ES2123006T3 - Levaduras recombinantes altamente estables para la produccion de proteinas recombinantes. - Google Patents

Levaduras recombinantes altamente estables para la produccion de proteinas recombinantes.

Info

Publication number
ES2123006T3
ES2123006T3 ES92918054T ES92918054T ES2123006T3 ES 2123006 T3 ES2123006 T3 ES 2123006T3 ES 92918054 T ES92918054 T ES 92918054T ES 92918054 T ES92918054 T ES 92918054T ES 2123006 T3 ES2123006 T3 ES 2123006T3
Authority
ES
Spain
Prior art keywords
highly stable
production
recombinant
yeast
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918054T
Other languages
English (en)
Inventor
Reinhard Fleer
Alain Fournier
Patrice Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2123006T3 publication Critical patent/ES2123006T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS LEVADURAS RECOMBINANTES MUY ESTABLES EN MEDIO COMPLEJO, CARACTERIZADAS PORQUE SE TRATA DE LEVADURAS DEL GENERO KLUYVEROMYCES, EN LAS QUE UN GEN ESENCIAL ES NO FUNCIONAL, CONTENIENDO UN VECTOR QUE LLEVA UNA COPIA FUNCIONAL DEL CITADO GEN.
ES92918054T 1991-08-02 1992-08-03 Levaduras recombinantes altamente estables para la produccion de proteinas recombinantes. Expired - Lifetime ES2123006T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109854A FR2679920A1 (fr) 1991-08-02 1991-08-02 Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
ES2123006T3 true ES2123006T3 (es) 1999-01-01

Family

ID=9415866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918054T Expired - Lifetime ES2123006T3 (es) 1991-08-02 1992-08-03 Levaduras recombinantes altamente estables para la produccion de proteinas recombinantes.

Country Status (13)

Country Link
US (2) US5593858A (es)
EP (2) EP0597035B1 (es)
JP (1) JPH06509234A (es)
AT (1) ATE171474T1 (es)
AU (1) AU2474892A (es)
CA (1) CA2113551A1 (es)
DE (1) DE69227116T2 (es)
DK (1) DK0597035T3 (es)
ES (1) ES2123006T3 (es)
FR (1) FR2679920A1 (es)
NZ (1) NZ243782A (es)
WO (1) WO1993003159A1 (es)
ZA (1) ZA925735B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
AU3731400A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US6489308B1 (en) 1999-03-05 2002-12-03 Trustees Of University Of Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
ES2347239T3 (es) * 2002-12-02 2010-10-27 Amgen Fremont Inc. Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos.
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
DE102008057451A1 (de) * 2008-11-14 2010-05-20 Martin-Luther-Universität Halle-Wittenberg Verfahren zur oralen Vakzinierung mittels rekombinanter Hefen
JP5821132B2 (ja) 2008-12-24 2015-11-24 ディーエスエム アイピー アセッツ ビー．ブイ． キシロース異性化酵素遺伝子及びペントース糖の発酵におけるそれらの使用
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
MX2012012171A (es) 2010-04-21 2013-02-27 Dsm Ip Assets Bv Proceso para la produccion de celulas que tienen la capacidad de convertir arabinosa.
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
EP2576804B1 (en) 2010-05-28 2016-12-14 Codexis, Inc. Pentose fermentation by a recombinant microorganism
AU2011315572B2 (en) 2010-10-13 2015-09-03 Dsm Ip Assets B.V. Polypeptides with permease activity
PL2663645T3 (pl) 2010-11-18 2015-05-29 Dsm Ip Assets Bv Szczepy drożdży zmodyfikowane do wytwarzania etanolu z glicerolu
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
WO2012135110A1 (en) 2011-03-30 2012-10-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
US20140141473A1 (en) 2011-04-22 2014-05-22 Dsm Ip Assets B.V. Yeast cell capable of converting sugars including arabinose and xlose
US8778652B2 (en) 2011-06-30 2014-07-15 Codexis, Inc. Pentose fermentation by a recombinant microorganism
EP2546336A1 (en) 2011-07-11 2013-01-16 DSM IP Assets B.V. Yeast strains that consume uronic acids and produce fermentation products such as ethanol
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
EP2554668A1 (en) 2011-08-04 2013-02-06 DSM IP Assets B.V. A pentose sugar fermenting cell
MY169074A (en) 2011-11-30 2019-02-13 Dsm Ip Assets Bv Yeast strains engineered to produce ethanol from acetic acid and glycerol
DK3327112T3 (en) 2012-07-19 2020-05-04 Dsm Ip Assets Bv Agse-deficient stamme
WO2014033018A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
IN2015DN01042A (es) 2012-08-28 2015-06-26 Dsm Ip Assets Bv
MY171218A (en) 2012-10-16 2019-10-02 Dsm Ip Assets Bv Cells with improved pentose conversion
BR112015011466A8 (pt) 2012-11-20 2018-05-02 Codexis Inc Célula hospedeira fúngica recombinante, constructo de ácido nucleico recombinante, sequência de polpeptídeo isolada, e, métodos para produzir um produto de fermentação e pelo menos um produto final a partir de pelo menos um substrato celulósico
EP3447136B1 (en) 2013-02-04 2020-05-13 DSM IP Assets B.V. Carbohydrate degrading polypeptide and uses thereof
WO2014202624A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202622A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202620A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202621A1 (en) 2013-06-20 2014-12-24 Dsm Ip Assets B.V. Carbohydrate degrading polypeptide and uses thereof
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US20180030482A1 (en) 2014-04-18 2018-02-01 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
DE102014210308A1 (de) 2014-05-30 2015-12-03 Wacker Chemie Ag Hefestamm zur Produktion von Carotinoiden
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
JP2019500041A (ja) 2015-12-30 2019-01-10 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． トリアシルグリセロールの部分的酵素加水分解
CA3009871A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
US10829748B2 (en) 2016-06-10 2020-11-10 Dsm Ip Assets B.V. Mutant lipase and use thereof
WO2018115251A1 (en) 2016-12-21 2018-06-28 Vib Vzw Xylose isomerases that confer efficient xylose fermentation capability to yeast
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
EP4415737A2 (en) * 2021-10-15 2024-08-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating skin conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2635115B1 (fr) * 1988-08-05 1992-04-03 Rhone Poulenc Sante Procede de preparation de la serum albumine humaine a partir d'une levure

Also Published As

Publication number Publication date
DE69227116D1 (de) 1998-10-29
EP0531181A1 (fr) 1993-03-10
DK0597035T3 (da) 1999-02-15
NZ243782A (en) 1994-07-26
ATE171474T1 (de) 1998-10-15
EP0597035A1 (fr) 1994-05-18
FR2679920B1 (es) 1994-08-19
WO1993003159A1 (fr) 1993-02-18
EP0597035B1 (fr) 1998-09-23
AU2474892A (en) 1993-03-02
JPH06509234A (ja) 1994-10-20
US5593858A (en) 1997-01-14
USRE37767E1 (en) 2002-06-25
CA2113551A1 (fr) 1993-02-18
DE69227116T2 (de) 1999-03-25
FR2679920A1 (fr) 1993-02-05
ZA925735B (en) 1993-04-28

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