-10-20
EP0531181A1 (de) 1993-03-10
AU2474892A (en) 1993-03-02
ATE171474T1 (de) 1998-10-15
DE69227116T2 (de) 1999-03-25
USRE37767E1 (en) 2002-06-25
ZA925735B (en) 1993-04-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

R071 Expiry of right

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