ATE546456T1 - Triheterocyclische verbindungen, zusammensetzungen, und verfahren zur behandlung von krebs - Google Patents
Triheterocyclische verbindungen, zusammensetzungen, und verfahren zur behandlung von krebsInfo
- Publication number
- ATE546456T1 ATE546456T1 AT04735171T AT04735171T ATE546456T1 AT E546456 T1 ATE546456 T1 AT E546456T1 AT 04735171 T AT04735171 T AT 04735171T AT 04735171 T AT04735171 T AT 04735171T AT E546456 T1 ATE546456 T1 AT E546456T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- treating cancer
- triheterocyclic
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000005170 neoplastic cell Anatomy 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47474103P | 2003-05-30 | 2003-05-30 | |
PCT/CA2004/000793 WO2004106328A1 (en) | 2003-05-30 | 2004-05-28 | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE546456T1 true ATE546456T1 (de) | 2012-03-15 |
Family
ID=33490730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04735171T ATE546456T1 (de) | 2003-05-30 | 2004-05-28 | Triheterocyclische verbindungen, zusammensetzungen, und verfahren zur behandlung von krebs |
Country Status (24)
Country | Link |
---|---|
US (4) | US7425553B2 (de) |
EP (1) | EP1644363B1 (de) |
JP (1) | JP4980715B2 (de) |
KR (1) | KR101168441B1 (de) |
CN (1) | CN1832939B (de) |
AT (1) | ATE546456T1 (de) |
AU (1) | AU2004242928B2 (de) |
BR (1) | BRPI0410870A (de) |
CA (1) | CA2527583C (de) |
CY (1) | CY1113038T1 (de) |
DK (1) | DK1644363T3 (de) |
ES (1) | ES2382377T3 (de) |
HK (1) | HK1082737A1 (de) |
HR (1) | HRP20120379T1 (de) |
IL (1) | IL172189A (de) |
MX (1) | MXPA05012799A (de) |
NO (1) | NO333006B1 (de) |
NZ (1) | NZ543897A (de) |
PL (1) | PL1644363T3 (de) |
PT (1) | PT1644363E (de) |
RU (1) | RU2360913C2 (de) |
SI (1) | SI1644363T1 (de) |
WO (1) | WO2004106328A1 (de) |
ZA (1) | ZA200509718B (de) |
Families Citing this family (127)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060035945A1 (en) * | 2003-05-30 | 2006-02-16 | Giorgio Attardo | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
ES2382377T3 (es) | 2003-05-30 | 2012-06-07 | Gemin X Pharmaceuticals Canada Inc. | Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer |
EP1746888A2 (de) * | 2004-05-13 | 2007-01-31 | Viropharma Incorporated | Verbindungen, zusammensetzungen und verfahren zur behandlung und prophylaxe von hepatitis-c-virusinfektionen und relevanten erkrankungen |
EP1836165B1 (de) | 2004-12-28 | 2014-02-12 | Gemin X Pharmaceuticals Canada Inc. | Dipyrrolverbindungen, zusammensetzungen und verfahren zur behandlung von krebs oder viruskrankheiten |
WO2006089397A1 (en) * | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
US7994360B2 (en) * | 2005-05-16 | 2011-08-09 | Xtl Biopharmaceuticals Ltd. | Benzofuran compounds |
US20080051400A1 (en) * | 2006-07-06 | 2008-02-28 | Gemin X Biotechnologies Inc. | Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound |
CN101611002A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 用于治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
CN101611025A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 5,6-环化的吲哚衍生物及其使用方法 |
CN101631773A (zh) * | 2006-12-22 | 2010-01-20 | 先灵公司 | 治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
WO2008121814A1 (en) | 2007-03-28 | 2008-10-09 | Ats Medical, Inc. | Method for inhibiting platelet interaction with biomaterial surfaces |
ES2447543T3 (es) | 2007-08-29 | 2014-03-12 | Merck Sharp & Dohme Corp. | Derivados de indol sustituidos y métodos de utilización de los mismos |
MX2010002318A (es) | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. |
AU2008295476B2 (en) | 2007-08-29 | 2013-08-01 | Merck Sharp & Dohme Corp. | 2, 3-Substituted Indole Derivatives for treating viral infections |
CN101130539B (zh) * | 2007-09-26 | 2012-05-30 | 浙江大学 | 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途 |
US20090098118A1 (en) | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
US8765757B2 (en) | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
JP5580814B2 (ja) | 2008-06-13 | 2014-08-27 | メルク・シャープ・アンド・ドーム・コーポレーション | 3環式インドール誘導体およびその使用方法 |
WO2012136851A1 (en) * | 2011-04-08 | 2012-10-11 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for inhibiting influenza viruses replication |
WO2013053045A1 (en) * | 2011-10-12 | 2013-04-18 | Beta Pharma Canada Inc. | Heterocyclic molecules as apoptosis inducers |
US20150313906A1 (en) * | 2012-12-19 | 2015-11-05 | Glaxosmithkline Llc | Combination |
CN103044311B (zh) * | 2012-12-26 | 2015-04-22 | 山东大学 | 一种多取代吲哚类化合物及其制备方法和应用 |
US20160022708A1 (en) * | 2013-03-14 | 2016-01-28 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
AU2015222865B2 (en) | 2014-02-28 | 2019-06-20 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
US11331328B2 (en) | 2014-05-05 | 2022-05-17 | Bioventures, Llc | Compositions and methods for inhibiting antiapoptotic Bcl-2 proteins as anti-aging agents |
US10071087B2 (en) | 2014-07-22 | 2018-09-11 | Bioventures, Llc | Compositions and methods for selectively depleting senescent cells |
US11311512B2 (en) | 2014-08-12 | 2022-04-26 | Monash University | Lymph directing prodrugs |
ES2930585T3 (es) | 2015-02-27 | 2022-12-19 | Nimbus Lakshmi Inc | Inhibidores de TYK2 y usos de los mismos |
EP3331546B1 (de) | 2015-08-03 | 2023-10-04 | Biokine Therapeutics Ltd. | Cxcr4-antagonist zur behandlung von krebs |
JP6802263B2 (ja) | 2015-09-02 | 2020-12-16 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
CA2997106C (en) | 2015-09-08 | 2024-06-04 | Monash University | Lymph directing prodrugs |
WO2017044720A1 (en) | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
US20170087125A1 (en) * | 2015-09-30 | 2017-03-30 | Augusta University Research Institute, Inc. | Flavonoid compositions for the treatment of cancer |
CA3234750A1 (en) | 2015-10-23 | 2017-04-27 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
US11370792B2 (en) | 2015-12-14 | 2022-06-28 | Raze Therapeutics, Inc. | Caffeine inhibitors of MTHFD2 and uses thereof |
DK3426243T3 (da) | 2016-03-09 | 2021-07-19 | Raze Therapeutics Inc | 3-phosphoglyceratdehydrogenase-inhibitorer og anvendelser deraf |
ES2949357T3 (es) | 2016-03-09 | 2023-09-28 | Raze Therapeutics Inc | Inhibidores de 3-fosfoglicerato deshidrogenasa y usos de los mismos |
KR20230042756A (ko) | 2016-03-15 | 2023-03-29 | 오리존 지노믹스 에스.에이. | 고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물 |
AU2017233886B2 (en) | 2016-03-15 | 2022-10-20 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for the treatment of hematological malignancies |
WO2017177216A1 (en) * | 2016-04-08 | 2017-10-12 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Prodigiosin analogs |
JP2019510785A (ja) | 2016-04-08 | 2019-04-18 | エックス4 ファーマシューティカルズ, インコーポレイテッド | 癌を処置する方法 |
US10870640B2 (en) | 2016-04-08 | 2020-12-22 | Institute For Cancer Research | Prodigiosin analogs and methods of use |
AU2017254687B2 (en) | 2016-04-21 | 2021-09-30 | Bioventures, Llc. | Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof |
CN116554168A (zh) | 2016-06-21 | 2023-08-08 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
TWI763722B (zh) | 2016-10-14 | 2022-05-11 | 美商林伯士拉克許米公司 | Tyk2抑制劑及其用途 |
JP7082120B2 (ja) | 2016-10-21 | 2022-06-07 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
US10414727B2 (en) | 2016-11-08 | 2019-09-17 | Navitor Pharmaceuticals, Inc. | Phenyl amino piperidine mTORC inhibitors and uses thereof |
CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
US11091451B2 (en) | 2016-12-05 | 2021-08-17 | Raze Therapeutics, Inc. | SHMT inhibitors and uses thereof |
EP3565638B8 (de) | 2017-01-06 | 2024-04-10 | BicycleRD Limited | Bizyklische konjugat zur behandlung von krebs |
JP7160824B2 (ja) | 2017-03-08 | 2022-10-25 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤、使用およびその製造のための方法 |
EP3375778A1 (de) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidinderivate |
EP3375784A1 (de) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridonderivate |
WO2018191146A1 (en) | 2017-04-10 | 2018-10-18 | Navitor Pharmaceuticals, Inc. | Heteroaryl rheb inhibitors and uses thereof |
AU2018258355B2 (en) | 2017-04-26 | 2024-05-30 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
CN111194317A (zh) | 2017-07-28 | 2020-05-22 | 林伯士拉克许米公司 | Tyk2抑制剂与其用途 |
WO2019025811A1 (en) | 2017-08-04 | 2019-02-07 | Bicycletx Limited | SPECIFIC BICYCLIC PEPTIDE LIGANDS OF CD137 |
US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
AU2018324037A1 (en) | 2017-08-29 | 2020-04-16 | Monash University | Lymphatic system-directing lipid prodrugs |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
EP3684365A4 (de) | 2017-09-22 | 2021-09-08 | Kymera Therapeutics, Inc. | Proteinabbaumittel und verwendungen davon |
US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
EP3727362A4 (de) | 2017-12-19 | 2021-10-06 | PureTech LYT, Inc. | Lipidprodrugs von mycophenolsäure und ihre verwendungen |
US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | IRAK joints and used in them |
US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2019144117A1 (en) | 2018-01-22 | 2019-07-25 | Bioventures, Llc | Bcl-2 proteins degraders for cancer treatment |
AU2019211485A1 (en) | 2018-01-29 | 2020-08-06 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
IL312674A (en) | 2018-01-29 | 2024-07-01 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
EP3759086A1 (de) | 2018-02-27 | 2021-01-06 | Artax Biopharma Inc. | Chromenderivate als inhibitoren der tcr-nck-interaktion |
JP7479293B2 (ja) | 2018-04-24 | 2024-05-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | プテリジノン化合物およびその使用 |
HRP20220710T1 (hr) | 2018-04-24 | 2022-07-22 | Merck Patent Gmbh | Antiproliferacijski spojevi i njihova uporaba |
WO2019221755A1 (en) | 2018-05-18 | 2019-11-21 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
FI3813946T3 (fi) | 2018-06-15 | 2024-06-25 | Janssen Pharmaceutica Nv | Rapamysiinianalogeja ja niiden käyttötapoja |
US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
EP3846793B1 (de) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e-inhibitoren und verwendungen davon |
AU2019360941A1 (en) | 2018-10-15 | 2021-04-29 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
MX2021004710A (es) | 2018-10-24 | 2021-06-04 | Navitor Pharm Inc | Compuestos polimorficos y usos de los mismos. |
EP3886904A4 (de) | 2018-11-30 | 2022-07-13 | Kymera Therapeutics, Inc. | Irak-degrader und verwendungen davon |
JP7530360B2 (ja) | 2018-11-30 | 2024-08-07 | 武田薬品工業株式会社 | Tyk2阻害剤およびその使用 |
EP3670659A1 (de) | 2018-12-20 | 2020-06-24 | Abivax | Biomarker und verwendungen bei der behandlung von viralen infektionen, entzündlichen oder krebserkrankungen |
EP3914357A4 (de) | 2019-01-23 | 2022-10-12 | Nimbus Lakshmi, Inc. | Tyk2-inhibitoren und verwendungen davon |
AU2020253990A1 (en) | 2019-04-02 | 2021-10-28 | Bicycletx Limited | Bicycle toxin conjugates and uses thereof |
TW202106676A (zh) | 2019-04-05 | 2021-02-16 | 美商凱麥拉醫療公司 | Stat降解劑及其用途 |
US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
CA3150492A1 (en) | 2019-09-11 | 2021-03-18 | Donna L. Romero | USP30 INHIBITORS AND USES THEREOF |
CN114945366A (zh) | 2019-09-13 | 2022-08-26 | 林伯士萨顿公司 | Hpk1拮抗剂和其用途 |
MX2022005215A (es) | 2019-11-01 | 2022-06-08 | Navitor Pharm Inc | Metodos de tratamiento que usan un modulador de la diana mecanicista del complejo 1 de rapamicina (mtorc1). |
KR20220128345A (ko) | 2019-12-05 | 2022-09-20 | 아나쿠리아 테라퓨틱스, 인코포레이티드 | 라파마이신 유사체 및 이의 용도 |
WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
EP4076520A4 (de) | 2019-12-17 | 2024-03-27 | Kymera Therapeutics, Inc. | Irak-degrader und verwendungen davon |
MX2022007841A (es) | 2019-12-23 | 2022-07-19 | Kymera Therapeutics Inc | Degradadores del regulador dependiente de actina asociado a la matriz relacionado con el complejo switch/sacarosa no fermentable de la subfamilia a de la cromatina (smarca)y usos de los mismos. |
WO2021159021A1 (en) | 2020-02-05 | 2021-08-12 | Puretech Lyt, Inc. | Lipid prodrugs of neurosteroids |
AR121506A1 (es) | 2020-03-03 | 2022-06-08 | Pic Therapeutics Inc | Inhibidores del eif4e y sus usos |
JP2023518423A (ja) | 2020-03-19 | 2023-05-01 | カイメラ セラピューティクス, インコーポレイテッド | Mdm2分解剤およびそれらの使用 |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
AU2021316053A1 (en) | 2020-07-30 | 2023-03-02 | Kymera Therapeutics, Inc. | Methods of treating mutant lymphomas |
WO2022038158A1 (en) | 2020-08-17 | 2022-02-24 | Bicycletx Limited | Bicycle conjugates specific for nectin-4 and uses thereof |
CA3200814A1 (en) | 2020-12-02 | 2022-06-09 | Alfredo C. Castro | Tead inhibitors and uses thereof |
WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
US20240041884A1 (en) | 2020-12-07 | 2024-02-08 | Cellestia Biotech Ag | Pharmaceutical Combinations for Treating Cancer |
EP4008324A1 (de) | 2020-12-07 | 2022-06-08 | Cellestia Biotech AG | Kombinationen, die einen inhibitor eines anti-apoptotischen proteins, wie bcl-2, bcl-xl, bclw oder mcl-1, und einen notch-signalweg-inhibitor zur behandlung von krebs umfassen |
JP2024505571A (ja) | 2021-02-02 | 2024-02-06 | リミナル・バイオサイエンシーズ・リミテッド | Gpr84アンタゴニストおよびその使用 |
CA3206499A1 (en) | 2021-02-02 | 2022-08-11 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
MX2023009178A (es) | 2021-02-15 | 2023-08-21 | Kymera Therapeutics Inc | Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos. |
EP4301756A1 (de) | 2021-03-05 | 2024-01-10 | Nimbus Saturn, Inc. | Hpk1-antagonisten und verwendungen davon |
WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
CA3215081A1 (en) | 2021-04-16 | 2022-10-20 | Alfredo C. Castro | Mek inhibitors and uses thereof |
MX2023013173A (es) | 2021-05-07 | 2023-11-30 | Kymera Therapeutics Inc | Degradadores de cinasa 2 dependiente de ciclina (cdk2) y sus usos. |
US20230150997A1 (en) | 2021-08-25 | 2023-05-18 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
EP4392421A1 (de) | 2021-08-25 | 2024-07-03 | PIC Therapeutics, Inc. | Eif4e-hemmer und verwendungen davon |
CA3241668A1 (en) | 2021-12-09 | 2023-06-15 | University Of Florida Research Foundation, Incorporated | Bcl-xl/bcl-2 dual degraders for treatment of cancers |
WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
US12091411B2 (en) | 2022-01-31 | 2024-09-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
TW202416950A (zh) | 2022-08-02 | 2024-05-01 | 英商利米那生物科技有限公司 | 雜芳基甲醯胺及相關gpr84拮抗劑及其用途 |
TW202415650A (zh) | 2022-08-02 | 2024-04-16 | 英商利米那生物科技有限公司 | 芳基-三唑基及相關gpr84拮抗劑及其用途 |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
WO2024112894A1 (en) | 2022-11-22 | 2024-05-30 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6134403A (ja) | 1984-07-26 | 1986-02-18 | Nec Corp | 光干渉計 |
US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
US5248782A (en) * | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
US5338854A (en) * | 1991-02-13 | 1994-08-16 | Molecular Probes, Inc. | Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes |
JPH0586374A (ja) | 1991-09-26 | 1993-04-06 | Teikoku Sekiyu Kk | 炭水化物を可燃性のガスに分解する方法 |
GB9326284D0 (en) * | 1993-12-23 | 1994-02-23 | Erba Carlo Spa | Pyrrolydenemethyl-derivatives and process for their preparation |
JP3357462B2 (ja) | 1994-06-21 | 2002-12-16 | 協和油化株式会社 | 立体障害性ニトロキシル化合物の製造方法 |
US5885574A (en) * | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
EP0756200B1 (de) | 1995-07-26 | 1999-11-10 | Konica Corporation | Farbphotographisches lichtempfindliches Silberhalogenidmaterial |
DE69713485T2 (de) * | 1996-02-01 | 2003-01-30 | Chugai Seiyaku K.K., Tokio/Tokyo | Medikamente für die Behandlung oder Vorbeugung von Thrombocytopenie |
JP3949196B2 (ja) | 1996-10-23 | 2007-07-25 | 赤穂化成株式会社 | 免疫抑制剤 |
JP3949198B2 (ja) | 1996-10-23 | 2007-07-25 | 赤穂化成株式会社 | V−ATPase 脱共役 H+ ポンプ阻害剤 |
GB9705035D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
US6162520A (en) | 1997-09-17 | 2000-12-19 | Mitsui Chemicals, Inc. | Optical recording medium and dipyrromethene metal chelate compound for use therein |
GB9726130D0 (en) * | 1997-12-10 | 1998-02-11 | Pharmacia & Upjohn Spa | 2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I |
AU736026B2 (en) | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
ATE355303T1 (de) | 1998-10-23 | 2006-03-15 | Amgen Inc | Methoden und zusammensetzungen zur prävention und behandlung der anämie |
AU2164300A (en) | 1998-12-04 | 2000-06-26 | N.V. Organon | Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin |
JP2000275435A (ja) | 1999-03-25 | 2000-10-06 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
JP4085574B2 (ja) | 2000-01-06 | 2008-05-14 | 東レ株式会社 | 発光素子 |
US6407244B1 (en) * | 2000-01-26 | 2002-06-18 | Gemin X Biotechnologies Inc. | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases |
JP2001223081A (ja) | 2000-02-08 | 2001-08-17 | Toray Ind Inc | 発光素子 |
JP2001223082A (ja) | 2000-02-08 | 2001-08-17 | Toray Ind Inc | 発光素子 |
JP4058881B2 (ja) | 2000-04-12 | 2008-03-12 | 東レ株式会社 | 発光素子 |
JP2001307884A (ja) | 2000-04-26 | 2001-11-02 | Toray Ind Inc | 発光素子 |
JP2001330729A (ja) | 2000-05-23 | 2001-11-30 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
JP2001330730A (ja) | 2000-05-23 | 2001-11-30 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
US7087224B2 (en) * | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
US6452014B1 (en) * | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
DE60223571T2 (de) * | 2001-07-18 | 2008-07-24 | Gemin X Pharmaceuticals Canada. Inc., Montreal | Verbindungen vom pyrroltyp, zusammensetzungen und verfahren zur behandlung von krebs, zur behandlung von virenerkrankungen und zur unterdrückung der immunreaktion |
RU2352568C9 (ru) | 2002-08-09 | 2009-06-27 | Астразенека Аб | [1,2,4]оксадиазолы (варианты), способ их получения, фармацевтическая композиция и способ ингибирования активации метаботропных глютаматных рецепторов-5 |
ES2382377T3 (es) | 2003-05-30 | 2012-06-07 | Gemin X Pharmaceuticals Canada Inc. | Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer |
US20060035945A1 (en) * | 2003-05-30 | 2006-02-16 | Giorgio Attardo | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
WO2005117908A2 (en) | 2004-05-28 | 2005-12-15 | Gemin X Biotechnologies, Inc. | Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases |
WO2006089397A1 (en) | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
US20080051400A1 (en) | 2006-07-06 | 2008-02-28 | Gemin X Biotechnologies Inc. | Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound |
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