DE69432176D1 - Verfahren zur herstellung von hiv protease inhibitoren - Google Patents
Verfahren zur herstellung von hiv protease inhibitorenInfo
- Publication number
- DE69432176D1 DE69432176D1 DE69432176T DE69432176T DE69432176D1 DE 69432176 D1 DE69432176 D1 DE 69432176D1 DE 69432176 T DE69432176 T DE 69432176T DE 69432176 T DE69432176 T DE 69432176T DE 69432176 D1 DE69432176 D1 DE 69432176D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv protease
- protease inhibitors
- producing hiv
- intermediates
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9262793A | 1993-07-16 | 1993-07-16 | |
| PCT/US1994/007695 WO1995002583A1 (en) | 1993-07-16 | 1994-07-11 | Process for making hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69432176D1 true DE69432176D1 (de) | 2003-04-03 |
| DE69432176T2 DE69432176T2 (de) | 2003-11-27 |
Family
ID=22234214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69432176T Expired - Fee Related DE69432176T2 (de) | 1993-07-16 | 1994-07-11 | Verfahren zur herstellung von hiv protease inhibitoren |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US5637711A (de) |
| EP (2) | EP1310495A3 (de) |
| JP (1) | JPH09500131A (de) |
| KR (2) | KR100362800B1 (de) |
| CN (1) | CN1046715C (de) |
| AT (1) | ATE233249T1 (de) |
| AU (1) | AU679770B2 (de) |
| CA (1) | CA2167408C (de) |
| CZ (1) | CZ13096A3 (de) |
| DE (1) | DE69432176T2 (de) |
| ES (1) | ES2191683T3 (de) |
| FI (1) | FI960206A (de) |
| HU (1) | HUT76789A (de) |
| IL (1) | IL110255A (de) |
| NZ (1) | NZ269400A (de) |
| RO (3) | RO117175B1 (de) |
| RU (1) | RU2134263C1 (de) |
| UA (1) | UA45317C2 (de) |
| WO (1) | WO1995002583A1 (de) |
| ZA (1) | ZA945194B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0560268T3 (da) * | 1992-03-13 | 1995-06-12 | Bio Mega Boehringer Ingelheim | Substituerede pipecolinsyrederivater som HIV-proteasehæmmere |
| WO1995014675A1 (fr) * | 1993-11-22 | 1995-06-01 | Koei Chemical Co., Ltd. | PROCEDE DE PRODUCTION DE N-tert-BUTYL-2-PYRAZINECARBOXAMIDE ET DE N-tert-BUTYL-2-PIPERAZINECARBOXAMIDE |
| ATE163642T1 (de) * | 1994-11-04 | 1998-03-15 | Yamakawa Chemical Ind | Verfahren zur herstellung von optisch aktiven piperazinderivaten und zwischenprodukten für ihre herstellung |
| ES2164187T3 (es) * | 1995-05-23 | 2002-02-16 | Lonza Ag | Procedimiento para la preparacion de derivados de acidos 2-piperazina-carboxilicos opticamente activos. |
| EP1125930A1 (de) * | 1995-05-23 | 2001-08-22 | Lonza Ag | Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung |
| CA2201218C (en) * | 1996-04-23 | 2004-09-28 | Rudolf Fuchs | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives |
| US5981759A (en) * | 1997-06-20 | 1999-11-09 | Merck & Co., Inc. | Process for indinavir intermediate |
| GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
| AU777824B2 (en) | 1999-11-24 | 2004-11-04 | Merck Sharp & Dohme Corp. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1- piperazinepentanamides as HIV protease inhibitors |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| US5075337A (en) * | 1989-07-26 | 1991-12-24 | G. D. Searle & Co. | Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| CA2072237A1 (en) * | 1991-07-02 | 1993-01-03 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral -amino epoxides |
| US5169952A (en) * | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
| CA2195027C (en) * | 1991-11-08 | 2000-01-11 | Joseph P. Vacca | Hiv protease inhibitors useful for the treatment of aids |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| HUT74583A (en) * | 1993-07-16 | 1997-01-28 | Merck & Co Inc | Process for making indeno[1,2-d]oxazole hiv protease inhibitors |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
-
1994
- 1994-07-08 IL IL11025594A patent/IL110255A/en not_active IP Right Cessation
- 1994-07-11 KR KR1020017010994A patent/KR100362800B1/ko not_active IP Right Cessation
- 1994-07-11 JP JP7504630A patent/JPH09500131A/ja active Pending
- 1994-07-11 DE DE69432176T patent/DE69432176T2/de not_active Expired - Fee Related
- 1994-07-11 CN CN94193331A patent/CN1046715C/zh not_active Expired - Fee Related
- 1994-07-11 CA CA002167408A patent/CA2167408C/en not_active Expired - Fee Related
- 1994-07-11 AU AU73267/94A patent/AU679770B2/en not_active Ceased
- 1994-07-11 NZ NZ269400A patent/NZ269400A/en unknown
- 1994-07-11 RU RU96105392A patent/RU2134263C1/ru not_active IP Right Cessation
- 1994-07-11 AT AT94923392T patent/ATE233249T1/de not_active IP Right Cessation
- 1994-07-11 EP EP03075406A patent/EP1310495A3/de not_active Withdrawn
- 1994-07-11 KR KR1019960700292A patent/KR100325279B1/ko not_active IP Right Cessation
- 1994-07-11 RO ROA200100412A patent/RO117175B1/ro unknown
- 1994-07-11 ES ES94923392T patent/ES2191683T3/es not_active Expired - Lifetime
- 1994-07-11 RO RO96-00068A patent/RO117019B1/ro unknown
- 1994-07-11 HU HU9600078A patent/HUT76789A/hu unknown
- 1994-07-11 UA UA96010308A patent/UA45317C2/uk unknown
- 1994-07-11 EP EP94923392A patent/EP0708763B1/de not_active Expired - Lifetime
- 1994-07-11 WO PCT/US1994/007695 patent/WO1995002583A1/en not_active Application Discontinuation
- 1994-07-11 CZ CZ96130A patent/CZ13096A3/cs unknown
- 1994-07-11 RO ROA200100414A patent/RO117176B1/ro unknown
- 1994-07-15 ZA ZA945194A patent/ZA945194B/xx unknown
-
1995
- 1995-06-07 US US08/474,626 patent/US5637711A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,800 patent/US5693803A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,926 patent/US5618939A/en not_active Expired - Fee Related
-
1996
- 1996-01-16 FI FI960206A patent/FI960206A/fi not_active IP Right Cessation
-
1997
- 1997-09-16 US US08/929,970 patent/US5861512A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI950650A0 (fi) | Retrovirusproteaasi-inhibiittoreina käyttökelpoisia hydroksietyyliaminosulfoniamideja | |
| DK0554400T3 (da) | Retrovirale proteaseinhibitorer | |
| DE69432176D1 (de) | Verfahren zur herstellung von hiv protease inhibitoren | |
| DK0503453T3 (da) | Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde | |
| ATE171164T1 (de) | Verfahren zur herstellung von heterocyclischen tertiäraminen | |
| ES2113975T3 (es) | Azida de tri-alquil superior-estaño y su uso. | |
| DE69426979T2 (de) | Verfahren zur herstellung von hiv-proteasehemmern | |
| ATE210662T1 (de) | Verfahren zur herstellung von epoxiden | |
| DK0662475T3 (da) | Fremgangsmåde til fremstilling af 2-perfluoralkyl-3-oxazolin-5-on. | |
| DK0675880T3 (da) | Quinolondisulfider som mellemprodukter | |
| FI944967A (fi) | Menetelmiä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten ja niiden välituotteiden valmistamiseksi | |
| EP0670305A4 (de) | Verfahren zur herstellung von 3-amino-2-hydroxy-1-propanol-derivaten. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |