ATE233249T1 - Verfahren zur herstellung von hiv protease inhibitoren - Google Patents
Verfahren zur herstellung von hiv protease inhibitorenInfo
- Publication number
- ATE233249T1 ATE233249T1 AT94923392T AT94923392T ATE233249T1 AT E233249 T1 ATE233249 T1 AT E233249T1 AT 94923392 T AT94923392 T AT 94923392T AT 94923392 T AT94923392 T AT 94923392T AT E233249 T1 ATE233249 T1 AT E233249T1
- Authority
- AT
- Austria
- Prior art keywords
- hiv protease
- protease inhibitors
- producing hiv
- intermediates
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9262793A | 1993-07-16 | 1993-07-16 | |
| PCT/US1994/007695 WO1995002583A1 (en) | 1993-07-16 | 1994-07-11 | Process for making hiv protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233249T1 true ATE233249T1 (de) | 2003-03-15 |
Family
ID=22234214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94923392T ATE233249T1 (de) | 1993-07-16 | 1994-07-11 | Verfahren zur herstellung von hiv protease inhibitoren |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US5637711A (de) |
| EP (2) | EP1310495A3 (de) |
| JP (1) | JPH09500131A (de) |
| KR (2) | KR100362800B1 (de) |
| CN (1) | CN1046715C (de) |
| AT (1) | ATE233249T1 (de) |
| AU (1) | AU679770B2 (de) |
| CA (1) | CA2167408C (de) |
| CZ (1) | CZ13096A3 (de) |
| DE (1) | DE69432176T2 (de) |
| ES (1) | ES2191683T3 (de) |
| FI (1) | FI960206A7 (de) |
| HU (1) | HUT76789A (de) |
| IL (1) | IL110255A (de) |
| NZ (1) | NZ269400A (de) |
| RO (3) | RO117175B1 (de) |
| RU (1) | RU2134263C1 (de) |
| UA (1) | UA45317C2 (de) |
| WO (1) | WO1995002583A1 (de) |
| ZA (1) | ZA945194B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE116640T1 (de) * | 1992-03-13 | 1995-01-15 | Bio Mega Boehringer Ingelheim | Substituierte pipecoline-säurederivate als hiv- protease-hemmer. |
| CN1046272C (zh) * | 1993-11-22 | 1999-11-10 | 广荣化学工业株式会社 | N-叔丁基-2-吡嗪羧基酰胺类的制造方法 |
| US5792869A (en) * | 1994-11-04 | 1998-08-11 | Yamakawa Chemical Industry Co., Ltd | Process for preparing optically active piperazine derivatives and Intermediates for preparation |
| EP1125930A1 (de) * | 1995-05-23 | 2001-08-22 | Lonza Ag | Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung |
| ES2164187T3 (es) * | 1995-05-23 | 2002-02-16 | Lonza Ag | Procedimiento para la preparacion de derivados de acidos 2-piperazina-carboxilicos opticamente activos. |
| CA2201218C (en) * | 1996-04-23 | 2004-09-28 | Rudolf Fuchs | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives |
| US5981759A (en) * | 1997-06-20 | 1999-11-09 | Merck & Co., Inc. | Process for indinavir intermediate |
| GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
| ES2295068T3 (es) | 1999-11-24 | 2008-04-16 | MERCK & CO., INC. | Gamma-hidroxi-2-(fluoroalquilaminocarbonil)-1-piperazinpentanamidas como inhibidores de la proteasa del vih. |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
| SU1273359A1 (ru) * | 1985-06-19 | 1986-11-30 | Институт Хлорорганического Синтеза Ан Азсср | 1-Пиперидино-4-(1-метил-2,2-гем.дихлорциклопропил)-2,3-эпоксибутан в качестве противозадирной и противоизносной присадки к смазочным маслам |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| US5075337A (en) * | 1989-07-26 | 1991-12-24 | G. D. Searle & Co. | Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| CA2072237A1 (en) * | 1991-07-02 | 1993-01-03 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral -amino epoxides |
| US5169952A (en) * | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
| DK0541168T3 (da) * | 1991-11-08 | 1998-05-11 | Merck & Co Inc | HIV-proteaseinhibitorer, som er egnede til behandling af AIDS |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CZ293953B6 (cs) * | 1993-07-16 | 2004-08-18 | Mercká@Áco@Źáinc | Způsob výroby meziproduktů pro výrobu inhibitorů HIV@proteázy a příslušné meziprodukty |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
-
1994
- 1994-07-08 IL IL11025594A patent/IL110255A/en not_active IP Right Cessation
- 1994-07-11 NZ NZ269400A patent/NZ269400A/en unknown
- 1994-07-11 RO ROA200100412A patent/RO117175B1/ro unknown
- 1994-07-11 KR KR1020017010994A patent/KR100362800B1/ko not_active Expired - Fee Related
- 1994-07-11 RO ROA200100414A patent/RO117176B1/ro unknown
- 1994-07-11 FI FI960206A patent/FI960206A7/fi not_active IP Right Cessation
- 1994-07-11 AT AT94923392T patent/ATE233249T1/de not_active IP Right Cessation
- 1994-07-11 AU AU73267/94A patent/AU679770B2/en not_active Ceased
- 1994-07-11 RU RU96105392A patent/RU2134263C1/ru not_active IP Right Cessation
- 1994-07-11 EP EP03075406A patent/EP1310495A3/de not_active Withdrawn
- 1994-07-11 UA UA96010308A patent/UA45317C2/uk unknown
- 1994-07-11 CZ CZ96130A patent/CZ13096A3/cs unknown
- 1994-07-11 KR KR1019960700292A patent/KR100325279B1/ko not_active Expired - Fee Related
- 1994-07-11 CA CA002167408A patent/CA2167408C/en not_active Expired - Fee Related
- 1994-07-11 EP EP94923392A patent/EP0708763B1/de not_active Expired - Lifetime
- 1994-07-11 RO RO96-00068A patent/RO117019B1/ro unknown
- 1994-07-11 WO PCT/US1994/007695 patent/WO1995002583A1/en not_active Ceased
- 1994-07-11 CN CN94193331A patent/CN1046715C/zh not_active Expired - Fee Related
- 1994-07-11 DE DE69432176T patent/DE69432176T2/de not_active Expired - Fee Related
- 1994-07-11 JP JP7504630A patent/JPH09500131A/ja active Pending
- 1994-07-11 ES ES94923392T patent/ES2191683T3/es not_active Expired - Lifetime
- 1994-07-11 HU HU9600078A patent/HUT76789A/hu unknown
- 1994-07-15 ZA ZA945194A patent/ZA945194B/xx unknown
-
1995
- 1995-06-07 US US08/474,626 patent/US5637711A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,926 patent/US5618939A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,800 patent/US5693803A/en not_active Expired - Fee Related
-
1997
- 1997-09-16 US US08/929,970 patent/US5861512A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |