DE69329540T2 - Verfahren zur Herstellung von Proteaseinhibitoren - Google Patents

Verfahren zur Herstellung von Proteaseinhibitoren

Info

Publication number
DE69329540T2
DE69329540T2 DE69329540T DE69329540T DE69329540T2 DE 69329540 T2 DE69329540 T2 DE 69329540T2 DE 69329540 T DE69329540 T DE 69329540T DE 69329540 T DE69329540 T DE 69329540T DE 69329540 T2 DE69329540 T2 DE 69329540T2
Authority
DE
Germany
Prior art keywords
preparation
protease inhibitors
production
novel
yeast strains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329540T
Other languages
English (en)
Other versions
DE69329540D1 (de
Inventor
Dr Heim
Dr Fuerst
Dr Hottiger
Dr Kuhla
Dr Pohlig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCP GEN-PHARMA AG ZUERICH CH
Original Assignee
UCP Gen Pharma AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCP Gen Pharma AG, Novartis AG filed Critical UCP Gen Pharma AG
Publication of DE69329540D1 publication Critical patent/DE69329540D1/de
Application granted granted Critical
Publication of DE69329540T2 publication Critical patent/DE69329540T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Indole Compounds (AREA)
DE69329540T 1992-09-04 1993-08-25 Verfahren zur Herstellung von Proteaseinhibitoren Expired - Lifetime DE69329540T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92810681 1992-09-04

Publications (2)

Publication Number Publication Date
DE69329540D1 DE69329540D1 (de) 2000-11-16
DE69329540T2 true DE69329540T2 (de) 2001-06-07

Family

ID=8211979

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329540T Expired - Lifetime DE69329540T2 (de) 1992-09-04 1993-08-25 Verfahren zur Herstellung von Proteaseinhibitoren

Country Status (20)

Country Link
US (1) US5726043A (de)
EP (2) EP0592358B1 (de)
JP (2) JP3949734B2 (de)
KR (1) KR940007180A (de)
AT (1) ATE196927T1 (de)
AU (1) AU675071B2 (de)
CA (1) CA2105425A1 (de)
DE (1) DE69329540T2 (de)
DK (1) DK0592358T3 (de)
ES (1) ES2152943T3 (de)
FI (1) FI933821A (de)
GR (1) GR3035201T3 (de)
HU (1) HU217094B (de)
IL (1) IL106897A0 (de)
MX (1) MX9305375A (de)
NO (1) NO933153L (de)
NZ (1) NZ248558A (de)
PT (1) PT592358E (de)
SG (1) SG49859A1 (de)
ZA (1) ZA936507B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990010008A (ko) * 1997-07-14 1999-02-05 구광시 효모용 프로모터 및 이 프로모터를 포함하는 효모용발현 벡터
US6358705B1 (en) 1998-07-16 2002-03-19 Novo Nordisk A/S Method of making proteins in transformed yeast cells
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
EP2044203B1 (de) 2006-07-14 2013-10-09 Novozymes, Inc. Verfahren für erhöhte genexpression in einer pilzzelle
CN102373216B (zh) * 2011-10-28 2013-06-05 元昊 一种含有医用水蛭素基因的重组真核汉逊酵母工程菌株的构建及重组水蛭素的生产工艺
EP3428282A1 (de) * 2017-07-11 2019-01-16 Alderys Ectoine-herstellende hefe

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4940661A (en) * 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
FR2593518B1 (fr) * 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
AU614959B2 (en) * 1987-05-07 1991-09-19 Commonwealth Scientific And Industrial Research Organisation Expression system
PT88556B (pt) * 1987-09-28 1992-11-30 Smithkline Biolog Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche

Also Published As

Publication number Publication date
SG49859A1 (en) 2002-03-19
NO933153L (no) 1994-03-07
GR3035201T3 (en) 2001-04-30
JPH06165691A (ja) 1994-06-14
HU9302503D0 (en) 1993-11-29
DK0592358T3 (da) 2001-02-05
ZA936507B (en) 1994-03-23
AU675071B2 (en) 1997-01-23
HUT67307A (en) 1995-03-28
EP0592358A2 (de) 1994-04-13
NO933153D0 (no) 1993-09-03
EP0592358A3 (en) 1994-09-28
IL106897A0 (en) 1993-12-28
MX9305375A (es) 1994-03-31
PT592358E (pt) 2001-03-30
DE69329540D1 (de) 2000-11-16
EP1031628A1 (de) 2000-08-30
CA2105425A1 (en) 1994-03-05
NZ248558A (en) 1995-04-27
KR940007180A (ko) 1994-04-26
JP3949734B2 (ja) 2007-07-25
EP0592358B1 (de) 2000-10-11
AU4499493A (en) 1994-03-10
FI933821A0 (fi) 1993-09-01
ATE196927T1 (de) 2000-10-15
ES2152943T3 (es) 2001-02-16
FI933821A (fi) 1994-03-05
US5726043A (en) 1998-03-10
HU217094B (hu) 1999-11-29
JP2004000288A (ja) 2004-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: UCP GEN-PHARMA AG, ZUERICH, CH

8328 Change in the person/name/address of the agent

Representative=s name: REITSTOETTER, KINZEBACH & PARTNER (GBR), 81679 MUENCHEN